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Protein

Type-1B angiotensin II receptor

Gene

Agtr1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. angiotensin type II receptor activity Source: InterPro
  2. angiotensin type I receptor activity Source: Ensembl
  3. peptide hormone binding Source: Ensembl

GO - Biological processi

  1. blood vessel development Source: MGI
  2. cellular response to dexamethasone stimulus Source: Ensembl
  3. drinking behavior Source: MGI
  4. inflammatory response Source: MGI
  5. kidney development Source: MGI
  6. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
  7. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  8. regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: MGI
  9. regulation of vasoconstriction Source: InterPro
  10. response to drug Source: Ensembl
  11. response to estrogen Source: Ensembl
  12. response to hypoxia Source: Ensembl
  13. response to immobilization stress Source: Ensembl
  14. response to nutrient Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1B angiotensin II receptor
Alternative name(s):
AT3
Angiotensin II type-1B receptor
Short name:
AT1B
Gene namesi
Name:Agtr1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:87965. Agtr1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 5225Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini53 – 6412CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei65 – 8723Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini88 – 10215ExtracellularSequence AnalysisAdd
BLAST
Transmembranei103 – 12422Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini125 – 14218CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei143 – 16220Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 19230ExtracellularSequence AnalysisAdd
BLAST
Transmembranei193 – 21422Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini215 – 24026CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26222Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini263 – 27513ExtracellularSequence AnalysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini297 – 35963CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. vesicle lumen Source: Ensembl
  4. vesicle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Type-1B angiotensin II receptorPRO_0000069156Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Lipidationi355 – 3551S-palmitoyl cysteineSequence Analysis

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiP29755.

Expressioni

Gene expression databases

BgeeiP29755.
CleanExiMM_AGTR1B.
GenevestigatoriP29755.

Interactioni

Subunit structurei

Interacts with MAS1.By similarity

Structurei

3D structure databases

ProteinModelPortaliP29755.
SMRiP29755. Positions 25-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256015.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiP29755.
KOiK04166.
OMAiTPRNDDI.
OrthoDBiEOG7J4473.
PhylomeDBiP29755.
TreeFamiTF330024.

Family and domain databases

InterProiIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILNSSIEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYQWPFGNHL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLMAGLAS LPAVIHRNVY FIENTNITVC AFHYESQNST LPIGLGLTKN
210 220 230 240 250
ILGFVFPFVI ILTSYTLIWK ALKKAYKIQK NTPRNDDIFR IIMAIVLFFF
260 270 280 290 300
FSWVPHQIFS FLDVLIQLGV IHDCEIADVV DTAMPITICI AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK RYFLQLLKYI PPKARSHAGL STKMSTLSYR PSDNMSSSAR

KSAYCFEVE
Length:359
Mass (Da):40,950
Last modified:April 1, 1993 - v1
Checksum:i95730F97058EAA4B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71I → T (PubMed:1497638).Curated
Sequence conflicti166 – 1661H → Y (PubMed:1497638).Curated
Sequence conflicti173 – 1731E → A (PubMed:1497638).Curated
Sequence conflicti205 – 2051V → E (PubMed:1497638).Curated
Sequence conflicti232 – 2321T → I (PubMed:1497638).Curated
Sequence conflicti239 – 2391F → G (PubMed:1497638).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S37491 Genomic DNA. Translation: AAB22270.1.
CCDSiCCDS17264.1.
PIRiJC1194.
RefSeqiNP_780295.2. NM_175086.3.
UniGeneiMm.134863.

Genome annotation databases

EnsembliENSMUST00000068316; ENSMUSP00000068298; ENSMUSG00000054988.
ENSMUST00000163776; ENSMUSP00000128724; ENSMUSG00000054988.
GeneIDi11608.
KEGGimmu:11608.
UCSCiuc008osr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S37491 Genomic DNA. Translation: AAB22270.1.
CCDSiCCDS17264.1.
PIRiJC1194.
RefSeqiNP_780295.2. NM_175086.3.
UniGeneiMm.134863.

3D structure databases

ProteinModelPortaliP29755.
SMRiP29755. Positions 25-313.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi34.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiP29755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068316; ENSMUSP00000068298; ENSMUSG00000054988.
ENSMUST00000163776; ENSMUSP00000128724; ENSMUSG00000054988.
GeneIDi11608.
KEGGimmu:11608.
UCSCiuc008osr.1. mouse.

Organism-specific databases

CTDi11608.
MGIiMGI:87965. Agtr1b.

Phylogenomic databases

eggNOGiNOG256015.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiP29755.
KOiK04166.
OMAiTPRNDDI.
OrthoDBiEOG7J4473.
PhylomeDBiP29755.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi279148.
PROiP29755.
SOURCEiSearch...

Gene expression databases

BgeeiP29755.
CleanExiMM_AGTR1B.
GenevestigatoriP29755.

Family and domain databases

InterProiIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome."
    Sasamura H., Hein L., Krieger J.E., Pratt R.E., Kobilka B.K., Dzau V.J.
    Biochem. Biophys. Res. Commun. 185:253-259(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Liver.
  2. "Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human)."
    Yoshida H., Kakuchi J., Guo D.F., Furuta H., Iwai N., van der Meer-De Jong R., Inagami T., Ichikawa I.
    Biochem. Biophys. Res. Commun. 186:1042-1049(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiAGTRB_MOUSE
AccessioniPrimary (citable) accession number: P29755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 1, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.