SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P29699

- FETUA_MOUSE

UniProt

P29699 - FETUA_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Alpha-2-HS-glycoprotein
Gene
Ahsg, Fetua
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probably involved in differentiation.

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. acute-phase response Source: UniProtKB
  2. negative regulation of bone mineralization Source: UniProtKB
  3. ossification Source: MGI
  4. positive regulation of phagocytosis Source: UniProtKB
  5. regulation of inflammatory response Source: UniProtKB
Complete GO annotation...

Protein family/group databases

MEROPSiI25.020.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2-HS-glycoprotein
Alternative name(s):
Countertrypin
Fetuin-A
Gene namesi
Name:Ahsg
Synonyms:Fetua
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:107189. Ahsg.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 345327Alpha-2-HS-glycoprotein
PRO_0000008891Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 336 By similarity
Disulfide bondi89 ↔ 100 By similarity
Glycosylationi99 – 991N-linked (GlcNAc...)1 Publication
Disulfide bondi114 ↔ 132 By similarity
Modified residuei138 – 1381Phosphoserine2 Publications
Disulfide bondi146 ↔ 149 By similarity
Glycosylationi156 – 1561N-linked (GlcNAc...)1 Publication
Glycosylationi176 – 1761N-linked (GlcNAc...)2 Publications
Disulfide bondi208 ↔ 219 By similarity
Disulfide bondi230 ↔ 247 By similarity
Modified residuei309 – 3091Phosphoserine2 Publications
Modified residuei312 – 3121Phosphoserine2 Publications
Modified residuei314 – 3141Phosphoserine2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP29699.
PaxDbiP29699.
PRIDEiP29699.

2D gel databases

REPRODUCTION-2DPAGEIPI00128249.

PTM databases

PhosphoSiteiP29699.

Expressioni

Tissue specificityi

Liver is the major site of synthesis, but fetuin is also expressed in limb buds and other extrahepatic tissues during development.

Gene expression databases

BgeeiP29699.
CleanExiMM_AHSG.
GenevestigatoriP29699.

Interactioni

Protein-protein interaction databases

IntActiP29699. 8 interactions.
MINTiMINT-1846156.

Structurei

3D structure databases

ProteinModelPortaliP29699.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 133115Cystatin fetuin-A-type 1
Add
BLAST
Domaini144 – 250107Cystatin fetuin-A-type 2
Add
BLAST

Sequence similaritiesi

Belongs to the fetuin family.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG44208.
HOGENOMiHOG000290189.
HOVERGENiHBG051607.
InParanoidiP29699.
OMAiYGFCKAT.
OrthoDBiEOG71K63R.
PhylomeDBiP29699.
TreeFamiTF333729.

Family and domain databases

InterProiIPR025760. Cystatin_Fetuin_A.
IPR000010. Prot_inh_cystat.
IPR001363. Prot_inh_fetuin_CS.
[Graphical view]
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 2 hits.
[Graphical view]
PROSITEiPS51529. CYSTATIN_FETUIN_A. 2 hits.
PS01254. FETUIN_1. 1 hit.
PS01255. FETUIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29699-1 [UniParc]FASTAAdd to Basket

« Hide

MKSLVLLLCF AQLWGCQSAP QGTGLGFREL ACDDPEAEQV ALLAVDYLNN    50
HLLQGFKQVL NQIDKVKVWS RRPFGVVYEM EVDTLETTCH ALDPTPLANC 100
SVRQLTEHAV EGDCDFHILK QDGQFRVMHT QCHSTPDSAE DVRKLCPRCP 150
LLTPFNDTNV VHTVNTALAA FNTQNNGTYF KLVEISRAQN VPLPVSTLVE 200
FVIAATDCTA KEVTDPAKCN LLAEKQHGFC KANLMHNLGG EEVSVACKLF 250
QTQPQPANAN AVGPVPTANA ALPADPPASV VVGPVVVPRG LSDHRTYHDL 300
RHAFSPVASV ESASGETLHS PKVGQPGAAG PVSPMCPGRI RHFKI 345
Length:345
Mass (Da):37,326
Last modified:April 1, 1993 - v1
Checksum:i4B7B9C9B1410658E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711R → RQ in CAA05210. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S96534 mRNA. Translation: AAB22070.1.
AF007900 Genomic DNA. Translation: AAB81718.1.
AJ002146 Genomic DNA. Translation: CAA05210.1.
BC012678 mRNA. Translation: AAH12678.1.
BC019822 mRNA. Translation: AAH19822.1.
CCDSiCCDS28071.1.
PIRiS21094.
RefSeqiNP_038493.1. NM_013465.2.
UniGeneiMm.197554.

