P29755 (AGTRB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Type-1B angiotensin II receptor

Alternative name(s):
AT3
Angiotensin II type-1B receptor
Short name=AT1B

Gene names

Name:

Agtr1b

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subunit structure	Interacts with MAS1 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Post-translational modification	C-terminal Ser or Thr residues may be phosphorylated.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blood vessel development Inferred from genetic interaction PubMed 9466969. Source: MGI cellular response to dexamethasone stimulus Inferred from electronic annotation. Source: Compara drinking behavior Inferred from mutant phenotype PubMed 10880053. Source: MGI elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara inflammatory response Inferred from genetic interaction PubMed 19404405. Source: MGI kidney development Inferred from genetic interaction PubMed 9466969. Source: MGI positive regulation of branching involved in ureteric bud morphogenesis Inferred from electronic annotation. Source: Compara regulation of systemic arterial blood pressure by circulatory renin-angiotensin Inferred from genetic interaction PubMed 9466969. Source: MGI response to drug Inferred from electronic annotation. Source: Compara response to estrogen stimulus Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara response to nutrient Inferred from electronic annotation. Source: Compara
Cellular_component	basolateral plasma membrane Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW vesicle lumen Inferred from electronic annotation. Source: Compara vesicle membrane Inferred from electronic annotation. Source: Compara
Molecular_function	angiotensin type I receptor activity Inferred from electronic annotation. Source: Compara angiotensin type II receptor activity Inferred from electronic annotation. Source: InterPro peptide hormone binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Type-1B angiotensin II receptor		PRO_0000069156
Regions
	Topological domain	1 – 27	27	Extracellular Potential
	Transmembrane	28 – 52	25	Helical; Name=1; Potential
	Topological domain	53 – 64	12	Cytoplasmic Potential
	Transmembrane	65 – 87	23	Helical; Name=2; Potential
	Topological domain	88 – 102	15	Extracellular Potential
	Transmembrane	103 – 124	22	Helical; Name=3; Potential
	Topological domain	125 – 142	18	Cytoplasmic Potential
	Transmembrane	143 – 162	20	Helical; Name=4; Potential
	Topological domain	163 – 192	30	Extracellular Potential
	Transmembrane	193 – 214	22	Helical; Name=5; Potential
	Topological domain	215 – 240	26	Cytoplasmic Potential
	Transmembrane	241 – 262	22	Helical; Name=6; Potential
	Topological domain	263 – 275	13	Extracellular Potential
	Transmembrane	276 – 296	21	Helical; Name=7; Potential
	Topological domain	297 – 359	63	Cytoplasmic Potential
Amino acid modifications
	Lipidation	355	1	S-palmitoyl cysteine Potential
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	176	1	N-linked (GlcNAc...) Potential
	Glycosylation	188	1	N-linked (GlcNAc...) Potential
	Disulfide bond	101 ↔ 180		By similarity
Experimental info
	Sequence conflict	7	1	I → T Ref.2
	Sequence conflict	166	1	H → Y Ref.2
	Sequence conflict	173	1	E → A Ref.2
	Sequence conflict	205	1	V → E Ref.2
	Sequence conflict	232	1	T → I Ref.2
	Sequence conflict	239	1	F → G Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P29755 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 95730F97058EAA4B	FASTA	359	40,950
	10 20 30 40 50 60 MILNSSIEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK 70 80 90 100 110 120 TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYQWPFGNHL CKIASASVSF NLYASVFLLT 130 140 150 160 170 180 CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLMAGLAS LPAVIHRNVY FIENTNITVC 190 200 210 220 230 240 AFHYESQNST LPIGLGLTKN ILGFVFPFVI ILTSYTLIWK ALKKAYKIQK NTPRNDDIFR 250 260 270 280 290 300 IIMAIVLFFF FSWVPHQIFS FLDVLIQLGV IHDCEIADVV DTAMPITICI AYFNNCLNPL 310 320 330 340 350 FYGFLGKKFK RYFLQLLKYI PPKARSHAGL STKMSTLSYR PSDNMSSSAR KSAYCFEVE

References

[1]	"Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome." Sasamura H., Hein L., Krieger J.E., Pratt R.E., Kobilka B.K., Dzau V.J. Biochem. Biophys. Res. Commun. 185:253-259(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c. Tissue: Liver.
[2]	"Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human)." Yoshida H., Kakuchi J., Guo D.F., Furuta H., Iwai N., van der Meer-De Jong R., Inagami T., Ichikawa I. Biochem. Biophys. Res. Commun. 186:1042-1049(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S37491 Genomic DNA. Translation: AAB22270.1.
IPI	IPI00323276.
PIR	JC1194.
RefSeq	NP_780295.2. NM_175086.3.
UniGene	Mm.134863.
3D structure databases
ProteinModelPortal	P29755.
SMR	P29755. Positions 25-313.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P29755.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000068316; ENSMUSP00000068298; ENSMUSG00000054988. ENSMUST00000163776; ENSMUSP00000128724; ENSMUSG00000054988.
GeneID	11608.
KEGG	mmu:11608.
UCSC	uc007pyu.2. mouse.
Organism-specific databases
CTD	11608.
MGI	MGI:87965. Agtr1b.
Phylogenomic databases
eggNOG	NOG256015.
GeneTree	ENSGT00700000104167.
HOGENOM	HOG000234122.
HOVERGEN	HBG104998.
InParanoid	P29755.
KO	K04166.
OMA	TPRNDDI.
OrthoDB	EOG48D0VX.
Gene expression databases
Bgee	P29755.
CleanEx	MM_AGTR1B.
Genevestigator	P29755.
GermOnline	ENSMUSG00000054988. Mus musculus.
Family and domain databases
InterPro	IPR000190. ATII_AT1_rcpt. IPR000248. ATII_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00241. ANGIOTENSINR. PR00635. ANGIOTENSN1R. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	279148.
SOURCE	Search...

Entry information

Entry name

AGTRB_MOUSE

Accession

Primary (citable) accession number: P29755

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	May 1, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program