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P29755 (AGTRB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type-1B angiotensin II receptor
Alternative name(s):
AT3
Angiotensin II type-1B receptor
Short name=AT1B
Gene names
Name:Agtr1b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subunit structure

Interacts with MAS1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Post-translational modification

C-terminal Ser or Thr residues may be phosphorylated.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processblood vessel development

Inferred from genetic interaction PubMed 9466969. Source: MGI

cellular response to dexamethasone stimulus

Inferred from electronic annotation. Source: Ensembl

drinking behavior

Inferred from mutant phenotype PubMed 10880053. Source: MGI

inflammatory response

Inferred from genetic interaction PubMed 19404405. Source: MGI

kidney development

Inferred from genetic interaction PubMed 9466969. Source: MGI

positive regulation of branching involved in ureteric bud morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

regulation of systemic arterial blood pressure by circulatory renin-angiotensin

Inferred from genetic interaction PubMed 9466969. Source: MGI

regulation of vasoconstriction

Inferred from electronic annotation. Source: InterPro

response to drug

Inferred from electronic annotation. Source: Ensembl

response to estrogen

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to nutrient

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentbasolateral plasma membrane

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

vesicle lumen

Inferred from electronic annotation. Source: Ensembl

vesicle membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionangiotensin type I receptor activity

Inferred from electronic annotation. Source: Ensembl

angiotensin type II receptor activity

Inferred from electronic annotation. Source: InterPro

peptide hormone binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Type-1B angiotensin II receptor
PRO_0000069156

Regions

Topological domain1 – 2727Extracellular Potential
Transmembrane28 – 5225Helical; Name=1; Potential
Topological domain53 – 6412Cytoplasmic Potential
Transmembrane65 – 8723Helical; Name=2; Potential
Topological domain88 – 10215Extracellular Potential
Transmembrane103 – 12422Helical; Name=3; Potential
Topological domain125 – 14218Cytoplasmic Potential
Transmembrane143 – 16220Helical; Name=4; Potential
Topological domain163 – 19230Extracellular Potential
Transmembrane193 – 21422Helical; Name=5; Potential
Topological domain215 – 24026Cytoplasmic Potential
Transmembrane241 – 26222Helical; Name=6; Potential
Topological domain263 – 27513Extracellular Potential
Transmembrane276 – 29621Helical; Name=7; Potential
Topological domain297 – 35963Cytoplasmic Potential

Amino acid modifications

Lipidation3551S-palmitoyl cysteine Potential
Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation1761N-linked (GlcNAc...) Potential
Glycosylation1881N-linked (GlcNAc...) Potential
Disulfide bond101 ↔ 180 By similarity

Experimental info

Sequence conflict71I → T Ref.2
Sequence conflict1661H → Y Ref.2
Sequence conflict1731E → A Ref.2
Sequence conflict2051V → E Ref.2
Sequence conflict2321T → I Ref.2
Sequence conflict2391F → G Ref.2

Sequences

Sequence LengthMass (Da)Tools
P29755 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 95730F97058EAA4B

FASTA35940,950
        10         20         30         40         50         60 
MILNSSIEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK 

        70         80         90        100        110        120 
TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYQWPFGNHL CKIASASVSF NLYASVFLLT 

       130        140        150        160        170        180 
CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLMAGLAS LPAVIHRNVY FIENTNITVC 

       190        200        210        220        230        240 
AFHYESQNST LPIGLGLTKN ILGFVFPFVI ILTSYTLIWK ALKKAYKIQK NTPRNDDIFR 

       250        260        270        280        290        300 
IIMAIVLFFF FSWVPHQIFS FLDVLIQLGV IHDCEIADVV DTAMPITICI AYFNNCLNPL 

       310        320        330        340        350 
FYGFLGKKFK RYFLQLLKYI PPKARSHAGL STKMSTLSYR PSDNMSSSAR KSAYCFEVE 

« Hide

References

[1]"Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome."
Sasamura H., Hein L., Krieger J.E., Pratt R.E., Kobilka B.K., Dzau V.J.
Biochem. Biophys. Res. Commun. 185:253-259(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
Tissue: Liver.
[2]"Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human)."
Yoshida H., Kakuchi J., Guo D.F., Furuta H., Iwai N., van der Meer-De Jong R., Inagami T., Ichikawa I.
Biochem. Biophys. Res. Commun. 186:1042-1049(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S37491 Genomic DNA. Translation: AAB22270.1.
PIRJC1194.
RefSeqNP_780295.2. NM_175086.3.
UniGeneMm.134863.

3D structure databases

ProteinModelPortalP29755.
SMRP29755. Positions 25-313.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY34.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP29755.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000068316; ENSMUSP00000068298; ENSMUSG00000054988.
ENSMUST00000163776; ENSMUSP00000128724; ENSMUSG00000054988.
GeneID11608.
KEGGmmu:11608.
UCSCuc008osr.1. mouse.

Organism-specific databases

CTD11608.
MGIMGI:87965. Agtr1b.

Phylogenomic databases

eggNOGNOG256015.
GeneTreeENSGT00720000108671.
HOGENOMHOG000234122.
HOVERGENHBG104998.
InParanoidP29755.
KOK04166.
OMATPRNDDI.
OrthoDBEOG7J4473.
PhylomeDBP29755.
TreeFamTF330024.

Gene expression databases

BgeeP29755.
CleanExMM_AGTR1B.
GenevestigatorP29755.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio279148.
PROP29755.
SOURCESearch...

Entry information

Entry nameAGTRB_MOUSE
AccessionPrimary (citable) accession number: P29755
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries