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Protein

Type-1A angiotensin II receptor

Gene

Agtr1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

  • activation of Janus kinase activity Source: Ensembl
  • aging Source: Ensembl
  • angiotensin-activated signaling pathway Source: MGI
  • blood vessel development Source: MGI
  • brain renin-angiotensin system Source: MGI
  • calcium-mediated signaling Source: MGI
  • cell chemotaxis Source: MGI
  • cellular response to dexamethasone stimulus Source: Ensembl
  • dopamine biosynthetic process Source: Ensembl
  • drinking behavior Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
  • heart development Source: MGI
  • inflammatory response Source: MGI
  • kidney development Source: MGI
  • negative regulation of smooth muscle cell apoptotic process Source: MGI
  • phospholipase C-activating angiotensin-activated signaling pathway Source: MGI
  • positive regulation of blood pressure Source: MGI
  • positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of cellular protein metabolic process Source: MGI
  • positive regulation of cholesterol esterification Source: MGI
  • positive regulation of cytokine secretion Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration Source: MGI
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: MGI
  • positive regulation of phospholipase A2 activity Source: MGI
  • positive regulation of receptor recycling Source: Ensembl
  • positive regulation of superoxide anion generation Source: Ensembl
  • regulation of pH Source: Ensembl
  • regulation of renal output by angiotensin Source: MGI
  • regulation of smooth muscle cell apoptotic process Source: MGI
  • regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: MGI
  • regulation of vasoconstriction Source: MGI
  • renin-angiotensin regulation of aldosterone production Source: MGI
  • renin secretion into blood stream Source: MGI
  • response to estrogen Source: Ensembl
  • Rho protein signal transduction Source: MGI
  • vasoconstriction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1A angiotensin II receptor
Alternative name(s):
Angiotensin II type-1A receptor
Short name:
AT1A
Gene namesi
Name:Agtr1a
Synonyms:Agtr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:87964. Agtr1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 5225Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini53 – 6412CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei65 – 8723Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini88 – 10215ExtracellularSequence AnalysisAdd
BLAST
Transmembranei103 – 12422Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini125 – 14218CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei143 – 16220Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 19230ExtracellularSequence AnalysisAdd
BLAST
Transmembranei193 – 21422Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini215 – 24026CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26222Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini263 – 27513ExtracellularSequence AnalysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini297 – 35963CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • basolateral plasma membrane Source: Ensembl
  • cytoplasm Source: MGI
  • cytoplasmic vesicle Source: Ensembl
  • cytosol Source: GOC
  • dendrite Source: Ensembl
  • endosome Source: MGI
  • Golgi apparatus Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • organelle outer membrane Source: Ensembl
  • plasma membrane Source: MGI
  • recycling endosome Source: Ensembl
  • vesicle lumen Source: Ensembl
  • vesicle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Type-1A angiotensin II receptorPRO_0000069155Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Lipidationi355 – 3551S-palmitoyl cysteineSequence Analysis

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiP29754.

PTM databases

PhosphoSiteiP29754.

Expressioni

Gene expression databases

BgeeiP29754.
CleanExiMM_AGTR1A.
GenevisibleiP29754. MM.

Interactioni

Subunit structurei

Interacts with MAS1. Interacts with ARRB1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AgtrapQ9WVK05EBI-765178,EBI-645964

Protein-protein interaction databases

BioGridi198029. 3 interactions.
IntActiP29754. 1 interaction.
MINTiMINT-1339574.
STRINGi10090.ENSMUSP00000070958.

Structurei

3D structure databases

ProteinModelPortaliP29754.
SMRiP29754. Positions 20-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256015.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiP29754.
KOiK04166.
OMAiCIVIWLL.
OrthoDBiEOG7J4473.
PhylomeDBiP29754.
TreeFamiTF330024.

Family and domain databases

InterProiIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALNSSTEDG IKRIQDDCPR AGRHSYIFVM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNHL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLMAGLAS LPAVIHRNVY FIENTNITVC AFHYESRNST LPIGLGLTKN
210 220 230 240 250
ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFR IIMAIVLFFF
260 270 280 290 300
FSWVPHQIFT FLDVLIQLGV IHDCKIADIV DTAMPITICI AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK KYFLQLLKYI PPKAKSHSSL STKMSTLSYR PSDNMSSAAK

KPASCSEVE
Length:359
Mass (Da):40,856
Last modified:April 1, 1993 - v1
Checksum:i966958A738D8F53E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71T → I (PubMed:1497638).Curated
Sequence conflicti20 – 212RA → IS (PubMed:1497638).Curated
Sequence conflicti38 – 381I → M (PubMed:1497638).Curated
Sequence conflicti134 – 1341M → K (PubMed:1497638).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S37484 Genomic DNA. Translation: AAB22269.1.
BC036175 mRNA. Translation: AAH36175.1.
CCDSiCCDS26415.1.
PIRiJH0621.
RefSeqiNP_796296.1. NM_177322.3.
XP_006516597.1. XM_006516534.1.
UniGeneiMm.35062.

Genome annotation databases

EnsembliENSMUST00000066412; ENSMUSP00000070958; ENSMUSG00000049115.
GeneIDi11607.
KEGGimmu:11607.
UCSCiuc007pyu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S37484 Genomic DNA. Translation: AAB22269.1.
BC036175 mRNA. Translation: AAH36175.1.
CCDSiCCDS26415.1.
PIRiJH0621.
RefSeqiNP_796296.1. NM_177322.3.
XP_006516597.1. XM_006516534.1.
UniGeneiMm.35062.

3D structure databases

ProteinModelPortaliP29754.
SMRiP29754. Positions 20-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198029. 3 interactions.
IntActiP29754. 1 interaction.
MINTiMINT-1339574.
STRINGi10090.ENSMUSP00000070958.

Chemistry

ChEMBLiCHEMBL5741.
GuidetoPHARMACOLOGYi34.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP29754.

Proteomic databases

PRIDEiP29754.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066412; ENSMUSP00000070958; ENSMUSG00000049115.
GeneIDi11607.
KEGGimmu:11607.
UCSCiuc007pyu.2. mouse.

Organism-specific databases

CTDi11607.
MGIiMGI:87964. Agtr1a.

Phylogenomic databases

eggNOGiNOG256015.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiP29754.
KOiK04166.
OMAiCIVIWLL.
OrthoDBiEOG7J4473.
PhylomeDBiP29754.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi279144.
PROiP29754.
SOURCEiSearch...

Gene expression databases

BgeeiP29754.
CleanExiMM_AGTR1A.
GenevisibleiP29754. MM.

Family and domain databases

InterProiIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome."
    Sasamura H., Hein L., Krieger J.E., Pratt R.E., Kobilka B.K., Dzau V.J.
    Biochem. Biophys. Res. Commun. 185:253-259(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Liver.
  2. "Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human)."
    Yoshida H., Kakuchi J., Guo D.F., Furuta H., Iwai N., van der Meer-De Jong R., Inagami T., Ichikawa I.
    Biochem. Biophys. Res. Commun. 186:1042-1049(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiAGTRA_MOUSE
AccessioniPrimary (citable) accession number: P29754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 24, 2015
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.