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P29754

- AGTRA_MOUSE

UniProt

P29754 - AGTRA_MOUSE

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Protein

Type-1A angiotensin II receptor

Gene

Agtr1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. angiotensin type II receptor activity Source: InterPro
  2. angiotensin type I receptor activity Source: MGI
  3. peptide hormone binding Source: Ensembl

GO - Biological processi

  1. activation of Janus kinase activity Source: Ensembl
  2. aging Source: Ensembl
  3. blood vessel development Source: MGI
  4. brain renin-angiotensin system Source: MGI
  5. cellular response to dexamethasone stimulus Source: Ensembl
  6. dopamine biosynthetic process Source: Ensembl
  7. drinking behavior Source: MGI
  8. G-protein coupled receptor signaling pathway Source: MGI
  9. heart development Source: MGI
  10. inflammatory response Source: MGI
  11. kidney development Source: MGI
  12. negative regulation of smooth muscle cell apoptotic process Source: MGI
  13. positive regulation of blood pressure Source: MGI
  14. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
  15. positive regulation of cell proliferation Source: MGI
  16. positive regulation of cytokine secretion Source: UniProtKB
  17. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  18. positive regulation of receptor recycling Source: Ensembl
  19. positive regulation of superoxide anion generation Source: Ensembl
  20. regulation of pH Source: Ensembl
  21. regulation of renal output by angiotensin Source: MGI
  22. regulation of smooth muscle cell apoptotic process Source: MGI
  23. regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: MGI
  24. regulation of vasoconstriction Source: InterPro
  25. renin-angiotensin regulation of aldosterone production Source: MGI
  26. renin secretion into blood stream Source: MGI
  27. response to estrogen Source: Ensembl
  28. vasoconstriction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1A angiotensin II receptor
Alternative name(s):
Angiotensin II type-1A receptor
Short name:
AT1A
Gene namesi
Name:Agtr1a
Synonyms:Agtr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:87964. Agtr1a.

Subcellular locationi

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. cytoplasm Source: MGI
  3. cytoplasmic vesicle Source: Ensembl
  4. dendrite Source: Ensembl
  5. endosome Source: MGI
  6. Golgi apparatus Source: Ensembl
  7. integral component of membrane Source: UniProtKB-KW
  8. organelle outer membrane Source: Ensembl
  9. plasma membrane Source: MGI
  10. recycling endosome Source: Ensembl
  11. vesicle lumen Source: Ensembl
  12. vesicle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Type-1A angiotensin II receptorPRO_0000069155Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Lipidationi355 – 3551S-palmitoyl cysteineSequence Analysis

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiP29754.

PTM databases

PhosphoSiteiP29754.

Expressioni

Gene expression databases

BgeeiP29754.
CleanExiMM_AGTR1A.
GenevestigatoriP29754.

Interactioni

Subunit structurei

Interacts with MAS1. Interacts with ARRB1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AgtrapQ9WVK05EBI-765178,EBI-645964

Protein-protein interaction databases

BioGridi198029. 3 interactions.
IntActiP29754. 1 interaction.
MINTiMINT-1339574.
STRINGi10090.ENSMUSP00000070958.

Structurei

3D structure databases

ProteinModelPortaliP29754.
SMRiP29754. Positions 20-318.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Topological domaini53 – 6412CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini88 – 10215ExtracellularSequence AnalysisAdd
BLAST
Topological domaini125 – 14218CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini163 – 19230ExtracellularSequence AnalysisAdd
BLAST
Topological domaini215 – 24026CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini263 – 27513ExtracellularSequence AnalysisAdd
BLAST
Topological domaini297 – 35963CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 5225Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei65 – 8723Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei103 – 12422Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei143 – 16220Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei193 – 21422Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei241 – 26222Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256015.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiP29754.
KOiK04166.
OMAiCIVIWLL.
OrthoDBiEOG7J4473.
PhylomeDBiP29754.
TreeFamiTF330024.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29754-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALNSSTEDG IKRIQDDCPR AGRHSYIFVM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNHL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLMAGLAS LPAVIHRNVY FIENTNITVC AFHYESRNST LPIGLGLTKN
210 220 230 240 250
ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFR IIMAIVLFFF
260 270 280 290 300
FSWVPHQIFT FLDVLIQLGV IHDCKIADIV DTAMPITICI AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK KYFLQLLKYI PPKAKSHSSL STKMSTLSYR PSDNMSSAAK

KPASCSEVE
Length:359
Mass (Da):40,856
Last modified:April 1, 1993 - v1
Checksum:i966958A738D8F53E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71T → I(PubMed:1497638)Curated
Sequence conflicti20 – 212RA → IS(PubMed:1497638)Curated
Sequence conflicti38 – 381I → M(PubMed:1497638)Curated
Sequence conflicti134 – 1341M → K(PubMed:1497638)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S37484 Genomic DNA. Translation: AAB22269.1.
BC036175 mRNA. Translation: AAH36175.1.
CCDSiCCDS26415.1.
PIRiJH0621.
RefSeqiNP_796296.1. NM_177322.3.
XP_006516597.1. XM_006516534.1.
UniGeneiMm.35062.

Genome annotation databases

EnsembliENSMUST00000066412; ENSMUSP00000070958; ENSMUSG00000049115.
GeneIDi11607.
KEGGimmu:11607.
UCSCiuc007pyu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S37484 Genomic DNA. Translation: AAB22269.1 .
BC036175 mRNA. Translation: AAH36175.1 .
CCDSi CCDS26415.1.
PIRi JH0621.
RefSeqi NP_796296.1. NM_177322.3.
XP_006516597.1. XM_006516534.1.
UniGenei Mm.35062.

3D structure databases

ProteinModelPortali P29754.
SMRi P29754. Positions 20-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198029. 3 interactions.
IntActi P29754. 1 interaction.
MINTi MINT-1339574.
STRINGi 10090.ENSMUSP00000070958.

Chemistry

ChEMBLi CHEMBL5741.
GuidetoPHARMACOLOGYi 34.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P29754.

Proteomic databases

PRIDEi P29754.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000066412 ; ENSMUSP00000070958 ; ENSMUSG00000049115 .
GeneIDi 11607.
KEGGi mmu:11607.
UCSCi uc007pyu.2. mouse.

Organism-specific databases

CTDi 11607.
MGIi MGI:87964. Agtr1a.

Phylogenomic databases

eggNOGi NOG256015.
GeneTreei ENSGT00760000119055.
HOGENOMi HOG000234122.
HOVERGENi HBG104998.
InParanoidi P29754.
KOi K04166.
OMAi CIVIWLL.
OrthoDBi EOG7J4473.
PhylomeDBi P29754.
TreeFami TF330024.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSi AGTR1. mouse.
NextBioi 279144.
PROi P29754.
SOURCEi Search...

Gene expression databases

Bgeei P29754.
CleanExi MM_AGTR1A.
Genevestigatori P29754.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome."
    Sasamura H., Hein L., Krieger J.E., Pratt R.E., Kobilka B.K., Dzau V.J.
    Biochem. Biophys. Res. Commun. 185:253-259(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Liver.
  2. "Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human)."
    Yoshida H., Kakuchi J., Guo D.F., Furuta H., Iwai N., van der Meer-De Jong R., Inagami T., Ichikawa I.
    Biochem. Biophys. Res. Commun. 186:1042-1049(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiAGTRA_MOUSE
AccessioniPrimary (citable) accession number: P29754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3