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Protein

Elongation factor 1-delta

Gene

EEF1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.
Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).

GO - Molecular functioni

  • activating transcription factor binding Source: UniProtKB
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • DNA binding Source: UniProtKB
  • heat shock protein binding Source: UniProtKB
  • signal transducer activity Source: UniProtKB
  • translation elongation factor activity Source: UniProtKB-KW
  • translation factor activity, RNA binding Source: ProtInc

GO - Biological processi

  • cellular response to ionizing radiation Source: UniProtKB
  • mRNA transcription Source: UniProtKB
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • regulation of cell death Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
  • translational elongation Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-156842. Eukaryotic Translation Elongation.
SIGNORiP29692.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-delta
Short name:
EF-1-delta
Alternative name(s):
Antigen NY-CO-4
Gene namesi
Name:EEF1D
Synonyms:EF1D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:3211. EEF1D.

Subcellular locationi

Isoform 2 :
  • Nucleus 1 Publication

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • eukaryotic translation elongation factor 1 complex Source: ProtInc
  • nucleolus Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27647.

Polymorphism and mutation databases

BioMutaiEEF1D.
DMDMi20141357.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources1 Publication
Chaini2 – 281280Elongation factor 1-deltaPRO_0000155046Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources1 Publication
Modified residuei17 – 171N6-acetyllysineCombined sources
Modified residuei37 – 371PhosphoserineCombined sources
Modified residuei44 – 441PhosphoserineCombined sources
Modified residuei60 – 601PhosphoserineCombined sources
Modified residuei73 – 731PhosphothreonineCombined sources
Modified residuei86 – 861PhosphoserineCombined sources
Modified residuei106 – 1061PhosphoserineBy similarity
Modified residuei107 – 1071N6-acetyllysineCombined sources
Modified residuei117 – 1171N6-acetyllysine; alternateCombined sources
Modified residuei117 – 1171N6-succinyllysine; alternateBy similarity
Modified residuei119 – 1191PhosphoserineCombined sources
Modified residuei129 – 1291PhosphothreonineCombined sources
Modified residuei133 – 1331PhosphoserineCombined sources
Modified residuei147 – 1471PhosphothreonineCombined sources
Modified residuei162 – 1621Phosphoserine; by CK2Combined sources1 Publication
Isoform 3 (identifier: P29692-3)
Modified residuei40 – 401PhosphoserineCombined sources
Isoform 2 (identifier: P29692-2)
Modified residuei91 – 911PhosphoserineCombined sourcesCurated
Modified residuei94 – 941PhosphoserineCombined sourcesCurated

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP29692.
MaxQBiP29692.
PaxDbiP29692.
PeptideAtlasiP29692.
PRIDEiP29692.
TopDownProteomicsiP29692-1. [P29692-1]
P29692-3. [P29692-3]
P29692-4. [P29692-4]

2D gel databases

OGPiP29692.

PTM databases

iPTMnetiP29692.
PhosphoSiteiP29692.
SwissPalmiP29692.

Expressioni

Tissue specificityi

Isoform 2 is specifically expressed in brain, cerebellum and testis.

Inductioni

By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress. Also induced following exposure to ionizing radiation.2 Publications

Gene expression databases

BgeeiENSG00000104529.
CleanExiHS_EEF1D.
ExpressionAtlasiP29692. baseline and differential.
GenevisibleiP29692. HS.

Organism-specific databases

HPAiHPA045101.
HPA051002.

Interactioni

Subunit structurei

EF-1 is composed of 4 subunits: alpha, beta, delta isoform 1, and gamma. Isoform 2 interacts with HSF1 and NFE2L2.

Binary interactionsi

WithEntry#Exp.IntActNotes
ARHGAP21Q5T5U32EBI-358607,EBI-1642518
ATG7O953522EBI-358607,EBI-987834
CAMSAP2Q08AD12EBI-358607,EBI-1051869
EEF1GP266413EBI-358607,EBI-351467
EEF1GP26641-23EBI-358607,EBI-10177695
ERP27Q96DN03EBI-358607,EBI-953772
MAXP612442EBI-358607,EBI-751711
PAQ670202EBI-358607,EBI-11514477From a different organism.
SIAH1Q8IUQ44EBI-358607,EBI-747107
TPT1P136933EBI-358607,EBI-1783169

GO - Molecular functioni

  • activating transcription factor binding Source: UniProtKB
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • heat shock protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108256. 126 interactions.
IntActiP29692. 87 interactions.
MINTiMINT-1139610.
STRINGi9606.ENSP00000391944.

Structurei

Secondary structure

1
281
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi153 – 1575Combined sources
Beta strandi159 – 1613Combined sources
Beta strandi162 – 1654Combined sources
Helixi169 – 18517Combined sources
Turni187 – 1904Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MVMNMR-A153-192[»]
2MVNNMR-A153-192[»]
2N51NMR-A153-281[»]
ProteinModelPortaliP29692.
SMRiP29692. Positions 153-281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni80 – 11536Leucine-zipperAdd
BLAST
Regioni173 – 281109Catalytic (GEF)Add
BLAST

Sequence similaritiesi

Belongs to the EF-1-beta/EF-1-delta family.Curated

Phylogenomic databases

eggNOGiKOG1668. Eukaryota.
COG2092. LUCA.
GeneTreeiENSGT00390000011747.
HOGENOMiHOG000207272.
HOVERGENiHBG000787.
InParanoidiP29692.
KOiK15410.
PhylomeDBiP29692.
TreeFamiTF313134.

Family and domain databases

CDDicd00292. EF1B. 1 hit.
Gene3Di3.30.70.60. 1 hit.
InterProiIPR018940. EF-1_beta_acid_region_euk.
IPR014038. EF1B_bsu/dsu_GNE.
IPR014717. Transl_elong_EF1B/ribosomal_S6.
IPR001326. Transl_elong_EF1B_B/D_CS.
[Graphical view]
PfamiPF10587. EF-1_beta_acid. 1 hit.
PF00736. EF1_GNE. 1 hit.
[Graphical view]
SMARTiSM01182. EF-1_beta_acid. 1 hit.
SM00888. EF1_GNE. 1 hit.
[Graphical view]
SUPFAMiSSF54984. SSF54984. 1 hit.
PROSITEiPS00824. EF1BD_1. 1 hit.
PS00825. EF1BD_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P29692-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATNFLAHEK IWFDKFKYDD AERRFYEQMN GPVAGASRQE NGASVILRDI
60 70 80 90 100
ARARENIQKS LAGSSGPGAS SGTSGDHGEL VVRIASLEVE NQSLRGVVQE
110 120 130 140 150
LQQAISKLEA RLNVLEKSSP GHRATAPQTQ HVSPMRQVEP PAKKPATPAE
160 170 180 190 200
DDEDDDIDLF GSDNEEEDKE AAQLREERLR QYAEKKAKKP ALVAKSSILL
210 220 230 240 250
DVKPWDDETD MAQLEACVRS IQLDGLVWGA SKLVPVGYGI RKLQIQCVVE
260 270 280
DDKVGTDLLE EEITKFEEHV QSVDIAAFNK I
Length:281
Mass (Da):31,122
Last modified:January 23, 2007 - v5
Checksum:iCE778D6D5D09BD6C
GO
Isoform 2 (identifier: P29692-2) [UniParc]FASTAAdd to basket
Also known as: eEF1BdeltaL

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRSGKASCTL...VSSLRPNRKM

Show »
Length:647
Mass (Da):71,408
Checksum:iA4CADBF40FCFCC09
GO
Isoform 3 (identifier: P29692-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-63: Missing.

Show »
Length:257
Mass (Da):28,558
Checksum:iE38BA673BE18FBE5
GO
Isoform 4 (identifier: P29692-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-96: Missing.

Note: No experimental confirmation available.
Show »
Length:262
Mass (Da):29,071
Checksum:i7F9682E53B69BC17
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341A → R in CAA79716 (PubMed:8334168).Curated
Sequence conflicti44 – 441S → T in CAA79716 (PubMed:8334168).Curated
Sequence conflicti209 – 2091T → A in BAG56855 (PubMed:14702039).Curated
Isoform 2 (identifier: P29692-2)
Sequence conflicti189 – 1891D → E in AAP35906 (Ref. 3) Combined sourcesCurated
Sequence conflicti189 – 1891D → E in EAW82228 (PubMed:14702039).Combined sourcesCurated
Sequence conflicti189 – 1891D → E in AAH07847 (PubMed:16421571).Combined sourcesCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MRSGKASCTLETVWEDKHKY EEAERRFYEHEATQAAASAQ QLPAEGPAMNGPGQDDPEDA DEAEAPDGGSRRDPRKSQDS RKPLQKKRKRSPKSGLGPAD LALLGLSAERVWLDKSLFDQ AESSYRQKLADVAAQAAWPP ALAPWGLCTHGNQVACHHVT WGIWVNKSSFDQAERAFVEW SQALLLAPDGSRRQGTPNTG QQVAVPDLAHQPSPPVNGQP PLGSLQALVREVWLEKPRYD AAERGFYEALFDGHPPGKVR LQERAGLAEGARRGRRDRRG RNILGNKRAGLRRADGEAPS ALPYCYFLQKDAEAPWLSKP AYDSAECRHHAAEALRVAWC LEAASLSHRPGPRSGLSVSS LRPNRKM in isoform 2. 2 PublicationsVSP_037884
Alternative sequencei40 – 6324Missing in isoform 3. 1 PublicationVSP_043812Add
BLAST
Alternative sequencei78 – 9619Missing in isoform 4. 1 PublicationVSP_045960Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21507 mRNA. Translation: CAA79716.1.
BT007242 mRNA. Translation: AAP35906.1.
AK293339 mRNA. Translation: BAG56855.1.
AC067930 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82227.1.
CH471162 Genomic DNA. Translation: EAW82228.1.
CH471162 Genomic DNA. Translation: EAW82229.1.
CH471162 Genomic DNA. Translation: EAW82230.1.
CH471162 Genomic DNA. Translation: EAW82232.1.
BC007847 mRNA. Translation: AAH07847.1.
BC009907 mRNA. Translation: AAH09907.1.
BC012819 mRNA. Translation: AAH12819.1.
BC062535 mRNA. Translation: AAH62535.1.
BC094806 mRNA. Translation: AAH94806.1.
CCDSiCCDS47930.1. [P29692-3]
CCDS56559.1. [P29692-4]
CCDS6404.1. [P29692-2]
CCDS6405.1. [P29692-1]
PIRiS34626.
RefSeqiNP_001123525.2. NM_001130053.2.
NP_001123527.1. NM_001130055.2. [P29692-1]
NP_001123528.1. NM_001130056.2. [P29692-3]
NP_001123529.1. NM_001130057.2. [P29692-1]
NP_001182132.1. NM_001195203.1. [P29692-4]
NP_001276879.1. NM_001289950.1. [P29692-1]
NP_001304672.1. NM_001317743.1. [P29692-3]
NP_001951.2. NM_001960.4. [P29692-1]
NP_115754.3. NM_032378.4.
XP_005250880.1. XM_005250823.1. [P29692-2]
XP_006716585.1. XM_006716522.1. [P29692-2]
XP_006716586.1. XM_006716523.1. [P29692-2]
XP_006716587.1. XM_006716524.1. [P29692-2]
XP_006716588.1. XM_006716525.1. [P29692-1]
XP_011515207.1. XM_011516905.2. [P29692-2]
XP_011515208.1. XM_011516906.2. [P29692-2]
UniGeneiHs.333388.
Hs.686554.
Hs.703306.

Genome annotation databases

EnsembliENST00000317198; ENSP00000317399; ENSG00000104529. [P29692-1]
ENST00000395119; ENSP00000378551; ENSG00000104529. [P29692-1]
ENST00000419152; ENSP00000388261; ENSG00000104529. [P29692-1]
ENST00000423316; ENSP00000410059; ENSG00000104529. [P29692-2]
ENST00000442189; ENSP00000391944; ENSG00000104529. [P29692-2]
ENST00000524624; ENSP00000435697; ENSG00000104529. [P29692-3]
ENST00000526838; ENSP00000436507; ENSG00000104529. [P29692-4]
ENST00000528610; ENSP00000431763; ENSG00000104529. [P29692-3]
ENST00000529272; ENSP00000434872; ENSG00000104529. [P29692-1]
ENST00000614575; ENSP00000478340; ENSG00000273594. [P29692-1]
ENST00000615067; ENSP00000479653; ENSG00000273594. [P29692-1]
ENST00000615698; ENSP00000483527; ENSG00000273594. [P29692-1]
ENST00000619144; ENSP00000477608; ENSG00000273594. [P29692-2]
ENST00000620155; ENSP00000480505; ENSG00000273594. [P29692-2]
ENST00000631698; ENSP00000488672; ENSG00000273594. [P29692-4]
ENST00000632587; ENSP00000487680; ENSG00000273594. [P29692-1]
ENST00000632675; ENSP00000488026; ENSG00000273594. [P29692-3]
ENST00000632965; ENSP00000488275; ENSG00000273594. [P29692-3]
GeneIDi1936.
KEGGihsa:1936.
UCSCiuc003yyr.4. human. [P29692-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21507 mRNA. Translation: CAA79716.1.
BT007242 mRNA. Translation: AAP35906.1.
AK293339 mRNA. Translation: BAG56855.1.
AC067930 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82227.1.
CH471162 Genomic DNA. Translation: EAW82228.1.
CH471162 Genomic DNA. Translation: EAW82229.1.
CH471162 Genomic DNA. Translation: EAW82230.1.
CH471162 Genomic DNA. Translation: EAW82232.1.
BC007847 mRNA. Translation: AAH07847.1.
BC009907 mRNA. Translation: AAH09907.1.
BC012819 mRNA. Translation: AAH12819.1.
BC062535 mRNA. Translation: AAH62535.1.
BC094806 mRNA. Translation: AAH94806.1.
CCDSiCCDS47930.1. [P29692-3]
CCDS56559.1. [P29692-4]
CCDS6404.1. [P29692-2]
CCDS6405.1. [P29692-1]
PIRiS34626.
RefSeqiNP_001123525.2. NM_001130053.2.
NP_001123527.1. NM_001130055.2. [P29692-1]
NP_001123528.1. NM_001130056.2. [P29692-3]
NP_001123529.1. NM_001130057.2. [P29692-1]
NP_001182132.1. NM_001195203.1. [P29692-4]
NP_001276879.1. NM_001289950.1. [P29692-1]
NP_001304672.1. NM_001317743.1. [P29692-3]
NP_001951.2. NM_001960.4. [P29692-1]
NP_115754.3. NM_032378.4.
XP_005250880.1. XM_005250823.1. [P29692-2]
XP_006716585.1. XM_006716522.1. [P29692-2]
XP_006716586.1. XM_006716523.1. [P29692-2]
XP_006716587.1. XM_006716524.1. [P29692-2]
XP_006716588.1. XM_006716525.1. [P29692-1]
XP_011515207.1. XM_011516905.2. [P29692-2]
XP_011515208.1. XM_011516906.2. [P29692-2]
UniGeneiHs.333388.
Hs.686554.
Hs.703306.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MVMNMR-A153-192[»]
2MVNNMR-A153-192[»]
2N51NMR-A153-281[»]
ProteinModelPortaliP29692.
SMRiP29692. Positions 153-281.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108256. 126 interactions.
IntActiP29692. 87 interactions.
MINTiMINT-1139610.
STRINGi9606.ENSP00000391944.

PTM databases

iPTMnetiP29692.
PhosphoSiteiP29692.
SwissPalmiP29692.

Polymorphism and mutation databases

BioMutaiEEF1D.
DMDMi20141357.

2D gel databases

OGPiP29692.

Proteomic databases

EPDiP29692.
MaxQBiP29692.
PaxDbiP29692.
PeptideAtlasiP29692.
PRIDEiP29692.
TopDownProteomicsiP29692-1. [P29692-1]
P29692-3. [P29692-3]
P29692-4. [P29692-4]

Protocols and materials databases

DNASUi1936.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317198; ENSP00000317399; ENSG00000104529. [P29692-1]
ENST00000395119; ENSP00000378551; ENSG00000104529. [P29692-1]
ENST00000419152; ENSP00000388261; ENSG00000104529. [P29692-1]
ENST00000423316; ENSP00000410059; ENSG00000104529. [P29692-2]
ENST00000442189; ENSP00000391944; ENSG00000104529. [P29692-2]
ENST00000524624; ENSP00000435697; ENSG00000104529. [P29692-3]
ENST00000526838; ENSP00000436507; ENSG00000104529. [P29692-4]
ENST00000528610; ENSP00000431763; ENSG00000104529. [P29692-3]
ENST00000529272; ENSP00000434872; ENSG00000104529. [P29692-1]
ENST00000614575; ENSP00000478340; ENSG00000273594. [P29692-1]
ENST00000615067; ENSP00000479653; ENSG00000273594. [P29692-1]
ENST00000615698; ENSP00000483527; ENSG00000273594. [P29692-1]
ENST00000619144; ENSP00000477608; ENSG00000273594. [P29692-2]
ENST00000620155; ENSP00000480505; ENSG00000273594. [P29692-2]
ENST00000631698; ENSP00000488672; ENSG00000273594. [P29692-4]
ENST00000632587; ENSP00000487680; ENSG00000273594. [P29692-1]
ENST00000632675; ENSP00000488026; ENSG00000273594. [P29692-3]
ENST00000632965; ENSP00000488275; ENSG00000273594. [P29692-3]
GeneIDi1936.
KEGGihsa:1936.
UCSCiuc003yyr.4. human. [P29692-1]

Organism-specific databases

CTDi1936.
GeneCardsiEEF1D.
H-InvDBHIX0034587.
HGNCiHGNC:3211. EEF1D.
HPAiHPA045101.
HPA051002.
MIMi130592. gene.
neXtProtiNX_P29692.
PharmGKBiPA27647.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1668. Eukaryota.
COG2092. LUCA.
GeneTreeiENSGT00390000011747.
HOGENOMiHOG000207272.
HOVERGENiHBG000787.
InParanoidiP29692.
KOiK15410.
PhylomeDBiP29692.
TreeFamiTF313134.

Enzyme and pathway databases

ReactomeiR-HSA-156842. Eukaryotic Translation Elongation.
SIGNORiP29692.

Miscellaneous databases

ChiTaRSiEEF1D. human.
GeneWikiiEEF1D.
GenomeRNAii1936.
PROiP29692.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104529.
CleanExiHS_EEF1D.
ExpressionAtlasiP29692. baseline and differential.
GenevisibleiP29692. HS.

Family and domain databases

CDDicd00292. EF1B. 1 hit.
Gene3Di3.30.70.60. 1 hit.
InterProiIPR018940. EF-1_beta_acid_region_euk.
IPR014038. EF1B_bsu/dsu_GNE.
IPR014717. Transl_elong_EF1B/ribosomal_S6.
IPR001326. Transl_elong_EF1B_B/D_CS.
[Graphical view]
PfamiPF10587. EF-1_beta_acid. 1 hit.
PF00736. EF1_GNE. 1 hit.
[Graphical view]
SMARTiSM01182. EF-1_beta_acid. 1 hit.
SM00888. EF1_GNE. 1 hit.
[Graphical view]
SUPFAMiSSF54984. SSF54984. 1 hit.
PROSITEiPS00824. EF1BD_1. 1 hit.
PS00825. EF1BD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEF1D_HUMAN
AccessioniPrimary (citable) accession number: P29692
Secondary accession number(s): B4DDU4
, D3DWK3, E9PBQ9, Q4VBZ6, Q969J1, Q96I38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 180 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.