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P29797 (GNAS_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein G(s) subunit alpha
Alternative name(s):
Adenylate cyclase-stimulating G alpha protein
Gene names
Name:GNAS
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Stimulates the Ras signaling pathway via RAPGEF2 By similarity.

Subunit structure

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Subcellular location

Cell membrane; Lipid-anchor By similarity.

Sequence similarities

Belongs to the G-alpha family. G(s) subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397Guanine nucleotide-binding protein G(s) subunit alpha
PRO_0000203724

Regions

Nucleotide binding47 – 548GTP By similarity
Nucleotide binding183 – 1897GTP By similarity
Nucleotide binding208 – 2125GTP By similarity
Nucleotide binding277 – 2804GTP By similarity

Sites

Metal binding541Magnesium By similarity
Metal binding1891Magnesium By similarity
Binding site3691GTP; via amide nitrogen By similarity

Amino acid modifications

Lipidation21N-palmitoyl glycine By similarity
Lipidation31S-palmitoyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P29797 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 9E0C10F42B6C4804

FASTA39746,477
        10         20         30         40         50         60 
MGCLGNSKTE DQRNEEKAQR EANKKIEKQL QKDKQVYRAT HRLLLLGAGE SGKSTIVKQM 

        70         80         90        100        110        120 
RILHVNGFNG DEKATKVQDI KNNLKEAIET IVAAMSNLVP PVELANPENQ FRVDYILSVM 

       130        140        150        160        170        180 
NVPDFDFPPE FYEHAKALWE DEGVRACYER SNEYQLIDCA QYFLDKIDVI KQDDYVPSDQ 

       190        200        210        220        230        240 
DLLRCRVLTS GIFETKFQVD KVNFHMFDVG GQRDERRKWI QCFNDVTAII FVVASSSYNM 

       250        260        270        280        290        300 
VIREDNQTNR LQEALNLFKS IWNNRWLRTI SVILFLNKQD LLAEKVLAGK SKIELFVLDD 

       310        320        330        340        350        360 
RLFQERPFSF IEDYFPEFAR YTTPEDATPE PGEDPRVTRA KYFIRDEFLR ISTASGDGRH 

       370        380        390 
YCYPHFTCAV DTENIRRVFN DCRDIIQRMH LRQYELL 

« Hide

References

[1]"Isolation and sequence of a porcine cDNA for the alpha-S subunit of the cardiac stimulatory GTP-binding protein (Gs)."
Roth D.A., Kay R.A.M., Hammond H.K.
Submitted (JAN-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X63893 mRNA. Translation: CAA45355.1.
PIRRGPGA2. S18963.
UniGeneSsc.6675.

3D structure databases

ProteinModelPortalP29797.
SMRP29797. Positions 35-394.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP29797.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG325092.
HOGENOMHOG000038729.
HOVERGENHBG063184.

Family and domain databases

Gene3D1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProIPR000367. Gprotein_alpha_S.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR10218. PTHR10218. 1 hit.
PfamPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSPR00318. GPROTEINA.
PR00443. GPROTEINAS.
SMARTSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNetSearch...

Entry information

Entry nameGNAS_PIG
AccessionPrimary (citable) accession number: P29797
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families