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P29564 (SUMT_METIV) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen-III C-methyltransferase

Short name=Urogen III methylase
EC=2.1.1.107
Alternative name(s):
SUMT
Uroporphyrinogen III methylase
Short name=UROM
Gene names
Name:cobA
Synonyms:corA
OrganismMethanobacterium ivanovii
Taxonomic identifier2163 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobacterium

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin.

Catalytic activity

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.

S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the precorrin methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 231230Uroporphyrinogen-III C-methyltransferase
PRO_0000150370

Regions

Region85 – 873S-adenosyl-L-methionine binding By similarity

Sites

Binding site101S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site1151S-adenosyl-L-methionine By similarity
Binding site1661S-adenosyl-L-methionine; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
P29564 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 6EB100DAA96EB37A

FASTA23124,916
        10         20         30         40         50         60 
MVVYLVGAGP GDPELITLKA VNVLKKADVV LYDKPANEEI LKYAEGAKLI YVGKQAGHHY 

        70         80         90        100        110        120 
KSQNEINTLL VEEAKENDLV VRLKGGDPFV FGRGGEEILA LVEEGIDFEL VPGVTSAIGV 

       130        140        150        160        170        180 
PTTIGLPVTH RGVATSFTVV TGHEDPTKCK KQVGWDFKAD TIVILMGIGN LAENTAEIMK 

       190        200        210        220        230 
HKDPETPVCV IENGTMEGQR IITGTLENIA GKDIKPPALV VLEMLSMFLK K 

« Hide

References

[1]"Purification, characterization, and molecular cloning of S-adenosyl-L-methionine: uroporphyrinogen III methyltransferase from Methanobacterium ivanovii."
Blanche F., Robin C., Couder M., Faucher D., Cauchois L., Cameron B., Crouzet J.
J. Bacteriol. 173:4637-4645(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-31 AND 201-212.
Strain: DSM 2611.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M62874 Genomic DNA. Translation: AAA72997.1.
PIRA42471.

3D structure databases

ProteinModelPortalP29564.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-12172.
UniPathwayUPA00148; UER00211.

Family and domain databases

Gene3D3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
InterProIPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PfamPF00590. TP_methylase. 1 hit.
[Graphical view]
SUPFAMSSF53790. SSF53790. 1 hit.
TIGRFAMsTIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEPS00839. SUMT_1. 1 hit.
PS00840. SUMT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUMT_METIV
AccessionPrimary (citable) accession number: P29564
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: October 16, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways