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P29808 (AACC3_PSEAI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aminoglycoside N(3')-acetyltransferase III

EC=2.3.1.81
Alternative name(s):
ACC(3)-III
Aminocyclitol 3-N-acetyltransferase type III
Gentamicin-(3)-N-acetyl-transferase
Gene names
Name:aacC3
OrganismPseudomonas aeruginosa
Taxonomic identifier287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Resistance to antibiotics containing the 2-deoxy-streptamine ring including dibekacin, gentamicin, kanamycin, sisomicin, tobramycin, neomycin and to a lesser extent netilmicin.

Catalytic activity

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

Sequence similarities

Belongs to the antibiotic N-acetyltransferase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionaminoglycoside 3-N-acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Aminoglycoside N(3')-acetyltransferase III
PRO_0000068546

Sequences

Sequence LengthMass (Da)Tools
P29808 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: A66D13D364AD1484

FASTA27129,618
        10         20         30         40         50         60 
MTDLNIPHTH AHLVDAFQAL GIRAGQALML HASVKAVGAV MGGPNVILQA LMDALTPDGT 

        70         80         90        100        110        120 
LMMYAGWQDI PDFIDSLPDA LKAVYLEQHP PFDPATARAV RENSVLAEFL RTWPCVHRSA 

       130        140        150        160        170        180 
NPEASMVAVG RQAALLTANH ALDYGYGVES PLAKLVAIEG YVLMLGAPLD TITLLHHAEY 

       190        200        210        220        230        240 
LAKMRHKNVV RYPCPILRDG RKVWVTVEDY DTGDPHDDYS FEQIARDYVA QGGGTRGKVG 

       250        260        270 
DADAYLFAAQ DLTRFAVQWL ESRFGDSASY G 

« Hide

References

[1]"Nucleotide sequence of the aacC3 gene, a gentamicin resistance determinant encoding aminoglycoside-(3)-N-acetyltransferase III expressed in Pseudomonas aeruginosa but not in Escherichia coli."
Vliegenthart J.S., Ketelaar-Van Gaalen P.A.G., van de Klundert J.A.M.
Antimicrob. Agents Chemother. 35:892-897(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: PST-I.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X55652 Genomic DNA. Translation: CAA39184.1.
PIRS18730.

3D structure databases

ProteinModelPortalP29808.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAACC3_PSEAI
AccessionPrimary (citable) accession number: P29808
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 9, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families