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Reviewed, UniProtKB/Swiss-Prot P29843 (HSP7A_DROME)

Last modified June 16, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Heat shock 70 kDa protein cognate 1
Alternative name(s):
    Heat shock 70 kDa protein 70C
Gene names
Name: Hsc70-1
Synonyms: Hsc1
ORF Names: CG8937
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length641 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Developmental stage

Heat shock cognate proteins are expressed constitutively during normal development.

Sequence similarities

Belongs to the heat shock protein 70 family.

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Ontologies

Keywords
   Biological processStress response
   LigandATP-binding
Nucleotide-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processresponse to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 641641Heat shock 70 kDa protein cognate 1
PRO_0000078337

Amino acid modifications

Modified residue3621Phosphoserine Ref.5

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Sequences

Sequence LengthMass (Da)Tools
P29843-1 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: DB86DB45E0C4BCA6

FASTA64170,686
        10         20         30         40         50         60 
MPKLPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTESERL IGDAAKNQVA 

        70         80         90        100        110        120 
MNPNNTIFDA KRLIGRRFDD ATVQSDMKHW PFEVFAENGK PRIRVEYKGE RKSFYPEEVS 

       130        140        150        160        170        180 
SMVLTKMRET AEAYLGGTVT DAVVTVPAYF NDSQRQATKD AGAIAGLNVL RIINEPTAAA 

       190        200        210        220        230        240 
IAYGLDKQGT SERNVLIFDL GGGTFDVSVL TIEDGIFEVK ATAGDTHLGG EDFDNRLVNH 

       250        260        270        280        290        300 
FVQEFQRKHK KDLGQNKRAL RRLRTACERA KRTLSSSTQA SIEIDSLFEG VDFYTSVTRA 

       310        320        330        340        350        360 
RFEELNGDLF RGTMEPVAKA LRDAKMDKGQ IHDIVLVGGS TRIPKVQRLL QDFFNGKELN 

       370        380        390        400        410        420 
KSINPDEAVA YGAAVQAAIL HGDKSEAVQD LLLLDVTPLS LGIETAGGVM TTLIKRNTTI 

       430        440        450        460        470        480 
PTKQTQIFTT YADNQPGVLI QVFEGERAMT RDNNSLGKFE LSAIPPAPRG VPQVEVTFDI 

       490        500        510        520        530        540 
DANGILNVTA LEKSTGKENR ITITNDKGRL SKEDIERMVN DAEAYRQADE QQRDRINAKN 

       550        560        570        580        590        600 
QLESYCFQLR STLDDEHLSS RFSPADRETI QQRSSETIAW LDANQLAERQ EFEHKQQELE 

       610        620        630        640 
RICSPIITRL YQGAGMAPPP TAGGSNPGAT GGSGPTIEEV D

« Hide

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References

« Hide 'large scale' references
[1]"Genomic structure and sequence analysis of Drosophila melanogaster HSC70 genes."
Rubin D.M., Mehta A., Zhu J., Shoham S., Chen X.J., Wells Q., Palter K.B.
Gene 128:155-163(1993) [PubMed: 8514184] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[4]"Drosophila gene related to the major heat shock-induced gene is transcribed at normal temperatures and not induced by heat shock."
Ingolia T.D., Craig E.A.
Proc. Natl. Acad. Sci. U.S.A. 79:525-529(1982) [PubMed: 6804941] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-68.
[5]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, MASS SPECTROMETRY.
Tissue: Embryo.

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Cross-references

Sequence databases

L01501 mRNA. Translation: AAA28625.1.
AE014296 Genomic DNA. Translation: AAF49782.1.
J01085 Genomic DNA. Translation: AAA28629.1.
PIRB03309.
JN0668.
RefSeqNP_524063.1.
UniGeneDm.1176

3D structure databases

HSSPHSSP built from PDB template 3HSC based on UniProtKB P19120.
SMRP29843. Positions 1-554.
ModBaseSearch...

Proteomic databases

PRIDEP29843.

Genome annotation databases

EnsemblFBgn0001216. Drosophila melanogaster. [Contig view]
GeneID39542.
KEGGdme:Dmel_CG8937.

Organism-specific databases

FlyBaseFBgn0001216. Hsc70-1.

Phylogenomic databases

OMAP29843. QELERIC.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-016592-MON.

Gene expression databases

ArrayExpressP29843.
GermOnlineCG8937. Drosophila melanogaster.

Family and domain databases

InterProIPR018181. Heat_shock_70_CS.
IPR001023. Hsp70.
IPR013126. Hsp_70.
[Graphical view]
PANTHERPTHR19375. Hsp70. 1 hit.
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
ProDomPD000089. Hsp70. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio814184.

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Entry information

Entry nameHSP7A_DROME
AccessionPrimary (citable) accession number: P29843
Secondary accession number(s): Q9VUA7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 16, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents