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Protein

Aminoglycoside N(3')-acetyltransferase IX

Gene

aacC9

Organism
Micromonospora chalcea
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Resistance to neomycin.

Catalytic activityi

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

GO - Molecular functioni

  1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoglycoside N(3')-acetyltransferase IX (EC:2.3.1.81)
Alternative name(s):
ACC(3)-IX
Aminocyclitol 3-N-acetyltransferase type IX
Gene namesi
Name:aacC9
OrganismiMicromonospora chalcea
Taxonomic identifieri1874 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeMicromonospora

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Aminoglycoside N(3')-acetyltransferase IXPRO_0000068551Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP29810.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29810-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEMSLLNHS GGPVTRSRIK HDLADLGLKD GDVVIFHTRM SAIGYVAGGT
60 70 80 90 100
QTIIGALLDV VGARGTLMVP CGWNNAPPYD FLDWPRDWQD ALRAEHPAYD
110 120 130 140 150
PDLSEADYNN GRLPEALPRW PGAIRSRHPD ASFAALGPAA AELMAEHPWD
160 170 180 190 200
HPHGPDTPLA RLIAHSGRVL LLGAPLDTMT LLHHAEALAD VRSKRFVTYE
210 220 230 240 250
QPILVNGQRV WRQFRDIDSE EGAFDYSTVR RGVEPFEAIA RDMLSAGIGR
260 270 280
QGRVGAADSY LFDAGPVFNF AINWIEAKLK R
Length:281
Mass (Da):30,989
Last modified:April 1, 1993 - v1
Checksum:iEB62D6B086F7F9E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55427 Genomic DNA. Translation: AAA25334.1.
PIRiJE0418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55427 Genomic DNA. Translation: AAA25334.1.
PIRiJE0418.

3D structure databases

ProteinModelPortaliP29810.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterisation of aminoglycoside acetyltransferase-encoding genes of neomycin-producing Micromonospora chalcea and Streptomyces fradiae."
    Salauze D., Perez-Gonzalez J.A., Piepersberg W., Davies J.
    Gene 101:143-148(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 69-683.

Entry informationi

Entry nameiAACC9_MICCH
AccessioniPrimary (citable) accession number: P29810
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.