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Protein

Cyclin-dependent kinase A-2

Gene

CDKA-2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-110056. MAPK3 (ERK1) activation.
R-OSA-1538133. G0 and Early G1.
R-OSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-OSA-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-OSA-2299718. Condensation of Prophase Chromosomes.
R-OSA-2500257. Resolution of Sister Chromatid Cohesion.
R-OSA-4419969. Depolymerisation of the Nuclear Lamina.
R-OSA-5693607. Processing of DNA double-strand break ends.
R-OSA-68911. G2 Phase.
R-OSA-68962. Activation of the pre-replicative complex.
R-OSA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-OSA-69200. Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes.
R-OSA-69202. Cyclin E associated events during G1/S transition.
R-OSA-69273. Cyclin A/B1/B2 associated events during G2/M transition.
R-OSA-69478. G2/M DNA replication checkpoint.
R-OSA-69656. Cyclin A:Cdk2-associated events at S phase entry.
R-OSA-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase A-2 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDKA;2
Alternative name(s):
CDC2Os-2
Cell division control protein 2 homolog 2
Gene namesi
Name:CDKA-2
Synonyms:CDC2-2
Ordered Locus Names:Os02g0123100, LOC_Os02g03060
ORF Names:P0575F10.10-1, P0575F10.10-2
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857561 – 292Cyclin-dependent kinase A-2Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphothreonineBy similarity1
Modified residuei15PhosphotyrosineBy similarity1
Modified residuei160PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP29619.
PRIDEiP29619.

Expressioni

Tissue specificityi

Expressed in the dividing region of the root apex and in differentiated cells such as those in the sclerenchyma, pericycle and parenchyma of the central cylinder. Expressed in the intercalary meristem and the elongation zone of internodes.2 Publications

Developmental stagei

Expression reaches a peak in the G1/S phases and then decreases in the G2/M phases.1 Publication

Inductioni

By gibberellic acid (GA3) and submergence. Down-regulated by auxin.3 Publications

Gene expression databases

ExpressionAtlasiP29619. baseline and differential.
GenevisibleiP29619. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os02g03060.1.

Structurei

3D structure databases

ProteinModelPortaliP29619.
SMRiP29619.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST283

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0594. Eukaryota.
ENOG410XPP3. LUCA.
HOGENOMiHOG000233024.
InParanoidiP29619.
KOiK02206.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

P29619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQYEKVEKI GEGTYGVVYK GKHRHTNETI ALKKIRLEQE DEGVPSTAIR
60 70 80 90 100
EISLLKEMQH RNIVRLQDVV HKEKCIYLVF EYLDLDLKKH MDSSPDFKNH
110 120 130 140 150
RIVKSFLYQI LRGIAYCHSH RVLHRDLKPQ NLLIDRRTNS LKLADFGLAR
160 170 180 190 200
AFGIPVRTFT HEVVTLWYRA PEILLGARHY STPVDMWSVG CIFAEMVNQK
210 220 230 240 250
PLFPGDSEID ELFKIFSIMG TPNEETWPGV ASLPDYISTF PKWPSVDLAT
260 270 280 290
VVPTLDSSGL DLLSKMLRLD PSKRINARAA LEHEYFKDLE VA
Length:292
Mass (Da):33,693
Last modified:April 1, 1993 - v1
Checksum:iC7791576349DFE22
GO

Sequence cautioni

The sequence BAD07950 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60375 mRNA. Translation: CAA42923.1.
AP004885 Genomic DNA. Translation: BAD07949.1.
AP004885 Genomic DNA. Translation: BAD07950.1. Sequence problems.
AP008208 Genomic DNA. Translation: BAF07645.1.
AP014958 Genomic DNA. Translation: BAS76730.1.
AK101344 mRNA. Translation: BAG95020.1.
PIRiS22441.
RefSeqiXP_015623588.1. XM_015768102.1.
UniGeneiOs.3428.

Genome annotation databases

EnsemblPlantsiOS02T0123100-03; OS02T0123100-03; OS02G0123100.
GeneIDi4328135.
GrameneiOS02T0123100-03; OS02T0123100-03; OS02G0123100.
KEGGiosa:4328135.

Similar proteinsi

Entry informationi

Entry nameiCDKA2_ORYSJ
AccessioniPrimary (citable) accession number: P29619
Secondary accession number(s): B7ERM3
, Q0E4E3, Q6Z721, Q6Z722
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 27, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families