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P29807 (AACC2_ACIBA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aminoglycoside N(3')-acetyltransferase III

EC=2.3.1.81
Alternative name(s):
AAC(3)II
Gentamicin-(3)-N-acetyl-transferase
Gene names
Name:aacC2
OrganismAcinetobacter baumannii
Taxonomic identifier470 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

Catalytic activity

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

Sequence similarities

Belongs to the antibiotic N-acetyltransferase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionaminoglycoside 3-N-acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286Aminoglycoside N(3')-acetyltransferase III
PRO_0000068542

Sequences

Sequence LengthMass (Da)Tools
P29807 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 44D0ADD033CBB71F

FASTA28630,608
        10         20         30         40         50         60 
MHTRKAITEA IRKLGVQTGD LLMVHASLKA IGPVEGGAET VVAALRSAVG PTGTVMGYAS 

        70         80         90        100        110        120 
WDRSPYEETL NGARLDDKAR RTWPPFDPAT AGTYRGFGLL NQFLVQAPGA RRSAHPDASM 

       130        140        150        160        170        180 
VAVGPLAETL TEPHELGHAL GKGSPVERFV RLGGKALLLG APLNSVTALH YAEAVADIPN 

       190        200        210        220        230        240 
KRWVTYEMPM LGRNGEVAWK TASEYDSNGI LDCFAIEGKP DAVETIANAY VKLGRHREGV 

       250        260        270        280 
VGFAQCYLFD AQDIVTFGVT YLEKHFGATP IVPAHEAAQR SCEPSG 

« Hide

References

[1]"High level kanamycin resistance associated with the hyperproduction of AAC(3)II and a generalised reduction in the accumulation of aminoglycosides in Acinetobacter spp."
Elisha B.G., Steyn L.M.
J. Antimicrob. Chemother. 34:457-464(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SAK.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M62833 Genomic DNA. Translation: AAA21890.1.

3D structure databases

ProteinModelPortalP29807.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAACC2_ACIBA
AccessionPrimary (citable) accession number: P29807
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families