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Protein

Lysozyme P

Gene

LysP

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food.2 Publications

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51PROSITE-ProRule annotation1
Active sitei69PROSITE-ProRule annotation1

GO - Molecular functioni

  • lysozyme activity Source: FlyBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-DME-5653890. Lactose synthesis.
R-DME-6798695. Neutrophil degranulation.
R-DME-6803157. Antimicrobial peptides.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme P (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase P
Gene namesi
Name:LysP
ORF Names:CG9116
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0004429. LysP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001851419 – 141Lysozyme PAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 140PROSITE-ProRule annotation
Disulfide bondi46 ↔ 130PROSITE-ProRule annotation
Disulfide bondi81 ↔ 97PROSITE-ProRule annotation
Disulfide bondi93 ↔ 111PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP29615.
PRIDEiP29615.

Expressioni

Tissue specificityi

Salivary gland.2 Publications

Developmental stagei

Only expressed in adults.2 Publications

Gene expression databases

BgeeiFBgn0004429.
GenevisibleiP29615. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0072529.

Structurei

3D structure databases

ProteinModelPortaliP29615.
SMRiP29615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXGD. Eukaryota.
ENOG4111QHM. LUCA.
GeneTreeiENSGT00550000074398.
InParanoidiP29615.
KOiK13915.
OMAiELMENNI.
OrthoDBiEOG091G0R9V.
PhylomeDBiP29615.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAFLVICAL TLTAVATQAR TMDRCSLARE MSKLGVPRDQ LAKWTCIAQH
60 70 80 90 100
ESSFRTGVVG PANSNGSNDY GIFQINNKYW CKPADGRFSY NECGLSCNAL
110 120 130 140
LTDDITNSVK CARKIQRQQG WTAWSTWKYC SGSLPSINSC F
Length:141
Mass (Da):15,648
Last modified:April 1, 1993 - v1
Checksum:i4D7C51B018FD5417
GO

Sequence cautioni

The sequence ABK57077 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58383 Genomic DNA. Translation: CAA41273.1.
AE014296 Genomic DNA. Translation: AAF47452.1.
BT023249 mRNA. Translation: AAY55665.1.
BT029420 mRNA. Translation: ABK57077.1. Different initiation.
PIRiS20915.
RefSeqiNP_476828.1. NM_057480.5.
UniGeneiDm.24595.

Genome annotation databases

EnsemblMetazoaiFBtr0072633; FBpp0072529; FBgn0004429.
GeneIDi38129.
KEGGidme:Dmel_CG9116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58383 Genomic DNA. Translation: CAA41273.1.
AE014296 Genomic DNA. Translation: AAF47452.1.
BT023249 mRNA. Translation: AAY55665.1.
BT029420 mRNA. Translation: ABK57077.1. Different initiation.
PIRiS20915.
RefSeqiNP_476828.1. NM_057480.5.
UniGeneiDm.24595.

3D structure databases

ProteinModelPortaliP29615.
SMRiP29615.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0072529.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Proteomic databases

PaxDbiP29615.
PRIDEiP29615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0072633; FBpp0072529; FBgn0004429.
GeneIDi38129.
KEGGidme:Dmel_CG9116.

Organism-specific databases

CTDi38129.
FlyBaseiFBgn0004429. LysP.

Phylogenomic databases

eggNOGiENOG410IXGD. Eukaryota.
ENOG4111QHM. LUCA.
GeneTreeiENSGT00550000074398.
InParanoidiP29615.
KOiK13915.
OMAiELMENNI.
OrthoDBiEOG091G0R9V.
PhylomeDBiP29615.

Enzyme and pathway databases

ReactomeiR-DME-5653890. Lactose synthesis.
R-DME-6798695. Neutrophil degranulation.
R-DME-6803157. Antimicrobial peptides.

Miscellaneous databases

GenomeRNAii38129.
PROiP29615.

Gene expression databases

BgeeiFBgn0004429.
GenevisibleiP29615. DM.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYSP_DROME
AccessioniPrimary (citable) accession number: P29615
Secondary accession number(s): A0JQ50, Q4V3V7, Q9W0J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.