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P29653 (COX1_SALTR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:mt-co1
Synonyms:coi, coxi, mtco1
Encoded onMitochondrion
OrganismSalmo trutta (Brown trout)
Taxonomic identifier8032 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo

Protein attributes

Sequence length109 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›109›109Cytochrome c oxidase subunit 1
PRO_0000183412

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane34 – 5421Helical; Potential
Transmembrane76 – 9621Helical; Potential

Sites

Metal binding61Copper B Probable
Metal binding101Copper B Probable
Metal binding561Copper B Probable
Metal binding571Copper B Probable

Amino acid modifications

Cross-link6 ↔ 101'-histidyl-3'-tyrosine (His-Tyr) By similarity

Experimental info

Non-terminal residue11
Non-terminal residue1091

Sequences

Sequence LengthMass (Da)Tools
P29653 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 0A513F2CE5B85C25

FASTA10912,251
        10         20         30         40         50         60 
FWFFGHPEVY ILILPGFGMI SHIVAYYSGK KEPFGYMGMV WAMMAIGLLG FIVWAHHMFT 

        70         80         90        100 
VGMDVDTRAY FTSATMIIAI PTGVKVFSWL ATLHGGSIKW ETPLLWALG 

« Hide

References

[1]"Phylogenetic relationships of neopterygian fishes, inferred from mitochondrial DNA sequences."
Normark B.B., McCune A.R., Harrison R.G.
Mol. Biol. Evol. 8:819-834(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M64917 Genomic DNA. Translation: AAB01484.1.

3D structure databases

ProteinModelPortalP29653.
SMRP29653. Positions 1-109.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_SALTR
AccessionPrimary (citable) accession number: P29653
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways