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Protein

Alpha-lactalbumin

Gene

Lalba

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi98 – 109Add BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Keywords - Biological processi

Lactose biosynthesis

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-5653890. Lactose synthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-lactalbumin
Alternative name(s):
Lactose synthase B protein
Gene namesi
Name:Lalba
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96742. Lalba.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001844621 – 143Alpha-lactalbuminAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 140
Disulfide bondi48 ↔ 131
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi81 ↔ 97
Disulfide bondi93 ↔ 111

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP29752.
PeptideAtlasiP29752.
PRIDEiP29752.

PTM databases

PhosphoSitePlusiP29752.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

BgeeiENSMUSG00000022991.
CleanExiMM_LALBA.
ExpressionAtlasiP29752. baseline and differential.
GenevisibleiP29752. MM.

Interactioni

Subunit structurei

Lactose synthase (LS) is heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
B4GALT1P0803710EBI-1031454,EBI-1031436From a different organism.

Protein-protein interaction databases

IntActiP29752. 1 interactor.
STRINGi10090.ENSMUSP00000023726.

Structurei

Secondary structure

1143
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 31Combined sources7
Helixi33 – 35Combined sources3
Helixi38 – 40Combined sources3
Helixi43 – 54Combined sources12
Beta strandi61 – 64Combined sources4
Beta strandi67 – 70Combined sources4
Turni71 – 74Combined sources4
Turni77 – 80Combined sources4
Beta strandi81 – 83Combined sources3
Beta strandi84 – 86Combined sources3
Helixi97 – 100Combined sources4
Beta strandi101 – 103Combined sources3
Helixi106 – 118Combined sources13
Helixi121 – 123Combined sources3
Helixi127 – 130Combined sources4
Beta strandi131 – 133Combined sources3
Helixi136 – 138Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NF5X-ray2.00A/C21-143[»]
1NHEX-ray2.50A/C21-143[»]
1NKHX-ray2.00A/C21-143[»]
1NMMX-ray2.00A/C21-143[»]
1NQIX-ray2.00A/C21-143[»]
1NWGX-ray2.32A/C21-143[»]
1O23X-ray2.32A/C21-143[»]
1OQMX-ray2.10A/C21-143[»]
1PZYX-ray2.30A/C21-143[»]
1YROX-ray1.90A/C21-143[»]
2FYCX-ray2.00A/C21-143[»]
2FYDX-ray2.00A/C21-143[»]
ProteinModelPortaliP29752.
SMRiP29752.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29752.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX41. Eukaryota.
ENOG410ZQK6. LUCA.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiP29752.
KOiK00704.
OMAiGIDYWKA.
OrthoDBiEOG091G0R9V.
PhylomeDBiP29752.
TreeFamiTF324882.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000545. Lactalbumin.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00136. LACTALBUMIN.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMHFVPLFLV CILSLPAFQA TELTKCKVSH AIKDIDGYQG ISLLEWACVL
60 70 80 90 100
FHTSGYDTQA VVNDNGSTEY GLFQISDRFW CKSSEFPESE NICGISCDKL
110 120 130 140
LDDELDDDIA CAKKILAIKG IDYWKAYKPM CSEKLEQWRC EKP
Length:143
Mass (Da):16,260
Last modified:April 1, 1993 - v1
Checksum:i0322892711FF4309
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80909 mRNA. Translation: AAA37208.1.
M87863 Genomic DNA. Translation: AAA37209.1.
BC006922 mRNA. Translation: AAH06922.1.
BC069916 mRNA. Translation: AAH69916.1.
CCDSiCCDS27795.1.
PIRiJC1302.
RefSeqiNP_034809.1. NM_010679.1.
XP_006520580.1. XM_006520517.1.
UniGeneiMm.448567.
Mm.5074.

Genome annotation databases

EnsembliENSMUST00000023726; ENSMUSP00000023726; ENSMUSG00000022991.
GeneIDi16770.
KEGGimmu:16770.
UCSCiuc007xmo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80909 mRNA. Translation: AAA37208.1.
M87863 Genomic DNA. Translation: AAA37209.1.
BC006922 mRNA. Translation: AAH06922.1.
BC069916 mRNA. Translation: AAH69916.1.
CCDSiCCDS27795.1.
PIRiJC1302.
RefSeqiNP_034809.1. NM_010679.1.
XP_006520580.1. XM_006520517.1.
UniGeneiMm.448567.
Mm.5074.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NF5X-ray2.00A/C21-143[»]
1NHEX-ray2.50A/C21-143[»]
1NKHX-ray2.00A/C21-143[»]
1NMMX-ray2.00A/C21-143[»]
1NQIX-ray2.00A/C21-143[»]
1NWGX-ray2.32A/C21-143[»]
1O23X-ray2.32A/C21-143[»]
1OQMX-ray2.10A/C21-143[»]
1PZYX-ray2.30A/C21-143[»]
1YROX-ray1.90A/C21-143[»]
2FYCX-ray2.00A/C21-143[»]
2FYDX-ray2.00A/C21-143[»]
ProteinModelPortaliP29752.
SMRiP29752.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP29752. 1 interactor.
STRINGi10090.ENSMUSP00000023726.

PTM databases

PhosphoSitePlusiP29752.

Proteomic databases

PaxDbiP29752.
PeptideAtlasiP29752.
PRIDEiP29752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023726; ENSMUSP00000023726; ENSMUSG00000022991.
GeneIDi16770.
KEGGimmu:16770.
UCSCiuc007xmo.1. mouse.

Organism-specific databases

CTDi3906.
MGIiMGI:96742. Lalba.

Phylogenomic databases

eggNOGiENOG410IX41. Eukaryota.
ENOG410ZQK6. LUCA.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiP29752.
KOiK00704.
OMAiGIDYWKA.
OrthoDBiEOG091G0R9V.
PhylomeDBiP29752.
TreeFamiTF324882.

Enzyme and pathway databases

ReactomeiR-MMU-5653890. Lactose synthesis.

Miscellaneous databases

ChiTaRSiLalba. mouse.
EvolutionaryTraceiP29752.
PROiP29752.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022991.
CleanExiMM_LALBA.
ExpressionAtlasiP29752. baseline and differential.
GenevisibleiP29752. MM.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000545. Lactalbumin.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00136. LACTALBUMIN.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLALBA_MOUSE
AccessioniPrimary (citable) accession number: P29752
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.