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P29754 (AGTRA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type-1A angiotensin II receptor
Alternative name(s):
Angiotensin II type-1A receptor
Short name=AT1A
Gene names
Name:Agtr1a
Synonyms:Agtr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subunit structure

Interacts with MAS1. Interacts with ARRB1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Post-translational modification

C-terminal Ser or Thr residues may be phosphorylated.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred by curator PubMed 12657564. Source: MGI

activation of Janus kinase activity

Inferred from electronic annotation. Source: Ensembl

aging

Inferred from electronic annotation. Source: Ensembl

blood vessel development

Inferred from genetic interaction PubMed 9466969. Source: MGI

brain renin-angiotensin system

Inferred from mutant phenotype PubMed 10880053PubMed 16585392. Source: MGI

cellular response to dexamethasone stimulus

Inferred from electronic annotation. Source: Ensembl

dopamine biosynthetic process

Inferred from electronic annotation. Source: Ensembl

drinking behavior

Inferred from mutant phenotype PubMed 10880053PubMed 12167595. Source: MGI

heart development

Inferred from mutant phenotype PubMed 16585392. Source: MGI

inflammatory response

Inferred from genetic interaction PubMed 19404405. Source: MGI

kidney development

Inferred from mutant phenotype PubMed 12167595. Source: MGI

negative regulation of smooth muscle cell apoptotic process

Inferred from mutant phenotype PubMed 19508861. Source: MGI

positive regulation of blood pressure

Inferred from direct assay PubMed 12486173. Source: MGI

positive regulation of branching involved in ureteric bud morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 19508861. Source: MGI

positive regulation of cytokine secretion

Inferred from mutant phenotype PubMed 19023134. Source: UniProtKB

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of receptor recycling

Inferred from electronic annotation. Source: Ensembl

positive regulation of superoxide anion generation

Inferred from electronic annotation. Source: Ensembl

regulation of pH

Inferred from electronic annotation. Source: Ensembl

regulation of renal output by angiotensin

Inferred from mutant phenotype PubMed 12167595. Source: MGI

regulation of smooth muscle cell apoptotic process

Inferred from genetic interaction PubMed 19508861. Source: MGI

regulation of systemic arterial blood pressure by circulatory renin-angiotensin

Inferred from genetic interaction PubMed 9466969. Source: MGI

regulation of vasoconstriction

Inferred from electronic annotation. Source: InterPro

renin secretion into blood stream

Inferred from mutant phenotype PubMed 12167595. Source: MGI

renin-angiotensin regulation of aldosterone production

Inferred from mutant phenotype PubMed 12167595. Source: MGI

response to estrogen

Inferred from electronic annotation. Source: Ensembl

vasoconstriction

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

basolateral plasma membrane

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 15499027. Source: MGI

cytoplasmic vesicle

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from electronic annotation. Source: Ensembl

endosome

Inferred from direct assay PubMed 14718562. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

organelle outer membrane

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay PubMed 14718562PubMed 15499027. Source: MGI

recycling endosome

Inferred from electronic annotation. Source: Ensembl

vesicle lumen

Inferred from electronic annotation. Source: Ensembl

vesicle membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionangiotensin type I receptor activity

Inferred from direct assay PubMed 12657564. Source: MGI

angiotensin type II receptor activity

Inferred from electronic annotation. Source: InterPro

peptide hormone binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

AgtrapQ9WVK05EBI-765178,EBI-645964

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Type-1A angiotensin II receptor
PRO_0000069155

Regions

Topological domain1 – 2727Extracellular Potential
Transmembrane28 – 5225Helical; Name=1; Potential
Topological domain53 – 6412Cytoplasmic Potential
Transmembrane65 – 8723Helical; Name=2; Potential
Topological domain88 – 10215Extracellular Potential
Transmembrane103 – 12422Helical; Name=3; Potential
Topological domain125 – 14218Cytoplasmic Potential
Transmembrane143 – 16220Helical; Name=4; Potential
Topological domain163 – 19230Extracellular Potential
Transmembrane193 – 21422Helical; Name=5; Potential
Topological domain215 – 24026Cytoplasmic Potential
Transmembrane241 – 26222Helical; Name=6; Potential
Topological domain263 – 27513Extracellular Potential
Transmembrane276 – 29621Helical; Name=7; Potential
Topological domain297 – 35963Cytoplasmic Potential

Amino acid modifications

Lipidation3551S-palmitoyl cysteine Potential
Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation1761N-linked (GlcNAc...) Potential
Glycosylation1881N-linked (GlcNAc...) Potential
Disulfide bond101 ↔ 180 By similarity

Experimental info

Sequence conflict71T → I Ref.2
Sequence conflict20 – 212RA → IS Ref.2
Sequence conflict381I → M Ref.2
Sequence conflict1341M → K Ref.2

Sequences

Sequence LengthMass (Da)Tools
P29754 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 966958A738D8F53E

FASTA35940,856
        10         20         30         40         50         60 
MALNSSTEDG IKRIQDDCPR AGRHSYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK 

        70         80         90        100        110        120 
TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNHL CKIASASVSF NLYASVFLLT 

       130        140        150        160        170        180 
CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLMAGLAS LPAVIHRNVY FIENTNITVC 

       190        200        210        220        230        240 
AFHYESRNST LPIGLGLTKN ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFR 

       250        260        270        280        290        300 
IIMAIVLFFF FSWVPHQIFT FLDVLIQLGV IHDCKIADIV DTAMPITICI AYFNNCLNPL 

       310        320        330        340        350 
FYGFLGKKFK KYFLQLLKYI PPKAKSHSSL STKMSTLSYR PSDNMSSAAK KPASCSEVE 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome."
Sasamura H., Hein L., Krieger J.E., Pratt R.E., Kobilka B.K., Dzau V.J.
Biochem. Biophys. Res. Commun. 185:253-259(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
Tissue: Liver.
[2]"Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human)."
Yoshida H., Kakuchi J., Guo D.F., Furuta H., Iwai N., van der Meer-De Jong R., Inagami T., Ichikawa I.
Biochem. Biophys. Res. Commun. 186:1042-1049(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S37484 Genomic DNA. Translation: AAB22269.1.
BC036175 mRNA. Translation: AAH36175.1.
PIRJH0621.
RefSeqNP_796296.1. NM_177322.3.
XP_006516597.1. XM_006516534.1.
UniGeneMm.35062.

3D structure databases

ProteinModelPortalP29754.
SMRP29754. Positions 28-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198029. 3 interactions.
IntActP29754. 1 interaction.
MINTMINT-1339574.
STRING10090.ENSMUSP00000070958.

Chemistry

ChEMBLCHEMBL5741.
GuidetoPHARMACOLOGY34.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP29754.

Proteomic databases

PRIDEP29754.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000066412; ENSMUSP00000070958; ENSMUSG00000049115.
GeneID11607.
KEGGmmu:11607.
UCSCuc007pyu.2. mouse.

Organism-specific databases

CTD11607.
MGIMGI:87964. Agtr1a.

Phylogenomic databases

eggNOGNOG256015.
GeneTreeENSGT00720000108671.
HOGENOMHOG000234122.
HOVERGENHBG104998.
InParanoidP29754.
KOK04166.
OMACIVIWLL.
OrthoDBEOG7J4473.
PhylomeDBP29754.
TreeFamTF330024.

Gene expression databases

BgeeP29754.
CleanExMM_AGTR1A.
GenevestigatorP29754.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAGTR1. mouse.
NextBio279144.
PROP29754.
SOURCESearch...

Entry information

Entry nameAGTRA_MOUSE
AccessionPrimary (citable) accession number: P29754
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries