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P29686

- G6PD_SYNE7

UniProt

P29686 - G6PD_SYNE7

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Protein
Glucose-6-phosphate 1-dehydrogenase
Gene
zwf, Synpcc7942_2334
Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631NADP By similarity
Binding sitei168 – 1681NADP By similarity
Binding sitei198 – 1981Substrate By similarity
Binding sitei202 – 2021Substrate By similarity
Binding sitei236 – 2361Substrate By similarity
Binding sitei255 – 2551Substrate By similarity
Active sitei260 – 2601Proton acceptor By similarity
Binding sitei360 – 3601Substrate By similarity
Binding sitei365 – 3651Substrate By similarity

GO - Molecular functioni

  1. NADP binding Source: UniProtKB-HAMAP
  2. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1190-MONOMER.
SYNEL:SYNPCC7942_2334-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:zwf
Ordered Locus Names:Synpcc7942_2334
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002717: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Glucose-6-phosphate 1-dehydrogenaseUniRule annotation
PRO_0000068134Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi1140.Synpcc7942_2334.

Structurei

3D structure databases

ProteinModelPortaliP29686.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29686-1 [UniParc]FASTAAdd to Basket

« Hide

MTPKLLENPL RIGLRQDKVP EPQILVIFGA TGDLTQRKLV PAIYEMHLER    50
RLPPELTIVG VARRDWSDDY FREHLRQGVE QFGGGIQAEE VWNTFAQGLF 100
FAPGNIDDPQ FYQTLRDRLA NLDELRGTRG NRTFYLSVAP RFFGEAAKQL 150
GAAGMLADPA KTRLVVEKPF GRDLSSAQVL NAILQNVCRE SQIYRIDHYL 200
GKETVQNLLV FRFANAIFEP LWNRQYIDHV QITVAETVGL EGRAGYYETA 250
GALRDMVQNH LMQLFSLTAM EPPNSLGADG IRNEKVKVVQ ATRLADIDDL 300
SLSAVRGQYK AGWMNGRSVP AYRDEEGADP QSFTPTYVAM KLLVDNWRWQ 350
GVPFYLRTGK RMPKKVTEIA IQFKTVPHLM FQSATQKVNS PNVLVLRIQP 400
NEGVSLRFEV KTPGSSQRTR SVDMDFRYDT AFGSPTQEAY SRLLVDCMLG 450
DQTLFTRADE VEASWRVVTP LLESWDDPRQ AAGISFYEAG TWEPAEAEQL 500
INRDGRRWRR L 511
Length:511
Mass (Da):58,095
Last modified:April 18, 2006 - v2
Checksum:i9F16062520B51B10
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti506 – 5116RRWRRL → AVGVVSRIPATQLNSSGDV1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33285 Genomic DNA. Translation: AAA98847.1.
CP000100 Genomic DNA. Translation: ABB58364.1.
PIRiS23520. DEYCG6.
RefSeqiYP_401351.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB58364; ABB58364; Synpcc7942_2334.
GeneIDi3774617.
KEGGisyf:Synpcc7942_2334.
PATRICi23790215. VBISynElo51371_2623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33285 Genomic DNA. Translation: AAA98847.1 .
CP000100 Genomic DNA. Translation: ABB58364.1 .
PIRi S23520. DEYCG6.
RefSeqi YP_401351.1. NC_007604.1.

3D structure databases

ProteinModelPortali P29686.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1140.Synpcc7942_2334.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB58364 ; ABB58364 ; Synpcc7942_2334 .
GeneIDi 3774617.
KEGGi syf:Synpcc7942_2334.
PATRICi 23790215. VBISynElo51371_2623.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046191.
KOi K00036.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci RETL1328306-WGS:GSTH-1190-MONOMER.
SYNEL:SYNPCC7942_2334-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of the glucose-6-phosphate dehydrogenase gene from the cyanobacterium Synechococcus PCC 7942."
    Scanlan D.J., Newman J., Sebaihia M., Mann N.H., Carr N.G.
    Plant Mol. Biol. 19:877-880(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7942.

Entry informationi

Entry nameiG6PD_SYNE7
AccessioniPrimary (citable) accession number: P29686
Secondary accession number(s): Q31KQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 18, 2006
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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