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P29807

- AACC2_ACIBA

UniProt

P29807 - AACC2_ACIBA

Protein

Aminoglycoside N(3')-acetyltransferase III

Gene

aacC2

Organism
Acinetobacter baumannii
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

    Catalytic activityi

    Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

    GO - Molecular functioni

    1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aminoglycoside N(3')-acetyltransferase III (EC:2.3.1.81)
    Alternative name(s):
    AAC(3)II
    Gentamicin-(3)-N-acetyl-transferase
    Gene namesi
    Name:aacC2
    OrganismiAcinetobacter baumannii
    Taxonomic identifieri470 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286Aminoglycoside N(3')-acetyltransferase IIIPRO_0000068542Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP29807.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR003679. Amioglycoside_AcTrfase.
    [Graphical view]
    PfamiPF02522. Antibiotic_NAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29807-1 [UniParc]FASTAAdd to Basket

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    MHTRKAITEA IRKLGVQTGD LLMVHASLKA IGPVEGGAET VVAALRSAVG    50
    PTGTVMGYAS WDRSPYEETL NGARLDDKAR RTWPPFDPAT AGTYRGFGLL 100
    NQFLVQAPGA RRSAHPDASM VAVGPLAETL TEPHELGHAL GKGSPVERFV 150
    RLGGKALLLG APLNSVTALH YAEAVADIPN KRWVTYEMPM LGRNGEVAWK 200
    TASEYDSNGI LDCFAIEGKP DAVETIANAY VKLGRHREGV VGFAQCYLFD 250
    AQDIVTFGVT YLEKHFGATP IVPAHEAAQR SCEPSG 286
    Length:286
    Mass (Da):30,608
    Last modified:April 1, 1993 - v1
    Checksum:i44D0ADD033CBB71F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62833 Genomic DNA. Translation: AAA21890.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62833 Genomic DNA. Translation: AAA21890.1 .

    3D structure databases

    ProteinModelPortali P29807.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR003679. Amioglycoside_AcTrfase.
    [Graphical view ]
    Pfami PF02522. Antibiotic_NAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High level kanamycin resistance associated with the hyperproduction of AAC(3)II and a generalised reduction in the accumulation of aminoglycosides in Acinetobacter spp."
      Elisha B.G., Steyn L.M.
      J. Antimicrob. Chemother. 34:457-464(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: SAK.

    Entry informationi

    Entry nameiAACC2_ACIBA
    AccessioniPrimary (citable) accession number: P29807
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3