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P29810 (AACC9_MICCH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aminoglycoside N(3')-acetyltransferase IX

EC=2.3.1.81
Alternative name(s):
ACC(3)-IX
Aminocyclitol 3-N-acetyltransferase type IX
Gene names
Name:aacC9
OrganismMicromonospora chalcea
Taxonomic identifier1874 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeMicromonospora

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Resistance to neomycin.

Catalytic activity

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

Sequence similarities

Belongs to the antibiotic N-acetyltransferase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionaminoglycoside 3-N-acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281Aminoglycoside N(3')-acetyltransferase IX
PRO_0000068551

Sequences

Sequence LengthMass (Da)Tools
P29810 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: EB62D6B086F7F9E4

FASTA28130,989
        10         20         30         40         50         60 
MEEMSLLNHS GGPVTRSRIK HDLADLGLKD GDVVIFHTRM SAIGYVAGGT QTIIGALLDV 

        70         80         90        100        110        120 
VGARGTLMVP CGWNNAPPYD FLDWPRDWQD ALRAEHPAYD PDLSEADYNN GRLPEALPRW 

       130        140        150        160        170        180 
PGAIRSRHPD ASFAALGPAA AELMAEHPWD HPHGPDTPLA RLIAHSGRVL LLGAPLDTMT 

       190        200        210        220        230        240 
LLHHAEALAD VRSKRFVTYE QPILVNGQRV WRQFRDIDSE EGAFDYSTVR RGVEPFEAIA 

       250        260        270        280 
RDMLSAGIGR QGRVGAADSY LFDAGPVFNF AINWIEAKLK R 

« Hide

References

[1]"Characterisation of aminoglycoside acetyltransferase-encoding genes of neomycin-producing Micromonospora chalcea and Streptomyces fradiae."
Salauze D., Perez-Gonzalez J.A., Piepersberg W., Davies J.
Gene 101:143-148(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 69-683.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M55427 Genomic DNA. Translation: AAA25334.1.
PIRJE0418.

3D structure databases

ProteinModelPortalP29810.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAACC9_MICCH
AccessionPrimary (citable) accession number: P29810
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families