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P29699 (FETUA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-2-HS-glycoprotein
Alternative name(s):
Countertrypin
Fetuin-A
Gene names
Name:Ahsg
Synonyms:Fetua
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably involved in differentiation.

Subcellular location

Secreted.

Tissue specificity

Liver is the major site of synthesis, but fetuin is also expressed in limb buds and other extrahepatic tissues during development.

Sequence similarities

Belongs to the fetuin family.

Contains 2 cystatin fetuin-A-type domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 345327Alpha-2-HS-glycoprotein
PRO_0000008891

Regions

Domain19 – 133115Cystatin fetuin-A-type 1
Domain144 – 250107Cystatin fetuin-A-type 2

Amino acid modifications

Modified residue1381Phosphoserine Ref.7 Ref.8
Modified residue3091Phosphoserine Ref.7 Ref.8
Modified residue3121Phosphoserine Ref.7 Ref.8
Modified residue3141Phosphoserine Ref.7 Ref.8
Glycosylation991N-linked (GlcNAc...) Ref.6
Glycosylation1561N-linked (GlcNAc...) Ref.6
Glycosylation1761N-linked (GlcNAc...) Ref.5 Ref.6
Disulfide bond32 ↔ 336 By similarity
Disulfide bond89 ↔ 100 By similarity
Disulfide bond114 ↔ 132 By similarity
Disulfide bond146 ↔ 149 By similarity
Disulfide bond208 ↔ 219 By similarity
Disulfide bond230 ↔ 247 By similarity

Experimental info

Sequence conflict711R → RQ in CAA05210. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P29699 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 4B7B9C9B1410658E

FASTA34537,326
        10         20         30         40         50         60 
MKSLVLLLCF AQLWGCQSAP QGTGLGFREL ACDDPEAEQV ALLAVDYLNN HLLQGFKQVL 

        70         80         90        100        110        120 
NQIDKVKVWS RRPFGVVYEM EVDTLETTCH ALDPTPLANC SVRQLTEHAV EGDCDFHILK 

       130        140        150        160        170        180 
QDGQFRVMHT QCHSTPDSAE DVRKLCPRCP LLTPFNDTNV VHTVNTALAA FNTQNNGTYF 

       190        200        210        220        230        240 
KLVEISRAQN VPLPVSTLVE FVIAATDCTA KEVTDPAKCN LLAEKQHGFC KANLMHNLGG 

       250        260        270        280        290        300 
EEVSVACKLF QTQPQPANAN AVGPVPTANA ALPADPPASV VVGPVVVPRG LSDHRTYHDL 

       310        320        330        340 
RHAFSPVASV ESASGETLHS PKVGQPGAAG PVSPMCPGRI RHFKI 

« Hide

References

« Hide 'large scale' references
[1]"Human alpha 2-HS-glycoprotein/bovine fetuin homologue in mice: identification and developmental regulation of the gene."
Yang F., Chen Z.-L., Bergeron J.M., Cupples R.L., Friedrichs W.E.
Biochim. Biophys. Acta 1130:149-156(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Liver.
[2]"Cloning and targeted deletion of the mouse fetuin gene."
Jahnen-Dechent W., Schinke T., Trindl A., Mueller-Esterl W., Sablitzky F., Kaiser S., Blessing M.
J. Biol. Chem. 272:31496-31503(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver and Salivary gland.
[4]"Isolation and characterization of mouse countertrypin, a new trypsin inhibitor belonging to the mammalian fetuin family."
Yamamoto K., Sinohara H.
J. Biol. Chem. 268:17750-17753(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE.
[5]"Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-176.
Strain: C57BL/6.
Tissue: Plasma.
[6]"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
Bernhard O.K., Kapp E.A., Simpson R.J.
J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-99; ASN-156 AND ASN-176.
Strain: C57BL/6.
Tissue: Plasma.
[7]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138; SER-309; SER-312 AND SER-314, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[8]"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138; SER-309; SER-312 AND SER-314, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S96534 mRNA. Translation: AAB22070.1.
AF007900 Genomic DNA. Translation: AAB81718.1.
AJ002146 Genomic DNA. Translation: CAA05210.1.
BC012678 mRNA. Translation: AAH12678.1.
BC019822 mRNA. Translation: AAH19822.1.
PIRS21094.
RefSeqNP_038493.1. NM_013465.2.
UniGeneMm.197554.

3D structure databases

ProteinModelPortalP29699.
SMRP29699. Positions 34-89.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP29699. 8 interactions.
MINTMINT-1846156.

Protein family/group databases

MEROPSI25.020.

PTM databases

PhosphoSiteP29699.

2D gel databases

REPRODUCTION-2DPAGEIPI00128249.

Proteomic databases

PaxDbP29699.
PRIDEP29699.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023583; ENSMUSP00000023583; ENSMUSG00000022868.
GeneID11625.
KEGGmmu:11625.
UCSCuc007ysr.1. mouse.

Organism-specific databases

CTD197.
MGIMGI:107189. Ahsg.

Phylogenomic databases

eggNOGNOG44208.
HOGENOMHOG000290189.
HOVERGENHBG051607.
InParanoidP29699.
OMAYGFCKAT.
OrthoDBEOG71K63R.
PhylomeDBP29699.
TreeFamTF333729.

Gene expression databases

BgeeP29699.
CleanExMM_AHSG.
GenevestigatorP29699.

Family and domain databases

InterProIPR025760. Cystatin_Fetuin_A.
IPR000010. Prot_inh_cystat.
IPR001363. Prot_inh_fetuin_CS.
[Graphical view]
PfamPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTSM00043. CY. 2 hits.
[Graphical view]
PROSITEPS51529. CYSTATIN_FETUIN_A. 2 hits.
PS01254. FETUIN_1. 1 hit.
PS01255. FETUIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio279179.
PROP29699.
SOURCESearch...

Entry information

Entry nameFETUA_MOUSE
AccessionPrimary (citable) accession number: P29699
Secondary accession number(s): O35634
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot