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Protein

Cellular retinoic acid-binding protein 1

Gene

CRABP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

GO - Molecular functioni

  1. retinal binding Source: UniProtKB-KW
  2. retinoic acid binding Source: Ensembl
  3. retinoid binding Source: ProtInc
  4. retinol binding Source: UniProtKB-KW
  5. transporter activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: ProtInc
  2. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Retinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiREACT_268561. RA biosynthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular retinoic acid-binding protein 1
Alternative name(s):
Cellular retinoic acid-binding protein I
Short name:
CRABP-I
Gene namesi
Name:CRABP1
Synonyms:RBP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:2338. CRABP1.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26858.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 137136Cellular retinoic acid-binding protein 1PRO_0000067406Add
BLAST

Proteomic databases

MaxQBiP29762.
PaxDbiP29762.
PRIDEiP29762.

PTM databases

PhosphoSiteiP29762.

Expressioni

Gene expression databases

BgeeiP29762.
CleanExiHS_CRABP1.
HS_RBP5.
ExpressionAtlasiP29762. baseline and differential.
GenevestigatoriP29762.

Organism-specific databases

HPAiHPA017203.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
P279583EBI-725950,EBI-8753518From a different organism.

Protein-protein interaction databases

BioGridi107772. 2 interactions.
IntActiP29762. 3 interactions.
MINTiMINT-5005962.
STRINGi9606.ENSP00000299529.

Structurei

3D structure databases

ProteinModelPortaliP29762.
SMRiP29762. Positions 2-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 1343Retinoic acid bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi21 – 3111Nuclear localization signalBy similarityAdd
BLAST

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG258792.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiP29762.
KOiK17337.
OMAiQDGEQFY.
OrthoDBiEOG7NW6BZ.
PhylomeDBiP29762.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNFAGTWKM RSSENFDELL KALGVNAMLR KVAVAAASKP HVEIRQDGDQ
60 70 80 90 100
FYIKTSTTVR TTEINFKVGE GFEEETVDGR KCRSLATWEN ENKIHCTQTL
110 120 130
LEGDGPKTYW TRELANDELI LTFGADDVVC TRIYVRE
Length:137
Mass (Da):15,566
Last modified:January 23, 2007 - v2
Checksum:iA3DB048973E4E8C4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121R → S in AAH22069 (PubMed:15489334).Curated
Sequence conflicti137 – 1371E → D in CAG33298 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74445 mRNA. Translation: AAB20773.1.
CR457017 mRNA. Translation: CAG33298.1.
BC022069 mRNA. Translation: AAH22069.1.
CCDSiCCDS10301.1.
PIRiJH0548. RJHU1.
RefSeqiNP_004369.1. NM_004378.2.
UniGeneiHs.346950.

Genome annotation databases

EnsembliENST00000299529; ENSP00000299529; ENSG00000166426.
GeneIDi1381.
KEGGihsa:1381.
UCSCiuc002bdp.2. human.

Polymorphism databases

DMDMi266904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74445 mRNA. Translation: AAB20773.1.
CR457017 mRNA. Translation: CAG33298.1.
BC022069 mRNA. Translation: AAH22069.1.
CCDSiCCDS10301.1.
PIRiJH0548. RJHU1.
RefSeqiNP_004369.1. NM_004378.2.
UniGeneiHs.346950.

3D structure databases

ProteinModelPortaliP29762.
SMRiP29762. Positions 2-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107772. 2 interactions.
IntActiP29762. 3 interactions.
MINTiMINT-5005962.
STRINGi9606.ENSP00000299529.

Chemistry

ChEMBLiCHEMBL2079.
DrugBankiDB00523. Alitretinoin.
DB00755. Tretinoin.

PTM databases

PhosphoSiteiP29762.

Polymorphism databases

DMDMi266904.

Proteomic databases

MaxQBiP29762.
PaxDbiP29762.
PRIDEiP29762.

Protocols and materials databases

DNASUi1381.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299529; ENSP00000299529; ENSG00000166426.
GeneIDi1381.
KEGGihsa:1381.
UCSCiuc002bdp.2. human.

Organism-specific databases

CTDi1381.
GeneCardsiGC15P078632.
HGNCiHGNC:2338. CRABP1.
HPAiHPA017203.
MIMi180230. gene.
neXtProtiNX_P29762.
PharmGKBiPA26858.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG258792.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiP29762.
KOiK17337.
OMAiQDGEQFY.
OrthoDBiEOG7NW6BZ.
PhylomeDBiP29762.
TreeFamiTF316894.

Enzyme and pathway databases

ReactomeiREACT_268561. RA biosynthesis pathway.

Miscellaneous databases

GeneWikiiCRABP1.
GenomeRNAii1381.
NextBioi5611.
PROiP29762.
SOURCEiSearch...

Gene expression databases

BgeeiP29762.
CleanExiHS_CRABP1.
HS_RBP5.
ExpressionAtlasiP29762. baseline and differential.
GenevestigatoriP29762.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The molecular cloning and expression of two CRABP cDNAs from human skin."
    Eller M.S., Oleksiak M.F., McQuaid T.J., McAfee S.G., Gilchrest B.A.
    Exp. Cell Res. 198:328-336(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro."
    Astroem A., Tavakkol A., Pettersson U., Cromie M., Elder J.T., Voorhees J.J.
    J. Biol. Chem. 266:17662-17666(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest."
    Budhu A.S., Noy N.
    Mol. Cell. Biol. 22:2632-2641(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRABP1_HUMAN
AccessioniPrimary (citable) accession number: P29762
Secondary accession number(s): Q6IAY7, Q8WTV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.