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P29762

- RABP1_HUMAN

UniProt

P29762 - RABP1_HUMAN

Protein

Cellular retinoic acid-binding protein 1

Gene

CRABP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. retinal binding Source: UniProtKB-KW
    3. retinoic acid binding Source: Ensembl
    4. retinoid binding Source: ProtInc
    5. retinol binding Source: UniProtKB-KW
    6. transporter activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: ProtInc
    2. signal transduction Source: ProtInc

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Retinol-binding, Vitamin A

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cellular retinoic acid-binding protein 1
    Alternative name(s):
    Cellular retinoic acid-binding protein I
    Short name:
    CRABP-I
    Gene namesi
    Name:CRABP1
    Synonyms:RBP5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:2338. CRABP1.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosol Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26858.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 137136Cellular retinoic acid-binding protein 1PRO_0000067406Add
    BLAST

    Proteomic databases

    MaxQBiP29762.
    PaxDbiP29762.
    PRIDEiP29762.

    PTM databases

    PhosphoSiteiP29762.

    Expressioni

    Gene expression databases

    ArrayExpressiP29762.
    BgeeiP29762.
    CleanExiHS_CRABP1.
    HS_RBP5.
    GenevestigatoriP29762.

    Organism-specific databases

    HPAiHPA017203.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    P279583EBI-725950,EBI-8753518From a different organism.

    Protein-protein interaction databases

    BioGridi107772. 2 interactions.
    IntActiP29762. 3 interactions.
    MINTiMINT-5005962.
    STRINGi9606.ENSP00000299529.

    Structurei

    3D structure databases

    ProteinModelPortaliP29762.
    SMRiP29762. Positions 2-137.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni132 – 1343Retinoic acid bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi21 – 3111Nuclear localization signalBy similarityAdd
    BLAST

    Domaini

    Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG258792.
    HOGENOMiHOG000004831.
    HOVERGENiHBG005633.
    InParanoidiP29762.
    KOiK17337.
    OMAiATWESEN.
    OrthoDBiEOG7NW6BZ.
    PhylomeDBiP29762.
    TreeFamiTF316894.

    Family and domain databases

    Gene3Di2.40.128.20. 1 hit.
    InterProiIPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000463. Fatty_acid-bd.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view]
    PfamiPF00061. Lipocalin. 1 hit.
    [Graphical view]
    PRINTSiPR00178. FATTYACIDBP.
    SUPFAMiSSF50814. SSF50814. 1 hit.
    PROSITEiPS00214. FABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P29762-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPNFAGTWKM RSSENFDELL KALGVNAMLR KVAVAAASKP HVEIRQDGDQ    50
    FYIKTSTTVR TTEINFKVGE GFEEETVDGR KCRSLATWEN ENKIHCTQTL 100
    LEGDGPKTYW TRELANDELI LTFGADDVVC TRIYVRE 137
    Length:137
    Mass (Da):15,566
    Last modified:January 23, 2007 - v2
    Checksum:iA3DB048973E4E8C4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti112 – 1121R → S in AAH22069. (PubMed:15489334)Curated
    Sequence conflicti137 – 1371E → D in CAG33298. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S74445 mRNA. Translation: AAB20773.1.
    CR457017 mRNA. Translation: CAG33298.1.
    BC022069 mRNA. Translation: AAH22069.1.
    CCDSiCCDS10301.1.
    PIRiJH0548. RJHU1.
    RefSeqiNP_004369.1. NM_004378.2.
    UniGeneiHs.346950.

    Genome annotation databases

    EnsembliENST00000299529; ENSP00000299529; ENSG00000166426.
    GeneIDi1381.
    KEGGihsa:1381.
    UCSCiuc002bdp.2. human.

    Polymorphism databases

    DMDMi266904.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S74445 mRNA. Translation: AAB20773.1 .
    CR457017 mRNA. Translation: CAG33298.1 .
    BC022069 mRNA. Translation: AAH22069.1 .
    CCDSi CCDS10301.1.
    PIRi JH0548. RJHU1.
    RefSeqi NP_004369.1. NM_004378.2.
    UniGenei Hs.346950.

    3D structure databases

    ProteinModelPortali P29762.
    SMRi P29762. Positions 2-137.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107772. 2 interactions.
    IntActi P29762. 3 interactions.
    MINTi MINT-5005962.
    STRINGi 9606.ENSP00000299529.

    Chemistry

    ChEMBLi CHEMBL2079.
    DrugBanki DB00523. Alitretinoin.
    DB00926. Etretinate.

    PTM databases

    PhosphoSitei P29762.

    Polymorphism databases

    DMDMi 266904.

    Proteomic databases

    MaxQBi P29762.
    PaxDbi P29762.
    PRIDEi P29762.

    Protocols and materials databases

    DNASUi 1381.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299529 ; ENSP00000299529 ; ENSG00000166426 .
    GeneIDi 1381.
    KEGGi hsa:1381.
    UCSCi uc002bdp.2. human.

    Organism-specific databases

    CTDi 1381.
    GeneCardsi GC15P078632.
    HGNCi HGNC:2338. CRABP1.
    HPAi HPA017203.
    MIMi 180230. gene.
    neXtProti NX_P29762.
    PharmGKBi PA26858.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG258792.
    HOGENOMi HOG000004831.
    HOVERGENi HBG005633.
    InParanoidi P29762.
    KOi K17337.
    OMAi ATWESEN.
    OrthoDBi EOG7NW6BZ.
    PhylomeDBi P29762.
    TreeFami TF316894.

    Miscellaneous databases

    GeneWikii CRABP1.
    GenomeRNAii 1381.
    NextBioi 5611.
    PROi P29762.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P29762.
    Bgeei P29762.
    CleanExi HS_CRABP1.
    HS_RBP5.
    Genevestigatori P29762.

    Family and domain databases

    Gene3Di 2.40.128.20. 1 hit.
    InterProi IPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000463. Fatty_acid-bd.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view ]
    Pfami PF00061. Lipocalin. 1 hit.
    [Graphical view ]
    PRINTSi PR00178. FATTYACIDBP.
    SUPFAMi SSF50814. SSF50814. 1 hit.
    PROSITEi PS00214. FABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The molecular cloning and expression of two CRABP cDNAs from human skin."
      Eller M.S., Oleksiak M.F., McQuaid T.J., McAfee S.G., Gilchrest B.A.
      Exp. Cell Res. 198:328-336(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro."
      Astroem A., Tavakkol A., Pettersson U., Cromie M., Elder J.T., Voorhees J.J.
      J. Biol. Chem. 266:17662-17666(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest."
      Budhu A.S., Noy N.
      Mol. Cell. Biol. 22:2632-2641(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiRABP1_HUMAN
    AccessioniPrimary (citable) accession number: P29762
    Secondary accession number(s): Q6IAY7, Q8WTV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3