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P29829

- GBB2_DROME

UniProt

P29829 - GBB2_DROME

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Protein
Guanine nucleotide-binding protein subunit beta-2
Gene
Gbeta76C, Gb76C, Gbe, CG8770
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. GTPase activity Source: FlyBase
  2. protein binding Source: IntAct
  3. protein heterodimerization activity Source: FlyBase
  4. signal transducer activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: FlyBase
  2. GTP catabolic process Source: GOC
  3. activation of phospholipase C activity Source: FlyBase
  4. deactivation of rhodopsin mediated signaling Source: FlyBase
  5. phototransduction Source: FlyBase
  6. rhodopsin mediated signaling pathway Source: FlyBase
  7. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Biological processi

Sensory transduction, Vision

Enzyme and pathway databases

SignaLinkiP29829.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit beta-2
Gene namesi
Name:Gbeta76C
Synonyms:Gb76C, Gbe
ORF Names:CG8770
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0004623. Gbeta76C.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. heterotrimeric G-protein complex Source: FlyBase
  3. plasma membrane Source: FlyBase
  4. rhabdomere Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Guanine nucleotide-binding protein subunit beta-2
PRO_0000127716Add
BLAST

Proteomic databases

PaxDbiP29829.

Expressioni

Tissue specificityi

In the Drosophila compound eye.

Gene expression databases

BgeeiP29829.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Binary interactionsi

WithEntry#Exp.IntActNotes
Ggamma30AQ9NFZ32EBI-128499,EBI-2695634

Protein-protein interaction databases

BioGridi65418. 4 interactions.
IntActiP29829. 3 interactions.
MINTiMINT-938155.
STRINGi7227.FBpp0074717.

Structurei

3D structure databases

ProteinModelPortaliP29829.
SMRiP29829. Positions 21-345.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati57 – 9640WD 1
Add
BLAST
Repeati99 – 13840WD 2
Add
BLAST
Repeati147 – 18539WD 3
Add
BLAST
Repeati188 – 22740WD 4
Add
BLAST
Repeati230 – 26940WD 5
Add
BLAST
Repeati274 – 31340WD 6
Add
BLAST
Repeati316 – 34530WD 7
Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00740000115438.
InParanoidiP29829.
KOiK07972.
OMAiIIWDTWT.
OrthoDBiEOG71ZP1T.
PhylomeDBiP29829.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 6 hits.
[Graphical view]
PIRSFiPIRSF002394. GN-bd_beta. 1 hit.
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29829-1 [UniParc]FASTAAdd to Basket

« Hide

MPKIDPETQK LYDEINGMIQ KFKDDQKSKA DCTLADKCGD MGDVPKIRFS    50
SKKILKGHIN KVNSVHFAGD SRHCVTGSLD GKLIIWDTWT ANKVQIIPLR 100
SAWVMTVAFS PSGNFVACGG MDNQCTVYDV NNRDASGVAK MVKELMGYEG 150
FLSSCRFLDD GHLITGSGDM KICHWDLEKG VKTMDFNGHA GDIAGLSLSP 200
DMKTYITGSV DKTAKLWDVR EEGHKQMFFG HDMDVSSVCY HPSGFGFASC 250
SEDQTARMYD LRADQQIAQY EPPQKNTGFT SCALSTSGRY LMCGGIEGNV 300
HSWDTMKQRH TGTLSGHENR ITCISLCPNG MCLASTSWDQ QVRLWL 346
Length:346
Mass (Da):38,336
Last modified:March 15, 2004 - v3
Checksum:iE9B22D937EC3A707
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti116 – 1161V → E in AAA73103. 1 Publication
Sequence conflicti136 – 1361S → P in AAA73103. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M76593 mRNA. Translation: AAA73103.1.
AE014296 Genomic DNA. Translation: AAF49124.1.
AY118886 mRNA. Translation: AAM50746.1.
PIRiJU0269. RGFFB.
RefSeqiNP_523720.2. NM_078996.3.
UniGeneiDm.9760.

Genome annotation databases

EnsemblMetazoaiFBtr0074949; FBpp0074717; FBgn0004623.
GeneIDi40148.
KEGGidme:Dmel_CG8770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M76593 mRNA. Translation: AAA73103.1 .
AE014296 Genomic DNA. Translation: AAF49124.1 .
AY118886 mRNA. Translation: AAM50746.1 .
PIRi JU0269. RGFFB.
RefSeqi NP_523720.2. NM_078996.3.
UniGenei Dm.9760.

3D structure databases

ProteinModelPortali P29829.
SMRi P29829. Positions 21-345.
ModBasei Search...

Protein-protein interaction databases

BioGridi 65418. 4 interactions.
IntActi P29829. 3 interactions.
MINTi MINT-938155.
STRINGi 7227.FBpp0074717.

Proteomic databases

PaxDbi P29829.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0074949 ; FBpp0074717 ; FBgn0004623 .
GeneIDi 40148.
KEGGi dme:Dmel_CG8770.

Organism-specific databases

CTDi 40148.
FlyBasei FBgn0004623. Gbeta76C.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00740000115438.
InParanoidi P29829.
KOi K07972.
OMAi IIWDTWT.
OrthoDBi EOG71ZP1T.
PhylomeDBi P29829.

Enzyme and pathway databases

SignaLinki P29829.

Miscellaneous databases

ChiTaRSi Gbeta76C. drosophila.
GenomeRNAii 40148.
NextBioi 817248.

Gene expression databases

Bgeei P29829.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 6 hits.
[Graphical view ]
PIRSFi PIRSF002394. GN-bd_beta. 1 hit.
PRINTSi PR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A G beta protein in the Drosophila compound eye is different from that in the brain."
    Yarfitz S., Niemi G.A., McConnell J.L., Fitch C.L., Hurley J.B.
    Neuron 7:429-438(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Eye.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Head.

Entry informationi

Entry nameiGBB2_DROME
AccessioniPrimary (citable) accession number: P29829
Secondary accession number(s): Q9VW29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: March 15, 2004
Last modified: July 9, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi