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Protein

Cyclic AMP-dependent transcription factor ATF-3

Gene

Atf3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

In solution, it binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters but also has affinity for related sites. May have a unique and critical role in growth regulation of regenerating liver and mitogen-stimulated cells.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-3
Short name:
cAMP-dependent transcription factor ATF-3
Alternative name(s):
Activating transcription factor 3
Liver regeneration factor 1
Short name:
LRF-1
Gene namesi
Name:Atf3
Synonyms:Lrf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi2165. Atf3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Cyclic AMP-dependent transcription factor ATF-3PRO_0000076583Add
BLAST

Proteomic databases

PaxDbiP29596.

Expressioni

Tissue specificityi

In tissues containing skeletal muscle or smooth muscle, and at low levels in some tumor cells.

Inductioni

Rapidly and highly induced in regenerating liver and mitogen-stimulated cells.

Gene expression databases

GenevisibleiP29596. RN.

Interactioni

Subunit structurei

ATF3 alone can bind DNA, but it preferentially forms heteromeric complexes with JUN and JUNB and does not interact with FOS.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005085.

Structurei

3D structure databases

ProteinModelPortaliP29596.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 14964bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni88 – 11023Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni114 – 14229Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110847.
HOGENOMiHOG000034126.
HOVERGENiHBG003381.
InParanoidiP29596.
KOiK09032.
OMAiMKAEVAP.
OrthoDBiEOG70S777.
PhylomeDBiP29596.
TreeFamiTF326301.

Family and domain databases

InterProiIPR000837. AP-1.
IPR029812. ATF3.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF23. PTHR23351:SF23. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLQHPGQVS ASEVSATAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ
60 70 80 90 100
NKHLCHRMSS ALESVTINNR PLEMSVTKSE VAPEEDERKR RRRERNKIAA
110 120 130 140 150
AKCRNKKKEK TECLQKESEK LESVNAELKA QIEELKNEKQ HLIYMLNLHR
160 170 180
PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ S
Length:181
Mass (Da):20,764
Last modified:April 1, 1993 - v1
Checksum:iE36971E1A96F262B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63282 mRNA. Translation: AAA41542.1.
BC078903 mRNA. Translation: AAH78903.1.
PIRiA39382.
RefSeqiNP_037044.1. NM_012912.2.
UniGeneiRn.9664.

Genome annotation databases

EnsembliENSRNOT00000005085; ENSRNOP00000005085; ENSRNOG00000003745.
ENSRNOT00000089841; ENSRNOP00000071188; ENSRNOG00000003745.
GeneIDi25389.
KEGGirno:25389.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63282 mRNA. Translation: AAA41542.1.
BC078903 mRNA. Translation: AAH78903.1.
PIRiA39382.
RefSeqiNP_037044.1. NM_012912.2.
UniGeneiRn.9664.

3D structure databases

ProteinModelPortaliP29596.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005085.

Proteomic databases

PaxDbiP29596.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005085; ENSRNOP00000005085; ENSRNOG00000003745.
ENSRNOT00000089841; ENSRNOP00000071188; ENSRNOG00000003745.
GeneIDi25389.
KEGGirno:25389.

Organism-specific databases

CTDi467.
RGDi2165. Atf3.

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110847.
HOGENOMiHOG000034126.
HOVERGENiHBG003381.
InParanoidiP29596.
KOiK09032.
OMAiMKAEVAP.
OrthoDBiEOG70S777.
PhylomeDBiP29596.
TreeFamiTF326301.

Miscellaneous databases

PROiP29596.

Gene expression databases

GenevisibleiP29596. RN.

Family and domain databases

InterProiIPR000837. AP-1.
IPR029812. ATF3.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF23. PTHR23351:SF23. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of LRF-1, a leucine-zipper protein that is rapidly and highly induced in regenerating liver."
    Hsu J.-C., Laz T., Mohn K.L., Taub R.
    Proc. Natl. Acad. Sci. U.S.A. 88:3511-3515(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiATF3_RAT
AccessioniPrimary (citable) accession number: P29596
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 8, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.