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P29808

- AACC3_PSEAI

UniProt

P29808 - AACC3_PSEAI

Protein

Aminoglycoside N(3')-acetyltransferase III

Gene

aacC3

Organism
Pseudomonas aeruginosa
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Resistance to antibiotics containing the 2-deoxy-streptamine ring including dibekacin, gentamicin, kanamycin, sisomicin, tobramycin, neomycin and to a lesser extent netilmicin.

    Catalytic activityi

    Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

    GO - Molecular functioni

    1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aminoglycoside N(3')-acetyltransferase III (EC:2.3.1.81)
    Alternative name(s):
    ACC(3)-III
    Aminocyclitol 3-N-acetyltransferase type III
    Gentamicin-(3)-N-acetyl-transferase
    Gene namesi
    Name:aacC3
    OrganismiPseudomonas aeruginosa
    Taxonomic identifieri287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Aminoglycoside N(3')-acetyltransferase IIIPRO_0000068546Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP29808.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR003679. Amioglycoside_AcTrfase.
    [Graphical view]
    PfamiPF02522. Antibiotic_NAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29808-1 [UniParc]FASTAAdd to Basket

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    MTDLNIPHTH AHLVDAFQAL GIRAGQALML HASVKAVGAV MGGPNVILQA    50
    LMDALTPDGT LMMYAGWQDI PDFIDSLPDA LKAVYLEQHP PFDPATARAV 100
    RENSVLAEFL RTWPCVHRSA NPEASMVAVG RQAALLTANH ALDYGYGVES 150
    PLAKLVAIEG YVLMLGAPLD TITLLHHAEY LAKMRHKNVV RYPCPILRDG 200
    RKVWVTVEDY DTGDPHDDYS FEQIARDYVA QGGGTRGKVG DADAYLFAAQ 250
    DLTRFAVQWL ESRFGDSASY G 271
    Length:271
    Mass (Da):29,618
    Last modified:April 1, 1993 - v1
    Checksum:iA66D13D364AD1484
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55652 Genomic DNA. Translation: CAA39184.1.
    PIRiS18730.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55652 Genomic DNA. Translation: CAA39184.1 .
    PIRi S18730.

    3D structure databases

    ProteinModelPortali P29808.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR003679. Amioglycoside_AcTrfase.
    [Graphical view ]
    Pfami PF02522. Antibiotic_NAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the aacC3 gene, a gentamicin resistance determinant encoding aminoglycoside-(3)-N-acetyltransferase III expressed in Pseudomonas aeruginosa but not in Escherichia coli."
      Vliegenthart J.S., Ketelaar-Van Gaalen P.A.G., van de Klundert J.A.M.
      Antimicrob. Agents Chemother. 35:892-897(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: PST-I.

    Entry informationi

    Entry nameiAACC3_PSEAI
    AccessioniPrimary (citable) accession number: P29808
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3