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Protein

Heat shock 70 kDa protein cognate 5

Gene

Hsc70-5

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • autophagy of mitochondrion Source: FlyBase
  • mitochondrion morphogenesis Source: FlyBase
  • positive regulation of mitochondrial membrane potential Source: FlyBase
  • protein folding Source: FlyBase

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein cognate 5
Gene namesi
Name:Hsc70-5
Synonyms:Hsc5
ORF Names:CG8542
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0001220 Hsc70-5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000783421 – 686Heat shock 70 kDa protein cognate 5Add BLAST686

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP29845
PRIDEiP29845

PTM databases

iPTMnetiP29845

Expressioni

Developmental stagei

Heat shock cognate proteins are expressed constitutively during normal development.

Gene expression databases

BgeeiFBgn0001220
ExpressionAtlasiP29845 baseline and differential
GenevisibleiP29845 DM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi62333, 23 interactors
IntActiP29845, 1 interactor
STRINGi7227.FBpp0086694

Structurei

3D structure databases

ProteinModelPortaliP29845
SMRiP29845
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0102 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00910000144045
InParanoidiP29845
KOiK04043
OMAiISIKRHM
OrthoDBiEOG091G0386
PhylomeDBiP29845

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
HAMAPiMF_00332 DnaK, 1 hit
InterProiView protein in InterPro
IPR012725 Chaperone_DnaK
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
TIGRFAMsiTIGR02350 prok_dnaK, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

P29845-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVPKFLPR LARQAGVVPS HMSGASSMFR NLPGASNGIS SQLRYKSGEV
60 70 80 90 100
KGAVIGIDLG TTNSCLAVME GKQAKVIENA EGARTTPSHV AFTKDGERLV
110 120 130 140 150
GMPAKRQAVT NSANTFYATK RLIGRRFDDP EVKKDITNLS YKVVKASNGD
160 170 180 190 200
AWVSSTDGKV YSPSQIGAFI LMKMKETAEA YLNTPVKNAV VTVPAYFNDS
210 220 230 240 250
QRQATKDAGQ IAGLNVLRVI NEPTAAALAY GMDKTEDKII AVYDLGGGTF
260 270 280 290 300
DISILEIQKG VFEVKSTNGD TLLGGEDFDN HIVNFLVAEF KKDSGIDIRK
310 320 330 340 350
DNIAMQRLKE AAEKAKCELS SSQQTDINLP YLTMDAAGPQ HMNLKLTRSK
360 370 380 390 400
LESLVGDLIK RTIQPCQKAL SDAEVSKSEI GEVLLVGGMT RMPKVQSTVQ
410 420 430 440 450
ELFGRQPSRS VNPDEAVAVG AAVQGGVLAG DVTDVLLLDV TPLSLGIETL
460 470 480 490 500
GGVFTRLISR NTTIPTKKSQ VFSTASDGQT QVEIKVHQGE REMANDNKLL
510 520 530 540 550
GSFTLVGIPP APRGVPQIEV VFDIDANGIV HVSAKDKGTG KEQQIVIQSS
560 570 580 590 600
GGLSKDEIEN MIKKAEEYAT ADKQKRELIE IVNQGESIVH DTETKMEEFK
610 620 630 640 650
SQLPAEECEK LKKEIADLRT LLANKETADL EEVRKATSSL QQSSLKLFEL
660 670 680
AYKKMSAERE SNAGAGSSDS SSSSDTSGEA KKEEKN
Length:686
Mass (Da):74,066
Last modified:November 23, 2004 - v2
Checksum:i61A0C0EDA8E74B9E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti288A → V in AAA28628 (PubMed:8514184).Curated1
Sequence conflicti661S → T in AAA28628 (PubMed:8514184).Curated1
Sequence conflicti678 – 686GEAKKEEKN → ASQEGREELN (PubMed:8514184).Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01502 mRNA Translation: AAA28628.1
AE013599 Genomic DNA Translation: AAF58270.1
AY118844 mRNA Translation: AAM50704.1
PIRiJN0667
RefSeqiNP_001286414.1, NM_001299485.1
NP_523741.2, NM_079017.2
UniGeneiDm.7248

Genome annotation databases

EnsemblMetazoaiFBtr0087568; FBpp0086694; FBgn0001220
FBtr0339969; FBpp0308990; FBgn0001220
GeneIDi36583
KEGGidme:Dmel_CG8542

Similar proteinsi

Entry informationi

Entry nameiHSP7E_DROME
AccessioniPrimary (citable) accession number: P29845
Secondary accession number(s): Q9V6Z7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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