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P29619

- CDKA2_ORYSJ

UniProt

P29619 - CDKA2_ORYSJ

Protein

Cyclin-dependent kinase A-2

Gene

CDKA-2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.
    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase A-2 (EC:2.7.11.22, EC:2.7.11.23)
    Short name:
    CDKA;2
    Alternative name(s):
    CDC2Os-2
    Cell division control protein 2 homolog 2
    Gene namesi
    Name:CDKA-2
    Synonyms:CDC2-2
    Ordered Locus Names:Os02g0123100, LOC_Os02g03060
    ORF Names:P0575F10.10-1, P0575F10.10-2
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 2

    Organism-specific databases

    GrameneiP29619.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Cyclin-dependent kinase A-2PRO_0000085756Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141PhosphothreonineBy similarity
    Modified residuei15 – 151PhosphotyrosineBy similarity
    Modified residuei160 – 1601PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP29619.

    Expressioni

    Tissue specificityi

    Expressed in the dividing region of the root apex and in differentiated cells such as those in the sclerenchyma, pericycle and parenchyma of the central cylinder. Expressed in the intercalary meristem and the elongation zone of internodes.2 Publications

    Developmental stagei

    Expression reaches a peak in the G1/S phases and then decreases in the G2/M phases.1 Publication

    Inductioni

    By gibberellic acid (GA3) and submergence. Down-regulated by auxin.3 Publications

    Structurei

    3D structure databases

    ProteinModelPortaliP29619.
    SMRiP29619. Positions 1-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 286283Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    KOiK02206.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29619-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQYEKVEKI GEGTYGVVYK GKHRHTNETI ALKKIRLEQE DEGVPSTAIR    50
    EISLLKEMQH RNIVRLQDVV HKEKCIYLVF EYLDLDLKKH MDSSPDFKNH 100
    RIVKSFLYQI LRGIAYCHSH RVLHRDLKPQ NLLIDRRTNS LKLADFGLAR 150
    AFGIPVRTFT HEVVTLWYRA PEILLGARHY STPVDMWSVG CIFAEMVNQK 200
    PLFPGDSEID ELFKIFSIMG TPNEETWPGV ASLPDYISTF PKWPSVDLAT 250
    VVPTLDSSGL DLLSKMLRLD PSKRINARAA LEHEYFKDLE VA 292
    Length:292
    Mass (Da):33,693
    Last modified:April 1, 1993 - v1
    Checksum:iC7791576349DFE22
    GO

    Sequence cautioni

    The sequence BAD07950.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60375 mRNA. Translation: CAA42923.1.
    AP004885 Genomic DNA. Translation: BAD07949.1.
    AP004885 Genomic DNA. Translation: BAD07950.1. Sequence problems.
    AP008208 Genomic DNA. Translation: BAF07645.1.
    PIRiS22441.
    RefSeqiNP_001045731.1. NM_001052266.1.
    UniGeneiOs.3428.

    Genome annotation databases

    EnsemblPlantsiOS02T0123100-03; OS02T0123100-03; OS02G0123100.
    GeneIDi4328135.
    KEGGiosa:4328135.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60375 mRNA. Translation: CAA42923.1 .
    AP004885 Genomic DNA. Translation: BAD07949.1 .
    AP004885 Genomic DNA. Translation: BAD07950.1 . Sequence problems.
    AP008208 Genomic DNA. Translation: BAF07645.1 .
    PIRi S22441.
    RefSeqi NP_001045731.1. NM_001052266.1.
    UniGenei Os.3428.

    3D structure databases

    ProteinModelPortali P29619.
    SMRi P29619. Positions 1-288.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P29619.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS02T0123100-03 ; OS02T0123100-03 ; OS02G0123100 .
    GeneIDi 4328135.
    KEGGi osa:4328135.

    Organism-specific databases

    Gramenei P29619.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    KOi K02206.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of cDNA clones encoding cdc2 homologues from Oryza sativa: a functional homologue and cognate variants."
      Hashimoto J., Hirabayashi T., Hayano Y., Hata S., Ohashi Y., Suzuka I., Utsugi T., Toh-e A., Kikuchi Y.
      Mol. Gen. Genet. 233:10-16(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    4. "Gibberellin promotes histone H1 kinase activity and the expression of cdc2 and cyclin genes during the induction of rapid growth in deepwater rice internodes."
      Sauter M., Mekhedov S.L., Kende H.
      Plant J. 7:623-632(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.
    5. "Differential expression of a CAK (cdc2-activating kinase)-like protein kinase, cyclins and cdc2 genes from rice during the cell cycle and in response to gibberellin."
      Sauter M.
      Plant J. 11:181-190(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    6. "Adventitious root growth and cell-cycle induction in deepwater rice."
      Lorbiecke R., Sauter M.
      Plant Physiol. 119:21-30(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    7. "Differential expression of genes for cyclin-dependent protein kinases in rice plants."
      Umeda M., Umeda-Hara C., Yamaguchi M., Hashimoto J., Uchimiya H.
      Plant Physiol. 119:31-40(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. "Genome-wide identification and expression analysis of rice cell cycle genes."
      Guo J., Song J., Wang F., Zhang X.S.
      Plant Mol. Biol. 64:349-360(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION AND GENE FAMILY.

    Entry informationi

    Entry nameiCDKA2_ORYSJ
    AccessioniPrimary (citable) accession number: P29619
    Secondary accession number(s): Q0E4E3, Q6Z721, Q6Z722
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3