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P29699

- FETUA_MOUSE

UniProt

P29699 - FETUA_MOUSE

Protein

Alpha-2-HS-glycoprotein

Gene

Ahsg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Probably involved in differentiation.

    GO - Molecular functioni

    1. cysteine-type endopeptidase inhibitor activity Source: InterPro

    GO - Biological processi

    1. acute-phase response Source: UniProtKB
    2. negative regulation of bone mineralization Source: UniProtKB
    3. ossification Source: MGI
    4. positive regulation of phagocytosis Source: UniProtKB
    5. regulation of inflammatory response Source: UniProtKB

    Protein family/group databases

    MEROPSiI25.020.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-2-HS-glycoprotein
    Alternative name(s):
    Countertrypin
    Fetuin-A
    Gene namesi
    Name:Ahsg
    Synonyms:Fetua
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:107189. Ahsg.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 345327Alpha-2-HS-glycoproteinPRO_0000008891Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 336PROSITE-ProRule annotation
    Disulfide bondi89 ↔ 100PROSITE-ProRule annotation
    Glycosylationi99 – 991N-linked (GlcNAc...)1 Publication
    Disulfide bondi114 ↔ 132PROSITE-ProRule annotation
    Modified residuei138 – 1381Phosphoserine2 Publications
    Disulfide bondi146 ↔ 149PROSITE-ProRule annotation
    Glycosylationi156 – 1561N-linked (GlcNAc...)1 Publication
    Glycosylationi176 – 1761N-linked (GlcNAc...)2 Publications
    Disulfide bondi208 ↔ 219PROSITE-ProRule annotation
    Disulfide bondi230 ↔ 247PROSITE-ProRule annotation
    Modified residuei309 – 3091Phosphoserine2 Publications
    Modified residuei312 – 3121Phosphoserine2 Publications
    Modified residuei314 – 3141Phosphoserine2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP29699.
    PaxDbiP29699.
    PRIDEiP29699.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00128249.

    PTM databases

    PhosphoSiteiP29699.

    Expressioni

    Tissue specificityi

    Liver is the major site of synthesis, but fetuin is also expressed in limb buds and other extrahepatic tissues during development.

    Gene expression databases

    BgeeiP29699.
    CleanExiMM_AHSG.
    GenevestigatoriP29699.

    Interactioni

    Protein-protein interaction databases

    IntActiP29699. 8 interactions.
    MINTiMINT-1846156.

    Structurei

    3D structure databases

    ProteinModelPortaliP29699.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 133115Cystatin fetuin-A-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini144 – 250107Cystatin fetuin-A-type 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the fetuin family.PROSITE-ProRule annotation
    Contains 2 cystatin fetuin-A-type domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG44208.
    HOGENOMiHOG000290189.
    HOVERGENiHBG051607.
    InParanoidiP29699.
    OMAiYGFCKAT.
    OrthoDBiEOG71K63R.
    PhylomeDBiP29699.
    TreeFamiTF333729.

    Family and domain databases

    InterProiIPR025760. Cystatin_Fetuin_A.
    IPR000010. Prot_inh_cystat.
    IPR001363. Prot_inh_fetuin_CS.
    [Graphical view]
    PfamiPF00031. Cystatin. 1 hit.
    [Graphical view]
    SMARTiSM00043. CY. 2 hits.
    [Graphical view]
    PROSITEiPS51529. CYSTATIN_FETUIN_A. 2 hits.
    PS01254. FETUIN_1. 1 hit.
    PS01255. FETUIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P29699-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSLVLLLCF AQLWGCQSAP QGTGLGFREL ACDDPEAEQV ALLAVDYLNN    50
    HLLQGFKQVL NQIDKVKVWS RRPFGVVYEM EVDTLETTCH ALDPTPLANC 100
    SVRQLTEHAV EGDCDFHILK QDGQFRVMHT QCHSTPDSAE DVRKLCPRCP 150
    LLTPFNDTNV VHTVNTALAA FNTQNNGTYF KLVEISRAQN VPLPVSTLVE 200
    FVIAATDCTA KEVTDPAKCN LLAEKQHGFC KANLMHNLGG EEVSVACKLF 250
    QTQPQPANAN AVGPVPTANA ALPADPPASV VVGPVVVPRG LSDHRTYHDL 300
    RHAFSPVASV ESASGETLHS PKVGQPGAAG PVSPMCPGRI RHFKI 345
    Length:345
    Mass (Da):37,326
    Last modified:April 1, 1993 - v1
    Checksum:i4B7B9C9B1410658E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti71 – 711R → RQ in CAA05210. (PubMed:9395485)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S96534 mRNA. Translation: AAB22070.1.
    AF007900 Genomic DNA. Translation: AAB81718.1.
    AJ002146 Genomic DNA. Translation: CAA05210.1.
    BC012678 mRNA. Translation: AAH12678.1.
    BC019822 mRNA. Translation: AAH19822.1.
    CCDSiCCDS28071.1.
    PIRiS21094.
    RefSeqiNP_038493.1. NM_013465.2.
    UniGeneiMm.197554.

