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P29755

- AGTRB_MOUSE

UniProt

P29755 - AGTRB_MOUSE

Protein

Type-1B angiotensin II receptor

Gene

Agtr1b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. angiotensin type II receptor activity Source: InterPro
    2. angiotensin type I receptor activity Source: Ensembl
    3. peptide hormone binding Source: Ensembl

    GO - Biological processi

    1. blood vessel development Source: MGI
    2. cellular response to dexamethasone stimulus Source: Ensembl
    3. drinking behavior Source: MGI
    4. inflammatory response Source: MGI
    5. kidney development Source: MGI
    6. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
    7. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    8. regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: MGI
    9. regulation of vasoconstriction Source: InterPro
    10. response to drug Source: Ensembl
    11. response to estrogen Source: Ensembl
    12. response to hypoxia Source: Ensembl
    13. response to nutrient Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type-1B angiotensin II receptor
    Alternative name(s):
    AT3
    Angiotensin II type-1B receptor
    Short name:
    AT1B
    Gene namesi
    Name:Agtr1b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:87965. Agtr1b.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. vesicle lumen Source: Ensembl
    4. vesicle membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Type-1B angiotensin II receptorPRO_0000069156Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Lipidationi355 – 3551S-palmitoyl cysteineSequence Analysis

    Post-translational modificationi

    C-terminal Ser or Thr residues may be phosphorylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PRIDEiP29755.

    Expressioni

    Gene expression databases

    BgeeiP29755.
    CleanExiMM_AGTR1B.
    GenevestigatoriP29755.

    Interactioni

    Subunit structurei

    Interacts with MAS1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP29755.
    SMRiP29755. Positions 25-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini53 – 6412CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini88 – 10215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini125 – 14218CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 19230ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini215 – 24026CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini263 – 27513ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini297 – 35963CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 5225Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei65 – 8723Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei103 – 12422Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei143 – 16220Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei193 – 21422Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26222Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei276 – 29621Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG256015.
    GeneTreeiENSGT00720000108671.
    HOGENOMiHOG000234122.
    HOVERGENiHBG104998.
    InParanoidiP29755.
    KOiK04166.
    OMAiTPRNDDI.
    OrthoDBiEOG7J4473.
    PhylomeDBiP29755.
    TreeFamiTF330024.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000190. ATII_AT1_rcpt.
    IPR000248. ATII_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00241. ANGIOTENSINR.
    PR00635. ANGIOTENSN1R.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29755-1 [UniParc]FASTAAdd to Basket

    « Hide

    MILNSSIEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV    50
    IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYQWPFGNHL 100
    CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI 150
    IIWLMAGLAS LPAVIHRNVY FIENTNITVC AFHYESQNST LPIGLGLTKN 200
    ILGFVFPFVI ILTSYTLIWK ALKKAYKIQK NTPRNDDIFR IIMAIVLFFF 250
    FSWVPHQIFS FLDVLIQLGV IHDCEIADVV DTAMPITICI AYFNNCLNPL 300
    FYGFLGKKFK RYFLQLLKYI PPKARSHAGL STKMSTLSYR PSDNMSSSAR 350
    KSAYCFEVE 359
    Length:359
    Mass (Da):40,950
    Last modified:April 1, 1993 - v1
    Checksum:i95730F97058EAA4B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71I → T(PubMed:1497638)Curated
    Sequence conflicti166 – 1661H → Y(PubMed:1497638)Curated
    Sequence conflicti173 – 1731E → A(PubMed:1497638)Curated
    Sequence conflicti205 – 2051V → E(PubMed:1497638)Curated
    Sequence conflicti232 – 2321T → I(PubMed:1497638)Curated
    Sequence conflicti239 – 2391F → G(PubMed:1497638)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S37491 Genomic DNA. Translation: AAB22270.1.
    CCDSiCCDS17264.1.
    PIRiJC1194.
    RefSeqiNP_780295.2. NM_175086.3.
    UniGeneiMm.134863.

    Genome annotation databases

    EnsembliENSMUST00000068316; ENSMUSP00000068298; ENSMUSG00000054988.
    ENSMUST00000163776; ENSMUSP00000128724; ENSMUSG00000054988.
    GeneIDi11608.
    KEGGimmu:11608.
    UCSCiuc008osr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S37491 Genomic DNA. Translation: AAB22270.1 .
    CCDSi CCDS17264.1.
    PIRi JC1194.
    RefSeqi NP_780295.2. NM_175086.3.
    UniGenei Mm.134863.

    3D structure databases

    ProteinModelPortali P29755.
    SMRi P29755. Positions 25-313.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 34.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi P29755.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000068316 ; ENSMUSP00000068298 ; ENSMUSG00000054988 .
    ENSMUST00000163776 ; ENSMUSP00000128724 ; ENSMUSG00000054988 .
    GeneIDi 11608.
    KEGGi mmu:11608.
    UCSCi uc008osr.1. mouse.

    Organism-specific databases

    CTDi 11608.
    MGIi MGI:87965. Agtr1b.

    Phylogenomic databases

    eggNOGi NOG256015.
    GeneTreei ENSGT00720000108671.
    HOGENOMi HOG000234122.
    HOVERGENi HBG104998.
    InParanoidi P29755.
    KOi K04166.
    OMAi TPRNDDI.
    OrthoDBi EOG7J4473.
    PhylomeDBi P29755.
    TreeFami TF330024.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 279148.
    PROi P29755.
    SOURCEi Search...

    Gene expression databases

    Bgeei P29755.
    CleanExi MM_AGTR1B.
    Genevestigatori P29755.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000190. ATII_AT1_rcpt.
    IPR000248. ATII_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00241. ANGIOTENSINR.
    PR00635. ANGIOTENSN1R.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome."
      Sasamura H., Hein L., Krieger J.E., Pratt R.E., Kobilka B.K., Dzau V.J.
      Biochem. Biophys. Res. Commun. 185:253-259(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
      Tissue: Liver.
    2. "Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human)."
      Yoshida H., Kakuchi J., Guo D.F., Furuta H., Iwai N., van der Meer-De Jong R., Inagami T., Ichikawa I.
      Biochem. Biophys. Res. Commun. 186:1042-1049(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiAGTRB_MOUSE
    AccessioniPrimary (citable) accession number: P29755
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3