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Protein

Erythropoietin

Gene

Epo

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Erythrocyte maturation

Names & Taxonomyi

Protein namesi
Recommended name:
Erythropoietin
Gene namesi
Name:Epo
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi2559. Epo.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: Ensembl
  • extracellular region Source: RGD
  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 192166ErythropoietinPRO_0000008408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 187By similarity
Glycosylationi50 – 501N-linked (GlcNAc...)By similarity
Glycosylationi64 – 641N-linked (GlcNAc...)By similarity
Glycosylationi109 – 1091N-linked (GlcNAc...)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

Gene expression databases

GenevisibleiP29676. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001914.

Structurei

3D structure databases

ProteinModelPortaliP29676.
SMRiP29676. Positions 27-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EPO/TPO family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43828.
GeneTreeiENSGT00390000017226.
HOGENOMiHOG000052505.
HOVERGENiHBG003978.
InParanoidiP29676.
KOiK05437.
OMAiNVTMGCA.
OrthoDBiEOG7DVDCR.
PhylomeDBiP29676.
TreeFamiTF333413.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003013. Erythroptn.
[Graphical view]
PANTHERiPTHR10370. PTHR10370. 1 hit.
PfamiPF00758. EPO_TPO. 1 hit.
[Graphical view]
PIRSFiPIRSF001951. EPO. 1 hit.
PRINTSiPR00272. ERYTHROPTN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00817. EPO_TPO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVPERPTLL LLLSLLLIPL GLPVLCAPPR LICDSRVLER YILEAKEAEN
60 70 80 90 100
VTMGCAEGPR LSENITVPDT KVNFYAWKRM KVEEQAVEVW QGLSLLSEAI
110 120 130 140 150
LQAQALQANS SQPPESLQLH IDKAISGLRS LTSLLRVLGA QKELMSPPDA
160 170 180 190
TQAAPLRTLT ADTFCKLFRV YSNFLRGKLK LYTGEACRRG DR
Length:192
Mass (Da):21,286
Last modified:April 1, 1993 - v1
Checksum:i3EA632737E7D2443
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10763 mRNA. Translation: BAA01593.1.
L10608 mRNA. Translation: AAA41126.1.
PIRiS28148.
RefSeqiNP_058697.1. NM_017001.1.
UniGeneiRn.11365.

Genome annotation databases

EnsembliENSRNOT00000001914; ENSRNOP00000001914; ENSRNOG00000001412.
GeneIDi24335.
KEGGirno:24335.
UCSCiRGD:2559. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10763 mRNA. Translation: BAA01593.1.
L10608 mRNA. Translation: AAA41126.1.
PIRiS28148.
RefSeqiNP_058697.1. NM_017001.1.
UniGeneiRn.11365.

3D structure databases

ProteinModelPortaliP29676.
SMRiP29676. Positions 27-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001914.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001914; ENSRNOP00000001914; ENSRNOG00000001412.
GeneIDi24335.
KEGGirno:24335.
UCSCiRGD:2559. rat.

Organism-specific databases

CTDi2056.
RGDi2559. Epo.

Phylogenomic databases

eggNOGiNOG43828.
GeneTreeiENSGT00390000017226.
HOGENOMiHOG000052505.
HOVERGENiHBG003978.
InParanoidiP29676.
KOiK05437.
OMAiNVTMGCA.
OrthoDBiEOG7DVDCR.
PhylomeDBiP29676.
TreeFamiTF333413.

Miscellaneous databases

NextBioi603023.
PROiP29676.

Gene expression databases

GenevisibleiP29676. RN.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003013. Erythroptn.
[Graphical view]
PANTHERiPTHR10370. PTHR10370. 1 hit.
PfamiPF00758. EPO_TPO. 1 hit.
[Graphical view]
PIRSFiPIRSF001951. EPO. 1 hit.
PRINTSiPR00272. ERYTHROPTN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00817. EPO_TPO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Kidney.
  2. "Erythropoietin structure-function relationships: high degree of sequence homology among mammals."
    Wen D., Boissel J.-P.R., Tracy T.E., Gruninger R.H., Mulcahy L.S., Czelusniak J., Goodman M., Bunn H.F.
    Blood 82:1507-1516(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-192.
    Strain: Sprague-Dawley.
    Tissue: Kidney.

Entry informationi

Entry nameiEPO_RAT
AccessioniPrimary (citable) accession number: P29676
Secondary accession number(s): P70504
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 24, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.