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Protein

Vitronectin

Gene

Vtn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-2129379 Molecules associated with elastic fibres
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000170 Syndecan interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Vitronectin
Short name:
VN
Alternative name(s):
S-protein
Serum-spreading factor
Gene namesi
Name:Vtn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98940 Vtn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000003639820 – 478VitronectinAdd BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 40PROSITE-ProRule annotation
Disulfide bondi24 ↔ 28PROSITE-ProRule annotation
Disulfide bondi28 ↔ 58PROSITE-ProRule annotation
Disulfide bondi38 ↔ 51PROSITE-ProRule annotation
Disulfide bondi38 ↔ 40PROSITE-ProRule annotation
Disulfide bondi44 ↔ 50PROSITE-ProRule annotation
Disulfide bondi51 ↔ 58PROSITE-ProRule annotation
Modified residuei69PhosphothreonineBy similarity1
Modified residuei75SulfotyrosineSequence analysis1
Modified residuei78SulfotyrosineSequence analysis1
Modified residuei80SulfotyrosineSequence analysis1
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi241N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei278SulfotyrosineSequence analysis1
Modified residuei281SulfotyrosineSequence analysis1
Disulfide bondi292 ↔ 431PROSITE-ProRule annotation
Modified residuei311PhosphoserineBy similarity1
Modified residuei362PhosphoserineCombined sources1
Modified residuei398Phosphoserine; by PKABy similarity1
Modified residuei416SulfotyrosineSequence analysis1
Modified residuei419SulfotyrosineSequence analysis1
Modified residuei421SulfotyrosineSequence analysis1

Post-translational modificationi

Sulfated on 2 tyrosine residues.By similarity
N- and O-glycosylated.By similarity
It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

MaxQBiP29788
PaxDbiP29788
PeptideAtlasiP29788
PRIDEiP29788

PTM databases

iPTMnetiP29788
PhosphoSitePlusiP29788

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSMUSG00000017344
CleanExiMM_VTN
GenevisibleiP29788 MM

Interactioni

Subunit structurei

Interacts with SERPINE1/PAI1, insulin and C1QBP.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204539, 1 interactor
ELMiP29788
IntActiP29788, 2 interactors
MINTiP29788
STRINGi10090.ENSMUSP00000017488

Structurei

3D structure databases

ProteinModelPortaliP29788
SMRiP29788
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 63SMBPROSITE-ProRule annotationAdd BLAST44
Repeati157 – 201Hemopexin 1Add BLAST45
Repeati202 – 249Hemopexin 2Add BLAST48
Repeati250 – 304Hemopexin 3Add BLAST55
Repeati420 – 473Hemopexin 4Add BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni366 – 399Heparin-bindingBy similarityAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi64 – 66Cell attachment site3

Domaini

The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin (By similarity).By similarity

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00530000063751
HOGENOMiHOG000133161
HOVERGENiHBG002902
InParanoidiP29788
KOiK06251
OMAiQPSQEEC
OrthoDBiEOG091G0817
PhylomeDBiP29788
TreeFamiTF332780

Family and domain databases

CDDicd00094 HX, 1 hit
Gene3Di2.110.10.10, 2 hits
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR036024 Somatomedin_B-like_dom_sf
IPR020436 Somatomedin_B_chordata
IPR001212 Somatomedin_B_dom
PfamiView protein in Pfam
PF00045 Hemopexin, 4 hits
PF01033 Somatomedin_B, 1 hit
PRINTSiPR00022 SOMATOMEDINB
SMARTiView protein in SMART
SM00120 HX, 4 hits
SM00201 SO, 1 hit
SUPFAMiSSF50923 SSF50923, 3 hits
SSF90188 SSF90188, 1 hit
PROSITEiView protein in PROSITE
PS00024 HEMOPEXIN, 2 hits
PS51642 HEMOPEXIN_2, 4 hits
PS00524 SMB_1, 1 hit
PS50958 SMB_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29788-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLRPFFIL ALVAWVSLAD QESCKGRCTQ GFMASKKCQC DELCTYYQSC
60 70 80 90 100
CADYMEQCKP QVTRGDVFTM PEDDYWSYDY VEEPKNNTNT GVQPENTSPP
110 120 130 140 150
GDLNPRTDGT LKPTAFLDPE EQPSTPAPKV EQQEEILRPD TTDQGTPEFP
160 170 180 190 200
EEELCSGKPF DAFTDLKNGS LFAFRGQYCY ELDETAVRPG YPKLIQDVWG
210 220 230 240 250
IEGPIDAAFT RINCQGKTYL FKGSQYWRFE DGVLDPGYPR NISEGFSGIP
260 270 280 290 300
DNVDAAFALP AHRYSGRERV YFFKGKQYWE YEFQQQPSQE ECEGSSLSAV
310 320 330 340 350
FEHFALLQRD SWENIFELLF WGRSSDGARE PQFISRNWHG VPGKVDAAMA
360 370 380 390 400
GRIYVTGSLS HSAQAKKQKS KRRSRKRYRS RRGRGHRRSQ SSNSRRSSRS
410 420 430 440 450
IWFSLFSSEE SGLGTYNNYD YDMDWLVPAT CEPIQSVYFF SGDKYYRVNL
460 470
RTRRVDSVNP PYPRSIAQYW LGCPTSEK
Length:478
Mass (Da):54,849
Last modified:October 1, 1996 - v2
Checksum:iEB0C772F8BD6A166
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti179 – 180CY → RC in AAL34534 (Ref. 4) Curated2
Sequence conflicti186A → T in AAH12690 (PubMed:15489334).Curated1
Sequence conflicti281Y → H in AAL34534 (Ref. 4) Curated1
Sequence conflicti348A → T in BAB27809 (PubMed:16141072).Curated1
Sequence conflicti369K → P in AAL34534 (Ref. 4) Curated1
Sequence conflicti383 – 384Missing in AAA40558 (PubMed:1719529).Curated2
Sequence conflicti416Y → K in AAA40558 (PubMed:1719529).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72091 Genomic DNA Translation: CAA50981.1
M77123 mRNA Translation: AAA40558.1
X63003 mRNA Translation: CAA44732.1
AF440693 mRNA Translation: AAL34534.1
AK011736 mRNA Translation: BAB27809.1
AK090325 mRNA Translation: BAC41171.1
AL591177 Genomic DNA Translation: CAI25547.1
CH466556 Genomic DNA Translation: EDL15582.1
BC012690 mRNA Translation: AAH12690.1
CCDSiCCDS25106.1
PIRiS19894 SGMSV
RefSeqiNP_035837.1, NM_011707.2
UniGeneiMm.3667

Genome annotation databases

EnsembliENSMUST00000017488; ENSMUSP00000017488; ENSMUSG00000017344
GeneIDi22370
KEGGimmu:22370
UCSCiuc007kjk.2 mouse

Similar proteinsi

Entry informationi

Entry nameiVTNC_MOUSE
AccessioniPrimary (citable) accession number: P29788
Secondary accession number(s): Q5SYG4
, Q8VII4, Q91X32, Q9D080
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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