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P29767 (NANH_CLOSE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sialidase

EC=3.2.1.18
Alternative name(s):
Neuraminidase
OrganismClostridium septicum
Taxonomic identifier1504 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length1014 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sialidases have been suggested to be pathogenic factors in microbial infections.

Catalytic activity

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Subcellular location

Secreted.

Sequence similarities

Belongs to the glycosyl hydrolase 33 family.

Contains 4 BNR repeats.

Contains 1 F5/8 type C domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 1014988Sialidase
PRO_0000012031

Regions

Domain39 – 186148F5/8 type C
Repeat431 – 44212BNR 1
Repeat563 – 57412BNR 2
Repeat627 – 63812BNR 3
Repeat700 – 71112BNR 4

Sites

Active site4211Proton acceptor By similarity
Active site9121Nucleophile By similarity
Binding site3961Substrate By similarity
Binding site6881Substrate By similarity
Binding site8731Substrate Potential

Sequences

Sequence LengthMass (Da)Tools
P29767 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: C4F49233473A2FAD

FASTA1,014110,653
        10         20         30         40         50         60 
MNKKKIMSIL VSAFLITNLS SNIIFADIKE NVYINQYSEG NRSQPIAEKL VPRSEIQASA 

        70         80         90        100        110        120 
TSALTGEGPE KAIDGNTSTL WHTPWAGVDI QINPQSLTLK LGKTRNISSI CVTPRQEGTN 

       130        140        150        160        170        180 
GMITDYKIYS GDDVIAEGKW KSDSSDKYVV FDNPISTDNI RIEAISTVGD ENNKHASIAE 

       190        200        210        220        230        240 
VEVYELADTP VKLAESNNKV INNGNGGNYE GDISEISLLE EGTAIIRFTN NGSSLFSISN 

       250        260        270        280        290        300 
NERTNEHFHV YINGGAIGYE LRKQSGNLAT GSVNKALNAG INTIAFKAEK GKGYSIYLNG 

       310        320        330        340        350        360 
EKILTSSSIT ANFLSTLEGL NTLSLGKTDR PSGSNEYNFT GEIDFFELYS KPLADRYLKE 

       370        380        390        400        410        420 
RTGETTSKDL PFPEGAVKTE PVDIFTPGEL GSNNFRIPAL YTTKDGTVLA SIDVRKGGGH 

       430        440        450        460        470        480 
DAPNNIDTGI KRSTDGGVTW DEGKIILDYP GASSAIDTSL LQDDETGRIF LIVTHFAEGY 

       490        500        510        520        530        540 
GFGNSKTGSG YVEIEGKRYL KLLGANDTIY TVREGVVYDS NGEATNYTVD NNNELYENGN 

       550        560        570        580        590        600 
RIGNVLLSNS PLKVMGTSFL SLIYSDDDGQ TWSDPIDLNK EVKTDWMRFL GTGPGKGHQI 

       610        620        630        640        650        660 
KTGRYAGRLL FPVYLTNASG FQSSAVIYSD DNGATWNIGE TATDGRLMDN GDRASAETIT 

       670        680        690        700        710        720 
TNTSGGVGQL TECQVVEMPN GQLKMFMRNT GGNSGRVRIA TSFDGGATWE DDVVRDENIK 

       730        740        750        760        770        780 
EPYCQLSVIN YSQKIDGKDA IIFAIPDANY PNRVNGTVRV GLITENGSYE NGEPRYDIEW 

       790        800        810        820        830        840 
RYNKVVAPGT YGYSCLSEMP NGEIGLFYEG RGSRQMSFTR MNIDYLKADL LQDVPAANIK 

       850        860        870        880        890        900 
SYTTNSENNI YDPGDKISLN VTFDQTVSLI GDRTITADIG GKEVLLTLAN SKGGSEYTFE 

       910        920        930        940        950        960 
GTVPADISNG NYTITIKGKS GLKIVNVVNK VTDITEDRNT GLNVQVGEEV QSVDKTLLQD 

       970        980        990       1000       1010 
LVDSTSNLIK EDYTEESWIL YEKALEVANK FLVNEIAVQE EVDAAKPTLE NAYK 

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References

[1]"The sialidase gene from Clostridium septicum: cloning, sequencing, expression in Escherichia coli and identification of conserved sequences in sialidases and other proteins."
Rothe B., Rothe B., Roggentin P., Schauer R.
Mol. Gen. Genet. 226:190-197(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NC 0054714.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X63266 Genomic DNA. Translation: CAA44916.1.
PIRNMCLSS. S15994.

3D structure databases

ProteinModelPortalP29767.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyCBM32. Carbohydrate-Binding Module Family 32.
GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
2.60.120.260. 1 hit.
InterProIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR008979. Galactose-bd-like.
IPR004124. Glyco_hydro_33_N.
IPR026948. Sialidase/anhydrosialidase.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF5. PTHR10628:SF5. 1 hit.
PfamPF00754. F5_F8_type_C. 1 hit.
PF02973. Sialidase. 1 hit.
[Graphical view]
SUPFAMSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
PROSITEPS50022. FA58C_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNANH_CLOSE
AccessionPrimary (citable) accession number: P29767
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 16, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries