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Protein

Heat shock 70 kDa protein cognate 1

Gene

Hsc70-1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-3371453 Regulation of HSF1-mediated heat shock response
R-DME-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-DME-3371568 Attenuation phase
R-DME-3371571 HSF1-dependent transactivation
R-DME-432722 Golgi Associated Vesicle Biogenesis
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DME-6798695 Neutrophil degranulation
R-DME-72163 mRNA Splicing - Major Pathway
R-DME-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein cognate 1
Alternative name(s):
Heat shock 70 kDa protein 70C
Gene namesi
Name:Hsc70-1
Synonyms:Hsc1
ORF Names:CG8937
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0001216 Hsc70-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000783371 – 641Heat shock 70 kDa protein cognate 1Add BLAST641

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei362Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP29843
PRIDEiP29843

PTM databases

iPTMnetiP29843

Expressioni

Developmental stagei

Heat shock cognate proteins are expressed constitutively during normal development.

Gene expression databases

BgeeiFBgn0001216
ExpressionAtlasiP29843 differential
GenevisibleiP29843 DM

Interactioni

Protein-protein interaction databases

BioGridi64882, 14 interactors
IntActiP29843, 1 interactor
MINTiP29843
STRINGi7227.FBpp0075504

Structurei

3D structure databases

ProteinModelPortaliP29843
SMRiP29843
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
InParanoidiP29843
KOiK03283
OMAiQRKHKRD
OrthoDBiEOG091G03SF
PhylomeDBiP29843

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

P29843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKLPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTESERL
60 70 80 90 100
IGDAAKNQVA MNPNNTIFDA KRLIGRRFDD ATVQSDMKHW PFEVFAENGK
110 120 130 140 150
PRIRVEYKGE RKSFYPEEVS SMVLTKMRET AEAYLGGTVT DAVVTVPAYF
160 170 180 190 200
NDSQRQATKD AGAIAGLNVL RIINEPTAAA IAYGLDKQGT SERNVLIFDL
210 220 230 240 250
GGGTFDVSVL TIEDGIFEVK ATAGDTHLGG EDFDNRLVNH FVQEFQRKHK
260 270 280 290 300
KDLGQNKRAL RRLRTACERA KRTLSSSTQA SIEIDSLFEG VDFYTSVTRA
310 320 330 340 350
RFEELNGDLF RGTMEPVAKA LRDAKMDKGQ IHDIVLVGGS TRIPKVQRLL
360 370 380 390 400
QDFFNGKELN KSINPDEAVA YGAAVQAAIL HGDKSEAVQD LLLLDVTPLS
410 420 430 440 450
LGIETAGGVM TTLIKRNTTI PTKQTQIFTT YADNQPGVLI QVFEGERAMT
460 470 480 490 500
RDNNSLGKFE LSAIPPAPRG VPQVEVTFDI DANGILNVTA LEKSTGKENR
510 520 530 540 550
ITITNDKGRL SKEDIERMVN DAEAYRQADE QQRDRINAKN QLESYCFQLR
560 570 580 590 600
STLDDEHLSS RFSPADRETI QQRSSETIAW LDANQLAERQ EFEHKQQELE
610 620 630 640
RICSPIITRL YQGAGMAPPP TAGGSNPGAT GGSGPTIEEV D
Length:641
Mass (Da):70,686
Last modified:April 1, 1993 - v1
Checksum:iDB86DB45E0C4BCA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01501 mRNA Translation: AAA28625.1
AE014296 Genomic DNA Translation: AAF49782.1
J01085 Genomic DNA Translation: AAA28629.1
PIRiB03309
JN0668
RefSeqiNP_524063.1, NM_079339.3
UniGeneiDm.1176

Genome annotation databases

EnsemblMetazoaiFBtr0075762; FBpp0075504; FBgn0001216
GeneIDi39542
KEGGidme:Dmel_CG8937

Similar proteinsi

Entry informationi

Entry nameiHSP7A_DROME
AccessioniPrimary (citable) accession number: P29843
Secondary accession number(s): Q9VUA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health