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Protein

Cyclin-dependent kinase A-2

Gene

CDKA-2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-110056. MAPK3 (ERK1) activation.
R-OSA-113510. E2F mediated regulation of DNA replication.
R-OSA-1538133. G0 and Early G1.
R-OSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-OSA-5693607. Processing of DNA double-strand break ends.
R-OSA-68911. G2 Phase.
R-OSA-68962. Activation of the pre-replicative complex.
R-OSA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-OSA-69200. Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes.
R-OSA-69202. Cyclin E associated events during G1/S transition.
R-OSA-69205. G1/S-Specific Transcription.
R-OSA-69273. Cyclin A/B1 associated events during G2/M transition.
R-OSA-69656. Cyclin A:Cdk2-associated events at S phase entry.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase A-2 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDKA;2
Alternative name(s):
CDC2Os-2
Cell division control protein 2 homolog 2
Gene namesi
Name:CDKA-2
Synonyms:CDC2-2
Ordered Locus Names:Os02g0123100, LOC_Os02g03060
ORF Names:P0575F10.10-1, P0575F10.10-2
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857561 – 292Cyclin-dependent kinase A-2Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphothreonineBy similarity1
Modified residuei15PhosphotyrosineBy similarity1
Modified residuei160PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP29619.
PRIDEiP29619.

Expressioni

Tissue specificityi

Expressed in the dividing region of the root apex and in differentiated cells such as those in the sclerenchyma, pericycle and parenchyma of the central cylinder. Expressed in the intercalary meristem and the elongation zone of internodes.2 Publications

Developmental stagei

Expression reaches a peak in the G1/S phases and then decreases in the G2/M phases.1 Publication

Inductioni

By gibberellic acid (GA3) and submergence. Down-regulated by auxin.3 Publications

Gene expression databases

ExpressionAtlasiP29619. baseline and differential.
GenevisibleiP29619. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os02g03060.1.

Structurei

3D structure databases

ProteinModelPortaliP29619.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST283

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0594. Eukaryota.
ENOG410XPP3. LUCA.
HOGENOMiHOG000233024.
InParanoidiP29619.
KOiK02206.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQYEKVEKI GEGTYGVVYK GKHRHTNETI ALKKIRLEQE DEGVPSTAIR
60 70 80 90 100
EISLLKEMQH RNIVRLQDVV HKEKCIYLVF EYLDLDLKKH MDSSPDFKNH
110 120 130 140 150
RIVKSFLYQI LRGIAYCHSH RVLHRDLKPQ NLLIDRRTNS LKLADFGLAR
160 170 180 190 200
AFGIPVRTFT HEVVTLWYRA PEILLGARHY STPVDMWSVG CIFAEMVNQK
210 220 230 240 250
PLFPGDSEID ELFKIFSIMG TPNEETWPGV ASLPDYISTF PKWPSVDLAT
260 270 280 290
VVPTLDSSGL DLLSKMLRLD PSKRINARAA LEHEYFKDLE VA
Length:292
Mass (Da):33,693
Last modified:April 1, 1993 - v1
Checksum:iC7791576349DFE22
GO

Sequence cautioni

The sequence BAD07950 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60375 mRNA. Translation: CAA42923.1.
AP004885 Genomic DNA. Translation: BAD07949.1.
AP004885 Genomic DNA. Translation: BAD07950.1. Sequence problems.
AP008208 Genomic DNA. Translation: BAF07645.1.
AP014958 Genomic DNA. Translation: BAS76730.1.
AK101344 mRNA. Translation: BAG95020.1.
PIRiS22441.
RefSeqiXP_015623588.1. XM_015768102.1.
UniGeneiOs.3428.

Genome annotation databases

EnsemblPlantsiOS02T0123100-03; OS02T0123100-03; OS02G0123100.
GeneIDi4328135.
GrameneiOS02T0123100-03; OS02T0123100-03; OS02G0123100.
KEGGiosa:4328135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60375 mRNA. Translation: CAA42923.1.
AP004885 Genomic DNA. Translation: BAD07949.1.
AP004885 Genomic DNA. Translation: BAD07950.1. Sequence problems.
AP008208 Genomic DNA. Translation: BAF07645.1.
AP014958 Genomic DNA. Translation: BAS76730.1.
AK101344 mRNA. Translation: BAG95020.1.
PIRiS22441.
RefSeqiXP_015623588.1. XM_015768102.1.
UniGeneiOs.3428.

3D structure databases

ProteinModelPortaliP29619.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os02g03060.1.

Proteomic databases

PaxDbiP29619.
PRIDEiP29619.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS02T0123100-03; OS02T0123100-03; OS02G0123100.
GeneIDi4328135.
GrameneiOS02T0123100-03; OS02T0123100-03; OS02G0123100.
KEGGiosa:4328135.

Phylogenomic databases

eggNOGiKOG0594. Eukaryota.
ENOG410XPP3. LUCA.
HOGENOMiHOG000233024.
InParanoidiP29619.
KOiK02206.

Enzyme and pathway databases

ReactomeiR-OSA-110056. MAPK3 (ERK1) activation.
R-OSA-113510. E2F mediated regulation of DNA replication.
R-OSA-1538133. G0 and Early G1.
R-OSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-OSA-5693607. Processing of DNA double-strand break ends.
R-OSA-68911. G2 Phase.
R-OSA-68962. Activation of the pre-replicative complex.
R-OSA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-OSA-69200. Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes.
R-OSA-69202. Cyclin E associated events during G1/S transition.
R-OSA-69205. G1/S-Specific Transcription.
R-OSA-69273. Cyclin A/B1 associated events during G2/M transition.
R-OSA-69656. Cyclin A:Cdk2-associated events at S phase entry.

Gene expression databases

ExpressionAtlasiP29619. baseline and differential.
GenevisibleiP29619. OS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDKA2_ORYSJ
AccessioniPrimary (citable) accession number: P29619
Secondary accession number(s): B7ERM3
, Q0E4E3, Q6Z721, Q6Z722
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.