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P29655 (COX2_AMICA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:mt-co2
Synonyms:coii, coxii, mtco2
Encoded onMitochondrion
OrganismAmia calva (Bowfin)
Taxonomic identifier7924 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiAmiiformesAmiidaeAmia

Protein attributes

Sequence length74 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›74›74Cytochrome c oxidase subunit 2
PRO_0000183491

Regions

Topological domain1 – 2626Mitochondrial intermembrane Potential
Transmembrane27 – 4822Helical; Potential
Topological domain49 – 6214Mitochondrial matrix Potential
Transmembrane63 – ›74›12Helical; Potential

Experimental info

Non-terminal residue741

Sequences

Sequence LengthMass (Da)Tools
P29655 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 6D779E3827E0C3E0

FASTA748,354
        10         20         30         40         50         60 
MAHPMQLGFQ DAASPVMEEL LHFHDHALMI VFLISTAVLY IIVVTVTTKL TDKYVLDAQE 

        70 
IEMVWTIMPA VVLI 

« Hide

References

[1]"Phylogenetic relationships of neopterygian fishes, inferred from mitochondrial DNA sequences."
Normark B.B., McCune A.R., Harrison R.G.
Mol. Biol. Evol. 8:819-834(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M64886 Genomic DNA. Translation: AAB01438.1.

3D structure databases

ProteinModelPortalP29655.
SMRP29655. Positions 1-66.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
InterProIPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF81464. SSF81464. 1 hit.
PROSITEPS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_AMICA
AccessionPrimary (citable) accession number: P29655
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families