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P29788

- VTNC_MOUSE

UniProt

P29788 - VTNC_MOUSE

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Protein

Vitronectin

Gene
Vtn
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

GO - Molecular functioni

  1. extracellular matrix binding Source: MGI
  2. heparin binding Source: UniProtKB-KW
  3. polysaccharide binding Source: InterPro
  4. scavenger receptor activity Source: InterPro

GO - Biological processi

  1. cell adhesion mediated by integrin Source: Ensembl
  2. cell-matrix adhesion Source: MGI
  3. extracellular matrix organization Source: MGI
  4. immune response Source: InterPro
  5. negative regulation of endopeptidase activity Source: Ensembl
  6. positive regulation of cell-substrate adhesion Source: MGI
  7. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  8. positive regulation of protein binding Source: Ensembl
  9. positive regulation of receptor-mediated endocytosis Source: Ensembl
  10. positive regulation of smooth muscle cell migration Source: Ensembl
  11. smooth muscle cell-matrix adhesion Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_196606. ECM proteoglycans.
REACT_196644. Syndecan interactions.
REACT_198562. Regulation of Complement cascade.
REACT_198998. Molecules associated with elastic fibres.
REACT_216309. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Vitronectin
Short name:
VN
Alternative name(s):
S-protein
Serum-spreading factor
Gene namesi
Name:Vtn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:98940. Vtn.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
  2. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 478459VitronectinPRO_0000036398Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 40Alternate; alternate By similarity
Disulfide bondi24 ↔ 28Alternate; alternate By similarity
Disulfide bondi28 ↔ 58Alternate; alternate By similarity
Disulfide bondi38 ↔ 51Alternate; alternate By similarity
Disulfide bondi38 ↔ 40Alternate; alternate By similarity
Disulfide bondi44 ↔ 50 By similarity
Disulfide bondi51 ↔ 58Alternate; alternate By similarity
Modified residuei69 – 691Phosphothreonine By similarity
Modified residuei75 – 751Sulfotyrosine Reviewed prediction
Modified residuei78 – 781Sulfotyrosine Reviewed prediction
Modified residuei80 – 801Sulfotyrosine Reviewed prediction
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi168 – 1681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi241 – 2411N-linked (GlcNAc...)1 Publication
Modified residuei278 – 2781Sulfotyrosine Reviewed prediction
Modified residuei281 – 2811Sulfotyrosine Reviewed prediction
Disulfide bondi292 ↔ 431 By similarity
Modified residuei311 – 3111Phosphoserine By similarity
Modified residuei398 – 3981Phosphoserine; by PKA By similarity
Modified residuei416 – 4161Sulfotyrosine Reviewed prediction
Modified residuei419 – 4191Sulfotyrosine Reviewed prediction
Modified residuei421 – 4211Sulfotyrosine Reviewed prediction

Post-translational modificationi

Sulfated on 2 tyrosine residues By similarity.
N- and O-glycosylated By similarity.
It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiP29788.
PRIDEiP29788.

PTM databases

PhosphoSiteiP29788.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiP29788.
CleanExiMM_VTN.
GenevestigatoriP29788.

Interactioni

Subunit structurei

Interacts with SERPINE1/PAI1, insulin and C1QBP By similarity.

Protein-protein interaction databases

IntActiP29788. 1 interaction.
MINTiMINT-4121605.
STRINGi10090.ENSMUSP00000017488.

Structurei

3D structure databases

ProteinModelPortaliP29788.
SMRiP29788. Positions 20-70, 154-345.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 6344SMBAdd
BLAST
Repeati157 – 20145Hemopexin 1Add
BLAST
Repeati202 – 24948Hemopexin 2Add
BLAST
Repeati250 – 30455Hemopexin 3Add
BLAST
Repeati420 – 47354Hemopexin 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni366 – 39934Heparin-binding By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi64 – 663Cell attachment site

Domaini

The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin By similarity.

Sequence similaritiesi

Contains 4 hemopexin repeats.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG245064.
GeneTreeiENSGT00530000063751.
HOGENOMiHOG000133161.
HOVERGENiHBG002902.
InParanoidiQ91X32.
KOiK06251.
OMAiLLQRDSW.
OrthoDBiEOG7MH0ZG.
PhylomeDBiP29788.
TreeFamiTF332780.

