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P29875

- COX2_LASSP

UniProt

P29875 - COX2_LASSP

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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Lasius sp.
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi160 – 1601Copper ACurated
Metal bindingi195 – 1951Copper ACurated
Metal bindingi199 – 1991Copper ACurated
Metal bindingi203 – 2031Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COII
Encoded oniMitochondrion
OrganismiLasius sp.
Taxonomic identifieri7483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeFormicinaeLasius

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Cytochrome c oxidase subunit 2PRO_0000183614Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP29875.
SMRiP29875. Positions 3-226.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini48 – 6114Mitochondrial matrixSequence AnalysisAdd
BLAST
Topological domaini82 – 226145Mitochondrial intermembraneSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4722HelicalSequence AnalysisAdd
BLAST
Transmembranei62 – 8120HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29875-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTWLLSLQN SNSPTYDMMI FFHDFTMMIL IFITLLILFI MFTMINNNLI
60 70 80 90 100
NRFLLQGHFI ELIWTITPMI ILILIAIPSF KILYLTDEMF NNKITIKSVG
110 120 130 140 150
HQWYWSYEYS DFLNIEFDSF MIPSNQLNPN EFRLLDTDNR CILPFNYPIR
160 170 180 190 200
ILTTSMDVIH SWTVPSLGIK MDSTPGRLNQ SLLYMYRPGL YFGQCSEICG
210 220
TNHSFMPIVI ESTNFSYFKN WLKSFL
Length:226
Mass (Da):26,782
Last modified:April 1, 1993 - v1
Checksum:i7231F2A6348CA8FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M83960 Genomic DNA. Translation: AAA31885.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M83960 Genomic DNA. Translation: AAA31885.1 .

3D structure databases

ProteinModelPortali P29875.
SMRi P29875. Positions 3-226.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of the mitochondrial cytochrome oxidase II gene among 10 orders of insects."
    Liu H., Beckenbach A.T.
    Mol. Phylogenet. Evol. 1:41-52(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX2_LASSP
AccessioniPrimary (citable) accession number: P29875
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3