P29810 (AACC9_MICCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminoglycoside N(3')-acetyltransferase IX
EC=2.3.1.81

Alternative name(s):
ACC(3)-IX
Aminocyclitol 3-N-acetyltransferase type IX

Gene names

Name:

aacC9

Organism

Micromonospora chalcea

Taxonomic identifier

1874 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Micromonospora

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Resistance to neomycin.
Catalytic activity	Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.
Sequence similarities	Belongs to the antibiotic N-acetyltransferase family.

Ontologies

Keywords
Biological process	Antibiotic resistance
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological_process	response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminoglycoside 3-N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 281	281	Aminoglycoside N(3')-acetyltransferase IX		PRO_0000068551

Sequences

	Sequence		Length	Mass (Da)
	P29810 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: EB62D6B086F7F9E4	FASTA	281	30,989
	10 20 30 40 50 60 MEEMSLLNHS GGPVTRSRIK HDLADLGLKD GDVVIFHTRM SAIGYVAGGT QTIIGALLDV 70 80 90 100 110 120 VGARGTLMVP CGWNNAPPYD FLDWPRDWQD ALRAEHPAYD PDLSEADYNN GRLPEALPRW 130 140 150 160 170 180 PGAIRSRHPD ASFAALGPAA AELMAEHPWD HPHGPDTPLA RLIAHSGRVL LLGAPLDTMT 190 200 210 220 230 240 LLHHAEALAD VRSKRFVTYE QPILVNGQRV WRQFRDIDSE EGAFDYSTVR RGVEPFEAIA 250 260 270 280 RDMLSAGIGR QGRVGAADSY LFDAGPVFNF AINWIEAKLK R

References

[1]

"Characterisation of aminoglycoside acetyltransferase-encoding genes of neomycin-producing Micromonospora chalcea and Streptomyces fradiae." Salauze D., Perez-Gonzalez J.A., Piepersberg W., Davies J. Gene 101:143-148(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 69-683.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M55427 Genomic DNA. Translation: AAA25334.1.
PIR	JE0418.
3D structure databases
ProteinModelPortal	P29810.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR003679. Amioglycoside_AcTrfase. [Graphical view]
Pfam	PF02522. Antibiotic_NAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AACC9_MICCH

Accession

Primary (citable) accession number: P29810

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	April 3, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program