Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein prospero

Gene

pros

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for proper neuronal differentiation of most or all neurons and their precursors in central and peripheral nervous systems, axonal outgrowth and pathfinding. Not required for the specification of neuronal identity. May regulate transcription by binding to DNA.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi1541 – 160363Prospero-type homeoboxAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: FlyBase
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • asymmetric cell division Source: FlyBase
  • asymmetric neuroblast division Source: FlyBase
  • asymmetric neuroblast division resulting in ganglion mother cell formation Source: FlyBase
  • axon guidance Source: FlyBase
  • axonogenesis Source: FlyBase
  • axonogenesis involved in innervation Source: FlyBase
  • brain development Source: FlyBase
  • cell fate commitment Source: FlyBase
  • cell fate specification Source: FlyBase
  • central nervous system development Source: UniProtKB
  • compound eye cone cell fate commitment Source: FlyBase
  • courtship behavior Source: FlyBase
  • dendrite guidance Source: FlyBase
  • dendrite morphogenesis Source: FlyBase
  • eye photoreceptor cell differentiation Source: FlyBase
  • G1 to G0 transition Source: FlyBase
  • ganglion mother cell fate determination Source: FlyBase
  • glial cell differentiation Source: FlyBase
  • male courtship behavior Source: FlyBase
  • negative regulation of axonogenesis Source: FlyBase
  • negative regulation of cell proliferation Source: FlyBase
  • negative regulation of gene expression Source: FlyBase
  • negative regulation of neuroblast proliferation Source: FlyBase
  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • nervous system development Source: FlyBase
  • neuroblast fate determination Source: FlyBase
  • neuroblast proliferation Source: FlyBase
  • peripheral nervous system development Source: UniProtKB
  • phagocytosis Source: FlyBase
  • positive regulation of gene expression Source: FlyBase
  • protein localization Source: FlyBase
  • R7 cell fate commitment Source: FlyBase
  • regulation of neuron differentiation Source: UniProtKB
  • regulation of protein localization to nucleus Source: FlyBase
  • regulation of R7 cell differentiation Source: FlyBase
  • regulation of retinal cone cell fate specification Source: FlyBase
  • regulation of transcription, DNA-templated Source: FlyBase
  • sensory organ development Source: FlyBase
  • sensory perception of taste Source: FlyBase
  • synapse assembly Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
  • ventral cord development Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein prospero
Gene namesi
Name:pros
ORF Names:CG17228
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0004595. pros.

Subcellular locationi

GO - Cellular componenti

  • apical cortex Source: FlyBase
  • basal cortex Source: FlyBase
  • basal part of cell Source: FlyBase
  • cell cortex Source: FlyBase
  • microtubule associated complex Source: FlyBase
  • nucleus Source: UniProtKB
  • plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Aberrant expression of the homeobox genes fushi tarazu, even-skipped and engrailed in a subset of neuroblast progeny.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17031703Homeobox protein prosperoPRO_0000208884Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei479 – 4791Phosphoserine1 Publication
Modified residuei482 – 4821Phosphoserine1 Publication
Modified residuei485 – 4851Phosphoserine1 Publication
Modified residuei497 – 4971Phosphoserine1 Publication
Modified residuei651 – 6511Phosphoserine1 Publication
Modified residuei654 – 6541Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP29617.

PTM databases

iPTMnetiP29617.

Expressioni

Tissue specificityi

Expressed in embryonic neuronal precursors. Expressed in the developing CNS, lens-secreting cone cells of the eye, and midgut.3 Publications

Developmental stagei

Expressed during embryogenesis.1 Publication

Gene expression databases

BgeeiP29617.
GenevisibleiP29617. DM.

Interactioni

Protein-protein interaction databases

BioGridi66496. 9 interactions.
IntActiP29617. 3 interactions.
MINTiMINT-851493.
STRINGi7227.FBpp0293146.

Structurei

Secondary structure

1
1703
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1550 – 155910Combined sources
Turni1560 – 15623Combined sources
Helixi1568 – 15747Combined sources
Helixi1582 – 161231Combined sources
Helixi1628 – 163710Combined sources
Helixi1647 – 166519Combined sources
Helixi1668 – 16703Combined sources
Turni1672 – 16754Combined sources
Helixi1676 – 16838Combined sources
Helixi1691 – 16944Combined sources
Helixi1696 – 16994Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MIJX-ray2.05A1545-1696[»]
1XPXX-ray2.80A1541-1703[»]
ProteinModelPortaliP29617.
SMRiP29617. Positions 1545-1701.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29617.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1604 – 1703100Prospero-likeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1291 – 12988Nuclear localization signal

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi516 – 56449Gln-richAdd
BLAST
Compositional biasi570 – 58617Asn-richAdd
BLAST
Compositional biasi618 – 65437Ser-richAdd
BLAST
Compositional biasi1000 – 1348349Gln-richAdd
BLAST
Compositional biasi1427 – 143711His-richAdd
BLAST

Sequence similaritiesi

Belongs to the Prospero homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3779. Eukaryota.
ENOG410ZE21. LUCA.
GeneTreeiENSGT00530000063507.
InParanoidiP29617.
OMAiPQQHAME.
OrthoDBiEOG72G16R.

Family and domain databases

Gene3Di1.10.10.500. 1 hit.
InterProiIPR023082. Homeo_prospero_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05044. HPD. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform F (identifier: P29617-1) [UniParc]FASTAAdd to basket

Also known as: L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSSEEYEAD CFGLYSDENN VLLKANEPET TAATKQQHQP QFQQQQQQQQ
60 70 80 90 100
QQQQHHHQHQ QPPPSSNGHT SPIPSQVNGD GSAANCGESG KTNTNTGSHS
110 120 130 140 150
HSNSGNTNTD ADKEQEREKA KEKANEEESE DSDDDVVVVL EGCEGNASSS
160 170 180 190 200
SSSSNSNSNA SSNNHKAAAT TTTTATTANH CNRSGGSSRS HRSARSSRQI
210 220 230 240 250
SQSTAVGKTT TCAAKKPTAA QATTTTAKNS NSNSNVNVNV NVNSNGSGNG
260 270 280 290 300
NANSKVNRRS RQRSLSKDIN NQPASSNSNS NSSNNSSNSN GGATATAAGF
310 320 330 340 350
MSSAAAAAAG AAGGGALFQP QSVSTANSSS SNNNNSSTPA ALATHSPTSN
360 370 380 390 400
SPVSGASSAS SLLTAAFGNL FGGSSAKMLN ELFGRQMKQA QDATSGLPQS
410 420 430 440 450
LDNAMLAAAM ETATSAELLI GSLNSTSKLL QQQHNNNSIA PANSTPMSNG
460 470 480 490 500
TNASISPGSA HSSSHSHQGV SPKGSRRVSA CSDRSLEAAA ADVAGGSPPR
510 520 530 540 550
AASVSSLNGG ASSGEQHQSQ LQHDLVAHHM LRNILQGKKE LMQLDQELRT
560 570 580 590 600
AMQQQQQQLQ EKEQLHSKLN NNNNNNIAAT ANNNNNTTME SINLIDDSEM
610 620 630 640 650
ADIKIKSEPQ TAPQPQQSPH GSSHSSRSGS GSGSHSSMAS DGSLRRKSSD
660 670 680 690 700
SLDSHGAQDD AQDEEDAAPT GQRSESRAPE EPQLPTKKES VDDMLDEVEL
710 720 730 740 750
LGLHSRGSDM DSLASPSHSD MMLLDKDDVL DEDDDDDCVE QKTSGSGCLK
760 770 780 790 800
KPGMDLKRAR VENIVSGMRC SPSSGLAQAG QLQVNGCKKR KLYQPQQHAM
810 820 830 840 850
ERYVAAAAGL NFGLNLQSMM LDQEDSESNE LESPQIQQKR VEKNALKSQL
860 870 880 890 900
RSMQEQLAEM QQKYVQLCSR MEQESECQEL DQDQDVEQEQ EPDNGSSDHI
910 920 930 940 950
ELSPSPTLTG DGDVSPNHKE ETGQERPGSS SPSPSPLKPK TSLGESSDSG
960 970 980 990 1000
ANMLSQMMSK MMSGKLHNPL VGVGHPALPQ GFPPLLQHMG DMSHAAAMYQ
1010 1020 1030 1040 1050
QFFFEQEARM AKEAAEQQQQ QQQQQQQQQQ QQQQEQQRRF EQEQQEQQRR
1060 1070 1080 1090 1100
KEEQQQQIQR QQQHLQQLQQ QQMEQQHVAT AAPRPQMHHP APARLPTRMG
1110 1120 1130 1140 1150
GAAGHTALKS ELSEKFQMLR ANNNSSMMRM SGTDLEGLAD VLKSEITTSL
1160 1170 1180 1190 1200
SALVDTIVTR FVHQRRLFSK QADSVTAAAE QLNKDLLLAS QILDRKSPRT
1210 1220 1230 1240 1250
KVADRPQNGP TPATQSAAAM FQAPKTPQGM NPVAAAALYN SMTGPFCLPP
1260 1270 1280 1290 1300
DQQQQQQTAQ QQQSAQQQQQ SSQQTQQQLE QNEALSLVVT PKKKRHKVTD
1310 1320 1330 1340 1350
TRITPRTVSR ILAQDGVVPP TGGPPSTPQQ QQQQQQQQQQ QQQQQQQQAS
1360 1370 1380 1390 1400
NGGNSNATPA QSPTRSSGGA AYHPQPPPPP PPMMPVSLPT SVAIPNPSLH
1410 1420 1430 1440 1450
ESKVFSPYSP FFNPHAAAGQ ATAAQLHQHH QQHHPHHQSM QLSSSPPGSL
1460 1470 1480 1490 1500
GALMDSRDSP PLPHPPSMLH PALLAAAHHG GSPDYKTCLR AVMDAQDRQS
1510 1520 1530 1540 1550
ECNSADMQFD GMAPTISFYK QMQLKTEHQE SLMAKHCESL TPLHSSTLTP
1560 1570 1580 1590 1600
MHLRKAKLMF FWVRYPSSAV LKMYFPDIKF NKNNTAQLVK WFSNFREFYY
1610 1620 1630 1640 1650
IQMEKYARQA VTEGIKTPDD LLIAGDSELY RVLNLHYNRN NHIEVPQNFR
1660 1670 1680 1690 1700
FVVESTLREF FRAIQGGKDT EQSWKKSIYK IISRMDDPVP EYFKSPNFLE

QLE
Length:1,703
Mass (Da):184,980
Last modified:March 24, 2009 - v3
Checksum:i35040F15C1CBB1D8
GO
Isoform E (identifier: P29617-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1216-1216: S → SGNNGSLLLA...PPPHIRPSPT
     1516-1544: Missing.

Note: No experimental confirmation available.
Show »
Length:1,835
Mass (Da):198,422
Checksum:i9C9F48EEEF8D2F3A
GO
Isoform G (identifier: P29617-4) [UniParc]FASTAAdd to basket

Also known as: S

The sequence of this isoform differs from the canonical sequence as follows:
     1516-1544: Missing.

Note: No experimental confirmation available.
Show »
Length:1,674
Mass (Da):181,539
Checksum:i7B55B08222C636A6
GO

Sequence cautioni

The sequence AAA28841.1 differs from that shown. Reason: Frameshift at positions 179 and 231. Curated
The sequence AAL28228.1 differs from that shown. Reason: Frameshift at position 1422. Curated
The sequence AAL28228.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAT94492.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA01464.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA77802.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 579QQQQQQHHH → HHQ in AAA28841 (PubMed:1720353).Curated
Sequence conflicti124 – 13512ANEEE…DSDDD → RTKRSPRIPTTT in AAA28841 (PubMed:1720353).CuratedAdd
BLAST
Sequence conflicti175 – 1751A → G in AAA28841 (PubMed:1720353).Curated
Sequence conflicti230 – 2301S → L in AAA28841 (PubMed:1720353).Curated
Sequence conflicti283 – 2831S → R in AAA28841 (PubMed:1720353).Curated
Sequence conflicti293 – 2931A → R in AAA28841 (PubMed:1720353).Curated
Sequence conflicti376 – 39823AKMLN…TSGLP → GQDAERAVWPPDEAGPGRNE WPA in AAA28841 (PubMed:1720353).CuratedAdd
BLAST
Sequence conflicti376 – 39823AKMLN…TSGLP → GQDAERAVWPPDEAGPGRNE WPA in AAF05703 (PubMed:11051550).CuratedAdd
BLAST
Sequence conflicti420 – 44425IGSLN…APANS → NLALQFHVQVAAAAAITTAL LPPIG in AAA28841 (PubMed:1720353).CuratedAdd
BLAST
Sequence conflicti420 – 44425IGSLN…APANS → NLALQFHVQVAAAAAITTAL LPPIG in AAF05703 (PubMed:11051550).CuratedAdd
BLAST
Sequence conflicti718 – 7181H → Q in BAA01464 (PubMed:1540176).Curated
Sequence conflicti977 – 9771A → C in AAA28841 (PubMed:1720353).Curated
Sequence conflicti1102 – 11021A → S in AAA28841 (PubMed:1720353).Curated
Sequence conflicti1258 – 12581T → S in AAA28841 (PubMed:1720353).Curated
Sequence conflicti1348 – 13481Q → QQQQQ in AAA28841 (PubMed:1720353).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1216 – 12161S → SGNNGSLLLANSQMPSQTTA SGSSAQQQQQQNAQQQHQGS QQQQQQNVVQQQNVAQQQHM QQQQQQQQSHPLLPPNCQQL ISAPRLNGSQLSFASPAAAA AAAMGLQMHHAAAAAAMSAQ QQQQQSGDPGANTNPNSGPA NPTNSSLSTLNIPPPHIRPS PT in isoform E. 1 PublicationVSP_002307
Alternative sequencei1516 – 154429Missing in isoform E and isoform G. 2 PublicationsVSP_002308Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81389 mRNA. Translation: AAA28841.1. Frameshift.
AE014297 Genomic DNA. Translation: AAF54628.3.
AE014297 Genomic DNA. Translation: AAN13500.3.
AE014297 Genomic DNA. Translation: AAN13501.3.
Z11743 mRNA. Translation: CAA77802.1. Different initiation.
D10609 mRNA. Translation: BAA01464.1. Different initiation.
BT015263 mRNA. Translation: AAT94492.1. Different initiation.
AF190403 Genomic DNA. Translation: AAF05703.1.
AY060680 mRNA. Translation: AAL28228.1. Sequence problems.
PIRiS24548.
RefSeqiNP_001247046.1. NM_001260117.2. [P29617-1]
NP_524317.4. NM_079593.6.
NP_731565.4. NM_169386.3.
NP_788636.3. NM_176459.4.
UniGeneiDm.7116.

