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Protein

60 kDa chaperonin

Gene

groL

Organism
Neisseria gonorrhoeae
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

Miscellaneous

This protein shows ATPase activity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
63 kDa stress protein
GSP63
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, hsp63, mopA
OrganismiNeisseria gonorrhoeae
Taxonomic identifieri485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000634571 – 54460 kDa chaperoninAdd BLAST544

Proteomic databases

PRIDEiP29842.

Expressioni

Inductioni

By iron limitation, glucose deprivation, and growth under low oxygen supply.1 Publication

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP29842.
SMRiP29842.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

P29842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKDVQFGN EVRQKMVNGV NILANAVRVT LGPKGRNVVV DRAFGGPHIT
60 70 80 90 100
KDGVTVAKEI ELKDKFENMG AQMVKEVASK TNDVAGDGTT TATVLAQSIV
110 120 130 140 150
AEGIKAVTAG MNPTDLKRGI DKAVAALVEE LKNIAKPCDT SKEIAQVGSI
160 170 180 190 200
SANSDEQVGA IIAEAMEKVG KEGVITVEDG KSLENELDVV EGMQFDRGYL
210 220 230 240 250
SPYFINDAEK QIAGLDNPFV LLFDKKISNI RDLLPVLEQV AKASRPLLII
260 270 280 290 300
AEDVEGEALA TLVVNNIRGV LKTVAVKAPG FGDRRKAMLQ DIAILTGAVV
310 320 330 340 350
ISEEVGLSLE KATLDDLGQA KRIEIGKENT TVIDGFGDAA QIEARVAEIR
360 370 380 390 400
QQIETATSDY DKEKLQERVA KLAGGVAVIK VGAATEVEMK EKKDRVEDAL
410 420 430 440 450
HATRAAVEEG VVAGGGVALL RARAALENLH TGNADQDAGV QIVLRAVESP
460 470 480 490 500
LRQIVANAGG EPSVVVNKVL EGKGNYGYNA GSGEYGDMIG MGVLDPAKVT
510 520 530 540
RSALQHAASI AGLMLTTDCM IAEIPEEKPA VPDMGGMGGM GGMM
Length:544
Mass (Da):57,241
Last modified:October 1, 1996 - v3
Checksum:i2D902B3D591D7655
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13R → C AA sequence (PubMed:1400243).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti106A → Y in strain: PID 2. 1
Natural varianti298A → G in strain: PID 2. 1
Natural varianti437D → E in strain: PID 2. 1
Natural varianti451L → V in strain: PID 2. 1
Natural varianti494L → H in strain: PID 2. 1
Natural varianti541 – 543Missing in strain: PID 2. 3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23008 Genomic DNA. Translation: CAA80550.1.
Z23009 Genomic DNA. Translation: CAA80551.1.
PIRiS61300.
S61301.

Similar proteinsi

Entry informationi

Entry nameiCH60_NEIGO
AccessioniPrimary (citable) accession number: P29842
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 104 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families