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Protein

Ferredoxin

Gene

fdxA

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

Cofactori

[4Fe-4S] cluster, [3Fe-4S] clusterNote: Binds 1 [4Fe-4S] cluster which readily converts to a stable [3Fe-4S] form.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi12 – 121Iron-sulfur (4Fe-4S)
Metal bindingi15 – 151Iron-sulfur (4Fe-4S)
Metal bindingi18 – 181Iron-sulfur (4Fe-4S)
Metal bindingi57 – 571Iron-sulfur (4Fe-4S)

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferredoxin
Gene namesi
Name:fdxA
Ordered Locus Names:PF1909
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi15 – 151D → C: No effect on the efficiency of electron transfer. 3 Publications
Mutagenesisi15 – 151D → S: The efficiency of electron transfer is compromised. 3 Publications
Mutagenesisi34 – 341A → C: The mixed spin cluster is converted into a homogeneous spin cluster (S=3/2). 2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 6766FerredoxinPRO_0000159199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 492 Publications

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP29603.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi186497.PF1909.

Structurei

Secondary structure

1
67
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 75Combined sources
Turni9 – 113Combined sources
Helixi17 – 215Combined sources
Turni23 – 253Combined sources
Beta strandi26 – 283Combined sources
Beta strandi34 – 374Combined sources
Helixi44 – 5613Combined sources
Beta strandi62 – 665Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SIZX-ray2.25A/C2-67[»]
1SJ1X-ray1.50A/B2-67[»]
2Z8QX-ray1.70A/B2-67[»]
3PNIX-ray2.80A/B2-67[»]
4DHVX-ray1.95A/B2-67[»]
ProteinModelPortaliP29603.
SMRiP29603. Positions 2-67.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29603.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 31294Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini36 – 67324Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiarCOG00349. Archaea.
COG1141. LUCA.
HOGENOMiHOG000044619.
KOiK05337.
OMAiDVFEMND.

Family and domain databases

InterProiIPR001080. 3Fe4S_ferredoxin.
IPR017896. 4Fe4S_Fe-S-bd.
[Graphical view]
PRINTSiPR00352. 3FE4SFRDOXIN.
PROSITEiPS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29603-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWKVSVDQD TCIGDAICAS LCPDVFEMND EGKAQPKVEV IEDEELYNCA
60
KEAMEACPVS AITIEEA
Length:67
Mass (Da):7,298
Last modified:January 23, 2007 - v2
Checksum:iAF9B062690B34420
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79502 Genomic DNA. Translation: CAA56040.1.
AE009950 Genomic DNA. Translation: AAL82033.1.
PIRiA44203.
RefSeqiWP_011013049.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL82033; AAL82033; PF1909.
GeneIDi1469789.
KEGGipfu:PF1909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79502 Genomic DNA. Translation: CAA56040.1.
AE009950 Genomic DNA. Translation: AAL82033.1.
PIRiA44203.
RefSeqiWP_011013049.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SIZX-ray2.25A/C2-67[»]
1SJ1X-ray1.50A/B2-67[»]
2Z8QX-ray1.70A/B2-67[»]
3PNIX-ray2.80A/B2-67[»]
4DHVX-ray1.95A/B2-67[»]
ProteinModelPortaliP29603.
SMRiP29603. Positions 2-67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF1909.

Proteomic databases

PRIDEiP29603.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL82033; AAL82033; PF1909.
GeneIDi1469789.
KEGGipfu:PF1909.

Phylogenomic databases

eggNOGiarCOG00349. Archaea.
COG1141. LUCA.
HOGENOMiHOG000044619.
KOiK05337.
OMAiDVFEMND.

Miscellaneous databases

EvolutionaryTraceiP29603.

Family and domain databases

InterProiIPR001080. 3Fe4S_ferredoxin.
IPR017896. 4Fe4S_Fe-S-bd.
[Graphical view]
PRINTSiPR00352. 3FE4SFRDOXIN.
PROSITEiPS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFER_PYRFU
AccessioniPrimary (citable) accession number: P29603
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.