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P29807

- AACC2_ACIBA

UniProt

P29807 - AACC2_ACIBA

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Protein

Aminoglycoside N(3')-acetyltransferase III

Gene

aacC2

Organism
Acinetobacter baumannii
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

Catalytic activityi

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

GO - Molecular functioni

  1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoglycoside N(3')-acetyltransferase III (EC:2.3.1.81)
Alternative name(s):
AAC(3)II
Gentamicin-(3)-N-acetyl-transferase
Gene namesi
Name:aacC2
OrganismiAcinetobacter baumannii
Taxonomic identifieri470 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Aminoglycoside N(3')-acetyltransferase IIIPRO_0000068542Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP29807.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29807-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MHTRKAITEA IRKLGVQTGD LLMVHASLKA IGPVEGGAET VVAALRSAVG
60 70 80 90 100
PTGTVMGYAS WDRSPYEETL NGARLDDKAR RTWPPFDPAT AGTYRGFGLL
110 120 130 140 150
NQFLVQAPGA RRSAHPDASM VAVGPLAETL TEPHELGHAL GKGSPVERFV
160 170 180 190 200
RLGGKALLLG APLNSVTALH YAEAVADIPN KRWVTYEMPM LGRNGEVAWK
210 220 230 240 250
TASEYDSNGI LDCFAIEGKP DAVETIANAY VKLGRHREGV VGFAQCYLFD
260 270 280
AQDIVTFGVT YLEKHFGATP IVPAHEAAQR SCEPSG
Length:286
Mass (Da):30,608
Last modified:April 1, 1993 - v1
Checksum:i44D0ADD033CBB71F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62833 Genomic DNA. Translation: AAA21890.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62833 Genomic DNA. Translation: AAA21890.1 .

3D structure databases

ProteinModelPortali P29807.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR003679. Amioglycoside_AcTrfase.
[Graphical view ]
Pfami PF02522. Antibiotic_NAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High level kanamycin resistance associated with the hyperproduction of AAC(3)II and a generalised reduction in the accumulation of aminoglycosides in Acinetobacter spp."
    Elisha B.G., Steyn L.M.
    J. Antimicrob. Chemother. 34:457-464(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SAK.

Entry informationi

Entry nameiAACC2_ACIBA
AccessioniPrimary (citable) accession number: P29807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3