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Protein

Trypsin 5G1

Gene

AAEL013712

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Major function may be to aid in digestion of the blood meal.

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei81Charge relay systemBy similarity1
Active sitei125Charge relay systemBy similarity1
Sitei215Required for specificityBy similarity1
Active sitei221Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processDigestion

Protein family/group databases

MEROPSiS01.130

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin 5G1 (EC:3.4.21.4)
Gene namesi
ORF Names:AAEL013712
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
Proteomesi
  • UP000008820 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000002824119 – 39Activation peptideAdd BLAST21
ChainiPRO_000002824240 – 266Trypsin 5G1Add BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi66 ↔ 82PROSITE-ProRule annotation
Disulfide bondi190 ↔ 206PROSITE-ProRule annotation
Disulfide bondi217 ↔ 241PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PRIDEiP29787

Expressioni

Tissue specificityi

Midgut.

Interactioni

Protein-protein interaction databases

STRINGi7159.AAEL013712-PA

Structurei

3D structure databases

ProteinModelPortaliP29787
SMRiP29787
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 265Peptidase S1PROSITE-ProRule annotationAdd BLAST226

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
HOGENOMiHOG000251820
InParanoidiP29787
KOiK01312
OMAiXMRCESI
OrthoDBiEOG091G0AH5
PhylomeDBiP29787

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRIILILTA TFFACALGAS TGGSHPLRPW WNALRSSGRI VGGFEVPVEE
60 70 80 90 100
VPFQVSLSGV GSSHFCGGSL LSERWVMTAG HCAASGQTNL QVRIGSSQHA
110 120 130 140 150
SGGQLIKVKK VNRHPKYDEV TTDYDFALLE LEETVTFSDS CAPVKLPQKD
160 170 180 190 200
APVNEGTCLQ VSGWGNTQNP SESSEVLRAA YVPAVSQKEC HKAYLSFGGV
210 220 230 240 250
TDRMVCAGFK EGGKDSCQGD SGGPLVHDNT LVGVVSWGYG CAQAGYPGVY
260
ARVASVRDWV KEVSGL
Length:266
Mass (Da):28,246
Last modified:September 2, 2008 - v2
Checksum:i63CB0B37F1B022C6
GO

Sequence cautioni

The sequence CAA45715 differs from that shown. Reason: Frameshift at position 35.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151A → T in CAA45715 (PubMed:9087545).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH478086 Genomic DNA Translation: EAT34029.1
X64363 mRNA Translation: CAA45715.1 Frameshift.
PIRiS19891 TRWV5Y
RefSeqiXP_001663895.1, XM_001663845.1

Genome annotation databases

EnsemblMetazoaiAAEL013712-RA; AAEL013712-PA; AAEL013712
GeneIDi5578510
KEGGiaag:5578510

Similar proteinsi

Entry informationi

Entry nameiTRY5_AEDAE
AccessioniPrimary (citable) accession number: P29787
Secondary accession number(s): Q16ID7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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