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P29597

- TYK2_HUMAN

UniProt

P29597 - TYK2_HUMAN

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Protein

Non-receptor tyrosine-protein kinase TYK2

Gene

TYK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei930 – 9301ATPPROSITE-ProRule annotation
Active sitei1023 – 10231Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi903 – 9119ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. growth hormone receptor binding Source: BHF-UCL
  3. non-membrane spanning protein tyrosine kinase activity Source: ProtInc
  4. protein tyrosine kinase activity Source: Reactome

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: Reactome
  2. intracellular signal transduction Source: InterPro
  3. peptidyl-tyrosine phosphorylation Source: GOC
  4. protein phosphorylation Source: ProtInc
  5. regulation of type I interferon-mediated signaling pathway Source: Reactome
  6. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2681.
ReactomeiREACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.
REACT_27307. Interleukin-6 signaling.
SignaLinkiP29597.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-receptor tyrosine-protein kinase TYK2 (EC:2.7.10.2)
Gene namesi
Name:TYK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:12440. TYK2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. cytoskeleton Source: InterPro
  3. cytosol Source: Reactome
  4. extracellular vesicular exosome Source: UniProt
  5. membrane Source: InterPro
  6. nucleus Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]: Consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Organism-specific databases

MIMi611521. phenotype.
Orphaneti331226. Autosomal recessive hyper-IgE syndrome due to TYK2 deficiency.
85408. Juvenile rheumatoid factor-negative polyarthritis.
85410. Oligoarticular juvenile arthritis.
PharmGKBiPA37094.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11871187Non-receptor tyrosine-protein kinase TYK2PRO_0000088177Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei292 – 2921Phosphotyrosine2 Publications
Modified residuei604 – 6041PhosphotyrosineBy similarity
Modified residuei884 – 8841Phosphoserine2 Publications
Modified residuei1054 – 10541Phosphotyrosine; by autocatalysis1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP29597.
PaxDbiP29597.
PRIDEiP29597.

PTM databases

PhosphoSiteiP29597.

Expressioni

Tissue specificityi

Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.1 Publication

Gene expression databases

BgeeiP29597.
CleanExiHS_TYK2.
ExpressionAtlasiP29597. baseline and differential.
GenevestigatoriP29597.

Organism-specific databases

HPAiHPA005157.

Interactioni

Subunit structurei

Interacts with JAKMIP1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP90AB1P082382EBI-1383454,EBI-352572

Protein-protein interaction databases

BioGridi113148. 40 interactions.
DIPiDIP-1062N.
IntActiP29597. 11 interactions.
MINTiMINT-107878.
STRINGi9606.ENSP00000264818.

Structurei

Secondary structure

1
1187
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 314
Beta strandi42 – 465
Beta strandi49 – 524
Helixi53 – 6412
Helixi68 – 736
Beta strandi74 – 785
Turni79 – 824
Beta strandi83 – 853
Beta strandi90 – 923
Turni93 – 986
Beta strandi101 – 1055
Turni110 – 1134
Beta strandi122 – 1243
Helixi146 – 16116
Helixi167 – 1693
Helixi173 – 19826
Helixi202 – 2087
Helixi211 – 2133
Helixi217 – 2259
Helixi228 – 24316
Helixi252 – 26615
Turni268 – 2714
Beta strandi273 – 28412
Helixi285 – 2873
Beta strandi314 – 3196
Turni320 – 3223
Beta strandi323 – 3286
Beta strandi375 – 3784
Helixi380 – 3823
Beta strandi383 – 3897
Beta strandi392 – 3976
Beta strandi400 – 4067
Helixi410 – 42718
Helixi436 – 4383
Helixi441 – 4499
Helixi457 – 4648
Beta strandi470 – 4756
Beta strandi483 – 49210
Beta strandi498 – 50811
Beta strandi514 – 5163
Beta strandi523 – 5253
Helixi526 – 5338
Beta strandi537 – 5404
Beta strandi543 – 5464
Beta strandi562 – 5654
Helixi586 – 5883
Beta strandi589 – 59810
Beta strandi601 – 6088
Beta strandi637 – 6448
Helixi649 – 66214
Beta strandi673 – 6797
Beta strandi682 – 6887
Helixi695 – 7017
Turni702 – 7043
Helixi708 – 72720
Helixi737 – 7393
Beta strandi740 – 7445
Beta strandi754 – 7574
Helixi764 – 7663
Helixi769 – 7746
Turni775 – 7784
Helixi781 – 7833
Helixi795 – 80814
Turni809 – 8113
Turni814 – 8174
Helixi820 – 8289
Helixi842 – 8487
Helixi853 – 8553
Helixi859 – 8679
Helixi894 – 8963
Beta strandi897 – 9059
Beta strandi907 – 91610
Beta strandi920 – 9223
Beta strandi925 – 9328
Helixi938 – 95316
Beta strandi962 – 9687
Turni969 – 9724
Beta strandi973 – 9786
Helixi986 – 9894
Helixi990 – 9923
Helixi997 – 101620
Helixi1026 – 10283
Beta strandi1029 – 10313
Beta strandi1037 – 10393
Helixi1042 – 10443
Beta strandi1053 – 10564
Helixi1065 – 10673
Helixi1070 – 10756
Beta strandi1077 – 10793
Helixi1080 – 109516
Turni1096 – 10983
Helixi1100 – 11023
Helixi1104 – 11129
Helixi1117 – 112913
Helixi1142 – 115110
Helixi1156 – 11583
Helixi1162 – 117716

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LXNX-ray2.50A888-1182[»]
3LXPX-ray1.65A888-1182[»]
3NYXX-ray2.50A885-1176[»]
3NZ0X-ray2.00A885-1176[»]
3ZONX-ray2.15A541-873[»]
4GFOX-ray2.30A884-1176[»]
4GIHX-ray2.00A885-1176[»]
4GIIX-ray2.31A885-1176[»]
4GJ2X-ray2.40A885-1176[»]
4GJ3X-ray2.50A885-1176[»]
4GVJX-ray2.03A885-1176[»]
4OLIX-ray2.80A566-1187[»]
4PO6X-ray1.99A23-583[»]
4PY1X-ray2.16A888-1182[»]
ProteinModelPortaliP29597.
SMRiP29597. Positions 26-566, 577-870, 890-1177.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29597.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 431406FERMPROSITE-ProRule annotationAdd
BLAST
Domaini450 – 52980SH2; atypicalAdd
BLAST
Domaini589 – 875287Protein kinase 1PROSITE-ProRule annotationAdd
BLAST
Domaini897 – 1176280Protein kinase 2PROSITE-ProRule annotationAdd
BLAST

Domaini

The FERM domain mediates interaction with JAKMIP1.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.PROSITE-ProRule annotation
Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 2 protein kinase domains.PROSITE-ProRule annotation
Contains 1 SH2 domain.Curated

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118799.
HOGENOMiHOG000049158.
HOVERGENiHBG006195.
InParanoidiP29597.
KOiK11219.
OMAiFCDFQDI.
PhylomeDBiP29597.
TreeFamiTF327041.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045. Tyr_kinase_non-rcpt_TYK2_N.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR00109. TYRKINASE.
PR01827. YKINASETYK2.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29597 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLRHWGMAR GSKPVGDGAQ PMAAMGGLKV LLHWAGPGGG EPWVTFSESS
60 70 80 90 100
LTAEEVCIHI AHKVGITPPC FNLFALFDAQ AQVWLPPNHI LEIPRDASLM
110 120 130 140 150
LYFRIRFYFR NWHGMNPREP AVYRCGPPGT EASSDQTAQG MQLLDPASFE
160 170 180 190 200
YLFEQGKHEF VNDVASLWEL STEEEIHHFK NESLGMAFLH LCHLALRHGI
210 220 230 240 250
PLEEVAKKTS FKDCIPRSFR RHIRQHSALT RLRLRNVFRR FLRDFQPGRL
260 270 280 290 300
SQQMVMVKYL ATLERLAPRF GTERVPVCHL RLLAQAEGEP CYIRDSGVAP
310 320 330 340 350
TDPGPESAAG PPTHEVLVTG TGGIQWWPVE EEVNKEEGSS GSSGRNPQAS
360 370 380 390 400
LFGKKAKAHK AVGQPADRPR EPLWAYFCDF RDITHVVLKE HCVSIHRQDN
410 420 430 440 450
KCLELSLPSR AAALSFVSLV DGYFRLTADS SHYLCHEVAP PRLVMSIRDG
460 470 480 490 500
IHGPLLEPFV QAKLRPEDGL YLIHWSTSHP YRLILTVAQR SQAPDGMQSL
510 520 530 540 550
RLRKFPIEQQ DGAFVLEGWG RSFPSVRELG AALQGCLLRA GDDCFSLRRC
560 570 580 590 600
CLPQPGETSN LIIMRGARAS PRTLNLSQLS FHRVDQKEIT QLSHLGQGTR
610 620 630 640 650
TNVYEGRLRV EGSGDPEEGK MDDEDPLVPG RDRGQELRVV LKVLDPSHHD
660 670 680 690 700
IALAFYETAS LMSQVSHTHL AFVHGVCVRG PENIMVTEYV EHGPLDVWLR
710 720 730 740 750
RERGHVPMAW KMVVAQQLAS ALSYLENKNL VHGNVCGRNI LLARLGLAEG
760 770 780 790 800
TSPFIKLSDP GVGLGALSRE ERVERIPWLA PECLPGGANS LSTAMDKWGF
810 820 830 840 850
GATLLEICFD GEAPLQSRSP SEKEHFYQRQ HRLPEPSCPQ LATLTSQCLT
860 870 880 890 900
YEPTQRPSFR TILRDLTRLQ PHNLADVLTV NPDSPASDPT VFHKRYLKKI
910 920 930 940 950
RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK ALKADCGPQH RSGWKQEIDI
960 970 980 990 1000
LRTLYHEHII KYKGCCEDQG EKSLQLVMEY VPLGSLRDYL PRHSIGLAQL
1010 1020 1030 1040 1050
LLFAQQICEG MAYLHAQHYI HRDLAARNVL LDNDRLVKIG DFGLAKAVPE
1060 1070 1080 1090 1100
GHEYYRVRED GDSPVFWYAP ECLKEYKFYY ASDVWSFGVT LYELLTHCDS
1110 1120 1130 1140 1150
SQSPPTKFLE LIGIAQGQMT VLRLTELLER GERLPRPDKC PCEVYHLMKN
1160 1170 1180
CWETEASFRP TFENLIPILK TVHEKYQGQA PSVFSVC
Length:1,187
Mass (Da):133,650
Last modified:December 7, 2004 - v3
Checksum:iF76C25D6A919EDBC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti869 – 8691L → V in CAA38449. (PubMed:2216457)Curated
Sequence conflicti882 – 8821P → R in CAA38449. (PubMed:2216457)Curated
Sequence conflicti887 – 8882SD → VG in CAA38449. (PubMed:2216457)Curated
Sequence conflicti891 – 8911V → T in CAA38449. (PubMed:2216457)Curated
Sequence conflicti1016 – 10161A → S in AAH14243. (PubMed:15489334)Curated
Sequence conflicti1017 – 10182QH → HD in CAA38449. (PubMed:2216457)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41R → C.
Corresponds to variant rs35163004 [ dbSNP | Ensembl ].
VAR_037796
Natural varianti4 – 41R → H.1 Publication
Corresponds to variant rs12720343 [ dbSNP | Ensembl ].
VAR_020597
Natural varianti81 – 811A → V.
Corresponds to variant rs1049619 [ dbSNP | Ensembl ].
VAR_037797
Natural varianti197 – 1971R → H.1 Publication
Corresponds to variant rs12720263 [ dbSNP | Ensembl ].
VAR_020598
Natural varianti362 – 3621V → F.3 Publications
Corresponds to variant rs2304256 [ dbSNP | Ensembl ].
VAR_020599
Natural varianti363 – 3631G → S.2 Publications
Corresponds to variant rs2304255 [ dbSNP | Ensembl ].
VAR_020600
Natural varianti386 – 3861V → M.1 Publication
Corresponds to variant rs55956017 [ dbSNP | Ensembl ].
VAR_041870
Natural varianti442 – 4421R → Q.
Corresponds to variant rs2304254 [ dbSNP | Ensembl ].
VAR_037798
Natural varianti684 – 6841I → S.3 Publications
Corresponds to variant rs12720356 [ dbSNP | Ensembl ].
VAR_020286
Natural varianti703 – 7031R → W.1 Publication
Corresponds to variant rs55882956 [ dbSNP | Ensembl ].
VAR_041871
Natural varianti732 – 7321H → R in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041872
Natural varianti820 – 8201P → H.
Corresponds to variant rs34046749 [ dbSNP | Ensembl ].
VAR_037799
Natural varianti928 – 9281A → V.1 Publication
Corresponds to variant rs35018800 [ dbSNP | Ensembl ].
VAR_041873
Natural varianti1104 – 11041P → A.1 Publication
Corresponds to variant rs34536443 [ dbSNP | Ensembl ].
VAR_041874
Natural varianti1163 – 11631E → G.1 Publication
Corresponds to variant rs55886939 [ dbSNP | Ensembl ].
VAR_041875

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54637 mRNA. Translation: CAA38449.1.
AY549314 Genomic DNA. Translation: AAS37680.1.
BC014243 mRNA. Translation: AAH14243.1.
CCDSiCCDS12236.1.
PIRiS12127. TVHUY2.
RefSeqiNP_003322.3. NM_003331.4.
UniGeneiHs.75516.

Genome annotation databases

EnsembliENST00000264818; ENSP00000264818; ENSG00000105397.
ENST00000525621; ENSP00000431885; ENSG00000105397.
GeneIDi7297.
KEGGihsa:7297.
UCSCiuc002moc.4. human.

Polymorphism databases

DMDMi56405328.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

TYK2base

TYK2 mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54637 mRNA. Translation: CAA38449.1 .
AY549314 Genomic DNA. Translation: AAS37680.1 .
BC014243 mRNA. Translation: AAH14243.1 .
CCDSi CCDS12236.1.
PIRi S12127. TVHUY2.
RefSeqi NP_003322.3. NM_003331.4.
UniGenei Hs.75516.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3LXN X-ray 2.50 A 888-1182 [» ]
3LXP X-ray 1.65 A 888-1182 [» ]
3NYX X-ray 2.50 A 885-1176 [» ]
3NZ0 X-ray 2.00 A 885-1176 [» ]
3ZON X-ray 2.15 A 541-873 [» ]
4GFO X-ray 2.30 A 884-1176 [» ]
4GIH X-ray 2.00 A 885-1176 [» ]
4GII X-ray 2.31 A 885-1176 [» ]
4GJ2 X-ray 2.40 A 885-1176 [» ]
4GJ3 X-ray 2.50 A 885-1176 [» ]
4GVJ X-ray 2.03 A 885-1176 [» ]
4OLI X-ray 2.80 A 566-1187 [» ]
4PO6 X-ray 1.99 A 23-583 [» ]
4PY1 X-ray 2.16 A 888-1182 [» ]
ProteinModelPortali P29597.
SMRi P29597. Positions 26-566, 577-870, 890-1177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113148. 40 interactions.
DIPi DIP-1062N.
IntActi P29597. 11 interactions.
MINTi MINT-107878.
STRINGi 9606.ENSP00000264818.

Chemistry

BindingDBi P29597.
ChEMBLi CHEMBL2363062.
GuidetoPHARMACOLOGYi 2269.

PTM databases

PhosphoSitei P29597.

Polymorphism databases

DMDMi 56405328.

Proteomic databases

MaxQBi P29597.
PaxDbi P29597.
PRIDEi P29597.

Protocols and materials databases

DNASUi 7297.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264818 ; ENSP00000264818 ; ENSG00000105397 .
ENST00000525621 ; ENSP00000431885 ; ENSG00000105397 .
GeneIDi 7297.
KEGGi hsa:7297.
UCSCi uc002moc.4. human.

Organism-specific databases

CTDi 7297.
GeneCardsi GC19M010461.
H-InvDB HIX0202831.
HGNCi HGNC:12440. TYK2.
HPAi HPA005157.
MIMi 176941. gene.
611521. phenotype.
neXtProti NX_P29597.
Orphaneti 331226. Autosomal recessive hyper-IgE syndrome due to TYK2 deficiency.
85408. Juvenile rheumatoid factor-negative polyarthritis.
85410. Oligoarticular juvenile arthritis.
PharmGKBi PA37094.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118799.
HOGENOMi HOG000049158.
HOVERGENi HBG006195.
InParanoidi P29597.
KOi K11219.
OMAi FCDFQDI.
PhylomeDBi P29597.
TreeFami TF327041.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 2681.
Reactomei REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.
REACT_27307. Interleukin-6 signaling.
SignaLinki P29597.

Miscellaneous databases

ChiTaRSi TYK2. human.
EvolutionaryTracei P29597.
GeneWikii Tyrosine_kinase_2.
GenomeRNAii 7297.
NextBioi 28539.
PROi P29597.
SOURCEi Search...

Gene expression databases

Bgeei P29597.
CleanExi HS_TYK2.
ExpressionAtlasi P29597. baseline and differential.
Genevestigatori P29597.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045. Tyr_kinase_non-rcpt_TYK2_N.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 2 hits.
[Graphical view ]
PIRSFi PIRSF000636. TyrPK_Jak. 1 hit.
PRINTSi PR01823. JANUSKINASE.
PR00109. TYRKINASE.
PR01827. YKINASETYK2.
SMARTi SM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEi PS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TYK2, prototype of a novel class of non-receptor tyrosine kinase genes."
    Firmbach-Kraft I., Byers M., Shows T., Dalla-Favera R., Krolewski J.J.
    Oncogene 5:1329-1336(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PHE-362 AND SER-684.
  2. SeattleSNPs variation discovery resource
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-4; HIS-197; PHE-362; SER-363 AND SER-684.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. "A protein tyrosine kinase in the interferon alpha/beta signaling pathway."
    Velazquez L., Fellous M., Stark G.R., Pellegrini S.
    Cell 70:313-322(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 289-1187.
  5. "Identification and chromosomal mapping of new human tyrosine kinase genes."
    Krolewski J.J., Lee R., Eddy R., Shows T.B., Dalla-Favera R.
    Oncogene 5:277-282(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1007-1162, TISSUE SPECIFICITY.
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1025-1082.
  7. "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase."
    Colamonici O., Yan H., Domanski P., Handa R., Smalley D., Mullersman J., Witte M., Krishnan K., Krolewski J.
    Mol. Cell. Biol. 14:8133-8142(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF IFNAR1.
  8. "Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules."
    Steindler C., Li Z., Algarte M., Alcover A., Libri V., Ragimbeau J., Pellegrini S.
    J. Biol. Chem. 279:43168-43177(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH JAKMIP1.
  9. Cited for: INVOLVEMENT IN TYK2 DEFICIENCY.
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-292 AND SER-884, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-292 AND SER-884, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 888-1182 IN COMPLEX WITH INHIBITOR, PHOSPHORYLATION AT TYR-1054.
  13. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] PHE-362; SER-363; MET-386; SER-684; TRP-703; ARG-732; VAL-928; ALA-1104 AND GLY-1163.

Entry informationi

Entry nameiTYK2_HUMAN
AccessioniPrimary (citable) accession number: P29597
Secondary accession number(s): Q6QB10, Q96CH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: December 7, 2004
Last modified: October 29, 2014
This is version 161 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3