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P29676

- EPO_RAT

UniProt

P29676 - EPO_RAT

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Protein

Erythropoietin

Gene
Epo
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

GO - Molecular functioni

  1. protein kinase activator activity Source: Ensembl

GO - Biological processi

  1. aging Source: RGD
  2. apoptotic process Source: Ensembl
  3. cellular hyperosmotic response Source: Ensembl
  4. embryo implantation Source: Ensembl
  5. erythrocyte maturation Source: UniProtKB-KW
  6. hemoglobin biosynthetic process Source: Ensembl
  7. negative regulation of calcium ion transport into cytosol Source: Ensembl
  8. negative regulation of cation channel activity Source: Ensembl
  9. negative regulation of erythrocyte apoptotic process Source: Ensembl
  10. negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Source: Ensembl
  11. peptidyl-serine phosphorylation Source: Ensembl
  12. positive regulation of cell proliferation Source: Ensembl
  13. positive regulation of DNA replication Source: Ensembl
  14. positive regulation of neuron differentiation Source: RGD
  15. positive regulation of Ras protein signal transduction Source: Ensembl
  16. positive regulation of transcription, DNA-templated Source: Ensembl
  17. positive regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
  18. regulation of transcription from RNA polymerase II promoter Source: Ensembl
  19. response to axon injury Source: RGD
  20. response to electrical stimulus Source: RGD
  21. response to estrogen Source: RGD
  22. response to hyperoxia Source: RGD
  23. response to hypoxia Source: RGD
  24. response to interleukin-1 Source: RGD
  25. response to lipopolysaccharide Source: RGD
  26. response to nutrient Source: RGD
  27. response to salt stress Source: RGD
  28. response to testosterone Source: RGD
  29. response to vitamin A Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Erythrocyte maturation

Enzyme and pathway databases

ReactomeiREACT_199199. Regulation of gene expression by Hypoxia-inducible Factor.

Names & Taxonomyi

Protein namesi
Recommended name:
Erythropoietin
Gene namesi
Name:Epo
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 12

Organism-specific databases

RGDi2559. Epo.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular region Source: RGD
  3. extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 By similarityAdd
BLAST
Chaini27 – 192166ErythropoietinPRO_0000008408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 187 By similarity
Glycosylationi50 – 501N-linked (GlcNAc...) By similarity
Glycosylationi64 – 641N-linked (GlcNAc...) By similarity
Glycosylationi109 – 1091N-linked (GlcNAc...) By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

Gene expression databases

GenevestigatoriP29676.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001914.

Structurei

3D structure databases

ProteinModelPortaliP29676.
SMRiP29676. Positions 27-192.

Family & Domainsi

Sequence similaritiesi

Belongs to the EPO/TPO family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43828.
GeneTreeiENSGT00390000017226.
HOGENOMiHOG000052505.
HOVERGENiHBG003978.
InParanoidiP29676.
KOiK05437.
OMAiNVTMGCA.
OrthoDBiEOG7DVDCR.
PhylomeDBiP29676.
TreeFamiTF333413.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003013. Erythroptn.
[Graphical view]
PANTHERiPTHR10370. PTHR10370. 1 hit.
PfamiPF00758. EPO_TPO. 1 hit.
[Graphical view]
PIRSFiPIRSF001951. EPO. 1 hit.
PRINTSiPR00272. ERYTHROPTN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00817. EPO_TPO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29676-1 [UniParc]FASTAAdd to Basket

« Hide

MGVPERPTLL LLLSLLLIPL GLPVLCAPPR LICDSRVLER YILEAKEAEN    50
VTMGCAEGPR LSENITVPDT KVNFYAWKRM KVEEQAVEVW QGLSLLSEAI 100
LQAQALQANS SQPPESLQLH IDKAISGLRS LTSLLRVLGA QKELMSPPDA 150
TQAAPLRTLT ADTFCKLFRV YSNFLRGKLK LYTGEACRRG DR 192
Length:192
Mass (Da):21,286
Last modified:April 1, 1993 - v1
Checksum:i3EA632737E7D2443
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10763 mRNA. Translation: BAA01593.1.
L10608 mRNA. Translation: AAA41126.1.
PIRiS28148.
RefSeqiNP_058697.1. NM_017001.1.
UniGeneiRn.11365.

Genome annotation databases

EnsembliENSRNOT00000001914; ENSRNOP00000001914; ENSRNOG00000001412.
GeneIDi24335.
KEGGirno:24335.
UCSCiRGD:2559. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10763 mRNA. Translation: BAA01593.1 .
L10608 mRNA. Translation: AAA41126.1 .
PIRi S28148.
RefSeqi NP_058697.1. NM_017001.1.
UniGenei Rn.11365.

3D structure databases

ProteinModelPortali P29676.
SMRi P29676. Positions 27-192.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000001914.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000001914 ; ENSRNOP00000001914 ; ENSRNOG00000001412 .
GeneIDi 24335.
KEGGi rno:24335.
UCSCi RGD:2559. rat.

Organism-specific databases

CTDi 2056.
RGDi 2559. Epo.

Phylogenomic databases

eggNOGi NOG43828.
GeneTreei ENSGT00390000017226.
HOGENOMi HOG000052505.
HOVERGENi HBG003978.
InParanoidi P29676.
KOi K05437.
OMAi NVTMGCA.
OrthoDBi EOG7DVDCR.
PhylomeDBi P29676.
TreeFami TF333413.

Enzyme and pathway databases

Reactomei REACT_199199. Regulation of gene expression by Hypoxia-inducible Factor.

Miscellaneous databases

NextBioi 603023.
PROi P29676.

Gene expression databases

Genevestigatori P29676.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003013. Erythroptn.
[Graphical view ]
PANTHERi PTHR10370. PTHR10370. 1 hit.
Pfami PF00758. EPO_TPO. 1 hit.
[Graphical view ]
PIRSFi PIRSF001951. EPO. 1 hit.
PRINTSi PR00272. ERYTHROPTN.
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00817. EPO_TPO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Kidney.
  2. "Erythropoietin structure-function relationships: high degree of sequence homology among mammals."
    Wen D., Boissel J.-P.R., Tracy T.E., Gruninger R.H., Mulcahy L.S., Czelusniak J., Goodman M., Bunn H.F.
    Blood 82:1507-1516(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-192.
    Strain: Sprague-Dawley.
    Tissue: Kidney.

Entry informationi

Entry nameiEPO_RAT
AccessioniPrimary (citable) accession number: P29676
Secondary accession number(s): P70504
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 3, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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