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P29619

- CDKA2_ORYSJ

UniProt

P29619 - CDKA2_ORYSJ

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Protein

Cyclin-dependent kinase A-2

Gene

CDKA-2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_221537. ERK1 activation.
REACT_225596. APC/C:Cdc20 mediated degradation of Cyclin B.
REACT_226419. G1/S-Specific Transcription.
REACT_236852. E2F mediated regulation of DNA replication.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase A-2 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDKA;2
Alternative name(s):
CDC2Os-2
Cell division control protein 2 homolog 2
Gene namesi
Name:CDKA-2
Synonyms:CDC2-2
Ordered Locus Names:Os02g0123100, LOC_Os02g03060
ORF Names:P0575F10.10-1, P0575F10.10-2
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 2

Organism-specific databases

GrameneiP29619.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Cyclin-dependent kinase A-2PRO_0000085756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphothreonineBy similarity
Modified residuei15 – 151PhosphotyrosineBy similarity
Modified residuei160 – 1601PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP29619.

Expressioni

Tissue specificityi

Expressed in the dividing region of the root apex and in differentiated cells such as those in the sclerenchyma, pericycle and parenchyma of the central cylinder. Expressed in the intercalary meristem and the elongation zone of internodes.2 Publications

Developmental stagei

Expression reaches a peak in the G1/S phases and then decreases in the G2/M phases.1 Publication

Inductioni

By gibberellic acid (GA3) and submergence. Down-regulated by auxin.3 Publications

Gene expression databases

ExpressionAtlasiP29619. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliP29619.
SMRiP29619. Positions 1-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 286283Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiP29619.
KOiK02206.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29619-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQYEKVEKI GEGTYGVVYK GKHRHTNETI ALKKIRLEQE DEGVPSTAIR
60 70 80 90 100
EISLLKEMQH RNIVRLQDVV HKEKCIYLVF EYLDLDLKKH MDSSPDFKNH
110 120 130 140 150
RIVKSFLYQI LRGIAYCHSH RVLHRDLKPQ NLLIDRRTNS LKLADFGLAR
160 170 180 190 200
AFGIPVRTFT HEVVTLWYRA PEILLGARHY STPVDMWSVG CIFAEMVNQK
210 220 230 240 250
PLFPGDSEID ELFKIFSIMG TPNEETWPGV ASLPDYISTF PKWPSVDLAT
260 270 280 290
VVPTLDSSGL DLLSKMLRLD PSKRINARAA LEHEYFKDLE VA
Length:292
Mass (Da):33,693
Last modified:April 1, 1993 - v1
Checksum:iC7791576349DFE22
GO

Sequence cautioni

The sequence BAD07950.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60375 mRNA. Translation: CAA42923.1.
AP004885 Genomic DNA. Translation: BAD07949.1.
AP004885 Genomic DNA. Translation: BAD07950.1. Sequence problems.
AP008208 Genomic DNA. Translation: BAF07645.1.
PIRiS22441.
RefSeqiNP_001045731.1. NM_001052266.1.
UniGeneiOs.3428.

Genome annotation databases

EnsemblPlantsiOS02T0123100-03; OS02T0123100-03; OS02G0123100.
GeneIDi4328135.
KEGGiosa:4328135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60375 mRNA. Translation: CAA42923.1 .
AP004885 Genomic DNA. Translation: BAD07949.1 .
AP004885 Genomic DNA. Translation: BAD07950.1 . Sequence problems.
AP008208 Genomic DNA. Translation: BAF07645.1 .
PIRi S22441.
RefSeqi NP_001045731.1. NM_001052266.1.
UniGenei Os.3428.

3D structure databases

ProteinModelPortali P29619.
SMRi P29619. Positions 1-288.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P29619.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS02T0123100-03 ; OS02T0123100-03 ; OS02G0123100 .
GeneIDi 4328135.
KEGGi osa:4328135.

Organism-specific databases

Gramenei P29619.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
InParanoidi P29619.
KOi K02206.

Enzyme and pathway databases

Reactomei REACT_221537. ERK1 activation.
REACT_225596. APC/C:Cdc20 mediated degradation of Cyclin B.
REACT_226419. G1/S-Specific Transcription.
REACT_236852. E2F mediated regulation of DNA replication.

Gene expression databases

ExpressionAtlasi P29619. baseline and differential.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of cDNA clones encoding cdc2 homologues from Oryza sativa: a functional homologue and cognate variants."
    Hashimoto J., Hirabayashi T., Hayano Y., Hata S., Ohashi Y., Suzuka I., Utsugi T., Toh-e A., Kikuchi Y.
    Mol. Gen. Genet. 233:10-16(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "Gibberellin promotes histone H1 kinase activity and the expression of cdc2 and cyclin genes during the induction of rapid growth in deepwater rice internodes."
    Sauter M., Mekhedov S.L., Kende H.
    Plant J. 7:623-632(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  5. "Differential expression of a CAK (cdc2-activating kinase)-like protein kinase, cyclins and cdc2 genes from rice during the cell cycle and in response to gibberellin."
    Sauter M.
    Plant J. 11:181-190(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  6. "Adventitious root growth and cell-cycle induction in deepwater rice."
    Lorbiecke R., Sauter M.
    Plant Physiol. 119:21-30(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  7. "Differential expression of genes for cyclin-dependent protein kinases in rice plants."
    Umeda M., Umeda-Hara C., Yamaguchi M., Hashimoto J., Uchimiya H.
    Plant Physiol. 119:31-40(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Genome-wide identification and expression analysis of rice cell cycle genes."
    Guo J., Song J., Wang F., Zhang X.S.
    Plant Mol. Biol. 64:349-360(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION AND GENE FAMILY.

Entry informationi

Entry nameiCDKA2_ORYSJ
AccessioniPrimary (citable) accession number: P29619
Secondary accession number(s): Q0E4E3, Q6Z721, Q6Z722
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3