Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine protease inhibitor A3C

Gene

Serpina3c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei381 – 3822Reactive bondBy similarity

GO - Molecular functioni

GO - Biological processi

  • response to cytokine Source: MGI
  • response to peptide hormone Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.053.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor A3C
Short name:
Serpin A3C
Alternative name(s):
Kallikrein-binding protein
Short name:
KBP
Gene namesi
Name:Serpina3c
Synonyms:Klkbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:102848. Serpina3c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 417395Serine protease inhibitor A3CPRO_0000032416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence analysis
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence analysis
Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP29621.
MaxQBiP29621.
PaxDbiP29621.
PRIDEiP29621.

PTM databases

iPTMnetiP29621.
PhosphoSiteiP29621.

Expressioni

Gene expression databases

BgeeiP29621.
GenevisibleiP29621. MM.

Interactioni

Protein-protein interaction databases

IntActiP29621. 1 interaction.
MINTiMINT-4099501.
STRINGi10090.ENSMUSP00000082125.

Structurei

3D structure databases

ProteinModelPortaliP29621.
SMRiP29621. Positions 47-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni367 – 39226RCLAdd
BLAST

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the serpin reactive site and the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina3 paralogs may determine target protease specificity.By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiP29621.
KOiK04525.
OMAiVPMMKIK.
OrthoDBiEOG78M027.
PhylomeDBiP29621.
TreeFamiTF343201.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFIVALGLV ITGICPGVLC FPDGTLERDT LFHKDKENGT QLDSLTLASI
60 70 80 90 100
NTDFAFSLYK KLALKNPDTN IVFSPLSISA ALAIVSLGAK GNTLEEILEG
110 120 130 140 150
LNFNLTETPE ADIHQGFGHL LQRLSHPGEQ VQISTGSALF VEKHLQILAE
160 170 180 190 200
FQEKARALYQ AEAFTADFQQ PLEATKLIND YVSNQTQRKI KGLISDLDTD
210 220 230 240 250
TLMVLVNYIY FKGKWKMPFN PRDTFESEFY LDVKRSVKVP MMKIKTLTTP
260 270 280 290 300
YFRDEELSCT VVELKYKGNA SALFILPDQG RMQQVEASLQ PETLRKWKNS
310 320 330 340 350
LRPRKMGELY LPKFSISTDY SLKNILPELG IKEIFSKQAD LSGITGTKDL
360 370 380 390 400
IVSQMVHKAV LDVAETGTEG VAATGVNFRI LSRRTSLWFN RTFLMVISHT
410
DVQTTLFIAK ITHPKRA
Length:417
Mass (Da):46,766
Last modified:April 1, 1993 - v1
Checksum:i5486D39E2C5156E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61597 Genomic DNA. Translation: CAA43794.1.
CCDSiCCDS26148.1.
PIRiS15631.
S19724.
RefSeqiNP_032484.1. NM_008458.2.
XP_011242305.1. XM_011244003.1.
UniGeneiMm.422814.

Genome annotation databases

EnsembliENSMUST00000085050; ENSMUSP00000082125; ENSMUSG00000066361.
GeneIDi16625.
KEGGimmu:16625.
UCSCiuc007owv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61597 Genomic DNA. Translation: CAA43794.1.
CCDSiCCDS26148.1.
PIRiS15631.
S19724.
RefSeqiNP_032484.1. NM_008458.2.
XP_011242305.1. XM_011244003.1.
UniGeneiMm.422814.

3D structure databases

ProteinModelPortaliP29621.
SMRiP29621. Positions 47-415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP29621. 1 interaction.
MINTiMINT-4099501.
STRINGi10090.ENSMUSP00000082125.

Protein family/group databases

MEROPSiI04.053.

PTM databases

iPTMnetiP29621.
PhosphoSiteiP29621.

Proteomic databases

EPDiP29621.
MaxQBiP29621.
PaxDbiP29621.
PRIDEiP29621.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085050; ENSMUSP00000082125; ENSMUSG00000066361.
GeneIDi16625.
KEGGimmu:16625.
UCSCiuc007owv.1. mouse.

Organism-specific databases

CTDi16625.
MGIiMGI:102848. Serpina3c.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiP29621.
KOiK04525.
OMAiVPMMKIK.
OrthoDBiEOG78M027.
PhylomeDBiP29621.
TreeFamiTF343201.

Miscellaneous databases

NextBioi290243.
PROiP29621.
SOURCEiSearch...

Gene expression databases

BgeeiP29621.
GenevisibleiP29621. MM.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and sequence analysis of the mouse kallikrein-binding protein gene."
    Chai K.X., Chao J., Chao L.
    Biochim. Biophys. Acta 1129:127-130(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins."
    Forsyth S., Horvath A., Coughlin P.
    Genomics 81:336-345(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  3. "Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus."
    Horvath A.J., Forsyth S.L., Coughlin P.B.
    J. Mol. Evol. 59:488-497(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGION RCL.

Entry informationi

Entry nameiSPA3C_MOUSE
AccessioniPrimary (citable) accession number: P29621
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 11, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster of 14 individual murine paralogs.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.