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P29875 (COX2_LASSP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COII
Encoded onMitochondrion
OrganismLasius sp.
Taxonomic identifier7483 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeFormicinaeLasius

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 226226Cytochrome c oxidase subunit 2
PRO_0000183614

Regions

Topological domain1 – 2525Mitochondrial intermembrane Potential
Transmembrane26 – 4722Helical; Potential
Topological domain48 – 6114Mitochondrial matrix Potential
Transmembrane62 – 8120Helical; Potential
Topological domain82 – 226145Mitochondrial intermembrane Potential

Sites

Metal binding1601Copper A Probable
Metal binding1951Copper A Probable
Metal binding1991Copper A Probable
Metal binding2031Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P29875 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 7231F2A6348CA8FF

FASTA22626,782
        10         20         30         40         50         60 
MNTWLLSLQN SNSPTYDMMI FFHDFTMMIL IFITLLILFI MFTMINNNLI NRFLLQGHFI 

        70         80         90        100        110        120 
ELIWTITPMI ILILIAIPSF KILYLTDEMF NNKITIKSVG HQWYWSYEYS DFLNIEFDSF 

       130        140        150        160        170        180 
MIPSNQLNPN EFRLLDTDNR CILPFNYPIR ILTTSMDVIH SWTVPSLGIK MDSTPGRLNQ 

       190        200        210        220 
SLLYMYRPGL YFGQCSEICG TNHSFMPIVI ESTNFSYFKN WLKSFL 

« Hide

References

[1]"Evolution of the mitochondrial cytochrome oxidase II gene among 10 orders of insects."
Liu H., Beckenbach A.T.
Mol. Phylogenet. Evol. 1:41-52(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M83960 Genomic DNA. Translation: AAA31885.1.

3D structure databases

ProteinModelPortalP29875.
SMRP29875. Positions 3-226.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_LASSP
AccessionPrimary (citable) accession number: P29875
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families