Type-1A angiotensin II receptor - Mus musculus (Mouse)

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P29754 (AGTRA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 120. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Type-1A angiotensin II receptor

Alternative name(s):
Angiotensin II type-1A receptor
Short name=AT1A

Gene names

Name:	Agtr1a
Synonyms:	Agtr1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subunit structure	Interacts with MAS1. Interacts with ARRB1 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Post-translational modification	C-terminal Ser or Thr residues may be phosphorylated.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of Janus kinase activity Inferred from electronic annotation. Source: Compara aging Inferred from electronic annotation. Source: Compara blood vessel development Inferred from genetic interaction PubMed 9466969. Source: MGI brain renin-angiotensin system Inferred from mutant phenotype PubMed 10880053 PubMed 16585392. Source: MGI cellular response to dexamethasone stimulus Inferred from electronic annotation. Source: Compara dopamine biosynthetic process Inferred from electronic annotation. Source: Compara drinking behavior Inferred from mutant phenotype PubMed 10880053 PubMed 12167595. Source: MGI elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara heart development Inferred from mutant phenotype PubMed 16585392. Source: MGI inflammatory response Inferred from genetic interaction PubMed 19404405. Source: MGI kidney development Inferred from mutant phenotype PubMed 12167595. Source: MGI negative regulation of smooth muscle cell apoptotic process Inferred from mutant phenotype PubMed 19508861. Source: MGI positive regulation of blood pressure Inferred from direct assay PubMed 12486173. Source: MGI positive regulation of branching involved in ureteric bud morphogenesis Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from mutant phenotype PubMed 19508861. Source: MGI positive regulation of cytokine secretion Inferred from mutant phenotype PubMed 19023134. Source: UniProtKB positive regulation of receptor recycling Inferred from electronic annotation. Source: Compara positive regulation of superoxide anion generation Inferred from electronic annotation. Source: Compara regulation of pH Inferred from electronic annotation. Source: Compara regulation of renal output by angiotensin Inferred from mutant phenotype PubMed 12167595. Source: MGI renin secretion into blood stream Inferred from mutant phenotype PubMed 12167595. Source: MGI renin-angiotensin regulation of aldosterone production Inferred from mutant phenotype PubMed 12167595. Source: MGI response to estrogen stimulus Inferred from electronic annotation. Source: Compara vasoconstriction Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara basolateral plasma membrane Inferred from electronic annotation. Source: Compara cytoplasmic vesicle Inferred from electronic annotation. Source: Compara dendrite Inferred from electronic annotation. Source: Compara endosome Inferred from direct assay PubMed 14718562. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW organelle outer membrane Inferred from electronic annotation. Source: Compara plasma membrane Inferred from direct assay PubMed 14718562 PubMed 15499027. Source: MGI recycling endosome Inferred from electronic annotation. Source: Compara vesicle lumen Inferred from electronic annotation. Source: Compara vesicle membrane Inferred from electronic annotation. Source: Compara
Molecular_function	angiotensin type I receptor activity Inferred from direct assay PubMed 12657564. Source: MGI angiotensin type II receptor activity Inferred from electronic annotation. Source: InterPro peptide hormone binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Agtrap	Q9WVK0	5	EBI-765178,EBI-645964

