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Protein

Lysozyme P

Gene

LysP

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food.2 Publications

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei511
Active sitei691

GO - Molecular functioni

  • lysozyme activity Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-DME-6798695. Neutrophil degranulation.
R-DME-6803157. Antimicrobial peptides.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme P (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase P
Gene namesi
Name:LysP
ORF Names:CG9116
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0004429. LysP.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001851419 – 141Lysozyme PAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 140
Disulfide bondi46 ↔ 130
Disulfide bondi81 ↔ 97
Disulfide bondi93 ↔ 111

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP29615.
PRIDEiP29615.

Expressioni

Tissue specificityi

Salivary gland.2 Publications

Developmental stagei

Only expressed in adults.2 Publications

Gene expression databases

BgeeiFBgn0004429.
ExpressionAtlasiP29615. differential.
GenevisibleiP29615. DM.

Interactioni

Protein-protein interaction databases

IntActiP29615. 1 interactor.
STRINGi7227.FBpp0072529.

Structurei

3D structure databases

ProteinModelPortaliP29615.
SMRiP29615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXGD. Eukaryota.
ENOG4111QHM. LUCA.
GeneTreeiENSGT00550000074398.
InParanoidiP29615.
KOiK13915.
OMAiTENICHV.
OrthoDBiEOG091G0R9V.
PhylomeDBiP29615.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiView protein in InterPro
IPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom_sf.
PfamiView protein in Pfam
PF00062. Lys. 1 hit.
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiView protein in SMART
SM00263. LYZ1. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiView protein in PROSITE
PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAFLVICAL TLTAVATQAR TMDRCSLARE MSKLGVPRDQ LAKWTCIAQH
60 70 80 90 100
ESSFRTGVVG PANSNGSNDY GIFQINNKYW CKPADGRFSY NECGLSCNAL
110 120 130 140
LTDDITNSVK CARKIQRQQG WTAWSTWKYC SGSLPSINSC F
Length:141
Mass (Da):15,648
Last modified:April 1, 1993 - v1
Checksum:i4D7C51B018FD5417
GO

Sequence cautioni

The sequence ABK57077 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58383 Genomic DNA. Translation: CAA41273.1.
AE014296 Genomic DNA. Translation: AAF47452.1.
BT023249 mRNA. Translation: AAY55665.1.
BT029420 mRNA. Translation: ABK57077.1. Different initiation.
PIRiS20915.
RefSeqiNP_476828.1. NM_057480.5.
UniGeneiDm.24595.

Genome annotation databases

EnsemblMetazoaiFBtr0072633; FBpp0072529; FBgn0004429.
GeneIDi38129.
KEGGidme:Dmel_CG9116.

Similar proteinsi

Entry informationi

Entry nameiLYSP_DROME
AccessioniPrimary (citable) accession number: P29615
Secondary accession number(s): A0JQ50, Q4V3V7, Q9W0J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 22, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families