Genome annotation databases

EnsembliENSMUST00000023583; ENSMUSP00000023583; ENSMUSG00000022868.
GeneIDi11625.
KEGGimmu:11625.
UCSCiuc007ysr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S96534 mRNA. Translation: AAB22070.1 .
AF007900 Genomic DNA. Translation: AAB81718.1 .
AJ002146 Genomic DNA. Translation: CAA05210.1 .
BC012678 mRNA. Translation: AAH12678.1 .
BC019822 mRNA. Translation: AAH19822.1 .
CCDSi CCDS28071.1.
PIRi S21094.
RefSeqi NP_038493.1. NM_013465.2.
UniGenei Mm.197554.

3D structure databases

ProteinModelPortali P29699.
ModBasei Search...

Protein-protein interaction databases

IntActi P29699. 8 interactions.
MINTi MINT-1846156.

Protein family/group databases

MEROPSi I25.020.

PTM databases

PhosphoSitei P29699.

2D gel databases

REPRODUCTION-2DPAGE IPI00128249.

Proteomic databases

MaxQBi P29699.
PaxDbi P29699.
PRIDEi P29699.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023583 ; ENSMUSP00000023583 ; ENSMUSG00000022868 .
GeneIDi 11625.
KEGGi mmu:11625.
UCSCi uc007ysr.1. mouse.

Organism-specific databases

CTDi 197.
MGIi MGI:107189. Ahsg.

Phylogenomic databases

eggNOGi NOG44208.
HOGENOMi HOG000290189.
HOVERGENi HBG051607.
InParanoidi P29699.
OMAi YGFCKAT.
OrthoDBi EOG71K63R.
PhylomeDBi P29699.
TreeFami TF333729.

Miscellaneous databases

NextBioi 279179.
PROi P29699.
SOURCEi Search...

Gene expression databases

Bgeei P29699.
CleanExi MM_AHSG.
Genevestigatori P29699.

Family and domain databases

InterProi IPR025760. Cystatin_Fetuin_A.
IPR000010. Prot_inh_cystat.
IPR001363. Prot_inh_fetuin_CS.
[Graphical view ]
Pfami PF00031. Cystatin. 1 hit.
[Graphical view ]
SMARTi SM00043. CY. 2 hits.
[Graphical view ]
PROSITEi PS51529. CYSTATIN_FETUIN_A. 2 hits.
PS01254. FETUIN_1. 1 hit.
PS01255. FETUIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human alpha 2-HS-glycoprotein/bovine fetuin homologue in mice: identification and developmental regulation of the gene."
    Yang F., Chen Z.-L., Bergeron J.M., Cupples R.L., Friedrichs W.E.
    Biochim. Biophys. Acta 1130:149-156(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver and Salivary gland.
  4. "Isolation and characterization of mouse countertrypin, a new trypsin inhibitor belonging to the mammalian fetuin family."
    Yamamoto K., Sinohara H.
    J. Biol. Chem. 268:17750-17753(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
  5. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-176.
    Strain: C57BL/6.
    Tissue: Plasma.
  6. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
    Bernhard O.K., Kapp E.A., Simpson R.J.
    J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-99; ASN-156 AND ASN-176.
    Strain: C57BL/6.
    Tissue: Plasma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138; SER-309; SER-312 AND SER-314, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138; SER-309; SER-312 AND SER-314, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiFETUA_MOUSE
AccessioniPrimary (citable) accession number: P29699
Secondary accession number(s): O35634
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi