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Protein

Ornithine aminotransferase, mitochondrial

Gene

Oat

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.

Cofactori

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine aminotransferase, mitochondrial (Oat)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi2.6.1.13. 3474.
ReactomeiR-MMU-70614. Amino acid synthesis and interconversion (transamination).
UniPathwayiUPA00098; UER00358.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine aminotransferase, mitochondrial (EC:2.6.1.13)
Alternative name(s):
Ornithine--oxo-acid aminotransferase
Gene namesi
Name:Oat
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:97394. Oat.

Subcellular locationi

  • Mitochondrion matrix By similarity

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075297.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25Mitochondrion1 PublicationAdd BLAST25
ChainiPRO_000000126426 – 439Ornithine aminotransferase, mitochondrialAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49N6-acetyllysineCombined sources1
Modified residuei66N6-acetyllysineCombined sources1
Modified residuei102N6-succinyllysineCombined sources1
Modified residuei107N6-acetyllysine; alternateCombined sources1
Modified residuei107N6-succinyllysine; alternateCombined sources1
Modified residuei292N6-(pyridoxal phosphate)lysineBy similarity1
Modified residuei362N6-acetyllysine; alternateCombined sources1
Modified residuei362N6-succinyllysine; alternateCombined sources1
Modified residuei386N6-acetyllysineCombined sources1
Modified residuei392N6-acetyllysineCombined sources1
Modified residuei405N6-acetyllysine; alternateCombined sources1
Modified residuei405N6-succinyllysine; alternateCombined sources1
Modified residuei421N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP29758.
PaxDbiP29758.
PeptideAtlasiP29758.
PRIDEiP29758.

2D gel databases

REPRODUCTION-2DPAGEIPI00129178.
P29758.
SWISS-2DPAGEP29758.

PTM databases

iPTMnetiP29758.
PhosphoSitePlusiP29758.
SwissPalmiP29758.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030934.
CleanExiMM_OAT.
ExpressionAtlasiP29758. baseline and differential.
GenevisibleiP29758. MM.

Interactioni

Subunit structurei

Homohexamer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201887. 2 interactors.
IntActiP29758. 4 interactors.
MINTiMINT-1844623.
STRINGi10090.ENSMUSP00000081544.

Structurei

3D structure databases

ProteinModelPortaliP29758.
SMRiP29758.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1402. Eukaryota.
COG4992. LUCA.
GeneTreeiENSGT00630000089895.
HOGENOMiHOG000020206.
HOVERGENiHBG000434.
InParanoidiP29758.
KOiK00819.
OMAiTHDHTIR.
OrthoDBiEOG091G06WM.
PhylomeDBiP29758.
TreeFamiTF105720.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR010164. Orn_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF18. PTHR11986:SF18. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01885. Orn_aminotrans. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKLASLQT IAALRRGVHT SVASATSVAT KKTEQGPPSS EYIFERESKY
60 70 80 90 100
GAHNYHPLPV ALERGKGIYM WDVEGRQYFD FLSAYGAVSQ GHCHPKIIDA
110 120 130 140 150
MKSQVDKLTL TSRAFYNNVL GEYEEYITKL FNYNKVLPMN TGVEAGETAC
160 170 180 190 200
KLARRWGYTV KGIQKYKAKI VFADGNFWGR TLSAISSSTD PTSYDGFGPF
210 220 230 240 250
MPGFETIPYN DLPALERALQ DPNVAAFMVE PIQGEAGVIV PDPGYLTGVR
260 270 280 290 300
ELCTRHQVLF IADEIQTGLA RTGRWLAVDH ENVRPDMVLL GKALSGGLYP
310 320 330 340 350
VSAVLCDDEI MLTIKPGEHG STYGGNPLGC RIAIAALEVL EEENLAENAD
360 370 380 390 400
KMGAILRKEL MKLPSDVVTS VRGKGLLNAI VIRETKDCDA WKVCLRLRDN
410 420 430
GLLAKPTHGD IIRLAPPLVI KEDEIRESVE IINKTILSF
Length:439
Mass (Da):48,355
Last modified:April 1, 1993 - v1
Checksum:i74299A63F6C48025
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64837 mRNA. Translation: CAA46049.1.
BC008119 mRNA. Translation: AAH08119.1.
CCDSiCCDS21923.1.
PIRiS19937. XNMSO.
RefSeqiNP_058674.1. NM_016978.2.
UniGeneiMm.13694.
Mm.310635.

Genome annotation databases

EnsembliENSMUST00000084500; ENSMUSP00000081544; ENSMUSG00000030934.
GeneIDi18242.
KEGGimmu:18242.
UCSCiuc009kcb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64837 mRNA. Translation: CAA46049.1.
BC008119 mRNA. Translation: AAH08119.1.
CCDSiCCDS21923.1.
PIRiS19937. XNMSO.
RefSeqiNP_058674.1. NM_016978.2.
UniGeneiMm.13694.
Mm.310635.

3D structure databases

ProteinModelPortaliP29758.
SMRiP29758.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201887. 2 interactors.
IntActiP29758. 4 interactors.
MINTiMINT-1844623.
STRINGi10090.ENSMUSP00000081544.

Chemistry databases

ChEMBLiCHEMBL1075297.

PTM databases

iPTMnetiP29758.
PhosphoSitePlusiP29758.
SwissPalmiP29758.

2D gel databases

REPRODUCTION-2DPAGEIPI00129178.
P29758.
SWISS-2DPAGEP29758.

Proteomic databases

EPDiP29758.
PaxDbiP29758.
PeptideAtlasiP29758.
PRIDEiP29758.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084500; ENSMUSP00000081544; ENSMUSG00000030934.
GeneIDi18242.
KEGGimmu:18242.
UCSCiuc009kcb.1. mouse.

Organism-specific databases

CTDi4942.
MGIiMGI:97394. Oat.

Phylogenomic databases

eggNOGiKOG1402. Eukaryota.
COG4992. LUCA.
GeneTreeiENSGT00630000089895.
HOGENOMiHOG000020206.
HOVERGENiHBG000434.
InParanoidiP29758.
KOiK00819.
OMAiTHDHTIR.
OrthoDBiEOG091G06WM.
PhylomeDBiP29758.
TreeFamiTF105720.

Enzyme and pathway databases

UniPathwayiUPA00098; UER00358.
BRENDAi2.6.1.13. 3474.
ReactomeiR-MMU-70614. Amino acid synthesis and interconversion (transamination).

Miscellaneous databases

ChiTaRSiOat. mouse.
PROiP29758.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030934.
CleanExiMM_OAT.
ExpressionAtlasiP29758. baseline and differential.
GenevisibleiP29758. MM.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR010164. Orn_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF18. PTHR11986:SF18. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01885. Orn_aminotrans. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOAT_MOUSE
AccessioniPrimary (citable) accession number: P29758
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.