Reviewed, UniProtKB/Swiss-Prot P29785 (STRO_STRGR)

Names and origin

Protein names

Recommended name:
    Glucose-1-phosphate thymidylyltransferase
    EC=2.7.7.24
Alternative name(s):
    dTDP-glucose synthase

Gene names

Name:

strO

Organism

Streptomyces griseus

Taxonomic identifier

1911 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-glucose.
Pathway	Antibiotic biosynthesis; streptomycin biosynthesis.

Ontologies

Keywords
Biological process	Antibiotic biosynthesis Streptomycin biosynthesis
Molecular function	Transferase
Gene Ontology (GO)
Biological process	streptomycin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glucose-1-phosphate thymidylyltransferase activity Inferred from electronic annotation. Source: EC inositol or phosphatidylinositol phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	Glucose-1-phosphate thymidylyltransferase		PRO_0000072287

Sequences

	Sequence		Length	Mass (Da)
	P29785-1 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: D2DA6E0E75AFF28A	FASTA	259	27,858
	10 20 30 40 50 60 MTDNDSDVRL AHRLAEIADT LAWEFFGGAP AVRHKSDGSP VSEADLAVEK ALLAVLAAER 70 80 90 100 110 120 PGDAVLTEES GSLGTRSSRR RWILDPIDGT IPFLAGERGW GTHVALEVDE ELRTAVLSRP 130 140 150 160 170 180 TERSRWWAVR GRGAFTSVRG EPLSAARPLR IPSAPLPLEA ARVGGFLMPD SPVEPVRDRM 190 200 210 220 230 240 RWVESSVCLV GDLLEGRVDA VIDEGGHVWD RAPAALLVHE AGGRVDDLRG GGRLDERWLV 250 YAADGVADGL AGLLRDVGA

References

[1]	Ahlert J., Distler J., Mansouri K., Roggel M., Altenbach H.J., Piepersberg W. Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION TO 33. Strain: N2-3-11.
[2]	"Genetics of streptomycin production in Streptomyces griseus: molecular structure and putative function of genes strELMB2N." Pissowotzki K., Mansouri K., Piepersberg W. Mol. Gen. Genet. 231:113-123(1991) [PubMed: 1661369] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-83. Strain: N2-3-11.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y08763 Genomic DNA. Translation: CAA70009.1. X62567 Genomic DNA. Translation: CAA44446.1. Sequence problems.
PIR	S19785.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.7.24. 1270.
Family and domain databases
InterPro	IPR000760. Inositol_P. [Graphical view]
PANTHER	PTHR20854. Inositol_P. 1 hit.
Pfam	PF00459. Inositol_P. 1 hit. [Graphical view]
PRINTS	PR00378. INOSPHPHTASE.
ProDom	PD023420. Inositol_P. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

STRO_STRGR

Accession

Primary (citable) accession number: P29785

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	November 1, 1997
Last modified:	January 20, 2009
This is version 39 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)