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P29649

- COX1_PANBU

UniProt

P29649 - COX1_PANBU

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Protein
Cytochrome c oxidase subunit 1
Gene
mt-co1, coi, coxi, mtco1
Organism
Pantodon buchholzi (Freshwater butterflyfish)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi5 – 51Copper B Inferred
Metal bindingi9 – 91Copper B Inferred
Metal bindingi55 – 551Copper B Inferred
Metal bindingi56 – 561Copper B Inferred
Metal bindingi141 – 1411Iron (heme A3 axial ligand) Inferred
Metal bindingi143 – 1431Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:mt-co1
Synonyms:coi, coxi, mtco1
Encoded oniMitochondrion
OrganismiPantodon buchholzi (Freshwater butterflyfish)
Taxonomic identifieri8276 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOsteoglossocephalaOsteoglossomorphaOsteoglossiformesPantodontidaePantodon

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821Helical; Reviewed prediction
Add
BLAST
Transmembranei33 – 5321Helical; Reviewed prediction
Add
BLAST
Transmembranei75 – 9521Helical; Reviewed prediction
Add
BLAST
Transmembranei103 – 12321Helical; Reviewed prediction
Add
BLAST
Transmembranei145 – 16521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›184›184Cytochrome c oxidase subunit 1
PRO_0000183377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki5 ↔ 91'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliP29649.
SMRiP29649. Positions 1-184.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P29649-1 [UniParc]FASTAAdd to Basket

« Hide

WFFGHPEVYI LILPGFGMIS HIVAYYSGKK EPFGYMGMVW AMMAIGLLGF    50
IVWAHHMFTV GMDVDTRAYF TSATMIIAIP TGVKVFSWLA TLHGGSIKWD 100
TPMLWALGFI FLFTVGGLTG IILANSSLDI VLHDTYYVVA HFHYVLSMGA 150
VFAIMGGFVH WFPLFSGYTL HNTWTKIHFG VMFM 184
Length:184
Mass (Da):20,709
Last modified:April 1, 1993 - v1
Checksum:i73B1A5B1715ED49A
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei184 – 1841

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64906 Genomic DNA. Translation: AAB01608.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64906 Genomic DNA. Translation: AAB01608.1 .

3D structure databases

ProteinModelPortali P29649.
SMRi P29649. Positions 1-184.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogenetic relationships of neopterygian fishes, inferred from mitochondrial DNA sequences."
    Normark B.B., McCune A.R., Harrison R.G.
    Mol. Biol. Evol. 8:819-834(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_PANBU
AccessioniPrimary (citable) accession number: P29649
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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