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P29809

- AACC8_STRFR

UniProt

P29809 - AACC8_STRFR

Protein

Aminoglycoside N(3')-acetyltransferase VIII

Gene

aacC8

Organism
Streptomyces fradiae (Streptomyces roseoflavus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Resistance to neomycin.

    Catalytic activityi

    Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

    GO - Molecular functioni

    1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aminoglycoside N(3')-acetyltransferase VIII (EC:2.3.1.81)
    Alternative name(s):
    ACC(3)-VIII
    Aminocyclitol 3-N-acetyltransferase type VIII
    Gene namesi
    Name:aacC8
    OrganismiStreptomyces fradiae (Streptomyces roseoflavus)
    Taxonomic identifieri1906 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286Aminoglycoside N(3')-acetyltransferase VIIIPRO_0000068550Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP29809.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR003679. Amioglycoside_AcTrfase.
    [Graphical view]
    PfamiPF02522. Antibiotic_NAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29809-1 [UniParc]FASTAAdd to Basket

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    MDEKELIERA GGPVTRGRLV RDLEALGVGA GDTVMVHTRM SAIGYVVGGP    50
    QTVIDAVRDA VGADGTLMAY CGWNDAPPYD LAEWPPAWRE AARAEWPAYD 100
    PLLSEADRGN GRVPEALRHQ PGAVRSRHPD ASFVAVGPAA HPLMDDHPWD 150
    DPHGPDSPLA RLAGAGGRVL LLGAPLDTLT LLHHAEARAE APGKRFVAYE 200
    QPVTVGGRRV WRRFRDVDTS RGVPYGRVVP EGVVPFTVIA QDMLAAGIGR 250
    TGRVAAAPVH LFEAADVVRF GVEWIESRMG GAAGGA 286
    Length:286
    Mass (Da):30,455
    Last modified:April 1, 1993 - v1
    Checksum:i9F5B846BD30D0FA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55426 Genomic DNA. Translation: AAA26685.1.
    PIRiJE0417.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55426 Genomic DNA. Translation: AAA26685.1 .
    PIRi JE0417.

    3D structure databases

    ProteinModelPortali P29809.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR003679. Amioglycoside_AcTrfase.
    [Graphical view ]
    Pfami PF02522. Antibiotic_NAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterisation of aminoglycoside acetyltransferase-encoding genes of neomycin-producing Micromonospora chalcea and Streptomyces fradiae."
      Salauze D., Perez-Gonzalez J.A., Piepersberg W., Davies J.
      Gene 101:143-148(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiAACC8_STRFR
    AccessioniPrimary (citable) accession number: P29809
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3