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P29618

- CDKA1_ORYSJ

UniProt

P29618 - CDKA1_ORYSJ

Protein

Cyclin-dependent kinase A-1

Gene

CDKA-1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.
    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei127 – 1271Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. protein binding Source: UniProtKB
    4. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase A-1 (EC:2.7.11.22, EC:2.7.11.23)
    Short name:
    CDKA;1
    Alternative name(s):
    CDC2Os-1
    Cell division control protein 2 homolog 1
    Gene namesi
    Name:CDKA-1
    Synonyms:CDC2-1
    Ordered Locus Names:Os03g0118400, LOC_Os03g02680
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 3

    Organism-specific databases

    GrameneiP29618.

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi161 – 1611T → A: Loss of phosphorylation by CDKD-1. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294Cyclin-dependent kinase A-1PRO_0000085755Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141PhosphothreonineBy similarity
    Modified residuei15 – 151PhosphotyrosineBy similarity
    Modified residuei161 – 1611Phosphothreonine; by CAK1 Publication

    Post-translational modificationi

    Phosphorylated at Thr-161 by CDKD-1.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP29618.

    Expressioni

    Tissue specificityi

    Expressed in the dividing region of the root apex and in differentiated cells such as those in the sclerenchyma, pericycle and parenchyma of the central cylinder.1 Publication

    Developmental stagei

    Expressed throughout the cell cycle.1 Publication

    Inductioni

    By submergence. Down-regulated by cytokinin.2 Publications

    Structurei

    3D structure databases

    ProteinModelPortaliP29618.
    SMRiP29618. Positions 1-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 287284Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    KOiK02206.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29618-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQYEKEEKI GEGTYGVVYR ARDKVTNETI ALKKIRLEQE DEGVPSTAIR    50
    EISLLKEMHH GNIVRLHDVI HSEKRIYLVF EYLDLDLKKF MDSCPEFAKN 100
    PTLIKSYLYQ ILRGVAYCHS HRVLHRDLKP QNLLIDRRTN ALKLADFGLA 150
    RAFGIPVRTF THEVVTLWYR APEILLGSRQ YSTPVDMWSV GCIFAEMVNQ 200
    KPLFPGDSEI DELFKIFRVL GTPNEQSWPG VSSLPDYKSA FPKWQAQDLA 250
    TIVPTLDPAG LDLLSKMLRY EPNKRITARQ ALEHEYFKDL EMVQ 294
    Length:294
    Mass (Da):34,071
    Last modified:April 1, 1993 - v1
    Checksum:i51322D93AEF4C131
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60374 mRNA. Translation: CAA42922.1.
    DP000009 Genomic DNA. Translation: ABF93669.1.
    AP008209 Genomic DNA. Translation: BAF10686.1.
    PIRiS22440.
    RefSeqiNP_001048772.1. NM_001055307.1.
    UniGeneiOs.11723.

    Genome annotation databases

    GeneIDi4331415.
    KEGGiosa:4331415.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60374 mRNA. Translation: CAA42922.1 .
    DP000009 Genomic DNA. Translation: ABF93669.1 .
    AP008209 Genomic DNA. Translation: BAF10686.1 .
    PIRi S22440.
    RefSeqi NP_001048772.1. NM_001055307.1.
    UniGenei Os.11723.

    3D structure databases

    ProteinModelPortali P29618.
    SMRi P29618. Positions 1-289.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P29618.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4331415.
    KEGGi osa:4331415.

    Organism-specific databases

    Gramenei P29618.

    Phylogenomic databases

    eggNOGi COG0515.
    KOi K02206.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of cDNA clones encoding cdc2 homologues from Oryza sativa: a functional homologue and cognate variants."
      Hashimoto J., Hirabayashi T., Hayano Y., Hata S., Ohashi Y., Suzuka I., Utsugi T., Toh-e A., Kikuchi Y.
      Mol. Gen. Genet. 233:10-16(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Nipponbare.
    2. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
      The rice chromosome 3 sequencing consortium
      Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
      , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
      Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    4. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    5. "Differential expression of a CAK (cdc2-activating kinase)-like protein kinase, cyclins and cdc2 genes from rice during the cell cycle and in response to gibberellin."
      Sauter M.
      Plant J. 11:181-190(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    6. "Adventitious root growth and cell-cycle induction in deepwater rice."
      Lorbiecke R., Sauter M.
      Plant Physiol. 119:21-30(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    7. "Differential expression of genes for cyclin-dependent protein kinases in rice plants."
      Umeda M., Umeda-Hara C., Yamaguchi M., Hashimoto J., Uchimiya H.
      Plant Physiol. 119:31-40(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. "Activation of CDK-activating kinase is dependent on interaction with H-type cyclins in plants."
      Yamaguchi M., Fabian T., Sauter M., Bhalerao R.P., Schrader J., Sandberg G., Umeda M., Uchimiya H.
      Plant J. 24:11-20(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, MUTAGENESIS OF THR-161.
    9. "Genome-wide identification and expression analysis of rice cell cycle genes."
      Guo J., Song J., Wang F., Zhang X.S.
      Plant Mol. Biol. 64:349-360(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION AND GENE FAMILY.

    Entry informationi

    Entry nameiCDKA1_ORYSJ
    AccessioniPrimary (citable) accession number: P29618
    Secondary accession number(s): Q10SL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3