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P29754

- AGTRA_MOUSE

UniProt

P29754 - AGTRA_MOUSE

Protein

Type-1A angiotensin II receptor

Gene

Agtr1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. angiotensin type II receptor activity Source: InterPro
    2. angiotensin type I receptor activity Source: MGI
    3. peptide hormone binding Source: Ensembl
    4. protein binding Source: IntAct

    GO - Biological processi

    1. activation of Janus kinase activity Source: Ensembl
    2. aging Source: Ensembl
    3. blood vessel development Source: MGI
    4. brain renin-angiotensin system Source: MGI
    5. cellular response to dexamethasone stimulus Source: Ensembl
    6. dopamine biosynthetic process Source: Ensembl
    7. drinking behavior Source: MGI
    8. G-protein coupled receptor signaling pathway Source: MGI
    9. heart development Source: MGI
    10. inflammatory response Source: MGI
    11. kidney development Source: MGI
    12. negative regulation of smooth muscle cell apoptotic process Source: MGI
    13. positive regulation of blood pressure Source: MGI
    14. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
    15. positive regulation of cell proliferation Source: MGI
    16. positive regulation of cytokine secretion Source: UniProtKB
    17. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    18. positive regulation of receptor recycling Source: Ensembl
    19. positive regulation of superoxide anion generation Source: Ensembl
    20. regulation of pH Source: Ensembl
    21. regulation of renal output by angiotensin Source: MGI
    22. regulation of smooth muscle cell apoptotic process Source: MGI
    23. regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: MGI
    24. regulation of vasoconstriction Source: InterPro
    25. renin-angiotensin regulation of aldosterone production Source: MGI
    26. renin secretion into blood stream Source: MGI
    27. response to estrogen Source: Ensembl
    28. vasoconstriction Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type-1A angiotensin II receptor
    Alternative name(s):
    Angiotensin II type-1A receptor
    Short name:
    AT1A
    Gene namesi
    Name:Agtr1a
    Synonyms:Agtr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:87964. Agtr1a.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: Ensembl
    2. cytoplasm Source: MGI
    3. cytoplasmic vesicle Source: Ensembl
    4. dendrite Source: Ensembl
    5. endosome Source: MGI
    6. Golgi apparatus Source: Ensembl
    7. integral component of membrane Source: UniProtKB-KW
    8. organelle outer membrane Source: Ensembl
    9. plasma membrane Source: MGI
    10. recycling endosome Source: Ensembl
    11. vesicle lumen Source: Ensembl
    12. vesicle membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Type-1A angiotensin II receptorPRO_0000069155Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Lipidationi355 – 3551S-palmitoyl cysteineSequence Analysis

    Post-translational modificationi

    C-terminal Ser or Thr residues may be phosphorylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PRIDEiP29754.

    PTM databases

    PhosphoSiteiP29754.

    Expressioni

    Gene expression databases

    BgeeiP29754.
    CleanExiMM_AGTR1A.
    GenevestigatoriP29754.

    Interactioni

    Subunit structurei

    Interacts with MAS1. Interacts with ARRB1 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AgtrapQ9WVK05EBI-765178,EBI-645964

    Protein-protein interaction databases

    BioGridi198029. 3 interactions.
    IntActiP29754. 1 interaction.
    MINTiMINT-1339574.
    STRINGi10090.ENSMUSP00000070958.