Family and domain databases

Gene3Di2.110.10.10. 3 hits.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR020436. Somatomedin_B_chordata.
IPR001212. Somatomedin_B_dom.
[Graphical view]
PfamiPF00045. Hemopexin. 4 hits.
PF01033. Somatomedin_B. 1 hit.
[Graphical view]
PRINTSiPR00022. SOMATOMEDINB.
SMARTiSM00120. HX. 4 hits.
SM00201. SO. 1 hit.
[Graphical view]
SUPFAMiSSF50923. SSF50923. 3 hits.
PROSITEiPS00024. HEMOPEXIN. 2 hits.
PS51642. HEMOPEXIN_2. 4 hits.
PS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29788-1 [UniParc]FASTAAdd to Basket

« Hide

MAPLRPFFIL ALVAWVSLAD QESCKGRCTQ GFMASKKCQC DELCTYYQSC    50
CADYMEQCKP QVTRGDVFTM PEDDYWSYDY VEEPKNNTNT GVQPENTSPP 100
GDLNPRTDGT LKPTAFLDPE EQPSTPAPKV EQQEEILRPD TTDQGTPEFP 150
EEELCSGKPF DAFTDLKNGS LFAFRGQYCY ELDETAVRPG YPKLIQDVWG 200
IEGPIDAAFT RINCQGKTYL FKGSQYWRFE DGVLDPGYPR NISEGFSGIP 250
DNVDAAFALP AHRYSGRERV YFFKGKQYWE YEFQQQPSQE ECEGSSLSAV 300
FEHFALLQRD SWENIFELLF WGRSSDGARE PQFISRNWHG VPGKVDAAMA 350
GRIYVTGSLS HSAQAKKQKS KRRSRKRYRS RRGRGHRRSQ SSNSRRSSRS 400
IWFSLFSSEE SGLGTYNNYD YDMDWLVPAT CEPIQSVYFF SGDKYYRVNL 450
RTRRVDSVNP PYPRSIAQYW LGCPTSEK 478
Length:478
Mass (Da):54,849
Last modified:October 1, 1996 - v2
Checksum:iEB0C772F8BD6A166
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1802CY → RC in AAL34534. 1 Publication
Sequence conflicti186 – 1861A → T in AAH12690. 1 Publication
Sequence conflicti281 – 2811Y → H in AAL34534. 1 Publication
Sequence conflicti348 – 3481A → T in BAB27809. 1 Publication
Sequence conflicti369 – 3691K → P in AAL34534. 1 Publication
Sequence conflicti383 – 3842Missing in AAA40558. 1 Publication
Sequence conflicti416 – 4161Y → K in AAA40558. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X72091 Genomic DNA. Translation: CAA50981.1.
M77123 mRNA. Translation: AAA40558.1.
X63003 mRNA. Translation: CAA44732.1.
AF440693 mRNA. Translation: AAL34534.1.
AK011736 mRNA. Translation: BAB27809.1.
AK090325 mRNA. Translation: BAC41171.1.
AL591177 Genomic DNA. Translation: CAI25547.1.
CH466556 Genomic DNA. Translation: EDL15582.1.
BC012690 mRNA. Translation: AAH12690.1.
CCDSiCCDS25106.1.
PIRiS19894. SGMSV.
RefSeqiNP_035837.1. NM_011707.2.
UniGeneiMm.3667.

Genome annotation databases

EnsembliENSMUST00000017488; ENSMUSP00000017488; ENSMUSG00000017344.
GeneIDi22370.
KEGGimmu:22370.
UCSCiuc007kjk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X72091 Genomic DNA. Translation: CAA50981.1 .
M77123 mRNA. Translation: AAA40558.1 .
X63003 mRNA. Translation: CAA44732.1 .
AF440693 mRNA. Translation: AAL34534.1 .
AK011736 mRNA. Translation: BAB27809.1 .
AK090325 mRNA. Translation: BAC41171.1 .
AL591177 Genomic DNA. Translation: CAI25547.1 .
CH466556 Genomic DNA. Translation: EDL15582.1 .
BC012690 mRNA. Translation: AAH12690.1 .
CCDSi CCDS25106.1.
PIRi S19894. SGMSV.
RefSeqi NP_035837.1. NM_011707.2.
UniGenei Mm.3667.

