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P29659

- COX2_LEPOC

UniProt

P29659 - COX2_LEPOC

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Protein

Cytochrome c oxidase subunit 2

Gene
mt-co2, coii, coxii, mtco2
Organism
Lepisosteus oculatus (Spotted gar)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:mt-co2
Synonyms:coii, coxii, mtco2
Encoded oniMitochondrion
OrganismiLepisosteus oculatus (Spotted gar)
Taxonomic identifieri7918 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiHolosteiSemionotiformesLepisosteidaeLepisosteus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembrane Reviewed predictionAdd
BLAST
Transmembranei27 – 4822Helical; Reviewed predictionAdd
BLAST
Topological domaini49 – 6214Mitochondrial matrix Reviewed predictionAdd
BLAST
Transmembranei63 – ›72›10Helical; Reviewed prediction

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›72›72Cytochrome c oxidase subunit 2PRO_0000183619Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP29659.
SMRiP29659. Positions 1-66.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
InterProiIPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF81464. SSF81464. 1 hit.
PROSITEiPS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P29659-1 [UniParc]FASTAAdd to Basket

« Hide

MAHPSQLGFQ DAASPVMEEL LHFHDHALMI VFLISTLVLY IIVAMVSTKL   50
TNKHILDSQE VEIVWTILPA VI 72
Length:72
Mass (Da):8,081
Last modified:April 1, 1993 - v1
Checksum:iAABC3332F740FA32
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei72 – 721

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64898 Genomic DNA. Translation: AAB01464.1.
M64901 Genomic DNA. Translation: AAB01467.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64898 Genomic DNA. Translation: AAB01464.1 .
M64901 Genomic DNA. Translation: AAB01467.1 .

3D structure databases

ProteinModelPortali P29659.
SMRi P29659. Positions 1-66.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
InterProi IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF81464. SSF81464. 1 hit.
PROSITEi PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogenetic relationships of neopterygian fishes, inferred from mitochondrial DNA sequences."
    Normark B.B., McCune A.R., Harrison R.G.
    Mol. Biol. Evol. 8:819-834(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX2_LEPOC
AccessioniPrimary (citable) accession number: P29659
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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