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P29597

- TYK2_HUMAN

UniProt

P29597 - TYK2_HUMAN

Protein

Non-receptor tyrosine-protein kinase TYK2

Gene

TYK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 160 (01 Oct 2014)
      Sequence version 3 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.1 Publication

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei930 – 9301ATPPROSITE-ProRule annotation
    Active sitei1023 – 10231Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi903 – 9119ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. growth hormone receptor binding Source: BHF-UCL
    3. non-membrane spanning protein tyrosine kinase activity Source: ProtInc
    4. protein binding Source: IntAct
    5. protein tyrosine kinase activity Source: Reactome

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: Reactome
    2. intracellular signal transduction Source: InterPro
    3. peptidyl-tyrosine phosphorylation Source: GOC
    4. protein phosphorylation Source: ProtInc
    5. regulation of type I interferon-mediated signaling pathway Source: Reactome
    6. type I interferon signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 2681.
    ReactomeiREACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.
    REACT_27307. Interleukin-6 signaling.
    SignaLinkiP29597.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-receptor tyrosine-protein kinase TYK2 (EC:2.7.10.2)
    Gene namesi
    Name:TYK2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:12440. TYK2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. cytoskeleton Source: InterPro
    3. cytosol Source: Reactome
    4. extracellular vesicular exosome Source: UniProt
    5. membrane Source: InterPro
    6. nucleus Source: BHF-UCL

    Pathology & Biotechi

    Involvement in diseasei

    Protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]: Consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi611521. phenotype.
    Orphaneti331226. Autosomal recessive hyper-IgE syndrome due to TYK2 deficiency.
    85408. Juvenile rheumatoid factor-negative polyarthritis.
    85410. Oligoarticular juvenile arthritis.
    PharmGKBiPA37094.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11871187Non-receptor tyrosine-protein kinase TYK2PRO_0000088177Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei292 – 2921Phosphotyrosine2 Publications
    Modified residuei604 – 6041PhosphotyrosineBy similarity
    Modified residuei884 – 8841Phosphoserine2 Publications
    Modified residuei1054 – 10541Phosphotyrosine; by autocatalysis1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP29597.
    PaxDbiP29597.
    PRIDEiP29597.

    PTM databases

    PhosphoSiteiP29597.

    Expressioni

    Tissue specificityi

    Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.1 Publication

    Gene expression databases

    ArrayExpressiP29597.
    BgeeiP29597.
    CleanExiHS_TYK2.
    GenevestigatoriP29597.

    Organism-specific databases

    HPAiHPA005157.

    Interactioni

    Subunit structurei

    Interacts with JAKMIP1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HSP90AB1P082382EBI-1383454,EBI-352572

    Protein-protein interaction databases

    BioGridi113148. 32 interactions.
    DIPiDIP-1062N.
    IntActiP29597. 11 interactions.
    MINTiMINT-107878.
    STRINGi9606.ENSP00000264818.

    Structurei

    Secondary structure

    1
    1187
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi28 – 314
    Beta strandi42 – 465
    Beta strandi49 – 524
    Helixi53 – 6412
    Helixi68 – 736
    Beta strandi74 – 785
    Turni79 – 824
    Beta strandi83 – 853
    Beta strandi90 – 923
    Turni93 – 986
    Beta strandi101 – 1055
    Turni110 – 1134
    Beta strandi122 – 1243
    Helixi146 – 16116
    Helixi167 – 1693
    Helixi173 – 19826
    Helixi202 – 2087
    Helixi211 – 2133
    Helixi217 – 2259
    Helixi228 – 24316
    Helixi252 – 26615
    Turni268 – 2714
    Beta strandi273 – 28412
    Helixi285 – 2873
    Beta strandi314 – 3196
    Turni320 – 3223
    Beta strandi323 – 3286
    Beta strandi375 – 3784
    Helixi380 – 3823
    Beta strandi383 – 3897
    Beta strandi392 – 3976
    Beta strandi400 – 4067
    Helixi410 – 42718
    Helixi436 – 4383
    Helixi441 – 4499
    Helixi457 – 4648
    Beta strandi470 – 4756
    Beta strandi483 – 49210
    Beta strandi498 – 50811
    Beta strandi514 – 5163
    Beta strandi523 – 5253
    Helixi526 – 5338
    Beta strandi537 – 5404
    Beta strandi543 – 5464
    Beta strandi562 – 5654
    Helixi586 – 5883
    Beta strandi589 – 59810
    Beta strandi601 – 6088
    Beta strandi637 – 6448
    Helixi649 – 66214
    Beta strandi673 – 6797
    Beta strandi682 – 6887
    Helixi695 – 7017
    Turni702 – 7043
    Helixi708 – 72720
    Helixi737 – 7393
    Beta strandi740 – 7445
    Beta strandi754 – 7574
    Helixi764 – 7663
    Helixi769 – 7746
    Turni775 – 7784
    Helixi781 – 7833
    Helixi795 – 80814
    Turni809 – 8113
    Turni814 – 8174
    Helixi820 – 8289
    Helixi842 – 8487
    Helixi853 – 8553
    Helixi859 – 8679
    Helixi894 – 8963
    Beta strandi897 – 9059
    Beta strandi907 – 91610
    Beta strandi920 – 9223
    Beta strandi925 – 9328
    Helixi938 – 95316
    Beta strandi962 – 9687
    Turni969 – 9724
    Beta strandi973 – 9786
    Helixi986 – 9894
    Helixi990 – 9923
    Helixi997 – 101620
    Helixi1026 – 10283
    Beta strandi1029 – 10313
    Beta strandi1037 – 10393
    Helixi1042 – 10443
    Beta strandi1053 – 10564
    Helixi1065 – 10673
    Helixi1070 – 10756
    Beta strandi1077 – 10793
    Helixi1080 – 109516
    Turni1096 – 10983
    Helixi1100 – 11023
    Helixi1104 – 11129
    Helixi1117 – 112913
    Helixi1142 – 115110
    Helixi1156 – 11583
    Helixi1162 – 117716

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3LXNX-ray2.50A888-1182[»]
    3LXPX-ray1.65A888-1182[»]
    3NYXX-ray2.50A885-1176[»]
    3NZ0X-ray2.00A885-1176[»]
    3ZONX-ray2.15A541-873[»]
    4GFOX-ray2.30A884-1176[»]
    4GIHX-ray2.00A885-1176[»]
    4GIIX-ray2.31A885-1176[»]
    4GJ2X-ray2.40A885-1176[»]
    4GJ3X-ray2.50A885-1176[»]
    4GVJX-ray2.03A885-1176[»]
    4OLIX-ray2.80A566-1187[»]
    4PO6X-ray1.99A23-583[»]
    ProteinModelPortaliP29597.
    SMRiP29597. Positions 26-566, 577-870, 890-1177.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP29597.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 431406FERMPROSITE-ProRule annotationAdd
    BLAST
    Domaini450 – 52980SH2; atypicalAdd
    BLAST
    Domaini589 – 875287Protein kinase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini897 – 1176280Protein kinase 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The FERM domain mediates interaction with JAKMIP1.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.PROSITE-ProRule annotation
    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 2 protein kinase domains.PROSITE-ProRule annotation
    Contains 1 SH2 domain.Curated

    Keywords - Domaini

    Repeat, SH2 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000049158.
    HOVERGENiHBG006195.
    InParanoidiP29597.
    KOiK11219.
    OMAiFCDFQDI.
    PhylomeDBiP29597.
    TreeFamiTF327041.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR019748. FERM_central.
    IPR000299. FERM_domain.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
    IPR016045. Tyr_kinase_non-rcpt_TYK2_N.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
    PRINTSiPR01823. JANUSKINASE.
    PR00109. TYRKINASE.
    PR01827. YKINASETYK2.
    SMARTiSM00295. B41. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 2 hits.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF55550. SSF55550. 2 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEiPS50057. FERM_3. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 2 hits.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29597-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLRHWGMAR GSKPVGDGAQ PMAAMGGLKV LLHWAGPGGG EPWVTFSESS     50
    LTAEEVCIHI AHKVGITPPC FNLFALFDAQ AQVWLPPNHI LEIPRDASLM 100
    LYFRIRFYFR NWHGMNPREP AVYRCGPPGT EASSDQTAQG MQLLDPASFE 150
    YLFEQGKHEF VNDVASLWEL STEEEIHHFK NESLGMAFLH LCHLALRHGI 200
    PLEEVAKKTS FKDCIPRSFR RHIRQHSALT RLRLRNVFRR FLRDFQPGRL 250
    SQQMVMVKYL ATLERLAPRF GTERVPVCHL RLLAQAEGEP CYIRDSGVAP 300
    TDPGPESAAG PPTHEVLVTG TGGIQWWPVE EEVNKEEGSS GSSGRNPQAS 350
    LFGKKAKAHK AVGQPADRPR EPLWAYFCDF RDITHVVLKE HCVSIHRQDN 400
    KCLELSLPSR AAALSFVSLV DGYFRLTADS SHYLCHEVAP PRLVMSIRDG 450
    IHGPLLEPFV QAKLRPEDGL YLIHWSTSHP YRLILTVAQR SQAPDGMQSL 500
    RLRKFPIEQQ DGAFVLEGWG RSFPSVRELG AALQGCLLRA GDDCFSLRRC 550
    CLPQPGETSN LIIMRGARAS PRTLNLSQLS FHRVDQKEIT QLSHLGQGTR 600
    TNVYEGRLRV EGSGDPEEGK MDDEDPLVPG RDRGQELRVV LKVLDPSHHD 650
    IALAFYETAS LMSQVSHTHL AFVHGVCVRG PENIMVTEYV EHGPLDVWLR 700
    RERGHVPMAW KMVVAQQLAS ALSYLENKNL VHGNVCGRNI LLARLGLAEG 750
    TSPFIKLSDP GVGLGALSRE ERVERIPWLA PECLPGGANS LSTAMDKWGF 800
    GATLLEICFD GEAPLQSRSP SEKEHFYQRQ HRLPEPSCPQ LATLTSQCLT 850
    YEPTQRPSFR TILRDLTRLQ PHNLADVLTV NPDSPASDPT VFHKRYLKKI 900
    RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK ALKADCGPQH RSGWKQEIDI 950
    LRTLYHEHII KYKGCCEDQG EKSLQLVMEY VPLGSLRDYL PRHSIGLAQL 1000
    LLFAQQICEG MAYLHAQHYI HRDLAARNVL LDNDRLVKIG DFGLAKAVPE 1050
    GHEYYRVRED GDSPVFWYAP ECLKEYKFYY ASDVWSFGVT LYELLTHCDS 1100
    SQSPPTKFLE LIGIAQGQMT VLRLTELLER GERLPRPDKC PCEVYHLMKN 1150
    CWETEASFRP TFENLIPILK TVHEKYQGQA PSVFSVC 1187
    Length:1,187
    Mass (Da):133,650
    Last modified:December 7, 2004 - v3
    Checksum:iF76C25D6A919EDBC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti869 – 8691L → V in CAA38449. (PubMed:2216457)Curated
    Sequence conflicti882 – 8821P → R in CAA38449. (PubMed:2216457)Curated
    Sequence conflicti887 – 8882SD → VG in CAA38449. (PubMed:2216457)Curated
    Sequence conflicti891 – 8911V → T in CAA38449. (PubMed:2216457)Curated
    Sequence conflicti1016 – 10161A → S in AAH14243. (PubMed:15489334)Curated
    Sequence conflicti1017 – 10182QH → HD in CAA38449. (PubMed:2216457)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41R → C.
    Corresponds to variant rs35163004 [ dbSNP | Ensembl ].
    VAR_037796
    Natural varianti4 – 41R → H.1 Publication
    Corresponds to variant rs12720343 [ dbSNP | Ensembl ].
    VAR_020597
    Natural varianti81 – 811A → V.
    Corresponds to variant rs1049619 [ dbSNP | Ensembl ].
    VAR_037797
    Natural varianti197 – 1971R → H.1 Publication
    Corresponds to variant rs12720263 [ dbSNP | Ensembl ].
    VAR_020598
    Natural varianti362 – 3621V → F.3 Publications
    Corresponds to variant rs2304256 [ dbSNP | Ensembl ].
    VAR_020599
    Natural varianti363 – 3631G → S.2 Publications
    Corresponds to variant rs2304255 [ dbSNP | Ensembl ].
    VAR_020600
    Natural varianti386 – 3861V → M.1 Publication
    Corresponds to variant rs55956017 [ dbSNP | Ensembl ].
    VAR_041870
    Natural varianti442 – 4421R → Q.
    Corresponds to variant rs2304254 [ dbSNP | Ensembl ].
    VAR_037798
    Natural varianti684 – 6841I → S.3 Publications
    Corresponds to variant rs12720356 [ dbSNP | Ensembl ].
    VAR_020286
    Natural varianti703 – 7031R → W.1 Publication
    Corresponds to variant rs55882956 [ dbSNP | Ensembl ].
    VAR_041871
    Natural varianti732 – 7321H → R in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_041872
    Natural varianti820 – 8201P → H.
    Corresponds to variant rs34046749 [ dbSNP | Ensembl ].
    VAR_037799
    Natural varianti928 – 9281A → V.1 Publication
    Corresponds to variant rs35018800 [ dbSNP | Ensembl ].
    VAR_041873
    Natural varianti1104 – 11041P → A.1 Publication
    Corresponds to variant rs34536443 [ dbSNP | Ensembl ].
    VAR_041874
    Natural varianti1163 – 11631E → G.1 Publication
    Corresponds to variant rs55886939 [ dbSNP | Ensembl ].
    VAR_041875

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54637 mRNA. Translation: CAA38449.1.
    AY549314 Genomic DNA. Translation: AAS37680.1.
    BC014243 mRNA. Translation: AAH14243.1.
    CCDSiCCDS12236.1.
    PIRiS12127. TVHUY2.
    RefSeqiNP_003322.3. NM_003331.4.
    UniGeneiHs.75516.

    Genome annotation databases

    EnsembliENST00000264818; ENSP00000264818; ENSG00000105397.
    ENST00000525621; ENSP00000431885; ENSG00000105397.
    GeneIDi7297.
    KEGGihsa:7297.
    UCSCiuc002moc.4. human.

    Polymorphism databases

    DMDMi56405328.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    TYK2base

    TYK2 mutation db

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54637 mRNA. Translation: CAA38449.1 .
    AY549314 Genomic DNA. Translation: AAS37680.1 .
    BC014243 mRNA. Translation: AAH14243.1 .
    CCDSi CCDS12236.1.
    PIRi S12127. TVHUY2.
    RefSeqi NP_003322.3. NM_003331.4.
    UniGenei Hs.75516.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3LXN X-ray 2.50 A 888-1182 [» ]
    3LXP X-ray 1.65 A 888-1182 [» ]
    3NYX X-ray 2.50 A 885-1176 [» ]
    3NZ0 X-ray 2.00 A 885-1176 [» ]
    3ZON X-ray 2.15 A 541-873 [» ]
    4GFO X-ray 2.30 A 884-1176 [» ]
    4GIH X-ray 2.00 A 885-1176 [» ]
    4GII X-ray 2.31 A 885-1176 [» ]
    4GJ2 X-ray 2.40 A 885-1176 [» ]
    4GJ3 X-ray 2.50 A 885-1176 [» ]
    4GVJ X-ray 2.03 A 885-1176 [» ]
    4OLI X-ray 2.80 A 566-1187 [» ]
    4PO6 X-ray 1.99 A 23-583 [» ]
    ProteinModelPortali P29597.
    SMRi P29597. Positions 26-566, 577-870, 890-1177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113148. 32 interactions.
    DIPi DIP-1062N.
    IntActi P29597. 11 interactions.
    MINTi MINT-107878.
    STRINGi 9606.ENSP00000264818.

    Chemistry

    BindingDBi P29597.
    ChEMBLi CHEMBL2363062.
    GuidetoPHARMACOLOGYi 2269.

    PTM databases

    PhosphoSitei P29597.

    Polymorphism databases

    DMDMi 56405328.

    Proteomic databases

    MaxQBi P29597.
    PaxDbi P29597.
    PRIDEi P29597.

    Protocols and materials databases

    DNASUi 7297.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264818 ; ENSP00000264818 ; ENSG00000105397 .
    ENST00000525621 ; ENSP00000431885 ; ENSG00000105397 .
    GeneIDi 7297.
    KEGGi hsa:7297.
    UCSCi uc002moc.4. human.

    Organism-specific databases

    CTDi 7297.
    GeneCardsi GC19M010461.
    H-InvDB HIX0202831.
    HGNCi HGNC:12440. TYK2.
    HPAi HPA005157.
    MIMi 176941. gene.
    611521. phenotype.
    neXtProti NX_P29597.
    Orphaneti 331226. Autosomal recessive hyper-IgE syndrome due to TYK2 deficiency.
    85408. Juvenile rheumatoid factor-negative polyarthritis.
    85410. Oligoarticular juvenile arthritis.
    PharmGKBi PA37094.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000049158.
    HOVERGENi HBG006195.
    InParanoidi P29597.
    KOi K11219.
    OMAi FCDFQDI.
    PhylomeDBi P29597.
    TreeFami TF327041.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 2681.
    Reactomei REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.
    REACT_27307. Interleukin-6 signaling.
    SignaLinki P29597.

    Miscellaneous databases

    ChiTaRSi TYK2. human.
    EvolutionaryTracei P29597.
    GeneWikii Tyrosine_kinase_2.
    GenomeRNAii 7297.
    NextBioi 28539.
    PROi P29597.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P29597.
    Bgeei P29597.
    CleanExi HS_TYK2.
    Genevestigatori P29597.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR019748. FERM_central.
    IPR000299. FERM_domain.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
    IPR016045. Tyr_kinase_non-rcpt_TYK2_N.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000636. TyrPK_Jak. 1 hit.
    PRINTSi PR01823. JANUSKINASE.
    PR00109. TYRKINASE.
    PR01827. YKINASETYK2.
    SMARTi SM00295. B41. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF55550. SSF55550. 2 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEi PS50057. FERM_3. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 2 hits.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "TYK2, prototype of a novel class of non-receptor tyrosine kinase genes."
      Firmbach-Kraft I., Byers M., Shows T., Dalla-Favera R., Krolewski J.J.
      Oncogene 5:1329-1336(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PHE-362 AND SER-684.
    2. SeattleSNPs variation discovery resource
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-4; HIS-197; PHE-362; SER-363 AND SER-684.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    4. "A protein tyrosine kinase in the interferon alpha/beta signaling pathway."
      Velazquez L., Fellous M., Stark G.R., Pellegrini S.
      Cell 70:313-322(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 289-1187.
    5. "Identification and chromosomal mapping of new human tyrosine kinase genes."
      Krolewski J.J., Lee R., Eddy R., Shows T.B., Dalla-Favera R.
      Oncogene 5:277-282(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1007-1162, TISSUE SPECIFICITY.
    6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1025-1082.
    7. "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase."
      Colamonici O., Yan H., Domanski P., Handa R., Smalley D., Mullersman J., Witte M., Krishnan K., Krolewski J.
      Mol. Cell. Biol. 14:8133-8142(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF IFNAR1.
    8. "Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules."
      Steindler C., Li Z., Algarte M., Alcover A., Libri V., Ragimbeau J., Pellegrini S.
      J. Biol. Chem. 279:43168-43177(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH JAKMIP1.
    9. Cited for: INVOLVEMENT IN TYK2 DEFICIENCY.
    10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-292 AND SER-884, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-292 AND SER-884, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 888-1182 IN COMPLEX WITH INHIBITOR, PHOSPHORYLATION AT TYR-1054.
    13. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] PHE-362; SER-363; MET-386; SER-684; TRP-703; ARG-732; VAL-928; ALA-1104 AND GLY-1163.

    Entry informationi

    Entry nameiTYK2_HUMAN
    AccessioniPrimary (citable) accession number: P29597
    Secondary accession number(s): Q6QB10, Q96CH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 160 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

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