P29762 (RABP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cellular retinoic acid-binding protein 1

Alternative name(s):
Cellular retinoic acid-binding protein I
Short name=CRABP-I

Gene names

Name:	CRABP1
Synonyms:	RBP5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.
Subcellular location	Cytoplasm Ref.5.
Domain	Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior By similarity.
Sequence similarities	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cytoplasm
Ligand	Retinol-binding Vitamin A
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Traceable author statement Ref.1. Source: ProtInc signal transduction Traceable author statement Ref.1. Source: ProtInc
Cellular_component	cytosol Inferred from electronic annotation. Source: Compara
Molecular_function	retinal binding Inferred from electronic annotation. Source: UniProtKB-KW retinoic acid binding Inferred from electronic annotation. Source: Compara retinoid binding Traceable author statement Ref.1. Source: ProtInc retinol binding Inferred from electronic annotation. Source: UniProtKB-KW transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 137	136	Cellular retinoic acid-binding protein 1		PRO_0000067406
Regions
	Region	132 – 134	3	Retinoic acid binding By similarity
	Motif	21 – 31	11	Nuclear localization signal By similarity
Experimental info
	Sequence conflict	112	1	R → S in AAH22069. Ref.4
	Sequence conflict	137	1	E → D in CAG33298. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P29762 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: A3DB048973E4E8C4	FASTA	137	15,566
	10 20 30 40 50 60 MPNFAGTWKM RSSENFDELL KALGVNAMLR KVAVAAASKP HVEIRQDGDQ FYIKTSTTVR 70 80 90 100 110 120 TTEINFKVGE GFEEETVDGR KCRSLATWEN ENKIHCTQTL LEGDGPKTYW TRELANDELI 130 LTFGADDVVC TRIYVRE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The molecular cloning and expression of two CRABP cDNAs from human skin." Eller M.S., Oleksiak M.F., McQuaid T.J., McAfee S.G., Gilchrest B.A. Exp. Cell Res. 198:328-336(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro." Astroem A., Tavakkol A., Pettersson U., Cromie M., Elder J.T., Voorhees J.J. J. Biol. Chem. 266:17662-17666(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest." Budhu A.S., Noy N. Mol. Cell. Biol. 22:2632-2641(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S74445 mRNA. Translation: AAB20773.1. CR457017 mRNA. Translation: CAG33298.1. BC022069 mRNA. Translation: AAH22069.1.
IPI	IPI00219930.
PIR	RJHU1. JH0548.
RefSeq	NP_004369.1. NM_004378.2.
UniGene	Hs.346950.
3D structure databases
ProteinModelPortal	P29762.
ModBase	Search...
Protein-protein interaction databases
IntAct	P29762. 1 interaction.
MINT	MINT-5005962.
STRING	9606.ENSP00000299529.
PTM databases
PhosphoSite	P29762.
Polymorphism databases
DMDM	266904.
Proteomic databases
PaxDb	P29762.
PRIDE	P29762.
Protocols and materials databases
DNASU	1381.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000299529; ENSP00000299529; ENSG00000166426.
GeneID	1381.
KEGG	hsa:1381.
UCSC	uc002bdp.2. human.
Organism-specific databases
CTD	1381.
GeneCards	GC15P078632.
HGNC	HGNC:2338. CRABP1.
HPA	HPA017203.
MIM	180230. gene.
neXtProt	NX_P29762.
PharmGKB	PA26858.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG258792.
HOGENOM	HOG000004831.
HOVERGEN	HBG005633.
InParanoid	P29762.
OMA	ATWESEN.
OrthoDB	EOG4KPTC5.
PhylomeDB	P29762.
Gene expression databases
ArrayExpress	P29762.
Bgee	P29762.
CleanEx	HS_CRABP1. HS_RBP5.
Genevestigator	P29762.
GermOnline	ENSG00000166426. Homo sapiens.
Family and domain databases
Gene3D	2.40.128.20. 1 hit.
InterPro	IPR012674. Calycin. IPR011038. Calycin-like. IPR000463. Fatty_acid-bd. IPR000566. Lipocln_cytosolic_FA-bd_dom. [Graphical view]
Pfam	PF00061. Lipocalin. 1 hit. [Graphical view]
PRINTS	PR00178. FATTYACIDBP.
SUPFAM	SSF50814. Calycin. 1 hit.
PROSITE	PS00214. FABP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL2079.
DrugBank	DB00523. Alitretinoin. DB00926. Etretinate.
GenomeRNAi	1381.
NextBio	5611.
SOURCE	Search...

Entry information

Entry name

RABP1_HUMAN

Accession

Primary (citable) accession number: P29762
Secondary accession number(s): Q6IAY7, Q8WTV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 114 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.