P29847 (CYSE_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine acetyltransferase
Short name=SAT
EC=2.3.1.30

Gene names

Name:	cysE
Ordered Locus Names:	STM3699

Organism

Salmonella typhimurium

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine.
Enzyme regulation	Sensitive to feedback inhibition by L-cysteine.
Pathway	Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.
Subunit structure	Homohexamer. Dimer of a homotrimer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Cysteine biosynthesis
Cellular component	Cytoplasm
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cysteine biosynthetic process from serine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	serine O-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Serine acetyltransferase		PRO_0000068672

Sequences

	Sequence		Length	Mass (Da)
	P29847 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 6A5736E656FBD25B	FASTA	273	29,291
	10 20 30 40 50 60 MPCEELEIVW KNIKAEARAL ADCEPMLASF YHATLLKHEN LGSALSYMLA NKLASPIMPA 70 80 90 100 110 120 IAIREVVEEA YAADPEMIAS AACDIQAVRT RDPAVDKYST PLLYLKGFHA LQAYRIGHWL 130 140 150 160 170 180 WNKGRRALAI FLQNQVSVSF QVDIHPAAKI GRGIMLDHAT GIVVGETAVI EDDVSILQSV 190 200 210 220 230 240 TLGGTGKTSG DRHPKIREGV MIGAGAKILG NIEVGRGAKI GAGSVVLQPV PPHTTAAGVP 250 260 270 ARIVGKPGSD KPSMDMDQHF NGIHHTFEYG DGI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Sivaprasad A.V., Kuczek E.S., Bawden C.S., Rogers G.E. Submitted (MAY-1991) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[2]	"Cysteine biosynthesis in transgenic animals." Rogers G.E. Patent number GB2227243, 25-JUL-1990 Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X59594 Genomic DNA. Translation: CAA42163.1. A00198 Unassigned DNA. Translation: CAA00039.1. AE006468 Genomic DNA. Translation: AAL22558.1.
PIR	S29568.
RefSeq	NP_462599.1. NC_003197.1.
3D structure databases
ProteinModelPortal	P29847.
SMR	P29847. Positions 1-262.
ModBase	Search...
Proteomic databases
PRIDE	P29847.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1255223.
GenomeReviews	Gene locus STM3699 in contig AE006468_GR.
KEGG	stm:STM3699.
PATRIC	32386231. VBISalEnt20916_3912.
Phylogenomic databases
HOGENOM	HBG754554.
OMA	VPPCKTV.
ProtClustDB	PRK11132.
Enzyme and pathway databases
BioCyc	STYP99287:STM3699-MONOMER.
BRENDA	2.3.1.30. 5542.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR010493. Ser_AcTrfase_N. IPR005881. Ser_O-AcTrfase. IPR011004. Trimer_LpxA-like. [Graphical view]
KO	K00640.
Pfam	PF00132. Hexapep. 1 hit. PF06426. SATase_N. 1 hit. [Graphical view]
SMART	SM00971. SATase_N. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01172. CysE. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYSE_SALTY

Accession

Primary (citable) accession number: P29847

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program