    Structurei

    3D structure databases

    ProteinModelPortaliP29754.
    SMRiP29754. Positions 20-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini53 – 6412CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini88 – 10215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini125 – 14218CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 19230ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini215 – 24026CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini263 – 27513ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini297 – 35963CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 5225Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei65 – 8723Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei103 – 12422Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei143 – 16220Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei193 – 21422Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26222Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei276 – 29621Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG256015.
    GeneTreeiENSGT00720000108671.
    HOGENOMiHOG000234122.
    HOVERGENiHBG104998.
    InParanoidiP29754.
    KOiK04166.
    OMAiCIVIWLL.
    OrthoDBiEOG7J4473.
    PhylomeDBiP29754.
    TreeFamiTF330024.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000190. ATII_AT1_rcpt.
    IPR000248. ATII_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00241. ANGIOTENSINR.
    PR00635. ANGIOTENSN1R.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29754-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALNSSTEDG IKRIQDDCPR AGRHSYIFVM IPTLYSIIFV VGIFGNSLVV    50
    IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNHL 100
    CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI 150
    IIWLMAGLAS LPAVIHRNVY FIENTNITVC AFHYESRNST LPIGLGLTKN 200
    ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFR IIMAIVLFFF 250
    FSWVPHQIFT FLDVLIQLGV IHDCKIADIV DTAMPITICI AYFNNCLNPL 300
    FYGFLGKKFK KYFLQLLKYI PPKAKSHSSL STKMSTLSYR PSDNMSSAAK 350
    KPASCSEVE 359
    Length:359
    Mass (Da):40,856
    Last modified:April 1, 1993 - v1
    Checksum:i966958A738D8F53E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71T → I(PubMed:1497638)Curated
    Sequence conflicti20 – 212RA → IS(PubMed:1497638)Curated
    Sequence conflicti38 – 381I → M(PubMed:1497638)Curated
    Sequence conflicti134 – 1341M → K(PubMed:1497638)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S37484 Genomic DNA. Translation: AAB22269.1.
    BC036175 mRNA. Translation: AAH36175.1.
    CCDSiCCDS26415.1.
    PIRiJH0621.
    RefSeqiNP_796296.1. NM_177322.3.
    XP_006516597.1. XM_006516534.1.
    UniGeneiMm.35062.

    Genome annotation databases

    EnsembliENSMUST00000066412; ENSMUSP00000070958; ENSMUSG00000049115.
    GeneIDi11607.
    KEGGimmu:11607.
    UCSCiuc007pyu.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S37484 Genomic DNA. Translation: AAB22269.1 .
    BC036175 mRNA. Translation: AAH36175.1 .
    CCDSi CCDS26415.1.
    PIRi JH0621.
    RefSeqi NP_796296.1. NM_177322.3.
    XP_006516597.1. XM_006516534.1.
    UniGenei Mm.35062.

    3D structure databases

    ProteinModelPortali P29754.
    SMRi P29754. Positions 20-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198029. 3 interactions.
    IntActi P29754. 1 interaction.
    MINTi MINT-1339574.
    STRINGi 10090.ENSMUSP00000070958.

    Chemistry

    ChEMBLi CHEMBL5741.
    GuidetoPHARMACOLOGYi 34.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P29754.

    Proteomic databases

    PRIDEi P29754.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000066412 ; ENSMUSP00000070958 ; ENSMUSG00000049115 .
    GeneIDi 11607.
    KEGGi mmu:11607.
    UCSCi uc007pyu.2. mouse.

    Organism-specific databases

    CTDi 11607.
    MGIi MGI:87964. Agtr1a.

    Phylogenomic databases

    eggNOGi NOG256015.
    GeneTreei ENSGT00720000108671.
    HOGENOMi HOG000234122.
    HOVERGENi HBG104998.
    InParanoidi P29754.
    KOi K04166.
    OMAi CIVIWLL.
    OrthoDBi EOG7J4473.
    PhylomeDBi P29754.
    TreeFami TF330024.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    ChiTaRSi AGTR1. mouse.
    NextBioi 279144.
    PROi P29754.
    SOURCEi Search...

    Gene expression databases

    Bgeei P29754.
    CleanExi MM_AGTR1A.
    Genevestigatori P29754.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000190. ATII_AT1_rcpt.
    IPR000248. ATII_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00241. ANGIOTENSINR.
    PR00635. ANGIOTENSN1R.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome."
      Sasamura H., Hein L., Krieger J.E., Pratt R.E., Kobilka B.K., Dzau V.J.
      Biochem. Biophys. Res. Commun. 185:253-259(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
      Tissue: Liver.
    2. "Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human)."
      Yoshida H., Kakuchi J., Guo D.F., Furuta H., Iwai N., van der Meer-De Jong R., Inagami T., Ichikawa I.
      Biochem. Biophys. Res. Commun. 186:1042-1049(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiAGTRA_MOUSE
    AccessioniPrimary (citable) accession number: P29754
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3