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P29676

- EPO_RAT

UniProt

P29676 - EPO_RAT

Protein

Erythropoietin

Gene

Epo

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

    GO - Molecular functioni

    1. protein kinase activator activity Source: Ensembl

    GO - Biological processi

    1. aging Source: RGD
    2. apoptotic process Source: Ensembl
    3. cellular hyperosmotic response Source: Ensembl
    4. embryo implantation Source: Ensembl
    5. erythrocyte maturation Source: UniProtKB-KW
    6. hemoglobin biosynthetic process Source: Ensembl
    7. negative regulation of calcium ion transport into cytosol Source: Ensembl
    8. negative regulation of cation channel activity Source: Ensembl
    9. negative regulation of erythrocyte apoptotic process Source: Ensembl
    10. negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Source: Ensembl
    11. peptidyl-serine phosphorylation Source: Ensembl
    12. positive regulation of cell proliferation Source: Ensembl
    13. positive regulation of DNA replication Source: Ensembl
    14. positive regulation of neuron differentiation Source: RGD
    15. positive regulation of Ras protein signal transduction Source: Ensembl
    16. positive regulation of transcription, DNA-templated Source: Ensembl
    17. positive regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
    18. regulation of transcription from RNA polymerase II promoter Source: Ensembl
    19. response to axon injury Source: RGD
    20. response to electrical stimulus Source: RGD
    21. response to estrogen Source: RGD
    22. response to hyperoxia Source: RGD
    23. response to hypoxia Source: RGD
    24. response to interleukin-1 Source: RGD
    25. response to lipopolysaccharide Source: RGD
    26. response to nutrient Source: RGD
    27. response to salt stress Source: RGD
    28. response to testosterone Source: RGD
    29. response to vitamin A Source: RGD

    Keywords - Molecular functioni

    Hormone

    Keywords - Biological processi

    Erythrocyte maturation

    Enzyme and pathway databases

    ReactomeiREACT_199199. Regulation of gene expression by Hypoxia-inducible Factor.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Erythropoietin
    Gene namesi
    Name:Epo
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 12

    Organism-specific databases

    RGDi2559. Epo.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular region Source: RGD
    3. extracellular space Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626By similarityAdd
    BLAST
    Chaini27 – 192166ErythropoietinPRO_0000008408Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 187By similarity
    Glycosylationi50 – 501N-linked (GlcNAc...)By similarity
    Glycosylationi64 – 641N-linked (GlcNAc...)By similarity
    Glycosylationi109 – 1091N-linked (GlcNAc...)By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

    Gene expression databases

    GenevestigatoriP29676.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000001914.

    Structurei

    3D structure databases

    ProteinModelPortaliP29676.
    SMRiP29676. Positions 27-192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EPO/TPO family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43828.
    GeneTreeiENSGT00390000017226.
    HOGENOMiHOG000052505.
    HOVERGENiHBG003978.
    InParanoidiP29676.
    KOiK05437.
    OMAiNVTMGCA.
    OrthoDBiEOG7DVDCR.
    PhylomeDBiP29676.
    TreeFamiTF333413.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR019767. EPO/TPO_CS.
    IPR001323. EPO_TPO.
    IPR003013. Erythroptn.
    [Graphical view]
    PANTHERiPTHR10370. PTHR10370. 1 hit.
    PfamiPF00758. EPO_TPO. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001951. EPO. 1 hit.
    PRINTSiPR00272. ERYTHROPTN.
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00817. EPO_TPO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P29676-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVPERPTLL LLLSLLLIPL GLPVLCAPPR LICDSRVLER YILEAKEAEN    50
    VTMGCAEGPR LSENITVPDT KVNFYAWKRM KVEEQAVEVW QGLSLLSEAI 100
    LQAQALQANS SQPPESLQLH IDKAISGLRS LTSLLRVLGA QKELMSPPDA 150
    TQAAPLRTLT ADTFCKLFRV YSNFLRGKLK LYTGEACRRG DR 192
    Length:192
    Mass (Da):21,286
    Last modified:April 1, 1993 - v1
    Checksum:i3EA632737E7D2443
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10763 mRNA. Translation: BAA01593.1.
    L10608 mRNA. Translation: AAA41126.1.
    PIRiS28148.
    RefSeqiNP_058697.1. NM_017001.1.
    UniGeneiRn.11365.

    Genome annotation databases

    EnsembliENSRNOT00000001914; ENSRNOP00000001914; ENSRNOG00000001412.
    GeneIDi24335.
    KEGGirno:24335.
    UCSCiRGD:2559. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10763 mRNA. Translation: BAA01593.1 .
    L10608 mRNA. Translation: AAA41126.1 .
    PIRi S28148.
    RefSeqi NP_058697.1. NM_017001.1.
    UniGenei Rn.11365.

    3D structure databases

    ProteinModelPortali P29676.
    SMRi P29676. Positions 27-192.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000001914.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000001914 ; ENSRNOP00000001914 ; ENSRNOG00000001412 .
    GeneIDi 24335.
    KEGGi rno:24335.
    UCSCi RGD:2559. rat.

    Organism-specific databases

    CTDi 2056.
    RGDi 2559. Epo.

    Phylogenomic databases

    eggNOGi NOG43828.
    GeneTreei ENSGT00390000017226.
    HOGENOMi HOG000052505.
    HOVERGENi HBG003978.
    InParanoidi P29676.
    KOi K05437.
    OMAi NVTMGCA.
    OrthoDBi EOG7DVDCR.
    PhylomeDBi P29676.
    TreeFami TF333413.

    Enzyme and pathway databases

    Reactomei REACT_199199. Regulation of gene expression by Hypoxia-inducible Factor.

    Miscellaneous databases

    NextBioi 603023.
    PROi P29676.

    Gene expression databases

    Genevestigatori P29676.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR019767. EPO/TPO_CS.
    IPR001323. EPO_TPO.
    IPR003013. Erythroptn.
    [Graphical view ]
    PANTHERi PTHR10370. PTHR10370. 1 hit.
    Pfami PF00758. EPO_TPO. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001951. EPO. 1 hit.
    PRINTSi PR00272. ERYTHROPTN.
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00817. EPO_TPO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Kidney.
    2. "Erythropoietin structure-function relationships: high degree of sequence homology among mammals."
      Wen D., Boissel J.-P.R., Tracy T.E., Gruninger R.H., Mulcahy L.S., Czelusniak J., Goodman M., Bunn H.F.
      Blood 82:1507-1516(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-192.
      Strain: Sprague-Dawley.
      Tissue: Kidney.

    Entry informationi

    Entry nameiEPO_RAT
    AccessioniPrimary (citable) accession number: P29676
    Secondary accession number(s): P70504
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3