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P29808

- AACC3_PSEAI

UniProt

P29808 - AACC3_PSEAI

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Protein
Aminoglycoside N(3')-acetyltransferase III
Gene
aacC3
Organism
Pseudomonas aeruginosa
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Resistance to antibiotics containing the 2-deoxy-streptamine ring including dibekacin, gentamicin, kanamycin, sisomicin, tobramycin, neomycin and to a lesser extent netilmicin.

Catalytic activityi

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

GO - Molecular functioni

  1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoglycoside N(3')-acetyltransferase III (EC:2.3.1.81)
Alternative name(s):
ACC(3)-III
Aminocyclitol 3-N-acetyltransferase type III
Gentamicin-(3)-N-acetyl-transferase
Gene namesi
Name:aacC3
OrganismiPseudomonas aeruginosa
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Aminoglycoside N(3')-acetyltransferase III
PRO_0000068546Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP29808.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29808-1 [UniParc]FASTAAdd to Basket

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MTDLNIPHTH AHLVDAFQAL GIRAGQALML HASVKAVGAV MGGPNVILQA    50
LMDALTPDGT LMMYAGWQDI PDFIDSLPDA LKAVYLEQHP PFDPATARAV 100
RENSVLAEFL RTWPCVHRSA NPEASMVAVG RQAALLTANH ALDYGYGVES 150
PLAKLVAIEG YVLMLGAPLD TITLLHHAEY LAKMRHKNVV RYPCPILRDG 200
RKVWVTVEDY DTGDPHDDYS FEQIARDYVA QGGGTRGKVG DADAYLFAAQ 250
DLTRFAVQWL ESRFGDSASY G 271
Length:271
Mass (Da):29,618
Last modified:April 1, 1993 - v1
Checksum:iA66D13D364AD1484
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55652 Genomic DNA. Translation: CAA39184.1.
PIRiS18730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55652 Genomic DNA. Translation: CAA39184.1 .
PIRi S18730.

3D structure databases

ProteinModelPortali P29808.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR003679. Amioglycoside_AcTrfase.
[Graphical view ]
Pfami PF02522. Antibiotic_NAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the aacC3 gene, a gentamicin resistance determinant encoding aminoglycoside-(3)-N-acetyltransferase III expressed in Pseudomonas aeruginosa but not in Escherichia coli."
    Vliegenthart J.S., Ketelaar-Van Gaalen P.A.G., van de Klundert J.A.M.
    Antimicrob. Agents Chemother. 35:892-897(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PST-I.

Entry informationi

Entry nameiAACC3_PSEAI
AccessioniPrimary (citable) accession number: P29808
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 9, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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