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P29809 (AACC8_STRFR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aminoglycoside N(3')-acetyltransferase VIII

EC=2.3.1.81
Alternative name(s):
ACC(3)-VIII
Aminocyclitol 3-N-acetyltransferase type VIII
Gene names
Name:aacC8
OrganismStreptomyces fradiae (Streptomyces roseoflavus)
Taxonomic identifier1906 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Resistance to neomycin.

Catalytic activity

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

Sequence similarities

Belongs to the antibiotic N-acetyltransferase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionaminoglycoside 3-N-acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286Aminoglycoside N(3')-acetyltransferase VIII
PRO_0000068550

Sequences

Sequence LengthMass (Da)Tools
P29809 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 9F5B846BD30D0FA9

FASTA28630,455
        10         20         30         40         50         60 
MDEKELIERA GGPVTRGRLV RDLEALGVGA GDTVMVHTRM SAIGYVVGGP QTVIDAVRDA 

        70         80         90        100        110        120 
VGADGTLMAY CGWNDAPPYD LAEWPPAWRE AARAEWPAYD PLLSEADRGN GRVPEALRHQ 

       130        140        150        160        170        180 
PGAVRSRHPD ASFVAVGPAA HPLMDDHPWD DPHGPDSPLA RLAGAGGRVL LLGAPLDTLT 

       190        200        210        220        230        240 
LLHHAEARAE APGKRFVAYE QPVTVGGRRV WRRFRDVDTS RGVPYGRVVP EGVVPFTVIA 

       250        260        270        280 
QDMLAAGIGR TGRVAAAPVH LFEAADVVRF GVEWIESRMG GAAGGA 

« Hide

References

[1]"Characterisation of aminoglycoside acetyltransferase-encoding genes of neomycin-producing Micromonospora chalcea and Streptomyces fradiae."
Salauze D., Perez-Gonzalez J.A., Piepersberg W., Davies J.
Gene 101:143-148(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M55426 Genomic DNA. Translation: AAA26685.1.
PIRJE0417.

3D structure databases

ProteinModelPortalP29809.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAACC8_STRFR
AccessionPrimary (citable) accession number: P29809
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families