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Protein

Heat shock 70 kDa protein cognate 1

Gene

Hsc70-1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein cognate 1
Alternative name(s):
Heat shock 70 kDa protein 70C
Gene namesi
Name:Hsc70-1
Synonyms:Hsc1
ORF Names:CG8937
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0001216. Hsc70-1.

Subcellular locationi

GO - Cellular componenti

  • lipid particle Source: FlyBase
  • microtubule associated complex Source: FlyBase
  • mitochondrion Source: FlyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000783371 – 641Heat shock 70 kDa protein cognate 1Add BLAST641

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei362Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP29843.
PRIDEiP29843.

PTM databases

iPTMnetiP29843.

Expressioni

Developmental stagei

Heat shock cognate proteins are expressed constitutively during normal development.

Gene expression databases

BgeeiFBgn0001216.
ExpressionAtlasiP29843. differential.
GenevisibleiP29843. DM.

Interactioni

Protein-protein interaction databases

BioGridi64882. 13 interactors.
IntActiP29843. 1 interactor.
STRINGi7227.FBpp0075504.

Structurei

3D structure databases

ProteinModelPortaliP29843.
SMRiP29843.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
InParanoidiP29843.
KOiK03283.
OMAiQLESYCF.
OrthoDBiEOG091G03SF.
PhylomeDBiP29843.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiView protein in InterPro
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
PfamiView protein in Pfam
PF00012. HSP70. 1 hit.
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiView protein in PROSITE
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.

Sequencei

Sequence statusi: Complete.

P29843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKLPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTESERL
60 70 80 90 100
IGDAAKNQVA MNPNNTIFDA KRLIGRRFDD ATVQSDMKHW PFEVFAENGK
110 120 130 140 150
PRIRVEYKGE RKSFYPEEVS SMVLTKMRET AEAYLGGTVT DAVVTVPAYF
160 170 180 190 200
NDSQRQATKD AGAIAGLNVL RIINEPTAAA IAYGLDKQGT SERNVLIFDL
210 220 230 240 250
GGGTFDVSVL TIEDGIFEVK ATAGDTHLGG EDFDNRLVNH FVQEFQRKHK
260 270 280 290 300
KDLGQNKRAL RRLRTACERA KRTLSSSTQA SIEIDSLFEG VDFYTSVTRA
310 320 330 340 350
RFEELNGDLF RGTMEPVAKA LRDAKMDKGQ IHDIVLVGGS TRIPKVQRLL
360 370 380 390 400
QDFFNGKELN KSINPDEAVA YGAAVQAAIL HGDKSEAVQD LLLLDVTPLS
410 420 430 440 450
LGIETAGGVM TTLIKRNTTI PTKQTQIFTT YADNQPGVLI QVFEGERAMT
460 470 480 490 500
RDNNSLGKFE LSAIPPAPRG VPQVEVTFDI DANGILNVTA LEKSTGKENR
510 520 530 540 550
ITITNDKGRL SKEDIERMVN DAEAYRQADE QQRDRINAKN QLESYCFQLR
560 570 580 590 600
STLDDEHLSS RFSPADRETI QQRSSETIAW LDANQLAERQ EFEHKQQELE
610 620 630 640
RICSPIITRL YQGAGMAPPP TAGGSNPGAT GGSGPTIEEV D
Length:641
Mass (Da):70,686
Last modified:April 1, 1993 - v1
Checksum:iDB86DB45E0C4BCA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01501 mRNA. Translation: AAA28625.1.
AE014296 Genomic DNA. Translation: AAF49782.1.
J01085 Genomic DNA. Translation: AAA28629.1.
PIRiB03309.
JN0668.
RefSeqiNP_524063.1. NM_079339.3.
UniGeneiDm.1176.

Genome annotation databases

EnsemblMetazoaiFBtr0075762; FBpp0075504; FBgn0001216.
GeneIDi39542.
KEGGidme:Dmel_CG8937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01501 mRNA. Translation: AAA28625.1.
AE014296 Genomic DNA. Translation: AAF49782.1.
J01085 Genomic DNA. Translation: AAA28629.1.
PIRiB03309.
JN0668.
RefSeqiNP_524063.1. NM_079339.3.
UniGeneiDm.1176.

3D structure databases

ProteinModelPortaliP29843.
SMRiP29843.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64882. 13 interactors.
IntActiP29843. 1 interactor.
STRINGi7227.FBpp0075504.

PTM databases

iPTMnetiP29843.

Proteomic databases

PaxDbiP29843.
PRIDEiP29843.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0075762; FBpp0075504; FBgn0001216.
GeneIDi39542.
KEGGidme:Dmel_CG8937.

Organism-specific databases

CTDi39542.
FlyBaseiFBgn0001216. Hsc70-1.

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
InParanoidiP29843.
KOiK03283.
OMAiQLESYCF.
OrthoDBiEOG091G03SF.
PhylomeDBiP29843.

Miscellaneous databases

GenomeRNAii39542.
PROiPR:P29843.

Gene expression databases

BgeeiFBgn0001216.
ExpressionAtlasiP29843. differential.
GenevisibleiP29843. DM.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiView protein in InterPro
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
PfamiView protein in Pfam
PF00012. HSP70. 1 hit.
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiView protein in PROSITE
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHSP7A_DROME
AccessioniPrimary (citable) accession number: P29843
Secondary accession number(s): Q9VUA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 7, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.