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P29762

- RABP1_HUMAN

UniProt

P29762 - RABP1_HUMAN

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Protein
Cellular retinoic acid-binding protein 1
Gene
CRABP1, RBP5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. retinal binding Source: UniProtKB-KW
  3. retinoic acid binding Source: Ensembl
  4. retinoid binding Source: ProtInc
  5. retinol binding Source: UniProtKB-KW
  6. transporter activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. multicellular organismal development Source: ProtInc
  2. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Retinol-binding, Vitamin A

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular retinoic acid-binding protein 1
Alternative name(s):
Cellular retinoic acid-binding protein I
Short name:
CRABP-I
Gene namesi
Name:CRABP1
Synonyms:RBP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:2338. CRABP1.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosol Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26858.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 137136Cellular retinoic acid-binding protein 1
PRO_0000067406Add
BLAST

Proteomic databases

MaxQBiP29762.
PaxDbiP29762.
PRIDEiP29762.

PTM databases

PhosphoSiteiP29762.

Expressioni

Gene expression databases

ArrayExpressiP29762.
BgeeiP29762.
CleanExiHS_CRABP1.
HS_RBP5.
GenevestigatoriP29762.

Organism-specific databases

HPAiHPA017203.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
P279583EBI-725950,EBI-8753518From a different organism.

Protein-protein interaction databases

BioGridi107772. 2 interactions.
IntActiP29762. 3 interactions.
MINTiMINT-5005962.
STRINGi9606.ENSP00000299529.

Structurei

3D structure databases

ProteinModelPortaliP29762.
SMRiP29762. Positions 2-137.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 1343Retinoic acid binding By similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi21 – 3111Nuclear localization signal By similarity
Add
BLAST

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior By similarity.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG258792.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiP29762.
KOiK17337.
OMAiATWESEN.
OrthoDBiEOG7NW6BZ.
PhylomeDBiP29762.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29762-1 [UniParc]FASTAAdd to Basket

« Hide

MPNFAGTWKM RSSENFDELL KALGVNAMLR KVAVAAASKP HVEIRQDGDQ    50
FYIKTSTTVR TTEINFKVGE GFEEETVDGR KCRSLATWEN ENKIHCTQTL 100
LEGDGPKTYW TRELANDELI LTFGADDVVC TRIYVRE 137
Length:137
Mass (Da):15,566
Last modified:January 23, 2007 - v2
Checksum:iA3DB048973E4E8C4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121R → S in AAH22069. 1 Publication
Sequence conflicti137 – 1371E → D in CAG33298. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S74445 mRNA. Translation: AAB20773.1.
CR457017 mRNA. Translation: CAG33298.1.
BC022069 mRNA. Translation: AAH22069.1.
CCDSiCCDS10301.1.
PIRiJH0548. RJHU1.
RefSeqiNP_004369.1. NM_004378.2.
UniGeneiHs.346950.

Genome annotation databases

EnsembliENST00000299529; ENSP00000299529; ENSG00000166426.
GeneIDi1381.
KEGGihsa:1381.
UCSCiuc002bdp.2. human.

Polymorphism databases

DMDMi266904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S74445 mRNA. Translation: AAB20773.1 .
CR457017 mRNA. Translation: CAG33298.1 .
BC022069 mRNA. Translation: AAH22069.1 .
CCDSi CCDS10301.1.
PIRi JH0548. RJHU1.
RefSeqi NP_004369.1. NM_004378.2.
UniGenei Hs.346950.

3D structure databases

ProteinModelPortali P29762.
SMRi P29762. Positions 2-137.
ModBasei Search...

Protein-protein interaction databases

BioGridi 107772. 2 interactions.
IntActi P29762. 3 interactions.
MINTi MINT-5005962.
STRINGi 9606.ENSP00000299529.

Chemistry

ChEMBLi CHEMBL2079.
DrugBanki DB00523. Alitretinoin.
DB00926. Etretinate.

PTM databases

PhosphoSitei P29762.

Polymorphism databases

DMDMi 266904.

Proteomic databases

MaxQBi P29762.
PaxDbi P29762.
PRIDEi P29762.

Protocols and materials databases

DNASUi 1381.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000299529 ; ENSP00000299529 ; ENSG00000166426 .
GeneIDi 1381.
KEGGi hsa:1381.
UCSCi uc002bdp.2. human.

Organism-specific databases

CTDi 1381.
GeneCardsi GC15P078632.
HGNCi HGNC:2338. CRABP1.
HPAi HPA017203.
MIMi 180230. gene.
neXtProti NX_P29762.
PharmGKBi PA26858.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG258792.
HOGENOMi HOG000004831.
HOVERGENi HBG005633.
InParanoidi P29762.
KOi K17337.
OMAi ATWESEN.
OrthoDBi EOG7NW6BZ.
PhylomeDBi P29762.
TreeFami TF316894.

Miscellaneous databases

GeneWikii CRABP1.
GenomeRNAii 1381.
NextBioi 5611.
PROi P29762.
SOURCEi Search...

Gene expression databases

ArrayExpressi P29762.
Bgeei P29762.
CleanExi HS_CRABP1.
HS_RBP5.
Genevestigatori P29762.

Family and domain databases

Gene3Di 2.40.128.20. 1 hit.
InterProi IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view ]
Pfami PF00061. Lipocalin. 1 hit.
[Graphical view ]
PRINTSi PR00178. FATTYACIDBP.
SUPFAMi SSF50814. SSF50814. 1 hit.
PROSITEi PS00214. FABP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The molecular cloning and expression of two CRABP cDNAs from human skin."
    Eller M.S., Oleksiak M.F., McQuaid T.J., McAfee S.G., Gilchrest B.A.
    Exp. Cell Res. 198:328-336(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro."
    Astroem A., Tavakkol A., Pettersson U., Cromie M., Elder J.T., Voorhees J.J.
    J. Biol. Chem. 266:17662-17666(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest."
    Budhu A.S., Noy N.
    Mol. Cell. Biol. 22:2632-2641(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRABP1_HUMAN
AccessioniPrimary (citable) accession number: P29762
Secondary accession number(s): Q6IAY7, Q8WTV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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