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P29657

- COX2_GEOSD

UniProt

P29657 - COX2_GEOSD

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Protein

Cytochrome c oxidase subunit 2

Gene

mt-co2

Organism
Geophagus steindachneri (Red hump earth eater)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:mt-co2
Synonyms:coii, coxii, mtco2
Encoded oniMitochondrion
OrganismiGeophagus steindachneri (Red hump earth eater)
Taxonomic identifieri13074 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeNew World cichlidsGeophaginaeGeophaginiGeophagus

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›64›64Cytochrome c oxidase subunit 2PRO_0000183602Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP29657.
SMRiP29657. Positions 1-64.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini49 – 6214Mitochondrial matrixSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4822HelicalSequence AnalysisAdd
BLAST
Transmembranei63 – ›64›2HelicalSequence Analysis

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
InterProiIPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF81464. SSF81464. 1 hit.
PROSITEiPS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P29657-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHPSQLGFQ DAASPMMEEL LHFHDHALMV VFLISTFVLY IILTMLTTKL
60
TDKLILESHE IEII
Length:64
Mass (Da):7,339
Last modified:April 1, 1993 - v1
Checksum:iD8C634D7B3BA03A7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei64 – 641

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64892 Genomic DNA. Translation: AAB01458.1. Sequence problems.
PIRiT09849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64892 Genomic DNA. Translation: AAB01458.1 . Sequence problems.
PIRi T09849.

3D structure databases

ProteinModelPortali P29657.
SMRi P29657. Positions 1-64.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
InterProi IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF81464. SSF81464. 1 hit.
PROSITEi PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogenetic relationships of neopterygian fishes, inferred from mitochondrial DNA sequences."
    Normark B.B., McCune A.R., Harrison R.G.
    Mol. Biol. Evol. 8:819-834(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX2_GEOSD
AccessioniPrimary (citable) accession number: P29657
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3