Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P29661

- COX2_POLSX

UniProt

P29661 - COX2_POLSX

Protein

Cytochrome c oxidase subunit 2

Gene

mt-co2

Organism
Polypterus sp. (Bichir)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:mt-co2
    Synonyms:coii, coxii, mtco2
    Encoded oniMitochondrion
    OrganismiPolypterus sp. (Bichir)
    Taxonomic identifieri8291 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiPolypteriformesPolypteridaePolypterus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›48›48Cytochrome c oxidase subunit 2PRO_0000183667Add
    BLAST

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4822HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    InterProiIPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF81464. SSF81464. 1 hit.
    PROSITEiPS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P29661-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHPAQLGLQ DASSPIXEEL LHFHEDALMI VFLISTLVLY IITTTVST     48
    Length:48
    Mass (Da):5,292
    Last modified:April 1, 1993 - v1
    Checksum:iC80C5D8592303862
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei48 – 481

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64912 Genomic DNA. Translation: AAB01476.1. Sequence problems.
    PIRiT09945.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64912 Genomic DNA. Translation: AAB01476.1 . Sequence problems.
    PIRi T09945.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    InterProi IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81464. SSF81464. 1 hit.
    PROSITEi PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phylogenetic relationships of neopterygian fishes, inferred from mitochondrial DNA sequences."
      Normark B.B., McCune A.R., Harrison R.G.
      Mol. Biol. Evol. 8:819-834(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX2_POLSX
    AccessioniPrimary (citable) accession number: P29661
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3