Reviewed, UniProtKB/Swiss-Prot P29906 (BIRA_PARDE)

Names and origin

Protein names

Recommended name:
    Biotin--[acetyl-CoA-carboxylase] synthetase
    EC=6.3.4.15
Alternative name(s):
    Biotin--protein ligase

Gene names

Name:

birA

Organism

Paracoccus denitrificans

Taxonomic identifier

266 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Paracoccus

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins.
Catalytic activity	ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)].
Sequence similarities	Belongs to the biotin--protein ligase family.

Ontologies

Keywords
Ligand	ATP-binding Biotin Nucleotide-binding
Molecular function	Ligase
Gene Ontology (GO)
Biological process	protein modification process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW biotin-[acetyl-CoA-carboxylase] ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 240	240	Biotin--[acetyl-CoA-carboxylase] synthetase		PRO_0000064934

Sequences

	Sequence		Length	Mass (Da)
	P29906-1 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 9FD9184ACC1221D8	FASTA	240	24,407
	10 20 30 40 50 60 MLARTDSTNA EALKLAPGLS GSAWVLAREQ FAGRGRRGRE WVMPAGNFAG TLVLRPQGGA 70 80 90 100 110 120 LAAAQLSFVA ALALYDALGL ACGPAARLAI KWPNDVLLNG GKVAGILLES SGSGPGVQAV 130 140 150 160 170 180 AVGIGVNLAG APDAGAVEPG ATPPVSVQGE TGHAVDPEEF LDLLAPAFAR WQAQLDTYGF 190 200 210 220 230 240 APIRNAWLAR AARLGEPIIA RTGTAESHGI FEGIDDSGAL ILRGPAGRQV IPAAEVFFGG

References

[1]

"DNA sequencing of the seven remaining structural genes of the gene cluster encoding the energy-transducing NADH-quinone oxidoreductase of Paracoccus denitrificans." Xu X., Matsuno-Yagi A., Yagi T. Biochemistry 32:968-981(1993) [PubMed: 8422400] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 13543 / NRRL B-3784.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L02354 Genomic DNA. Translation: AAA25601.1.
PIR	B47751.
3D structure databases
SMR	P29906. Positions 2-238.
ModBase	Search...
Enzyme and pathway databases
BRENDA	6.3.4.15. 59.
Family and domain databases
InterPro	IPR004408. Biotin_CoA_COase_ligase. IPR003142. BPL_C. IPR004143. BPL_LipA_LipB. [Graphical view]
PANTHER	PTHR12835. BirA_ligase. 1 hit.
Pfam	PF02237. BPL_C. 1 hit. PF03099. BPL_LipA_LipB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00121. birA_ligase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

BIRA_PARDE

Accession

Primary (citable) accession number: P29906

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	February 9, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)