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Protein

Aminoglycoside N(3')-acetyltransferase III

Gene

aacC3

Organism
Pseudomonas aeruginosa
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Resistance to antibiotics containing the 2-deoxy-streptamine ring including dibekacin, gentamicin, kanamycin, sisomicin, tobramycin, neomycin and to a lesser extent netilmicin.

Catalytic activityi

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

GO - Molecular functioni

  1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoglycoside N(3')-acetyltransferase III (EC:2.3.1.81)
Alternative name(s):
ACC(3)-III
Aminocyclitol 3-N-acetyltransferase type III
Gentamicin-(3)-N-acetyl-transferase
Gene namesi
Name:aacC3
OrganismiPseudomonas aeruginosa
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Aminoglycoside N(3')-acetyltransferase IIIPRO_0000068546Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP29808.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLNIPHTH AHLVDAFQAL GIRAGQALML HASVKAVGAV MGGPNVILQA
60 70 80 90 100
LMDALTPDGT LMMYAGWQDI PDFIDSLPDA LKAVYLEQHP PFDPATARAV
110 120 130 140 150
RENSVLAEFL RTWPCVHRSA NPEASMVAVG RQAALLTANH ALDYGYGVES
160 170 180 190 200
PLAKLVAIEG YVLMLGAPLD TITLLHHAEY LAKMRHKNVV RYPCPILRDG
210 220 230 240 250
RKVWVTVEDY DTGDPHDDYS FEQIARDYVA QGGGTRGKVG DADAYLFAAQ
260 270
DLTRFAVQWL ESRFGDSASY G
Length:271
Mass (Da):29,618
Last modified:April 1, 1993 - v1
Checksum:iA66D13D364AD1484
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55652 Genomic DNA. Translation: CAA39184.1.
PIRiS18730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55652 Genomic DNA. Translation: CAA39184.1.
PIRiS18730.

3D structure databases

ProteinModelPortaliP29808.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of the aacC3 gene, a gentamicin resistance determinant encoding aminoglycoside-(3)-N-acetyltransferase III expressed in Pseudomonas aeruginosa but not in Escherichia coli."
    Vliegenthart J.S., Ketelaar-Van Gaalen P.A.G., van de Klundert J.A.M.
    Antimicrob. Agents Chemother. 35:892-897(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PST-I.

Entry informationi

Entry nameiAACC3_PSEAI
AccessioniPrimary (citable) accession number: P29808
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 1, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.