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 359

359

Type-1A angiotensin II receptor

PRO_0000069155

Regions

Topological domain

1 – 27

Extracellular Potential

Transmembrane

28 – 52

Helical; Name=1; Potential

Topological domain

53 – 64

Cytoplasmic Potential

Transmembrane

65 – 87

Helical; Name=2; Potential

Topological domain

88 – 102

Extracellular Potential

Transmembrane

103 – 124

Helical; Name=3; Potential

Topological domain

125 – 142

Cytoplasmic Potential

Transmembrane

143 – 162

Helical; Name=4; Potential

Topological domain

163 – 192

Extracellular Potential

Transmembrane

193 – 214

Helical; Name=5; Potential

Topological domain

215 – 240

Cytoplasmic Potential

Transmembrane

241 – 262

Helical; Name=6; Potential

Topological domain

263 – 275

Extracellular Potential

Transmembrane

276 – 296

Helical; Name=7; Potential

Topological domain

297 – 359

Cytoplasmic Potential

Amino acid modifications

Lipidation

355

S-palmitoyl cysteine Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

176

N-linked (GlcNAc...) Potential

Glycosylation

188

N-linked (GlcNAc...) Potential

Disulfide bond

101 ↔ 180

By similarity

Experimental info

Sequence conflict

T → I Ref.2

Sequence conflict

20 – 21

RA → IS Ref.2

Sequence conflict

I → M Ref.2

Sequence conflict

134

M → K Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P29754 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 966958A738D8F53E
Show »

FASTA

359

40,856

        10         20         30         40         50         60 
MALNSSTEDG IKRIQDDCPR AGRHSYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK 

        70         80         90        100        110        120 
TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNHL CKIASASVSF NLYASVFLLT 

       130        140        150        160        170        180 
CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLMAGLAS LPAVIHRNVY FIENTNITVC 

       190        200        210        220        230        240 
AFHYESRNST LPIGLGLTKN ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFR 

       250        260        270        280        290        300 
IIMAIVLFFF FSWVPHQIFT FLDVLIQLGV IHDCKIADIV DTAMPITICI AYFNNCLNPL 

       310        320        330        340        350 
FYGFLGKKFK KYFLQLLKYI PPKAKSHSSL STKMSTLSYR PSDNMSSAAK KPASCSEVE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome." Sasamura H., Hein L., Krieger J.E., Pratt R.E., Kobilka B.K., Dzau V.J. Biochem. Biophys. Res. Commun. 185:253-259(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c. Tissue: Liver.
[2]	"Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human)." Yoshida H., Kakuchi J., Guo D.F., Furuta H., Iwai N., van der Meer-De Jong R., Inagami T., Ichikawa I. Biochem. Biophys. Res. Commun. 186:1042-1049(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S37484 Genomic DNA. Translation: AAB22269.1. BC036175 mRNA. Translation: AAH36175.1.
IPI	IPI00129168.
PIR	JH0621.
RefSeq	NP_796296.1. NM_177322.3.
UniGene	Mm.35062.
3D structure databases
ProteinModelPortal	P29754.
SMR	P29754. Positions 29-320.
ModBase	Search...
Protein-protein interaction databases
IntAct	P29754. 1 interaction.
MINT	MINT-1339574.
STRING	10090.ENSMUSP00000070958.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P29754.
Proteomic databases
PRIDE	P29754.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000066412; ENSMUSP00000070958; ENSMUSG00000049115.
GeneID	11607.
KEGG	mmu:11607.
UCSC	uc008osr.1. mouse.
Organism-specific databases
CTD	11607.
MGI	MGI:87964. Agtr1a.
Phylogenomic databases
eggNOG	NOG256015.
GeneTree	ENSGT00700000104167.
HOGENOM	HOG000234122.
HOVERGEN	HBG104998.
InParanoid	P29754.
KO	K04166.
OMA	CIVIWLL.
OrthoDB	EOG48D0VX.
Gene expression databases
Bgee	P29754.
CleanEx	MM_AGTR1A.
Genevestigator	P29754.
GermOnline	ENSMUSG00000049115. Mus musculus.
Family and domain databases
InterPro	IPR000190. ATII_AT1_rcpt. IPR000248. ATII_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00241. ANGIOTENSINR. PR00635. ANGIOTENSN1R. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL5741.
ChiTaRS	AGTR1. mouse.
NextBio	279144.
SOURCE	Search...

Entry information

Entry name

AGTRA_MOUSE

Accession

Primary (citable) accession number: P29754

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	May 1, 2013
This is version 120 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents