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Protein

Non-receptor tyrosine-protein kinase TYK2

Gene

TYK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei930ATPPROSITE-ProRule annotation1
Active sitei1023Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi903 – 911ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • growth hormone receptor binding Source: BHF-UCL
  • non-membrane spanning protein tyrosine kinase activity Source: ProtInc
  • protein tyrosine kinase activity Source: Reactome

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS02731-MONOMER.
BRENDAi2.7.10.2. 2681.
ReactomeiR-HSA-1059683. Interleukin-6 signaling.
R-HSA-110056. MAPK3 (ERK1) activation.
R-HSA-112411. MAPK1 (ERK2) activation.
R-HSA-6788467. IL-6-type cytokine receptor ligand interactions.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-912694. Regulation of IFNA signaling.
SignaLinkiP29597.
SIGNORiP29597.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-receptor tyrosine-protein kinase TYK2 (EC:2.7.10.2)
Gene namesi
Name:TYK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12440. TYK2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • cytoskeleton Source: InterPro
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
  • nucleus Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency 35 (IMD35)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
See also OMIM:611521

Organism-specific databases

DisGeNETi7297.
MalaCardsiTYK2.
MIMi611521. phenotype.
OpenTargetsiENSG00000105397.
Orphaneti331226. Autosomal recessive hyper-IgE syndrome due to TYK2 deficiency.
85408. Juvenile rheumatoid factor-negative polyarthritis.
85410. Oligoarticular juvenile arthritis.
PharmGKBiPA37094.

Chemistry databases

ChEMBLiCHEMBL3553.
GuidetoPHARMACOLOGYi2269.

Polymorphism and mutation databases

BioMutaiTYK2.
DMDMi56405328.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000881771 – 1187Non-receptor tyrosine-protein kinase TYK2Add BLAST1187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei292PhosphotyrosineCombined sources1
Modified residuei499PhosphoserineCombined sources1
Modified residuei525PhosphoserineBy similarity1
Modified residuei604PhosphotyrosineBy similarity1
Modified residuei884PhosphoserineCombined sources1
Modified residuei1054Phosphotyrosine; by autocatalysis1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP29597.
MaxQBiP29597.
PaxDbiP29597.
PeptideAtlasiP29597.
PRIDEiP29597.

PTM databases

iPTMnetiP29597.
PhosphoSitePlusiP29597.

Expressioni

Tissue specificityi

Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.1 Publication

Gene expression databases

BgeeiENSG00000105397.
CleanExiHS_TYK2.
ExpressionAtlasiP29597. baseline and differential.
GenevisibleiP29597. HS.

Organism-specific databases

HPAiHPA005157.

Interactioni

Subunit structurei

Interacts with JAKMIP1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL3Q136435EBI-1383454,EBI-741101
HNRPKQ6IBN13EBI-1383454,EBI-3440248
HSP90AB1P082382EBI-1383454,EBI-352572
KHDRBS2Q5VWX16EBI-1383454,EBI-742808
KRT40Q6A1623EBI-1383454,EBI-10171697
TRAF4Q9BUZ43EBI-1383454,EBI-3650647

GO - Molecular functioni

  • growth hormone receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi113148. 91 interactors.
DIPiDIP-1062N.
IntActiP29597. 42 interactors.
MINTiMINT-107878.
STRINGi9606.ENSP00000264818.

Chemistry databases

BindingDBiP29597.

Structurei

Secondary structure

11187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 31Combined sources4
Beta strandi42 – 46Combined sources5
Beta strandi49 – 52Combined sources4
Helixi53 – 64Combined sources12
Helixi68 – 73Combined sources6
Beta strandi74 – 78Combined sources5
Turni79 – 82Combined sources4
Beta strandi83 – 85Combined sources3
Beta strandi90 – 92Combined sources3
Turni93 – 98Combined sources6
Beta strandi101 – 105Combined sources5
Turni110 – 113Combined sources4
Beta strandi122 – 124Combined sources3
Helixi146 – 161Combined sources16
Helixi167 – 169Combined sources3
Helixi173 – 198Combined sources26
Helixi202 – 208Combined sources7
Helixi211 – 213Combined sources3
Helixi217 – 225Combined sources9
Helixi228 – 243Combined sources16
Helixi252 – 266Combined sources15
Turni268 – 271Combined sources4
Beta strandi273 – 284Combined sources12
Helixi285 – 287Combined sources3
Beta strandi314 – 319Combined sources6
Turni320 – 322Combined sources3
Beta strandi323 – 328Combined sources6
Beta strandi375 – 378Combined sources4
Helixi380 – 382Combined sources3
Beta strandi383 – 389Combined sources7
Beta strandi392 – 397Combined sources6
Beta strandi400 – 406Combined sources7
Helixi410 – 427Combined sources18
Helixi436 – 438Combined sources3
Helixi441 – 449Combined sources9
Helixi457 – 464Combined sources8
Beta strandi470 – 475Combined sources6
Beta strandi483 – 492Combined sources10
Beta strandi498 – 508Combined sources11
Beta strandi514 – 516Combined sources3
Beta strandi523 – 525Combined sources3
Helixi526 – 533Combined sources8
Beta strandi537 – 540Combined sources4
Beta strandi543 – 546Combined sources4
Beta strandi562 – 565Combined sources4
Helixi586 – 588Combined sources3
Beta strandi589 – 598Combined sources10
Beta strandi601 – 608Combined sources8
Beta strandi637 – 644Combined sources8
Helixi649 – 663Combined sources15
Beta strandi673 – 679Combined sources7
Beta strandi682 – 688Combined sources7
Helixi695 – 701Combined sources7
Turni702 – 704Combined sources3
Helixi708 – 727Combined sources20
Helixi737 – 739Combined sources3
Beta strandi740 – 744Combined sources5
Beta strandi754 – 757Combined sources4
Helixi764 – 766Combined sources3
Helixi769 – 774Combined sources6
Turni775 – 778Combined sources4
Helixi781 – 783Combined sources3
Helixi795 – 808Combined sources14
Turni809 – 811Combined sources3
Turni814 – 817Combined sources4
Helixi820 – 828Combined sources9
Helixi839 – 841Combined sources3
Helixi842 – 848Combined sources7
Helixi853 – 855Combined sources3
Helixi859 – 867Combined sources9
Helixi894 – 896Combined sources3
Beta strandi897 – 905Combined sources9
Beta strandi907 – 916Combined sources10
Beta strandi920 – 922Combined sources3
Beta strandi925 – 932Combined sources8
Helixi938 – 953Combined sources16
Beta strandi962 – 968Combined sources7
Turni969 – 972Combined sources4
Beta strandi973 – 978Combined sources6
Helixi986 – 989Combined sources4
Helixi990 – 992Combined sources3
Helixi997 – 1016Combined sources20
Helixi1026 – 1028Combined sources3
Beta strandi1029 – 1031Combined sources3
Beta strandi1037 – 1039Combined sources3
Helixi1042 – 1044Combined sources3
Beta strandi1053 – 1056Combined sources4
Helixi1065 – 1067Combined sources3
Helixi1070 – 1075Combined sources6
Beta strandi1077 – 1079Combined sources3
Helixi1080 – 1095Combined sources16
Turni1096 – 1098Combined sources3
Helixi1100 – 1102Combined sources3
Helixi1104 – 1112Combined sources9
Helixi1117 – 1129Combined sources13
Helixi1142 – 1151Combined sources10
Helixi1156 – 1158Combined sources3
Helixi1162 – 1177Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LXNX-ray2.50A888-1182[»]
3LXPX-ray1.65A888-1182[»]
3NYXX-ray2.50A885-1176[»]
3NZ0X-ray2.00A885-1176[»]
3ZONX-ray2.15A541-873[»]
4GFOX-ray2.30A884-1176[»]
4GIHX-ray2.00A885-1176[»]
4GIIX-ray2.31A885-1176[»]
4GJ2X-ray2.40A885-1176[»]
4GJ3X-ray2.50A885-1176[»]
4GVJX-ray2.03A885-1176[»]
4OLIX-ray2.80A566-1187[»]
4PO6X-ray1.99A23-583[»]
4PY1X-ray2.16A888-1182[»]
4WOVX-ray1.80A/B575-869[»]
5C01X-ray2.15A/B556-871[»]
5C03X-ray1.90A/B556-871[»]
5F1ZX-ray2.65A884-1176[»]
5F20X-ray2.91A884-1176[»]
ProteinModelPortaliP29597.
SMRiP29597.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29597.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 431FERMPROSITE-ProRule annotationAdd BLAST406
Domaini450 – 529SH2; atypicalAdd BLAST80
Domaini589 – 875Protein kinase 1PROSITE-ProRule annotationAdd BLAST287
Domaini897 – 1176Protein kinase 2PROSITE-ProRule annotationAdd BLAST280

Domaini

The FERM domain mediates interaction with JAKMIP1.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.PROSITE-ProRule annotation
Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 2 protein kinase domains.PROSITE-ProRule annotation
Contains 1 SH2 domain.Curated

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118799.
HOGENOMiHOG000049158.
HOVERGENiHBG006195.
InParanoidiP29597.
KOiK11219.
OMAiFCDFQDI.
OrthoDBiEOG091G01IS.
PhylomeDBiP29597.
TreeFamiTF327041.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045. Tyr_kinase_non-rcpt_TYK2_N.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR00109. TYRKINASE.
PR01827. YKINASETYK2.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLRHWGMAR GSKPVGDGAQ PMAAMGGLKV LLHWAGPGGG EPWVTFSESS
60 70 80 90 100
LTAEEVCIHI AHKVGITPPC FNLFALFDAQ AQVWLPPNHI LEIPRDASLM
110 120 130 140 150
LYFRIRFYFR NWHGMNPREP AVYRCGPPGT EASSDQTAQG MQLLDPASFE
160 170 180 190 200
YLFEQGKHEF VNDVASLWEL STEEEIHHFK NESLGMAFLH LCHLALRHGI
210 220 230 240 250
PLEEVAKKTS FKDCIPRSFR RHIRQHSALT RLRLRNVFRR FLRDFQPGRL
260 270 280 290 300
SQQMVMVKYL ATLERLAPRF GTERVPVCHL RLLAQAEGEP CYIRDSGVAP
310 320 330 340 350
TDPGPESAAG PPTHEVLVTG TGGIQWWPVE EEVNKEEGSS GSSGRNPQAS
360 370 380 390 400
LFGKKAKAHK AVGQPADRPR EPLWAYFCDF RDITHVVLKE HCVSIHRQDN
410 420 430 440 450
KCLELSLPSR AAALSFVSLV DGYFRLTADS SHYLCHEVAP PRLVMSIRDG
460 470 480 490 500
IHGPLLEPFV QAKLRPEDGL YLIHWSTSHP YRLILTVAQR SQAPDGMQSL
510 520 530 540 550
RLRKFPIEQQ DGAFVLEGWG RSFPSVRELG AALQGCLLRA GDDCFSLRRC
560 570 580 590 600
CLPQPGETSN LIIMRGARAS PRTLNLSQLS FHRVDQKEIT QLSHLGQGTR
610 620 630 640 650
TNVYEGRLRV EGSGDPEEGK MDDEDPLVPG RDRGQELRVV LKVLDPSHHD
660 670 680 690 700
IALAFYETAS LMSQVSHTHL AFVHGVCVRG PENIMVTEYV EHGPLDVWLR
710 720 730 740 750
RERGHVPMAW KMVVAQQLAS ALSYLENKNL VHGNVCGRNI LLARLGLAEG
760 770 780 790 800
TSPFIKLSDP GVGLGALSRE ERVERIPWLA PECLPGGANS LSTAMDKWGF
810 820 830 840 850
GATLLEICFD GEAPLQSRSP SEKEHFYQRQ HRLPEPSCPQ LATLTSQCLT
860 870 880 890 900
YEPTQRPSFR TILRDLTRLQ PHNLADVLTV NPDSPASDPT VFHKRYLKKI
910 920 930 940 950
RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK ALKADCGPQH RSGWKQEIDI
960 970 980 990 1000
LRTLYHEHII KYKGCCEDQG EKSLQLVMEY VPLGSLRDYL PRHSIGLAQL
1010 1020 1030 1040 1050
LLFAQQICEG MAYLHAQHYI HRDLAARNVL LDNDRLVKIG DFGLAKAVPE
1060 1070 1080 1090 1100
GHEYYRVRED GDSPVFWYAP ECLKEYKFYY ASDVWSFGVT LYELLTHCDS
1110 1120 1130 1140 1150
SQSPPTKFLE LIGIAQGQMT VLRLTELLER GERLPRPDKC PCEVYHLMKN
1160 1170 1180
CWETEASFRP TFENLIPILK TVHEKYQGQA PSVFSVC
Length:1,187
Mass (Da):133,650
Last modified:December 7, 2004 - v3
Checksum:iF76C25D6A919EDBC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti869L → V in CAA38449 (PubMed:2216457).Curated1
Sequence conflicti882P → R in CAA38449 (PubMed:2216457).Curated1
Sequence conflicti887 – 888SD → VG in CAA38449 (PubMed:2216457).Curated2
Sequence conflicti891V → T in CAA38449 (PubMed:2216457).Curated1
Sequence conflicti1016A → S in AAH14243 (PubMed:15489334).Curated1
Sequence conflicti1017 – 1018QH → HD in CAA38449 (PubMed:2216457).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0377964R → C.Corresponds to variant rs35163004dbSNPEnsembl.1
Natural variantiVAR_0205974R → H.1 PublicationCorresponds to variant rs12720343dbSNPEnsembl.1
Natural variantiVAR_03779781A → V.Corresponds to variant rs1049619dbSNPEnsembl.1
Natural variantiVAR_020598197R → H.1 PublicationCorresponds to variant rs12720263dbSNPEnsembl.1
Natural variantiVAR_020599362V → F.3 PublicationsCorresponds to variant rs2304256dbSNPEnsembl.1
Natural variantiVAR_020600363G → S.2 PublicationsCorresponds to variant rs2304255dbSNPEnsembl.1
Natural variantiVAR_041870386V → M.1 PublicationCorresponds to variant rs55956017dbSNPEnsembl.1
Natural variantiVAR_037798442R → Q.Corresponds to variant rs2304254dbSNPEnsembl.1
Natural variantiVAR_020286684I → S.3 PublicationsCorresponds to variant rs12720356dbSNPEnsembl.1
Natural variantiVAR_041871703R → W.1 PublicationCorresponds to variant rs55882956dbSNPEnsembl.1
Natural variantiVAR_041872732H → R in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_037799820P → H.Corresponds to variant rs34046749dbSNPEnsembl.1
Natural variantiVAR_041873928A → V.1 PublicationCorresponds to variant rs35018800dbSNPEnsembl.1
Natural variantiVAR_0418741104P → A.1 PublicationCorresponds to variant rs34536443dbSNPEnsembl.1
Natural variantiVAR_0418751163E → G.1 PublicationCorresponds to variant rs55886939dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54637 mRNA. Translation: CAA38449.1.
AY549314 Genomic DNA. Translation: AAS37680.1.
BC014243 mRNA. Translation: AAH14243.1.
CCDSiCCDS12236.1.
PIRiS12127. TVHUY2.
RefSeqiNP_003322.3. NM_003331.4.
XP_011526547.1. XM_011528245.1.
UniGeneiHs.75516.

Genome annotation databases

EnsembliENST00000264818; ENSP00000264818; ENSG00000105397.
ENST00000525621; ENSP00000431885; ENSG00000105397.
GeneIDi7297.
KEGGihsa:7297.
UCSCiuc002moc.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

TYK2base

TYK2 mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54637 mRNA. Translation: CAA38449.1.
AY549314 Genomic DNA. Translation: AAS37680.1.
BC014243 mRNA. Translation: AAH14243.1.
CCDSiCCDS12236.1.
PIRiS12127. TVHUY2.
RefSeqiNP_003322.3. NM_003331.4.
XP_011526547.1. XM_011528245.1.
UniGeneiHs.75516.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LXNX-ray2.50A888-1182[»]
3LXPX-ray1.65A888-1182[»]
3NYXX-ray2.50A885-1176[»]
3NZ0X-ray2.00A885-1176[»]
3ZONX-ray2.15A541-873[»]
4GFOX-ray2.30A884-1176[»]
4GIHX-ray2.00A885-1176[»]
4GIIX-ray2.31A885-1176[»]
4GJ2X-ray2.40A885-1176[»]
4GJ3X-ray2.50A885-1176[»]
4GVJX-ray2.03A885-1176[»]
4OLIX-ray2.80A566-1187[»]
4PO6X-ray1.99A23-583[»]
4PY1X-ray2.16A888-1182[»]
4WOVX-ray1.80A/B575-869[»]
5C01X-ray2.15A/B556-871[»]
5C03X-ray1.90A/B556-871[»]
5F1ZX-ray2.65A884-1176[»]
5F20X-ray2.91A884-1176[»]
ProteinModelPortaliP29597.
SMRiP29597.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113148. 91 interactors.
DIPiDIP-1062N.
IntActiP29597. 42 interactors.
MINTiMINT-107878.
STRINGi9606.ENSP00000264818.

Chemistry databases

BindingDBiP29597.
ChEMBLiCHEMBL3553.
GuidetoPHARMACOLOGYi2269.

PTM databases

iPTMnetiP29597.
PhosphoSitePlusiP29597.

Polymorphism and mutation databases

BioMutaiTYK2.
DMDMi56405328.

Proteomic databases

EPDiP29597.
MaxQBiP29597.
PaxDbiP29597.
PeptideAtlasiP29597.
PRIDEiP29597.

Protocols and materials databases

DNASUi7297.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264818; ENSP00000264818; ENSG00000105397.
ENST00000525621; ENSP00000431885; ENSG00000105397.
GeneIDi7297.
KEGGihsa:7297.
UCSCiuc002moc.5. human.

Organism-specific databases

CTDi7297.
DisGeNETi7297.
GeneCardsiTYK2.
H-InvDBHIX0202831.
HGNCiHGNC:12440. TYK2.
HPAiHPA005157.
MalaCardsiTYK2.
MIMi176941. gene.
611521. phenotype.
neXtProtiNX_P29597.
OpenTargetsiENSG00000105397.
Orphaneti331226. Autosomal recessive hyper-IgE syndrome due to TYK2 deficiency.
85408. Juvenile rheumatoid factor-negative polyarthritis.
85410. Oligoarticular juvenile arthritis.
PharmGKBiPA37094.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118799.
HOGENOMiHOG000049158.
HOVERGENiHBG006195.
InParanoidiP29597.
KOiK11219.
OMAiFCDFQDI.
OrthoDBiEOG091G01IS.
PhylomeDBiP29597.
TreeFamiTF327041.

Enzyme and pathway databases

BioCyciZFISH:HS02731-MONOMER.
BRENDAi2.7.10.2. 2681.
ReactomeiR-HSA-1059683. Interleukin-6 signaling.
R-HSA-110056. MAPK3 (ERK1) activation.
R-HSA-112411. MAPK1 (ERK2) activation.
R-HSA-6788467. IL-6-type cytokine receptor ligand interactions.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-912694. Regulation of IFNA signaling.
SignaLinkiP29597.
SIGNORiP29597.

Miscellaneous databases

ChiTaRSiTYK2. human.
EvolutionaryTraceiP29597.
GeneWikiiTyrosine_kinase_2.
GenomeRNAii7297.
PROiP29597.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105397.
CleanExiHS_TYK2.
ExpressionAtlasiP29597. baseline and differential.
GenevisibleiP29597. HS.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045. Tyr_kinase_non-rcpt_TYK2_N.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR00109. TYRKINASE.
PR01827. YKINASETYK2.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTYK2_HUMAN
AccessioniPrimary (citable) accession number: P29597
Secondary accession number(s): Q6QB10, Q96CH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: December 7, 2004
Last modified: November 30, 2016
This is version 185 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.