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P29829

- GBB2_DROME

UniProt

P29829 - GBB2_DROME

Protein

Guanine nucleotide-binding protein subunit beta-2

Gene

Gbeta76C

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 3 (15 Mar 2004)
      Previous versions | rss
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    Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

    GO - Molecular functioni

    1. GTPase activity Source: FlyBase
    2. protein binding Source: IntAct
    3. protein heterodimerization activity Source: FlyBase
    4. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. activation of phospholipase C activity Source: FlyBase
    2. deactivation of rhodopsin mediated signaling Source: FlyBase
    3. G-protein coupled receptor signaling pathway Source: FlyBase
    4. GTP catabolic process Source: GOC
    5. phototransduction Source: FlyBase
    6. rhodopsin mediated signaling pathway Source: FlyBase
    7. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transducer

    Keywords - Biological processi

    Sensory transduction, Vision

    Enzyme and pathway databases

    SignaLinkiP29829.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein subunit beta-2
    Gene namesi
    Name:Gbeta76C
    Synonyms:Gb76C, Gbe
    ORF Names:CG8770
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3L

    Organism-specific databases

    FlyBaseiFBgn0004623. Gbeta76C.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: FlyBase
    2. heterotrimeric G-protein complex Source: FlyBase
    3. plasma membrane Source: FlyBase
    4. rhabdomere Source: FlyBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Guanine nucleotide-binding protein subunit beta-2PRO_0000127716Add
    BLAST

    Proteomic databases

    PaxDbiP29829.

    Expressioni

    Tissue specificityi

    In the Drosophila compound eye.

    Gene expression databases

    BgeeiP29829.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Ggamma30AQ9NFZ32EBI-128499,EBI-2695634

    Protein-protein interaction databases

    BioGridi65418. 4 interactions.
    IntActiP29829. 3 interactions.
    MINTiMINT-938155.
    STRINGi7227.FBpp0074717.

    Structurei

    3D structure databases

    ProteinModelPortaliP29829.
    SMRiP29829. Positions 21-345.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati57 – 9640WD 1Add
    BLAST
    Repeati99 – 13840WD 2Add
    BLAST
    Repeati147 – 18539WD 3Add
    BLAST
    Repeati188 – 22740WD 4Add
    BLAST
    Repeati230 – 26940WD 5Add
    BLAST
    Repeati274 – 31340WD 6Add
    BLAST
    Repeati316 – 34530WD 7Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat G protein beta family.Curated
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00740000115438.
    InParanoidiP29829.
    KOiK07972.
    OMAiIIWDTWT.
    OrthoDBiEOG71ZP1T.
    PhylomeDBiP29829.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR001632. Gprotein_B.
    IPR016346. Guanine_nucleotide-bd_bsu.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 6 hits.
    [Graphical view]
    PIRSFiPIRSF002394. GN-bd_beta. 1 hit.
    PRINTSiPR00319. GPROTEINB.
    PR00320. GPROTEINBRPT.
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 4 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29829-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKIDPETQK LYDEINGMIQ KFKDDQKSKA DCTLADKCGD MGDVPKIRFS    50
    SKKILKGHIN KVNSVHFAGD SRHCVTGSLD GKLIIWDTWT ANKVQIIPLR 100
    SAWVMTVAFS PSGNFVACGG MDNQCTVYDV NNRDASGVAK MVKELMGYEG 150
    FLSSCRFLDD GHLITGSGDM KICHWDLEKG VKTMDFNGHA GDIAGLSLSP 200
    DMKTYITGSV DKTAKLWDVR EEGHKQMFFG HDMDVSSVCY HPSGFGFASC 250
    SEDQTARMYD LRADQQIAQY EPPQKNTGFT SCALSTSGRY LMCGGIEGNV 300
    HSWDTMKQRH TGTLSGHENR ITCISLCPNG MCLASTSWDQ QVRLWL 346
    Length:346
    Mass (Da):38,336
    Last modified:March 15, 2004 - v3
    Checksum:iE9B22D937EC3A707
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti116 – 1161V → E in AAA73103. (PubMed:1910788)Curated
    Sequence conflicti136 – 1361S → P in AAA73103. (PubMed:1910788)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76593 mRNA. Translation: AAA73103.1.
    AE014296 Genomic DNA. Translation: AAF49124.1.
    AY118886 mRNA. Translation: AAM50746.1.
    PIRiJU0269. RGFFB.
    RefSeqiNP_523720.2. NM_078996.3.
    UniGeneiDm.9760.

    Genome annotation databases

    EnsemblMetazoaiFBtr0074949; FBpp0074717; FBgn0004623.
    GeneIDi40148.
    KEGGidme:Dmel_CG8770.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76593 mRNA. Translation: AAA73103.1 .
    AE014296 Genomic DNA. Translation: AAF49124.1 .
    AY118886 mRNA. Translation: AAM50746.1 .
    PIRi JU0269. RGFFB.
    RefSeqi NP_523720.2. NM_078996.3.
    UniGenei Dm.9760.

    3D structure databases

    ProteinModelPortali P29829.
    SMRi P29829. Positions 21-345.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 65418. 4 interactions.
    IntActi P29829. 3 interactions.
    MINTi MINT-938155.
    STRINGi 7227.FBpp0074717.

    Proteomic databases

    PaxDbi P29829.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0074949 ; FBpp0074717 ; FBgn0004623 .
    GeneIDi 40148.
    KEGGi dme:Dmel_CG8770.

    Organism-specific databases

    CTDi 40148.
    FlyBasei FBgn0004623. Gbeta76C.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00740000115438.
    InParanoidi P29829.
    KOi K07972.
    OMAi IIWDTWT.
    OrthoDBi EOG71ZP1T.
    PhylomeDBi P29829.

    Enzyme and pathway databases

    SignaLinki P29829.

    Miscellaneous databases

    ChiTaRSi Gbeta76C. drosophila.
    GenomeRNAii 40148.
    NextBioi 817248.

    Gene expression databases

    Bgeei P29829.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR001632. Gprotein_B.
    IPR016346. Guanine_nucleotide-bd_bsu.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 6 hits.
    [Graphical view ]
    PIRSFi PIRSF002394. GN-bd_beta. 1 hit.
    PRINTSi PR00319. GPROTEINB.
    PR00320. GPROTEINBRPT.
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 4 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A G beta protein in the Drosophila compound eye is different from that in the brain."
      Yarfitz S., Niemi G.A., McConnell J.L., Fitch C.L., Hurley J.B.
      Neuron 7:429-438(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Eye.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Head.

    Entry informationi

    Entry nameiGBB2_DROME
    AccessioniPrimary (citable) accession number: P29829
    Secondary accession number(s): Q9VW29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: March 15, 2004
    Last modified: October 1, 2014
    This is version 121 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3