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Protein

Aminoglycoside N(3)-acetyltransferase VIII

Gene

aacC8

Organism
Streptomyces fradiae (Streptomyces roseoflavus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Resistance to neomycin.

Catalytic activityi

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N3-acetyl-2-deoxystreptamine antibiotic.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAntibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoglycoside N(3)-acetyltransferase VIII (EC:2.3.1.81)
Alternative name(s):
ACC(3)-VIII
Aminocyclitol 3-N-acetyltransferase type VIII
Gene namesi
Name:aacC8
OrganismiStreptomyces fradiae (Streptomyces roseoflavus)
Taxonomic identifieri1906 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000685501 – 286Aminoglycoside N(3)-acetyltransferase VIIIAdd BLAST286

Proteomic databases

PRIDEiP29809

Structurei

3D structure databases

ProteinModelPortaliP29809
SMRiP29809
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00662

Family and domain databases

InterProiView protein in InterPro
IPR003679 Amioglycoside_AcTrfase
IPR028345 Antibiotic_NAT-like
PANTHERiPTHR11104 PTHR11104, 1 hit
PfamiView protein in Pfam
PF02522 Antibiotic_NAT, 1 hit
SUPFAMiSSF110710 SSF110710, 1 hit

Sequencei

Sequence statusi: Complete.

P29809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEKELIERA GGPVTRGRLV RDLEALGVGA GDTVMVHTRM SAIGYVVGGP
60 70 80 90 100
QTVIDAVRDA VGADGTLMAY CGWNDAPPYD LAEWPPAWRE AARAEWPAYD
110 120 130 140 150
PLLSEADRGN GRVPEALRHQ PGAVRSRHPD ASFVAVGPAA HPLMDDHPWD
160 170 180 190 200
DPHGPDSPLA RLAGAGGRVL LLGAPLDTLT LLHHAEARAE APGKRFVAYE
210 220 230 240 250
QPVTVGGRRV WRRFRDVDTS RGVPYGRVVP EGVVPFTVIA QDMLAAGIGR
260 270 280
TGRVAAAPVH LFEAADVVRF GVEWIESRMG GAAGGA
Length:286
Mass (Da):30,455
Last modified:April 1, 1993 - v1
Checksum:i9F5B846BD30D0FA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55426 Genomic DNA Translation: AAA26685.1
PIRiJE0417
RefSeqiWP_063856943.1, NG_048574.1

Genome annotation databases

KEGGiag:AAA26685

Similar proteinsi

Entry informationi

Entry nameiAACC8_STRFR
AccessioniPrimary (citable) accession number: P29809
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health