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P29844

- HSP7C_DROME

UniProt

P29844 - HSP7C_DROME

Protein

Heat shock 70 kDa protein cognate 3

Gene

Hsc70-3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. centrosome duplication Source: FlyBase
    2. RNA interference Source: FlyBase
    3. sleep Source: FlyBase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_93794. ATF6-alpha activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat shock 70 kDa protein cognate 3
    Alternative name(s):
    78 kDa glucose-regulated protein homolog
    GRP 78
    Heat shock protein cognate 72
    Gene namesi
    Name:Hsc70-3
    Synonyms:Hsc3
    ORF Names:CG4147
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0001218. Hsc70-3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: FlyBase
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    3. extracellular space Source: FlyBase
    4. lipid particle Source: FlyBase
    5. microtubule associated complex Source: FlyBase

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 656638Heat shock 70 kDa protein cognate 3PRO_0000013546Add
    BLAST

    Proteomic databases

    PaxDbiP29844.
    PRIDEiP29844.

    Expressioni

    Gene expression databases

    BgeeiP29844.

    Interactioni

    Protein-protein interaction databases

    BioGridi58539. 17 interactions.
    DIPiDIP-19696N.
    IntActiP29844. 3 interactions.
    MINTiMINT-1330773.

    Structurei

    3D structure databases

    ProteinModelPortaliP29844.
    SMRiP29844. Positions 27-598.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi653 – 6564Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0443.
    GeneTreeiENSGT00750000117237.
    InParanoidiP29844.
    KOiK09490.
    OMAiDKRAVQK.
    OrthoDBiEOG780RKX.
    PhylomeDBiP29844.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P29844-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLCILLAVV AFVGLSLGEE KKEKDKELGT VIGIDLGTTY SCVGVYKNGR    50
    VEIIANDQGN RITPSYVAFT ADGERLIGDA AKNQLTTNPE NTVFDAKRLI 100
    GREWSDTNVQ HDIKFFPFKV VEKNSKPHIS VDTSQGAKVF APEEISAMVL 150
    GKMKETAEAY LGKKVTHAVV TVPAYFNDAQ RQATKDAGVI AGLQVMRIIN 200
    EPTAAAIAYG LDKKEGEKNV LVFDLGGGTF DVSLLTIDNG VFEVVATNGD 250
    THLGGEDFDQ RVMDHFIKLY KKKKGKDIRK DNRAVQKLRR EVEKAKRALS 300
    GSHQVRIEIE SFFEGDDFSE TLTRAKFEEL NLDLFRSTLK PVQKVLEDAD 350
    MNKKDVHEIV LVGGSTRIPK VQQLVKDFFG GKEPSRGINP DEAVAYGAAV 400
    QAGVLSGEQD TDAIVLLDVN PLTMGIETVG GVMTKLIPRN TVIPTKKSQV 450
    FSTASDNQHT VTIQVYEGER PMTKDNHLLG KFDLTGIPPA PRGIPQIEVS 500
    FEIDANGILQ VSAEDKGTGN KEKIVITNDQ NRLTPEDIDR MIRDAEKFAD 550
    EDKKLKERVE SRNELESYAY SLKNQIGDKD KLGAKLSDDE KNKLESAIDE 600
    SIKWLEQNPD ADPEEYKKQK KDLEAIVQPV IAKLYQGAGG APPPEGGDDA 650
    DLKDEL 656
    Length:656
    Mass (Da):72,261
    Last modified:July 5, 2004 - v2
    Checksum:i06A68F839A06337D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti313 – 3131Missing in AAO45194. 1 PublicationCurated
    Sequence conflicti507 – 5071G → A in AAA28626. (PubMed:8514184)Curated
    Sequence conflicti510 – 5101Q → T in AAA28626. (PubMed:8514184)Curated
    Sequence conflicti592 – 5921N → T in AAA28626. (PubMed:8514184)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01498 mRNA. Translation: AAA28626.1.
    AE014298 Genomic DNA. Translation: AAF48095.1.
    AE014298 Genomic DNA. Translation: AAN09299.1.
    AE014298 Genomic DNA. Translation: AAN09300.1.
    AE014298 Genomic DNA. Translation: AAN09301.1.
    BT004838 mRNA. Translation: AAO45194.1.
    PIRiJN0666.
    RefSeqiNP_511132.2. NM_078577.2.
    NP_727563.1. NM_167306.1.
    NP_727564.1. NM_167307.1.
    NP_727565.1. NM_167308.1.
    UniGeneiDm.2924.

    Genome annotation databases

    EnsemblMetazoaiFBtr0073608; FBpp0073445; FBgn0001218.
    FBtr0073609; FBpp0073446; FBgn0001218.
    FBtr0073610; FBpp0073447; FBgn0001218.
    FBtr0073611; FBpp0073448; FBgn0001218.
    GeneIDi32133.
    KEGGidme:Dmel_CG4147.
    UCSCiCG4147-RB. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01498 mRNA. Translation: AAA28626.1 .
    AE014298 Genomic DNA. Translation: AAF48095.1 .
    AE014298 Genomic DNA. Translation: AAN09299.1 .
    AE014298 Genomic DNA. Translation: AAN09300.1 .
    AE014298 Genomic DNA. Translation: AAN09301.1 .
    BT004838 mRNA. Translation: AAO45194.1 .
    PIRi JN0666.
    RefSeqi NP_511132.2. NM_078577.2.
    NP_727563.1. NM_167306.1.
    NP_727564.1. NM_167307.1.
    NP_727565.1. NM_167308.1.
    UniGenei Dm.2924.

    3D structure databases

    ProteinModelPortali P29844.
    SMRi P29844. Positions 27-598.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 58539. 17 interactions.
    DIPi DIP-19696N.
    IntActi P29844. 3 interactions.
    MINTi MINT-1330773.

    Proteomic databases

    PaxDbi P29844.
    PRIDEi P29844.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0073608 ; FBpp0073445 ; FBgn0001218 .
    FBtr0073609 ; FBpp0073446 ; FBgn0001218 .
    FBtr0073610 ; FBpp0073447 ; FBgn0001218 .
    FBtr0073611 ; FBpp0073448 ; FBgn0001218 .
    GeneIDi 32133.
    KEGGi dme:Dmel_CG4147.
    UCSCi CG4147-RB. d. melanogaster.

    Organism-specific databases

    CTDi 32133.
    FlyBasei FBgn0001218. Hsc70-3.

    Phylogenomic databases

    eggNOGi COG0443.
    GeneTreei ENSGT00750000117237.
    InParanoidi P29844.
    KOi K09490.
    OMAi DKRAVQK.
    OrthoDBi EOG780RKX.
    PhylomeDBi P29844.

    Enzyme and pathway databases

    Reactomei REACT_93794. ATF6-alpha activates chaperone genes.

    Miscellaneous databases

    ChiTaRSi Hsc70-3. drosophila.
    GenomeRNAii 32133.
    NextBioi 777024.
    PROi P29844.

    Gene expression databases

    Bgeei P29844.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic structure and sequence analysis of Drosophila melanogaster HSC70 genes."
      Rubin D.M., Mehta A., Zhu J., Shoham S., Chen X.J., Wells Q., Palter K.B.
      Gene 128:155-163(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Larva.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Head.

    Entry informationi

    Entry nameiHSP7C_DROME
    AccessioniPrimary (citable) accession number: P29844
    Secondary accession number(s): A4V4C4
    , Q86NM3, Q9VYU2, Q9VYU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3