    Genome annotation databases

    EnsembliENSMUST00000023583; ENSMUSP00000023583; ENSMUSG00000022868.
    GeneIDi11625.
    KEGGimmu:11625.
    UCSCiuc007ysr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S96534 mRNA. Translation: AAB22070.1 .
    AF007900 Genomic DNA. Translation: AAB81718.1 .
    AJ002146 Genomic DNA. Translation: CAA05210.1 .
    BC012678 mRNA. Translation: AAH12678.1 .
    BC019822 mRNA. Translation: AAH19822.1 .
    CCDSi CCDS28071.1.
    PIRi S21094.
    RefSeqi NP_038493.1. NM_013465.2.
    UniGenei Mm.197554.

    3D structure databases

    ProteinModelPortali P29699.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P29699. 8 interactions.
    MINTi MINT-1846156.

    Protein family/group databases

    MEROPSi I25.020.

    PTM databases

    PhosphoSitei P29699.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00128249.

    Proteomic databases

    MaxQBi P29699.
    PaxDbi P29699.
    PRIDEi P29699.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023583 ; ENSMUSP00000023583 ; ENSMUSG00000022868 .
    GeneIDi 11625.
    KEGGi mmu:11625.
    UCSCi uc007ysr.1. mouse.

    Organism-specific databases

    CTDi 197.
    MGIi MGI:107189. Ahsg.

    Phylogenomic databases

    eggNOGi NOG44208.
    HOGENOMi HOG000290189.
    HOVERGENi HBG051607.
    InParanoidi P29699.
    OMAi YGFCKAT.
    OrthoDBi EOG71K63R.
    PhylomeDBi P29699.
    TreeFami TF333729.

    Miscellaneous databases

    NextBioi 279179.
    PROi P29699.
    SOURCEi Search...

    Gene expression databases

    Bgeei P29699.
    CleanExi MM_AHSG.
    Genevestigatori P29699.

    Family and domain databases

    InterProi IPR025760. Cystatin_Fetuin_A.
    IPR000010. Prot_inh_cystat.
    IPR001363. Prot_inh_fetuin_CS.
    [Graphical view ]
    Pfami PF00031. Cystatin. 1 hit.
    [Graphical view ]
    SMARTi SM00043. CY. 2 hits.
    [Graphical view ]
    PROSITEi PS51529. CYSTATIN_FETUIN_A. 2 hits.
    PS01254. FETUIN_1. 1 hit.
    PS01255. FETUIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human alpha 2-HS-glycoprotein/bovine fetuin homologue in mice: identification and developmental regulation of the gene."
      Yang F., Chen Z.-L., Bergeron J.M., Cupples R.L., Friedrichs W.E.
      Biochim. Biophys. Acta 1130:149-156(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver and Salivary gland.
    4. "Isolation and characterization of mouse countertrypin, a new trypsin inhibitor belonging to the mammalian fetuin family."
      Yamamoto K., Sinohara H.
      J. Biol. Chem. 268:17750-17753(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE.
    5. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
      Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
      J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-176.
      Strain: C57BL/6.
      Tissue: Plasma.
    6. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
      Bernhard O.K., Kapp E.A., Simpson R.J.
      J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-99; ASN-156 AND ASN-176.
      Strain: C57BL/6.
      Tissue: Plasma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138; SER-309; SER-312 AND SER-314, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    8. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138; SER-309; SER-312 AND SER-314, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiFETUA_MOUSE
    AccessioniPrimary (citable) accession number: P29699
    Secondary accession number(s): O35634
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3