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P29619 (CDKA2_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase A-2

Short name=CDKA;2
EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
CDC2Os-2
Cell division control protein 2 homolog 2
Gene names
Name:CDKA-2
Synonyms:CDC2-2
Ordered Locus Names:Os02g0123100, LOC_Os02g03060
ORF Names:P0575F10.10-1, P0575F10.10-2
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Tissue specificity

Expressed in the dividing region of the root apex and in differentiated cells such as those in the sclerenchyma, pericycle and parenchyma of the central cylinder. Expressed in the intercalary meristem and the elongation zone of internodes. Ref.4 Ref.7

Developmental stage

Expression reaches a peak in the G1/S phases and then decreases in the G2/M phases. Ref.5

Induction

By gibberellic acid (GA3) and submergence. Down-regulated by auxin. Ref.4 Ref.6 Ref.8

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence BAD07950.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Cyclin-dependent kinase A-2
PRO_0000085756

Regions

Domain4 – 286283Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1261Proton acceptor By similarity
Binding site331ATP By similarity

Amino acid modifications

Modified residue141Phosphothreonine By similarity
Modified residue151Phosphotyrosine By similarity
Modified residue1601Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
P29619 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: C7791576349DFE22

FASTA29233,693
        10         20         30         40         50         60 
MEQYEKVEKI GEGTYGVVYK GKHRHTNETI ALKKIRLEQE DEGVPSTAIR EISLLKEMQH 

        70         80         90        100        110        120 
RNIVRLQDVV HKEKCIYLVF EYLDLDLKKH MDSSPDFKNH RIVKSFLYQI LRGIAYCHSH 

       130        140        150        160        170        180 
RVLHRDLKPQ NLLIDRRTNS LKLADFGLAR AFGIPVRTFT HEVVTLWYRA PEILLGARHY 

       190        200        210        220        230        240 
STPVDMWSVG CIFAEMVNQK PLFPGDSEID ELFKIFSIMG TPNEETWPGV ASLPDYISTF 

       250        260        270        280        290 
PKWPSVDLAT VVPTLDSSGL DLLSKMLRLD PSKRINARAA LEHEYFKDLE VA 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of cDNA clones encoding cdc2 homologues from Oryza sativa: a functional homologue and cognate variants."
Hashimoto J., Hirabayashi T., Hayano Y., Hata S., Ohashi Y., Suzuka I., Utsugi T., Toh-e A., Kikuchi Y.
Mol. Gen. Genet. 233:10-16(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Nipponbare.
[2]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[3]"The rice annotation project database (RAP-DB): 2008 update."
The rice annotation project (RAP)
Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: cv. Nipponbare.
[4]"Gibberellin promotes histone H1 kinase activity and the expression of cdc2 and cyclin genes during the induction of rapid growth in deepwater rice internodes."
Sauter M., Mekhedov S.L., Kende H.
Plant J. 7:623-632(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INDUCTION.
[5]"Differential expression of a CAK (cdc2-activating kinase)-like protein kinase, cyclins and cdc2 genes from rice during the cell cycle and in response to gibberellin."
Sauter M.
Plant J. 11:181-190(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
[6]"Adventitious root growth and cell-cycle induction in deepwater rice."
Lorbiecke R., Sauter M.
Plant Physiol. 119:21-30(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[7]"Differential expression of genes for cyclin-dependent protein kinases in rice plants."
Umeda M., Umeda-Hara C., Yamaguchi M., Hashimoto J., Uchimiya H.
Plant Physiol. 119:31-40(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[8]"Genome-wide identification and expression analysis of rice cell cycle genes."
Guo J., Song J., Wang F., Zhang X.S.
Plant Mol. Biol. 64:349-360(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION AND GENE FAMILY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X60375 mRNA. Translation: CAA42923.1.
AP004885 Genomic DNA. Translation: BAD07949.1.
AP004885 Genomic DNA. Translation: BAD07950.1. Sequence problems.
AP008208 Genomic DNA. Translation: BAF07645.1.
PIRS22441.
RefSeqNP_001045731.1. NM_001052266.1.
UniGeneOs.3428.

3D structure databases

ProteinModelPortalP29619.
SMRP29619. Positions 1-288.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP29619.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsOS02T0123100-03; OS02T0123100-03; OS02G0123100.
GeneID4328135.
KEGGosa:4328135.

Organism-specific databases

GrameneP29619.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
KOK02206.
ProtClustDBPLN00009.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDKA2_ORYSJ
AccessionPrimary (citable) accession number: P29619
Secondary accession number(s): Q0E4E3, Q6Z721, Q6Z722
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations