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Protein

Serine protease inhibitor A3C

Gene

Serpina3c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster of 14 individual murine paralogs.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei381 – 382Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

  • response to cytokine Source: MGI
  • response to peptide hormone Source: MGI

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiI04.053

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor A3C
Short name:
Serpin A3C
Alternative name(s):
Kallikrein-binding protein
Short name:
KBP
Gene namesi
Name:Serpina3c
Synonyms:Klkbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:102848 Serpina3c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003241623 – 417Serine protease inhibitor A3CAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP29621
PaxDbiP29621
PeptideAtlasiP29621
PRIDEiP29621

PTM databases

iPTMnetiP29621
PhosphoSitePlusiP29621

Expressioni

Gene expression databases

BgeeiENSMUSG00000066361
GenevisibleiP29621 MM

Interactioni

Protein-protein interaction databases

BioGridi200987, 1 interactor
IntActiP29621, 1 interactor
MINTiP29621
STRINGi10090.ENSMUSP00000082125

Structurei

3D structure databases

ProteinModelPortaliP29621
SMRiP29621
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni367 – 392RCLAdd BLAST26

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the serpin reactive site and the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina3 paralogs may determine target protease specificity.By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiP29621
KOiK04525
OMAiSLQPRHI
OrthoDBiEOG091G0ION
PhylomeDBiP29621
TreeFamiTF343201

Family and domain databases

InterProiView protein in InterPro
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFIVALGLV ITGICPGVLC FPDGTLERDT LFHKDKENGT QLDSLTLASI
60 70 80 90 100
NTDFAFSLYK KLALKNPDTN IVFSPLSISA ALAIVSLGAK GNTLEEILEG
110 120 130 140 150
LNFNLTETPE ADIHQGFGHL LQRLSHPGEQ VQISTGSALF VEKHLQILAE
160 170 180 190 200
FQEKARALYQ AEAFTADFQQ PLEATKLIND YVSNQTQRKI KGLISDLDTD
210 220 230 240 250
TLMVLVNYIY FKGKWKMPFN PRDTFESEFY LDVKRSVKVP MMKIKTLTTP
260 270 280 290 300
YFRDEELSCT VVELKYKGNA SALFILPDQG RMQQVEASLQ PETLRKWKNS
310 320 330 340 350
LRPRKMGELY LPKFSISTDY SLKNILPELG IKEIFSKQAD LSGITGTKDL
360 370 380 390 400
IVSQMVHKAV LDVAETGTEG VAATGVNFRI LSRRTSLWFN RTFLMVISHT
410
DVQTTLFIAK ITHPKRA
Length:417
Mass (Da):46,766
Last modified:April 1, 1993 - v1
Checksum:i5486D39E2C5156E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61597 Genomic DNA Translation: CAA43794.1
CCDSiCCDS26148.1
PIRiS15631
S19724
RefSeqiNP_032484.1, NM_008458.2
UniGeneiMm.422814

Genome annotation databases

EnsembliENSMUST00000085050; ENSMUSP00000082125; ENSMUSG00000066361
GeneIDi16625
KEGGimmu:16625
UCSCiuc007owv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSPA3C_MOUSE
AccessioniPrimary (citable) accession number: P29621
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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