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Protein

Cyclin-dependent kinase D-1

Gene

CDKD-1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

CDK-activating kinase that may control G1/S phase progression. May control the rate of cell differentiation to accomplish proper development of organs, or in response to a changing environment. Forms a complex with cyclin CYCH1-1 that phosphorylates CDKA-1 and the C-terminal domain (CTD) of the large subunit of RNA polymerase II.4 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei48ATPPROSITE-ProRule annotation1
Active sitei141Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi25 – 33ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase D-1 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDKD;1
Alternative name(s):
CDC2+/CDC28-related protein kinase R2
CDK-activating kinase R2
Short name:
CAK-R2
Gene namesi
Name:CDKD-1
Synonyms:R2
Ordered Locus Names:Os05g0392300, LOC_Os05g32600
ORF Names:OJ1764_D01.12
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 5

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000860741 – 424Cyclin-dependent kinase D-1Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphothreonineBy similarity1
Modified residuei30PhosphotyrosineBy similarity1
Modified residuei168PhosphoserineBy similarity1
Modified residuei174PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP29620.

Expressioni

Tissue specificityi

Expressed in actively dividing cells of roots, leaves and shoots. Expressed in the intercalary meristem and the elongation zone of internodes.4 Publications

Developmental stagei

Expression reaches a peak in the G1/S phases and then decreases in the G2/M phases.2 Publications

Inductioni

By gibberellic acid (GA3) and submergence in the meristematic zone of internodes. Down-regulated by auxin.4 Publications

Gene expression databases

GenevisibleiP29620. OS.

Interactioni

Subunit structurei

Interacts with CYCH1-1.1 Publication

Protein-protein interaction databases

STRINGi39947.LOC_Os05g32600.1.

Structurei

3D structure databases

ProteinModelPortaliP29620.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 299Protein kinasePROSITE-ProRule annotationAdd BLAST281

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0659. Eukaryota.
ENOG410XQDH. LUCA.
InParanoidiP29620.
KOiK02202.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29620-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGDGGDDA GVKRVADRYL KREVLGEGTY GVVFKAVDTK TGNTVAIKKI
60 70 80 90 100
RLGKYKEGVN FTALREIKLL KELKDSNIIE LIDAFPYKGN LHLVFEFMET
110 120 130 140 150
DLEAVIRDRN IVLSPADTKS YIQMMLKGLA FCHKKWVLHR DMKPNNLLIG
160 170 180 190 200
ADGQLKLADF GLARIFGSPE RNFTHQVFAR WYRAPELLFG TKQYGSAVDI
210 220 230 240 250
WAAGCIFAEL LLRRPFLQGS SDIDQLGKIF AAFGTPKSSQ WPDMVYLPDY
260 270 280 290 300
VEYQFVSAPP LRSLFPMASD DALDLLSRMF TYDPKARITA QQALEHRYFL
310 320 330 340 350
SVPAPTKPSQ LPRPPPKGDS GNNKIPDLNL QDGPVVLSPP RKLRRVTAHE
360 370 380 390 400
GMEVHMHRAD RTEEHPSGAR HMDDMSSQSS RIPMSVDVGA IFGTRPAPRP
410 420
TLNSADKSRL KRKLDMDPEF GYTE
Length:424
Mass (Da):47,613
Last modified:April 1, 1993 - v1
Checksum:i28606BE7120BB048
GO

Sequence cautioni

The sequence AAV31263 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58194 mRNA. Translation: CAA41172.1.
AC107085 Genomic DNA. Translation: AAV31263.1. Sequence problems.
AP008211 Genomic DNA. Translation: BAF17364.1.
AP014961 Genomic DNA. No translation available.
PIRiS13934.
RefSeqiXP_015640677.1. XM_015785191.1.
UniGeneiOs.2689.

Genome annotation databases

GeneIDi4338689.
KEGGiosa:4338689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58194 mRNA. Translation: CAA41172.1.
AC107085 Genomic DNA. Translation: AAV31263.1. Sequence problems.
AP008211 Genomic DNA. Translation: BAF17364.1.
AP014961 Genomic DNA. No translation available.
PIRiS13934.
RefSeqiXP_015640677.1. XM_015785191.1.
UniGeneiOs.2689.

3D structure databases

ProteinModelPortaliP29620.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os05g32600.1.

Proteomic databases

PaxDbiP29620.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4338689.
KEGGiosa:4338689.

Phylogenomic databases

eggNOGiKOG0659. Eukaryota.
ENOG410XQDH. LUCA.
InParanoidiP29620.
KOiK02202.

Gene expression databases

GenevisibleiP29620. OS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDKD1_ORYSJ
AccessioniPrimary (citable) accession number: P29620
Secondary accession number(s): Q0DIF9, Q60ES0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 5, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.