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Protein

Mitochondrial-processing peptidase subunit alpha

Gene

MPP

Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cleaves presequences (transit peptides) from mitochondrial protein precursors.By similarity
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. Mediate formation of the complex between cytochromes c and c1.

Catalytic activityi

Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.
Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+.

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Oxidoreductase, Protease
Biological processElectron transport, Respiratory chain, Transport

Protein family/group databases

MEROPSiM16.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial-processing peptidase subunit alpha (EC:3.4.24.64)
Alternative name(s):
Alpha-MPP
Ubiquinol-cytochrome-c reductase subunit II (EC:1.10.2.2)
Gene namesi
Name:MPP
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi
  • UP000011115 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000026776? – 504Mitochondrial-processing peptidase subunit alpha
Transit peptidei1 – ?Mitochondrion

Proteomic databases

PRIDEiP29677.
ProMEXiP29677.

Interactioni

Subunit structurei

Heterodimer of alpha and beta subunits.

Protein-protein interaction databases

IntActiP29677. 1 interactor.
STRINGi4113.PGSC0003DMT400000784.

Structurei

3D structure databases

ProteinModelPortaliP29677.
SMRiP29677.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M16 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2067. Eukaryota.
COG0612. LUCA.
InParanoidiP29677.
KOiK01412.

Family and domain databases

InterProiView protein in InterPro
IPR011249. Metalloenz_LuxS/M16.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
PfamiView protein in Pfam
PF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
SUPFAMiSSF63411. SSF63411. 2 hits.
PROSITEiView protein in PROSITE
PS00143. INSULINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRCASSRLS SLKARQGNRV LTRFSSSAAV ATKPSGGLFS WITGDTSSSV
60 70 80 90 100
TPLDFPLNDV KLSPPLPDYV EPAKTQITTL ANGLKVASEA SVNPAASIGL
110 120 130 140 150
YVDCGSIYET PASYGATHLL ERMAFKSTLN RSHLRIVREI EAIGGNVTAS
160 170 180 190 200
ASREHMIYTY DALKTYVPQM VEMLADCVRN PAFLDWEVKE QLEKVKAEIS
210 220 230 240 250
EYSKNPQHLL LEAVHSAGYA GPYGNSLMAT EATINRLNST VLEEFVAENY
260 270 280 290 300
TAPRMVLAAS GVEHEEFLKV AEPLLSDLPK VATIEEPKPV YVGGDYRCQA
310 320 330 340 350
DAEMTHFALA FEVPGGWMSE KESMTLTVLQ MLMGGGGSFS AGGPGKGMYS
360 370 380 390 400
RLYLRVLNQY PQIHAFSAFS SIYNNTGLFG IQGTTSSDFG PQAVDVAVKE
410 420 430 440 450
LIAVANPSEV DQVQLNRAKQ ATKSAILMNL ESRMVASEDI GRQLLTYGER
460 470 480 490 500
NPVEHFLKAI DAVSAKDIAS VVQKLISSPL TMASYGDVLS LPSYDAVSSR

FRSK
Length:504
Mass (Da):54,677
Last modified:April 1, 1993 - v1
Checksum:iFD3053688571D987
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66284 mRNA. Translation: CAA46990.1.
PIRiS23558.
RefSeqiNP_001275168.1. NM_001288239.1.
UniGeneiStu.18155.

Genome annotation databases

GeneIDi102580877.
KEGGisot:102580877.

Similar proteinsi

Entry informationi

Entry nameiMPPA_SOLTU
AccessioniPrimary (citable) accession number: P29677
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 10, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families