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Protein

Methanol dehydrogenase [cytochrome c] subunit 2

Gene

moxI

Organism
Paracoccus denitrificans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of primary alcohols including methanol.By similarity

Catalytic activityi

A primary alcohol + 2 cytochrome c(L) = an aldehyde + 2 reduced cytochrome c(L) + 2 H+.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Methanol utilization

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-3924.

Names & Taxonomyi

Protein namesi
Recommended name:
Methanol dehydrogenase [cytochrome c] subunit 2 (EC:1.1.2.7)
Alternative name(s):
MDH small subunit beta
MDH-associated peptide
MEDH
Gene namesi
Name:moxI
OrganismiParacoccus denitrificans
Taxonomic identifieri266 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 10383Methanol dehydrogenase [cytochrome c] subunit 2PRO_0000025571Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 321 Publication

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Heterotetramer composed of 2 alpha and 2 beta subunits.1 Publication

Protein-protein interaction databases

STRINGi318586.Pden_2996.

Structurei

Secondary structure

1
103
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi54 – 574Combined sources
Helixi59 – 8123Combined sources
Helixi88 – 903Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LRWX-ray2.50B/D21-103[»]
ProteinModelPortaliP29898.
SMRiP29898. Positions 21-103.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29898.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105P0N. Bacteria.
ENOG4111V4Q. LUCA.

Family and domain databases

Gene3Di4.10.160.10. 1 hit.
InterProiIPR003420. Meth_DH_bsu.
[Graphical view]
PfamiPF02315. MDH. 1 hit.
[Graphical view]
PIRSFiPIRSF029163. Meth_DH_beta. 1 hit.
SUPFAMiSSF48666. SSF48666. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRILTLTVA ALALGTPALA YDGTNCKAPG NCWEPKPDYP AKVEGSKYDP
60 70 80 90 100
QHDPAELSKQ GESLAVMDAR NEWRVWNMKK TGKFEYDVKK IDGYDETKAP

PAE
Length:103
Mass (Da):11,458
Last modified:April 1, 1993 - v1
Checksum:i7AF8E6BD3B8731AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57684 Genomic DNA. Translation: AAA25584.1.
PIRiC41377.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57684 Genomic DNA. Translation: AAA25584.1.
PIRiC41377.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LRWX-ray2.50B/D21-103[»]
ProteinModelPortaliP29898.
SMRiP29898. Positions 21-103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi318586.Pden_2996.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105P0N. Bacteria.
ENOG4111V4Q. LUCA.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-3924.

Miscellaneous databases

EvolutionaryTraceiP29898.

Family and domain databases

Gene3Di4.10.160.10. 1 hit.
InterProiIPR003420. Meth_DH_bsu.
[Graphical view]
PfamiPF02315. MDH. 1 hit.
[Graphical view]
PIRSFiPIRSF029163. Meth_DH_beta. 1 hit.
SUPFAMiSSF48666. SSF48666. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Isolation and characterization of the moxJ, moxG, moxI, and moxR genes of Paracoccus denitrificans: inactivation of moxJ, moxG, and moxR and the resultant effect on methylotrophic growth."
    van Spanning R.J.M., Wansell C.W., de Boer T., Hazelaar M.J., Anazawa H., Harms N., Oltmann L.F., Stouthamer A.H.
    J. Bacteriol. 173:6948-6961(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "X-ray structure of methanol dehydrogenase from Paracoccus denitrificans and molecular modeling of its interactions with cytochrome c-551i."
    Xia Z.-X., Dai W.W., He Y.-N., White S.A., Mathews F.S., Davidson V.L.
    J. Biol. Inorg. Chem. 8:843-854(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 21-103 IN COMPLEX WITH ALPHA SUBUNIT, SUBUNIT, DISULFIDE BOND.

Entry informationi

Entry nameiDHM2_PARDE
AccessioniPrimary (citable) accession number: P29898
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: December 9, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.