P29849 (PHSM_STRPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Maltodextrin phosphorylase
EC=2.4.1.1

Gene names

Name:	malP
Ordered Locus Names:	SP_2106

Organism

Streptococcus pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

1313 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	752 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Catalytic activity	(1,4-alpha-D-glucosyl)(n) + phosphate = (1,4-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.
Cofactor	Pyridoxal phosphate.
Sequence similarities	Belongs to the glycogen phosphorylase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	Pyridoxal phosphate
Molecular function	Glycosyltransferase Transferase
Technical term	Allosteric enzyme Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphorylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 752	752	Maltodextrin phosphorylase		PRO_0000188562
Amino acid modifications
	Modified residue	603	1	N6-(pyridoxal phosphate)lysine By similarity
Experimental info
	Sequence conflict	82 – 89	8	GKDLIEVE → ATPTTKGT in AAA26924. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P29849 [UniParc]. Last modified September 26, 2001. Version 2. Checksum: BC3A15893EC4C4C0	FASTA	752	85,202
	10 20 30 40 50 60 MLSLQEFVQN RYNKTIAECS NEELYLALLN YSKLASSQKP VNTGKKKVYY ISAEFLIGKL 70 80 90 100 110 120 LSNNLINLGL YDDVKKELAA AGKDLIEVEE VELEPSLGNG GLGRLAACFI DSIATLGLNG 130 140 150 160 170 180 DGVGLNYHFG LFQQVLKNNQ QETIPNAWLT EQNWLVRSSR SYQVPFADFT LTSTLYDIDV 190 200 210 220 230 240 TGYETATKNR LRLFDLDSVD SSIIKDGINF DKTDIARNLT LFLYPDDSDR QGELLRIFQQ 250 260 270 280 290 300 YFMVSNGAQL IIDEAIEKGS NLHDLADYAV VQINDTHPSM VIPELIRLLT ARGIDLDEAI 310 320 330 340 350 360 SIVRSMTAYT NHTILAEALE KWPLEFLQEV VPHLVPIIEE LDRRVKAEYK DPAVQIIDES 370 380 390 400 410 420 GRVHMAHMDI HYGYSVNGVA ALHTEILKNS ELKAFYDLYP EKFNNKTNGI TFRRWLMHAN 430 440 450 460 470 480 PRLSHYLDEI LGDGWHHEAD ELEKLLSYED KAVVKEKLES IKAHNKRKLA RHLKEHQGVE 490 500 510 520 530 540 INPNSIFDIQ IKRLHEYKRQ QMNALYVIHK YLDIKAGNIP ARPITIFFGG KAAPAYTIAQ 550 560 570 580 590 600 DIIHLILCMS EVIANDPAVA PHLQVVMVEN YNVTAASFLI PACDISEQIS LASKEASGTG 610 620 630 640 650 660 NMKFMLNGAL TLGTMDGANV EIAELVGEEN IYIFGEDSET VIDLYAKAAY KSSEFYAREA 670 680 690 700 710 720 IKPLVDFIVS DAVLAAGNKE RLERFYNELI NKDWFMTLLD LEDYIKVKEQ MLADYEDRDA 730 740 750 WLDKVIVNIS KAGFFSSDRT IAQYNEDIWH LN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae." Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. , Lewis M.R., Radune D., Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M. Science 293:498-506(2001) [PubMed: 11463916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-334 / TIGR4.
[2]	"Identification of base mismatches recognized by the heteroduplex-DNA-repair system of Streptococcus pneumoniae." Lacks S.A., Dunn J.J., Greenberg B. Cell 31:327-336(1982) [PubMed: 6297760] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-89.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005672 Genomic DNA. Translation: AAK76165.1. J01796 Genomic DNA. Translation: AAA26924.1.
PIR	D95246.
RefSeq	NP_346525.1. NC_003028.3.
3D structure databases
ProteinModelPortal	P29849.
ModBase	Search...
Protein family/group databases
CAZy	GT35. Glycosyltransferase Family 35.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000025879; EBSTRP00000024971; EBSTRG00000025879.
GeneID	930239.
GenomeReviews	Gene locus SP_2106 in contig AE005672_GR.
KEGG	spn:SP_2106.
PATRIC	19708799. VBIStrPne105772_2190.
TIGR	SP_2106.
Phylogenomic databases
GeneTree	EBGT00050000027705.
HOGENOM	HBG444050.
OMA	ANQELAD.
ProtClustDB	CLSK2518147.
Enzyme and pathway databases
BioCyc	SPNE170187-1:SP_2106-MONOMER.
Family and domain databases
InterPro	IPR011833. Glycg_phsphrylas. IPR000811. Glyco_trans_35. [Graphical view]
KO	K00688.
PANTHER	PTHR11468. Glyco_trans_35. 1 hit.
Pfam	PF00343. Phosphorylase. 1 hit. [Graphical view]
PIRSF	PIRSF000460. Pprylas_GlgP. 1 hit.
TIGRFAMs	TIGR02093. P_ylase. 1 hit.
PROSITE	PS00102. PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHSM_STRPN

Accession

Primary (citable) accession number: P29849

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	September 26, 2001
Last modified:	January 25, 2012
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program