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P29686

- G6PD_SYNE7

UniProt

P29686 - G6PD_SYNE7

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (18 Apr 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei63 – 631NADPUniRule annotation
    Binding sitei168 – 1681NADPUniRule annotation
    Binding sitei198 – 1981SubstrateUniRule annotation
    Binding sitei202 – 2021SubstrateUniRule annotation
    Binding sitei236 – 2361SubstrateUniRule annotation
    Binding sitei255 – 2551SubstrateUniRule annotation
    Active sitei260 – 2601Proton acceptorUniRule annotation
    Binding sitei360 – 3601SubstrateUniRule annotation
    Binding sitei365 – 3651SubstrateUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-1190-MONOMER.
    SYNEL:SYNPCC7942_2334-MONOMER.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:Synpcc7942_2334
    OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
    Taxonomic identifieri1140 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000002717: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 511511Glucose-6-phosphate 1-dehydrogenasePRO_0000068134Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi1140.Synpcc7942_2334.

    Structurei

    3D structure databases

    ProteinModelPortaliP29686.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    HOGENOMiHOG000046191.
    KOiK00036.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29686-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPKLLENPL RIGLRQDKVP EPQILVIFGA TGDLTQRKLV PAIYEMHLER    50
    RLPPELTIVG VARRDWSDDY FREHLRQGVE QFGGGIQAEE VWNTFAQGLF 100
    FAPGNIDDPQ FYQTLRDRLA NLDELRGTRG NRTFYLSVAP RFFGEAAKQL 150
    GAAGMLADPA KTRLVVEKPF GRDLSSAQVL NAILQNVCRE SQIYRIDHYL 200
    GKETVQNLLV FRFANAIFEP LWNRQYIDHV QITVAETVGL EGRAGYYETA 250
    GALRDMVQNH LMQLFSLTAM EPPNSLGADG IRNEKVKVVQ ATRLADIDDL 300
    SLSAVRGQYK AGWMNGRSVP AYRDEEGADP QSFTPTYVAM KLLVDNWRWQ 350
    GVPFYLRTGK RMPKKVTEIA IQFKTVPHLM FQSATQKVNS PNVLVLRIQP 400
    NEGVSLRFEV KTPGSSQRTR SVDMDFRYDT AFGSPTQEAY SRLLVDCMLG 450
    DQTLFTRADE VEASWRVVTP LLESWDDPRQ AAGISFYEAG TWEPAEAEQL 500
    INRDGRRWRR L 511
    Length:511
    Mass (Da):58,095
    Last modified:April 18, 2006 - v2
    Checksum:i9F16062520B51B10
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti506 – 5116RRWRRL → AVGVVSRIPATQLNSSGDV(PubMed:1643289)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33285 Genomic DNA. Translation: AAA98847.1.
    CP000100 Genomic DNA. Translation: ABB58364.1.
    PIRiS23520. DEYCG6.
    RefSeqiYP_401351.1. NC_007604.1.

    Genome annotation databases

    EnsemblBacteriaiABB58364; ABB58364; Synpcc7942_2334.
    GeneIDi3774617.
    KEGGisyf:Synpcc7942_2334.
    PATRICi23790215. VBISynElo51371_2623.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33285 Genomic DNA. Translation: AAA98847.1 .
    CP000100 Genomic DNA. Translation: ABB58364.1 .
    PIRi S23520. DEYCG6.
    RefSeqi YP_401351.1. NC_007604.1.

    3D structure databases

    ProteinModelPortali P29686.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1140.Synpcc7942_2334.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB58364 ; ABB58364 ; Synpcc7942_2334 .
    GeneIDi 3774617.
    KEGGi syf:Synpcc7942_2334.
    PATRICi 23790215. VBISynElo51371_2623.

    Phylogenomic databases

    eggNOGi COG0364.
    HOGENOMi HOG000046191.
    KOi K00036.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    BioCyci RETL1328306-WGS:GSTH-1190-MONOMER.
    SYNEL:SYNPCC7942_2334-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence analysis of the glucose-6-phosphate dehydrogenase gene from the cyanobacterium Synechococcus PCC 7942."
      Scanlan D.J., Newman J., Sebaihia M., Mann N.H., Carr N.G.
      Plant Mol. Biol. 19:877-880(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7942.

    Entry informationi

    Entry nameiG6PD_SYNE7
    AccessioniPrimary (citable) accession number: P29686
    Secondary accession number(s): Q31KQ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3