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Protein

Cyclic AMP-dependent transcription factor ATF-3

Gene

Atf3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

In solution, it binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters but also has affinity for related sites. May have a unique and critical role in growth regulation of regenerating liver and mitogen-stimulated cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-3
Short name:
cAMP-dependent transcription factor ATF-3
Alternative name(s):
Activating transcription factor 3
Liver regeneration factor 1
Short name:
LRF-1
Gene namesi
Name:Atf3
Synonyms:Lrf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi2165. Atf3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765831 – 181Cyclic AMP-dependent transcription factor ATF-3Add BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki78Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei162PhosphothreonineBy similarity1
Cross-linki175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP29596.

Expressioni

Tissue specificityi

In tissues containing skeletal muscle or smooth muscle, and at low levels in some tumor cells.

Inductioni

Rapidly and highly induced in regenerating liver and mitogen-stimulated cells.

Gene expression databases

BgeeiENSRNOG00000003745.
GenevisibleiP29596. RN.

Interactioni

Subunit structurei

ATF3 alone can bind DNA, but it preferentially forms heteromeric complexes with JUN and JUNB and does not interact with FOS.

GO - Molecular functioni

Protein-protein interaction databases

CORUMiP29596.
STRINGi10116.ENSRNOP00000005085.

Structurei

3D structure databases

ProteinModelPortaliP29596.
SMRiP29596.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 149bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 110Basic motifPROSITE-ProRule annotationAdd BLAST23
Regioni114 – 142Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110847.
HOGENOMiHOG000034126.
HOVERGENiHBG003381.
InParanoidiP29596.
KOiK09032.
OMAiLVYMLNL.
OrthoDBiEOG091G0M4N.
PhylomeDBiP29596.
TreeFamiTF326301.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiView protein in InterPro
IPR000837. AP-1.
IPR029812. ATF3.
IPR004827. bZIP.
IPR008917. TF_DNA-bd_sf.
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF23. PTHR23351:SF23. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

P29596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLQHPGQVS ASEVSATAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ
60 70 80 90 100
NKHLCHRMSS ALESVTINNR PLEMSVTKSE VAPEEDERKR RRRERNKIAA
110 120 130 140 150
AKCRNKKKEK TECLQKESEK LESVNAELKA QIEELKNEKQ HLIYMLNLHR
160 170 180
PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ S
Length:181
Mass (Da):20,764
Last modified:April 1, 1993 - v1
Checksum:iE36971E1A96F262B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63282 mRNA. Translation: AAA41542.1.
BC078903 mRNA. Translation: AAH78903.1.
PIRiA39382.
RefSeqiNP_037044.1. NM_012912.2.
UniGeneiRn.9664.

Genome annotation databases

EnsembliENSRNOT00000005085; ENSRNOP00000005085; ENSRNOG00000003745.
ENSRNOT00000089841; ENSRNOP00000071188; ENSRNOG00000003745.
GeneIDi25389.
KEGGirno:25389.

Similar proteinsi

Entry informationi

Entry nameiATF3_RAT
AccessioniPrimary (citable) accession number: P29596
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 22, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families