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P29807

- AACC2_ACIBA

UniProt

P29807 - AACC2_ACIBA

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Protein
Aminoglycoside N(3')-acetyltransferase III
Gene
aacC2
Organism
Acinetobacter baumannii
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

Catalytic activityi

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

GO - Molecular functioni

  1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoglycoside N(3')-acetyltransferase III (EC:2.3.1.81)
Alternative name(s):
AAC(3)II
Gentamicin-(3)-N-acetyl-transferase
Gene namesi
Name:aacC2
OrganismiAcinetobacter baumannii
Taxonomic identifieri470 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Aminoglycoside N(3')-acetyltransferase III
PRO_0000068542Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP29807.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29807-1 [UniParc]FASTAAdd to Basket

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MHTRKAITEA IRKLGVQTGD LLMVHASLKA IGPVEGGAET VVAALRSAVG    50
PTGTVMGYAS WDRSPYEETL NGARLDDKAR RTWPPFDPAT AGTYRGFGLL 100
NQFLVQAPGA RRSAHPDASM VAVGPLAETL TEPHELGHAL GKGSPVERFV 150
RLGGKALLLG APLNSVTALH YAEAVADIPN KRWVTYEMPM LGRNGEVAWK 200
TASEYDSNGI LDCFAIEGKP DAVETIANAY VKLGRHREGV VGFAQCYLFD 250
AQDIVTFGVT YLEKHFGATP IVPAHEAAQR SCEPSG 286
Length:286
Mass (Da):30,608
Last modified:April 1, 1993 - v1
Checksum:i44D0ADD033CBB71F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62833 Genomic DNA. Translation: AAA21890.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62833 Genomic DNA. Translation: AAA21890.1 .

3D structure databases

ProteinModelPortali P29807.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR003679. Amioglycoside_AcTrfase.
[Graphical view ]
Pfami PF02522. Antibiotic_NAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High level kanamycin resistance associated with the hyperproduction of AAC(3)II and a generalised reduction in the accumulation of aminoglycosides in Acinetobacter spp."
    Elisha B.G., Steyn L.M.
    J. Antimicrob. Chemother. 34:457-464(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SAK.

Entry informationi

Entry nameiAACC2_ACIBA
AccessioniPrimary (citable) accession number: P29807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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