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P29873 (COX2_EXERO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COII
Encoded onMitochondrion
OrganismExeristes roborator (Parasitoid wasp)
Taxonomic identifier7412 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaIchneumonoideaIchneumonidaePimplinaeEphialtiniExeristes

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 224224Cytochrome c oxidase subunit 2
PRO_0000183595

Regions

Topological domain1 – 2626Mitochondrial intermembrane Potential
Transmembrane27 – 4822Helical; Potential
Topological domain49 – 6214Mitochondrial matrix Potential
Transmembrane63 – 8220Helical; Potential
Topological domain83 – 224142Mitochondrial intermembrane Potential

Sites

Metal binding1591Copper A Probable
Metal binding1941Copper A Probable
Metal binding1981Copper A Probable
Metal binding2021Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P29873 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 13DB12E072650247

FASTA22426,165
        10         20         30         40         50         60 
MSTWSMMNLQ DANSPMMEQL IFFHDHTLMI LLLITITIIY IISSIIMNNL TNKFIMQNQT 

        70         80         90        100        110        120 
IEIIWTIIPM IILIYMAIPS LKILYLNDEI NNPLMTIKSI GHQWYWSYEY SDFKNIDFNS 

       130        140        150        160        170        180 
FMINSKNLNH FRLLDVDNRM IIPMNNQIRM LINSADVIHS WTVPSLGVKI DSVPGRINQT 

       190        200        210        220 
LMMINRPGIY FGQCSEICGM NHSFMPIVIE STSNNNFISW LKSL 

« Hide

References

[1]"Evolution of the mitochondrial cytochrome oxidase II gene among 10 orders of insects."
Liu H., Beckenbach A.T.
Mol. Phylogenet. Evol. 1:41-52(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M83969 Genomic DNA. Translation: AAA31743.1.
PIRF45170.

3D structure databases

ProteinModelPortalP29873.
SMRP29873. Positions 1-224.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_EXERO
AccessionPrimary (citable) accession number: P29873
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families