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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631NADPUniRule annotation
Binding sitei168 – 1681NADPUniRule annotation
Binding sitei198 – 1981SubstrateUniRule annotation
Binding sitei202 – 2021SubstrateUniRule annotation
Binding sitei236 – 2361SubstrateUniRule annotation
Binding sitei255 – 2551SubstrateUniRule annotation
Active sitei260 – 2601Proton acceptorUniRule annotation
Binding sitei360 – 3601SubstrateUniRule annotation
Binding sitei365 – 3651SubstrateUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glucose metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1190-MONOMER.
SYNEL:SYNPCC7942_2334-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:Synpcc7942_2334
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002717: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Glucose-6-phosphate 1-dehydrogenasePRO_0000068134Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi1140.Synpcc7942_2334.

Structurei

3D structure databases

ProteinModelPortaliP29686.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29686-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPKLLENPL RIGLRQDKVP EPQILVIFGA TGDLTQRKLV PAIYEMHLER
60 70 80 90 100
RLPPELTIVG VARRDWSDDY FREHLRQGVE QFGGGIQAEE VWNTFAQGLF
110 120 130 140 150
FAPGNIDDPQ FYQTLRDRLA NLDELRGTRG NRTFYLSVAP RFFGEAAKQL
160 170 180 190 200
GAAGMLADPA KTRLVVEKPF GRDLSSAQVL NAILQNVCRE SQIYRIDHYL
210 220 230 240 250
GKETVQNLLV FRFANAIFEP LWNRQYIDHV QITVAETVGL EGRAGYYETA
260 270 280 290 300
GALRDMVQNH LMQLFSLTAM EPPNSLGADG IRNEKVKVVQ ATRLADIDDL
310 320 330 340 350
SLSAVRGQYK AGWMNGRSVP AYRDEEGADP QSFTPTYVAM KLLVDNWRWQ
360 370 380 390 400
GVPFYLRTGK RMPKKVTEIA IQFKTVPHLM FQSATQKVNS PNVLVLRIQP
410 420 430 440 450
NEGVSLRFEV KTPGSSQRTR SVDMDFRYDT AFGSPTQEAY SRLLVDCMLG
460 470 480 490 500
DQTLFTRADE VEASWRVVTP LLESWDDPRQ AAGISFYEAG TWEPAEAEQL
510
INRDGRRWRR L
Length:511
Mass (Da):58,095
Last modified:April 18, 2006 - v2
Checksum:i9F16062520B51B10
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti506 – 5116RRWRRL → AVGVVSRIPATQLNSSGDV (PubMed:1643289).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33285 Genomic DNA. Translation: AAA98847.1.
CP000100 Genomic DNA. Translation: ABB58364.1.
PIRiS23520. DEYCG6.
RefSeqiYP_401351.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB58364; ABB58364; Synpcc7942_2334.
GeneIDi3774617.
KEGGisyf:Synpcc7942_2334.
PATRICi23790215. VBISynElo51371_2623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33285 Genomic DNA. Translation: AAA98847.1.
CP000100 Genomic DNA. Translation: ABB58364.1.
PIRiS23520. DEYCG6.
RefSeqiYP_401351.1. NC_007604.1.

3D structure databases

ProteinModelPortaliP29686.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1140.Synpcc7942_2334.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB58364; ABB58364; Synpcc7942_2334.
GeneIDi3774617.
KEGGisyf:Synpcc7942_2334.
PATRICi23790215. VBISynElo51371_2623.

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OrthoDBiEOG61308Z.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.
BioCyciRETL1328306-WGS:GSTH-1190-MONOMER.
SYNEL:SYNPCC7942_2334-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of the glucose-6-phosphate dehydrogenase gene from the cyanobacterium Synechococcus PCC 7942."
    Scanlan D.J., Newman J., Sebaihia M., Mann N.H., Carr N.G.
    Plant Mol. Biol. 19:877-880(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7942.

Entry informationi

Entry nameiG6PD_SYNE7
AccessioniPrimary (citable) accession number: P29686
Secondary accession number(s): Q31KQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 18, 2006
Last modified: March 4, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.