Genome annotation databases

EnsemblMetazoaiFBtr0304608; FBpp0293150; FBgn0004595. [P29617-1]
GeneIDi41363.
KEGGidme:Dmel_CG17228.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81389 mRNA. Translation: AAA28841.1. Frameshift.
AE014297 Genomic DNA. Translation: AAF54628.3.
AE014297 Genomic DNA. Translation: AAN13500.3.
AE014297 Genomic DNA. Translation: AAN13501.3.
Z11743 mRNA. Translation: CAA77802.1. Different initiation.
D10609 mRNA. Translation: BAA01464.1. Different initiation.
BT015263 mRNA. Translation: AAT94492.1. Different initiation.
AF190403 Genomic DNA. Translation: AAF05703.1.
AY060680 mRNA. Translation: AAL28228.1. Sequence problems.
PIRiS24548.
RefSeqiNP_001247046.1. NM_001260117.2. [P29617-1]
NP_524317.4. NM_079593.6.
NP_731565.4. NM_169386.3.
NP_788636.3. NM_176459.4.
UniGeneiDm.7116.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MIJX-ray2.05A1545-1696[»]
1XPXX-ray2.80A1541-1703[»]
ProteinModelPortaliP29617.
SMRiP29617. Positions 1545-1701.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66496. 9 interactions.
IntActiP29617. 3 interactions.
MINTiMINT-851493.
STRINGi7227.FBpp0293146.

PTM databases

iPTMnetiP29617.

Proteomic databases

PaxDbiP29617.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0304608; FBpp0293150; FBgn0004595. [P29617-1]
GeneIDi41363.
KEGGidme:Dmel_CG17228.

Organism-specific databases

CTDi41363.
FlyBaseiFBgn0004595. pros.

Phylogenomic databases

eggNOGiKOG3779. Eukaryota.
ENOG410ZE21. LUCA.
GeneTreeiENSGT00530000063507.
InParanoidiP29617.
OMAiPQQHAME.
OrthoDBiEOG72G16R.

Miscellaneous databases

EvolutionaryTraceiP29617.
GenomeRNAii41363.
PROiP29617.

Gene expression databases

BgeeiP29617.
GenevisibleiP29617. DM.

Family and domain databases

Gene3Di1.10.10.500. 1 hit.
InterProiIPR023082. Homeo_prospero_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05044. HPD. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila."
    Vaessin H., Grell E., Wolff E., Bier E., Jan L.Y., Jan Y.N.
    Cell 67:941-953(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM F), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
    Tissue: Embryo.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  4. "The prospero gene encodes a divergent homeodomain protein that controls neuronal identity in Drosophila."
    Chu-Lagraff Q., Wright D.M., McNeil L.K., Doe C.Q.
    Development Suppl. 2:79-85(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 201-1703 (ISOFORM F), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    Tissue: Embryo.
  5. "Cloning of the Drosophila prospero gene and its expression in ganglion mother cells."
    Matsuzaki F., Koizumi K., Hama C., Yoshioka T., Nabeshima Y.
    Biochem. Biophys. Res. Commun. 182:1326-1332(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 201-1703 (ISOFORM F), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Canton-S.
  6. Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 205-1703 (ISOFORM G).
    Strain: Berkeley.
  7. "Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the Drosophila eye."
    Xu C., Kauffmann R.C., Zhang J., Kladny S., Carthew R.W.
    Cell 103:87-97(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 301-1703, FUNCTION.
  8. "A Drosophila full-length cDNA resource."
    Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
    Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1061-1703 (ISOFORM E).
    Strain: Berkeley.
    Tissue: Head.
  9. "A Caenorhabditis elegans prospero homologue defines a novel domain."
    Buerglin T.R.
    Trends Biochem. Sci. 19:70-71(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SIMILARITY TO C.ELEGANS CEH-26.
  10. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-479; SER-482; SER-485; SER-497; SER-651 AND SER-654, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiPROS_DROME
AccessioniPrimary (citable) accession number: P29617
Secondary accession number(s): Q6AWI5
, Q95SP0, Q9U6A2, Q9VGP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: March 24, 2009
Last modified: June 8, 2016
This is version 162 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.