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Protein

Aminoglycoside N(3')-acetyltransferase VIII

Gene

aacC8

Organism
Streptomyces fradiae (Streptomyces roseoflavus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Resistance to neomycin.

Catalytic activityi

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

GO - Molecular functioni

  1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoglycoside N(3')-acetyltransferase VIII (EC:2.3.1.81)
Alternative name(s):
ACC(3)-VIII
Aminocyclitol 3-N-acetyltransferase type VIII
Gene namesi
Name:aacC8
OrganismiStreptomyces fradiae (Streptomyces roseoflavus)
Taxonomic identifieri1906 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Aminoglycoside N(3')-acetyltransferase VIIIPRO_0000068550Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP29809.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEKELIERA GGPVTRGRLV RDLEALGVGA GDTVMVHTRM SAIGYVVGGP
60 70 80 90 100
QTVIDAVRDA VGADGTLMAY CGWNDAPPYD LAEWPPAWRE AARAEWPAYD
110 120 130 140 150
PLLSEADRGN GRVPEALRHQ PGAVRSRHPD ASFVAVGPAA HPLMDDHPWD
160 170 180 190 200
DPHGPDSPLA RLAGAGGRVL LLGAPLDTLT LLHHAEARAE APGKRFVAYE
210 220 230 240 250
QPVTVGGRRV WRRFRDVDTS RGVPYGRVVP EGVVPFTVIA QDMLAAGIGR
260 270 280
TGRVAAAPVH LFEAADVVRF GVEWIESRMG GAAGGA
Length:286
Mass (Da):30,455
Last modified:April 1, 1993 - v1
Checksum:i9F5B846BD30D0FA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55426 Genomic DNA. Translation: AAA26685.1.
PIRiJE0417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55426 Genomic DNA. Translation: AAA26685.1.
PIRiJE0417.

3D structure databases

ProteinModelPortaliP29809.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterisation of aminoglycoside acetyltransferase-encoding genes of neomycin-producing Micromonospora chalcea and Streptomyces fradiae."
    Salauze D., Perez-Gonzalez J.A., Piepersberg W., Davies J.
    Gene 101:143-148(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiAACC8_STRFR
AccessioniPrimary (citable) accession number: P29809
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 1, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.