3D structure databases

ProteinModelPortali P29788.
SMRi P29788. Positions 20-70, 154-345.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P29788. 1 interaction.
MINTi MINT-4121605.
STRINGi 10090.ENSMUSP00000017488.

PTM databases

PhosphoSitei P29788.

Proteomic databases

PaxDbi P29788.
PRIDEi P29788.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000017488 ; ENSMUSP00000017488 ; ENSMUSG00000017344 .
GeneIDi 22370.
KEGGi mmu:22370.
UCSCi uc007kjk.2. mouse.

Organism-specific databases

CTDi 7448.
MGIi MGI:98940. Vtn.

Phylogenomic databases

eggNOGi NOG245064.
GeneTreei ENSGT00530000063751.
HOGENOMi HOG000133161.
HOVERGENi HBG002902.
InParanoidi Q91X32.
KOi K06251.
OMAi LLQRDSW.
OrthoDBi EOG7MH0ZG.
PhylomeDBi P29788.
TreeFami TF332780.

Enzyme and pathway databases

Reactomei REACT_196606. ECM proteoglycans.
REACT_196644. Syndecan interactions.
REACT_198562. Regulation of Complement cascade.
REACT_198998. Molecules associated with elastic fibres.
REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

ChiTaRSi VTN. mouse.
NextBioi 302703.
PROi P29788.
SOURCEi Search...

Gene expression databases

Bgeei P29788.
CleanExi MM_VTN.
Genevestigatori P29788.

Family and domain databases

Gene3Di 2.110.10.10. 3 hits.
InterProi IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR020436. Somatomedin_B_chordata.
IPR001212. Somatomedin_B_dom.
[Graphical view ]
Pfami PF00045. Hemopexin. 4 hits.
PF01033. Somatomedin_B. 1 hit.
[Graphical view ]
PRINTSi PR00022. SOMATOMEDINB.
SMARTi SM00120. HX. 4 hits.
SM00201. SO. 1 hit.
[Graphical view ]
SUPFAMi SSF50923. SSF50923. 3 hits.
PROSITEi PS00024. HEMOPEXIN. 2 hits.
PS51642. HEMOPEXIN_2. 4 hits.
PS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Organization of the gene encoding mouse vitronectin."
    Seiffert D., Poenninger J., Binder B.R.
    Gene 134:303-304(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Liver.
  2. "Detection of vitronectin mRNA in tissues and cells of the mouse."
    Seiffert D., Keeton M., Eguchi Y., Sawdey M., Loskutoff D.J.
    Proc. Natl. Acad. Sci. U.S.A. 88:9402-9406(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "Primary structure of vitronectins and homology with other proteins."
    Ehrlich H.J., Richter B., von der Ahe D., Preissner K.T.
    (In) Preissner K.T., Rosenblatt S., Kost C., Wegerhoff J., Mosher D.F. (eds.); Biology of vitronectins, pp.1-1, Elsevier, Amsterdam (1996)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Liver.
  4. "Construction of a robust CHO cell-line for biopharmaceutical production."
    Lai D.-Z.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Liver.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Gall bladder.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  7. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  9. "Vitronectin diversity in evolution but uniformity in ligand binding and size of the core polypeptide."
    Nakashima N., Miyazaki K., Ishikawa M., Yatohgo T., Ogawa H., Uchibori H., Matsumoto I., Seno N., Hayashi M.
    Biochim. Biophys. Acta 1120:1-10(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-44.
  10. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
    Bernhard O.K., Kapp E.A., Simpson R.J.
    J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-241.
    Strain: C57BL/6.
    Tissue: Plasma.

Entry informationi

Entry nameiVTNC_MOUSE
AccessioniPrimary (citable) accession number: P29788
Secondary accession number(s): Q5SYG4
, Q8VII4, Q91X32, Q9D080
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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