P29751 (ACTB_RABIT) Reviewed, UniProtKB/Swiss-Prot
Last modified April 3, 2013. Version 99. History...
Names and origin
|Protein names||Recommended name:|
Actin, cytoplasmic 1
Cleaved into the following chain:
|Organism||Oryctolagus cuniculus (Rabbit) [Reference proteome]|
|Taxonomic identifier||9986 [NCBI]|
|Taxonomic lineage||Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus|
|Sequence length||375 AA.|
|Sequence processing||The displayed sequence is further processed into a mature form.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with XPO6 and EMD. Interacts with ERBB2 By similarity. Interacts with GCSAM By similarity.
ISGylated By similarity.
Oxidation of Met-44 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced By similarity.
In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
Belongs to the actin family.
|Technical term||Complete proteome|
|Gene Ontology (GO)|
Inferred from electronic annotation. Source: UniProtKB-SubCellcytosol
Traceable author statement. Source: Reactome
Inferred from electronic annotation. Source: UniProtKB-KW
|Complete GO annotation...|
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 375||375||Actin, cytoplasmic 1||PRO_0000367080|
|Initiator methionine||1||1||Removed; alternate By similarity|
|Chain||2 – 375||374||Actin, cytoplasmic 1, N-terminally processed||PRO_0000000779|
Amino acid modifications
|Modified residue||1||1||N-acetylmethionine By similarity|
|Modified residue||2||1||N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processed By similarity|
|Modified residue||44||1||Methionine sulfoxide By similarity|
|Modified residue||73||1||Tele-methylhistidine By similarity|
|||"Nucleotide sequences of the rabbit alpha-smooth-muscle and beta-non-muscle actin mRNAs."|
Harris D.E., Warshaw D.M., Periasamy M.
Gene 112:265-266(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: New Zealand white.
|+||Additional computationally mapped references.|
|X60733 mRNA. Translation: CAA43140.1.|
|PIR||ATRBB. JH0637. |
|RefSeq||NP_001095153.1. NM_001101683.1. |
3D structure databases
|SMR||P29751. Positions 2-375. |
Protein-protein interaction databases
|IntAct||P29751. 2 interactions.|
Protocols and materials databases
Genome annotation databases
Enzyme and pathway databases
|Reactome||REACT_96458. Hemostasis. |
Family and domain databases
|InterPro||IPR004000. Actin-related. |
|PANTHER||PTHR11937. PTHR11937. 1 hit. |
|Pfam||PF00022. Actin. 1 hit. |
|PRINTS||PR00190. ACTIN. |
|SMART||SM00268. ACTIN. 1 hit. |
|PROSITE||PS00406. ACTINS_1. 1 hit. |
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
|Accession||Primary (citable) accession number: P29751|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Chordata Protein Annotation Program|
Index of protein domains and families