Reviewed, UniProtKB/Swiss-Prot P29686 (G6PD_SYNE7)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	zwf
Ordered Locus Names:	Synpcc7942_2334

Organism

Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]

Taxonomic identifier

1140 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 511	511	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068134
Sites
	Active site	260	1	Proton acceptor By similarity
	Binding site	31	1	NADP By similarity
	Binding site	63	1	NADP By similarity
	Binding site	198	1	Substrate By similarity
	Binding site	202	1	Substrate By similarity
	Binding site	365	1	Substrate By similarity
Experimental info
	Sequence conflict	506 – 511	6	RRWRRL → AVGVVSRIPATQLNSSGDV Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P29686-1 [UniParc]. Last modified April 18, 2006. Version 2. Checksum: 9F16062520B51B10	FASTA	511	58,095
	10 20 30 40 50 60 MTPKLLENPL RIGLRQDKVP EPQILVIFGA TGDLTQRKLV PAIYEMHLER RLPPELTIVG 70 80 90 100 110 120 VARRDWSDDY FREHLRQGVE QFGGGIQAEE VWNTFAQGLF FAPGNIDDPQ FYQTLRDRLA 130 140 150 160 170 180 NLDELRGTRG NRTFYLSVAP RFFGEAAKQL GAAGMLADPA KTRLVVEKPF GRDLSSAQVL 190 200 210 220 230 240 NAILQNVCRE SQIYRIDHYL GKETVQNLLV FRFANAIFEP LWNRQYIDHV QITVAETVGL 250 260 270 280 290 300 EGRAGYYETA GALRDMVQNH LMQLFSLTAM EPPNSLGADG IRNEKVKVVQ ATRLADIDDL 310 320 330 340 350 360 SLSAVRGQYK AGWMNGRSVP AYRDEEGADP QSFTPTYVAM KLLVDNWRWQ GVPFYLRTGK 370 380 390 400 410 420 RMPKKVTEIA IQFKTVPHLM FQSATQKVNS PNVLVLRIQP NEGVSLRFEV KTPGSSQRTR 430 440 450 460 470 480 SVDMDFRYDT AFGSPTQEAY SRLLVDCMLG DQTLFTRADE VEASWRVVTP LLESWDDPRQ 490 500 510 AAGISFYEAG TWEPAEAEQL INRDGRRWRR L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequence analysis of the glucose-6-phosphate dehydrogenase gene from the cyanobacterium Synechococcus PCC 7942." Scanlan D.J., Newman J., Sebaihia M., Mann N.H., Carr N.G. Plant Mol. Biol. 19:877-880(1992) [PubMed: 1643289] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U33285 Genomic DNA. Translation: AAA98847.1. CP000100 Genomic DNA. Translation: ABB58364.1.
PIR	DEYCG6. S23520.
RefSeq	YP_401351.1.
3D structure databases
HSSP	HSSP built from PDB template 1QKI based on UniProtKB P11413.
ModBase	Search...
Genome annotation databases
GeneID	3774617.
GenomeReviews	Gene locus Synpcc7942_2334 in contig CP000100_GR.
KEGG	syf:Synpcc7942_2334.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P29686.
Enzyme and pathway databases
BioCyc	SELO1140:SYNPCC7942_2334-MON.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DH. IPR019796. Glc-6-P_DH_AS. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
ProDom	PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_SYNE7

Accession

Primary (citable) accession number: P29686
Secondary accession number(s): Q31KQ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 18, 2006
Last modified:	June 16, 2009
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)