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P29797

- GNAS_PIG

UniProt

P29797 - GNAS_PIG

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Protein
Guanine nucleotide-binding protein G(s) subunit alpha
Gene
GNAS
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Stimulates the Ras signaling pathway via RAPGEF2 By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541Magnesium By similarity
Metal bindingi189 – 1891Magnesium By similarity
Binding sitei369 – 3691GTP; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi47 – 548GTP By similarity
Nucleotide bindingi183 – 1897GTP By similarity
Nucleotide bindingi208 – 2125GTP By similarity
Nucleotide bindingi277 – 2804GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-activating adrenergic receptor signaling pathway Source: UniProtKB
  2. positive regulation of Ras GTPase activity Source: UniProtKB
  3. positive regulation of cAMP biosynthetic process Source: UniProtKB
  4. positive regulation of cAMP-mediated signaling Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(s) subunit alpha
Alternative name(s):
Adenylate cyclase-stimulating G alpha protein
Gene namesi
Name:GNAS
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Guanine nucleotide-binding protein G(s) subunit alpha
PRO_0000203724Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-palmitoyl glycine By similarity
Lipidationi3 – 31S-palmitoyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP29797.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Structurei

3D structure databases

ProteinModelPortaliP29797.
SMRiP29797. Positions 35-394.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG325092.
HOGENOMiHOG000038729.
HOVERGENiHBG063184.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR000367. Gprotein_alpha_S.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00443. GPROTEINAS.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

P29797-1 [UniParc]FASTAAdd to Basket

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MGCLGNSKTE DQRNEEKAQR EANKKIEKQL QKDKQVYRAT HRLLLLGAGE    50
SGKSTIVKQM RILHVNGFNG DEKATKVQDI KNNLKEAIET IVAAMSNLVP 100
PVELANPENQ FRVDYILSVM NVPDFDFPPE FYEHAKALWE DEGVRACYER 150
SNEYQLIDCA QYFLDKIDVI KQDDYVPSDQ DLLRCRVLTS GIFETKFQVD 200
KVNFHMFDVG GQRDERRKWI QCFNDVTAII FVVASSSYNM VIREDNQTNR 250
LQEALNLFKS IWNNRWLRTI SVILFLNKQD LLAEKVLAGK SKIELFVLDD 300
RLFQERPFSF IEDYFPEFAR YTTPEDATPE PGEDPRVTRA KYFIRDEFLR 350
ISTASGDGRH YCYPHFTCAV DTENIRRVFN DCRDIIQRMH LRQYELL 397
Length:397
Mass (Da):46,477
Last modified:April 1, 1993 - v1
Checksum:i9E0C10F42B6C4804
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63893 mRNA. Translation: CAA45355.1.
PIRiS18963. RGPGA2.
UniGeneiSsc.6675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63893 mRNA. Translation: CAA45355.1 .
PIRi S18963. RGPGA2.
UniGenei Ssc.6675.

3D structure databases

ProteinModelPortali P29797.
SMRi P29797. Positions 35-394.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P29797.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG325092.
HOGENOMi HOG000038729.
HOVERGENi HBG063184.

Family and domain databases

Gene3Di 1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR000367. Gprotein_alpha_S.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10218. PTHR10218. 1 hit.
Pfami PF00503. G-alpha. 1 hit.
[Graphical view ]
PRINTSi PR00318. GPROTEINA.
PR00443. GPROTEINAS.
SMARTi SM00275. G_alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Isolation and sequence of a porcine cDNA for the alpha-S subunit of the cardiac stimulatory GTP-binding protein (Gs)."
    Roth D.A., Kay R.A.M., Hammond H.K.
    Submitted (JAN-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiGNAS_PIG
AccessioniPrimary (citable) accession number: P29797
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi