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Protein

Trypsin 5G1

Gene

AAEL013712

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Major function may be to aid in digestion of the blood meal.

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei81Charge relay systemBy similarity1
Active sitei125Charge relay systemBy similarity1
Sitei215Required for specificityBy similarity1
Active sitei221Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Protein family/group databases

MEROPSiS01.130.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin 5G1 (EC:3.4.21.4)
Gene namesi
ORF Names:AAEL013712
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
Proteomesi
  • UP000008820 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000002824119 – 39Activation peptideAdd BLAST21
ChainiPRO_000002824240 – 266Trypsin 5G1Add BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi66 ↔ 82PROSITE-ProRule annotation
Disulfide bondi190 ↔ 206PROSITE-ProRule annotation
Disulfide bondi217 ↔ 241PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Expressioni

Tissue specificityi

Midgut.

Interactioni

Protein-protein interaction databases

STRINGi7159.AAEL013712-PA.

Structurei

3D structure databases

ProteinModelPortaliP29787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 265Peptidase S1PROSITE-ProRule annotationAdd BLAST226

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251820.
InParanoidiP29787.
KOiK01312.
OrthoDBiEOG091G0AH5.
PhylomeDBiP29787.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRIILILTA TFFACALGAS TGGSHPLRPW WNALRSSGRI VGGFEVPVEE
60 70 80 90 100
VPFQVSLSGV GSSHFCGGSL LSERWVMTAG HCAASGQTNL QVRIGSSQHA
110 120 130 140 150
SGGQLIKVKK VNRHPKYDEV TTDYDFALLE LEETVTFSDS CAPVKLPQKD
160 170 180 190 200
APVNEGTCLQ VSGWGNTQNP SESSEVLRAA YVPAVSQKEC HKAYLSFGGV
210 220 230 240 250
TDRMVCAGFK EGGKDSCQGD SGGPLVHDNT LVGVVSWGYG CAQAGYPGVY
260
ARVASVRDWV KEVSGL
Length:266
Mass (Da):28,246
Last modified:September 2, 2008 - v2
Checksum:i63CB0B37F1B022C6
GO

Sequence cautioni

The sequence CAA45715 differs from that shown. Reason: Frameshift at position 35.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151A → T in CAA45715 (PubMed:9087545).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH478086 Genomic DNA. Translation: EAT34029.1.
X64363 mRNA. Translation: CAA45715.1. Frameshift.
PIRiS19891. TRWV5Y.
RefSeqiXP_001663895.1. XM_001663845.1.
UniGeneiAae.25940.

Genome annotation databases

EnsemblMetazoaiAAEL013712-RA; AAEL013712-PA; AAEL013712.
GeneIDi5578510.
KEGGiaag:AaeL_AAEL013712.
VectorBaseiAAEL013712-RA; AAEL013712-PA; AAEL013712.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH478086 Genomic DNA. Translation: EAT34029.1.
X64363 mRNA. Translation: CAA45715.1. Frameshift.
PIRiS19891. TRWV5Y.
RefSeqiXP_001663895.1. XM_001663845.1.
UniGeneiAae.25940.

3D structure databases

ProteinModelPortaliP29787.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7159.AAEL013712-PA.

Protein family/group databases

MEROPSiS01.130.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAAEL013712-RA; AAEL013712-PA; AAEL013712.
GeneIDi5578510.
KEGGiaag:AaeL_AAEL013712.
VectorBaseiAAEL013712-RA; AAEL013712-PA; AAEL013712.

Organism-specific databases

CTDi5578510.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251820.
InParanoidiP29787.
KOiK01312.
OrthoDBiEOG091G0AH5.
PhylomeDBiP29787.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRY5_AEDAE
AccessioniPrimary (citable) accession number: P29787
Secondary accession number(s): Q16ID7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: September 2, 2008
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.