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Protein

Cyclin-dependent kinase A-1

Gene

CDKA-1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei127Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-110056. MAPK3 (ERK1) activation.
R-OSA-1538133. G0 and Early G1.
R-OSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-OSA-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-OSA-2299718. Condensation of Prophase Chromosomes.
R-OSA-2500257. Resolution of Sister Chromatid Cohesion.
R-OSA-4419969. Depolymerisation of the Nuclear Lamina.
R-OSA-5693607. Processing of DNA double-strand break ends.
R-OSA-68911. G2 Phase.
R-OSA-68962. Activation of the pre-replicative complex.
R-OSA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-OSA-69200. Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes.
R-OSA-69202. Cyclin E associated events during G1/S transition.
R-OSA-69273. Cyclin A/B1/B2 associated events during G2/M transition.
R-OSA-69478. G2/M DNA replication checkpoint.
R-OSA-69656. Cyclin A:Cdk2-associated events at S phase entry.
R-OSA-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase A-1 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDKA;1
Alternative name(s):
CDC2Os-1
Cell division control protein 2 homolog 1
Gene namesi
Name:CDKA-1
Synonyms:CDC2-1
Ordered Locus Names:Os03g0118400, LOC_Os03g02680
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi161T → A: Loss of phosphorylation by CDKD-1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857551 – 294Cyclin-dependent kinase A-1Add BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphothreonineBy similarity1
Modified residuei15PhosphotyrosineBy similarity1
Modified residuei161Phosphothreonine; by CAK1 Publication1

Post-translational modificationi

Phosphorylated at Thr-161 by CDKD-1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP29618.
PRIDEiP29618.

PTM databases

iPTMnetiP29618.

Expressioni

Tissue specificityi

Expressed in the dividing region of the root apex and in differentiated cells such as those in the sclerenchyma, pericycle and parenchyma of the central cylinder.1 Publication

Developmental stagei

Expressed throughout the cell cycle.1 Publication

Inductioni

By submergence. Down-regulated by cytokinin.2 Publications

Gene expression databases

ExpressionAtlasiP29618. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os03g02680.1.

Structurei

3D structure databases

ProteinModelPortaliP29618.
SMRiP29618.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 287Protein kinasePROSITE-ProRule annotationAdd BLAST284

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0594. Eukaryota.
ENOG410XPP3. LUCA.
InParanoidiP29618.
KOiK02206.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

P29618-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQYEKEEKI GEGTYGVVYR ARDKVTNETI ALKKIRLEQE DEGVPSTAIR
60 70 80 90 100
EISLLKEMHH GNIVRLHDVI HSEKRIYLVF EYLDLDLKKF MDSCPEFAKN
110 120 130 140 150
PTLIKSYLYQ ILRGVAYCHS HRVLHRDLKP QNLLIDRRTN ALKLADFGLA
160 170 180 190 200
RAFGIPVRTF THEVVTLWYR APEILLGSRQ YSTPVDMWSV GCIFAEMVNQ
210 220 230 240 250
KPLFPGDSEI DELFKIFRVL GTPNEQSWPG VSSLPDYKSA FPKWQAQDLA
260 270 280 290
TIVPTLDPAG LDLLSKMLRY EPNKRITARQ ALEHEYFKDL EMVQ
Length:294
Mass (Da):34,071
Last modified:April 1, 1993 - v1
Checksum:i51322D93AEF4C131
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60374 mRNA. Translation: CAA42922.1.
DP000009 Genomic DNA. Translation: ABF93669.1.
AP008209 Genomic DNA. Translation: BAF10686.1.
AP014959 Genomic DNA. No translation available.
PIRiS22440.
RefSeqiXP_015631633.1. XM_015776147.1.
UniGeneiOs.11723.

Genome annotation databases

GeneIDi4331415.
KEGGiosa:4331415.

Similar proteinsi

Entry informationi

Entry nameiCDKA1_ORYSJ
AccessioniPrimary (citable) accession number: P29618
Secondary accession number(s): Q10SL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome