Reviewed, UniProtKB/Swiss-Prot P29643 (COX1_AMICA)

Names and origin

Protein names

Recommended name:
    Cytochrome c oxidase subunit 1
    EC=1.9.3.1
Alternative name(s):
    Cytochrome c oxidase polypeptide I

Gene names

Name:	mt-co1
Synonyms:	coi, coxi, mtco1

Encoded on

Mitochondrion

Organism

Amia calva (Bowfin)

Taxonomic identifier

7924 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Amiiformes › Amiidae › Amia

Protein attributes

Sequence length	188 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Pathway	Energy metabolism; oxidative phosphorylation.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the heme-copper respiratory oxidase family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	aerobic respiration Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›188	›188	Cytochrome c oxidase subunit 1		PRO_0000183280
Regions
	Transmembrane	3 – 23	21	Potential
	Transmembrane	37 – 57	21	Potential
	Transmembrane	81 – 101	21	Potential
	Transmembrane	107 – 127	21	Potential
	Transmembrane	149 – 169	21	Potential
Sites
	Metal binding	9	1	Copper B Probable
	Metal binding	13	1	Copper B Probable
	Metal binding	59	1	Copper B Probable
	Metal binding	60	1	Copper B Probable
	Metal binding	145	1	Iron (heme A3 axial ligand) Probable
Amino acid modifications
	Cross-link	9 ↔ 13		1'-histidyl-3'-tyrosine (His-Tyr) By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	188	1

Sequences

	Sequence		Length	Mass (Da)
	P29643-1 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 64C1E7674CEDB580	FASTA	188	21,093
	10 20 30 40 50 60 QHLFWFFGHP EVYILILPGF GMVSHIVAYY AGKKEPFGYM GMVWAMMAIG LLGFIVWAHH 70 80 90 100 110 120 MFTVGMDVDT RAYFTSATMV IAIPTGVKVF SWLATLHGGA IKWETPLLWA LGFIFLFTVG 130 140 150 160 170 180 GLTGIVLANS SLDIVLHDTY YVVAHFHYVL SMGAVFAIMG GFVHWFPLFS GYTLHPTWSK IHFGVMFV

References

[1]	"Phylogenetic relationships of neopterygian fishes, inferred from mitochondrial DNA sequences." Normark B.B., McCune A.R., Harrison R.G. Mol. Biol. Evol. 8:819-834(1991) [PubMed: 1663569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M64885 Genomic DNA. Translation: AAB01437.1.
3D structure databases
SMR	P29643. Positions 1-188.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P29643.
Enzyme and pathway databases
BRENDA	1.9.3.1. 291467.
Family and domain databases
InterPro	IPR000883. Cyt_c_oxidase_su1. [Graphical view]
Gene3D	G3DSA:1.20.210.10. COX1. 1 hit.
PANTHER	PTHR10422. COX1. 1 hit.
Pfam	PF00115. COX1. 1 hit. [Graphical view]
PRINTS	PR01165. CYCOXIDASEI.
PROSITE	PS50855. COX1. 1 hit. PS00077. COX1_CUB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX1_AMICA

Accession

Primary (citable) accession number: P29643

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	June 16, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)