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P29560

- EDN1_RABIT

UniProt

P29560 - EDN1_RABIT

Protein

Endothelin-1

Gene

EDN1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Endothelins are endothelium-derived vasoconstrictor peptides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei73 – 742Cleavage; by KELBy similarity

    GO - Biological processi

    1. body fluid secretion Source: Ensembl
    2. calcium-mediated signaling Source: Ensembl
    3. cartilage development Source: Ensembl
    4. dorsal/ventral pattern formation Source: Ensembl
    5. glucose transport Source: Ensembl
    6. heart development Source: Ensembl
    7. inositol phosphate-mediated signaling Source: Ensembl
    8. in utero embryonic development Source: Ensembl
    9. middle ear morphogenesis Source: Ensembl
    10. negative regulation of cAMP biosynthetic process Source: Ensembl
    11. negative regulation of cellular protein metabolic process Source: Ensembl
    12. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
    13. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    14. neural crest cell development Source: Ensembl
    15. nitric oxide transport Source: Ensembl
    16. patterning of blood vessels Source: Ensembl
    17. peptide hormone secretion Source: Ensembl
    18. phosphatidylinositol 3-kinase signaling Source: Ensembl
    19. phospholipase D-activating G-protein coupled receptor signaling pathway Source: Ensembl
    20. positive regulation of cardiac muscle hypertrophy Source: Ensembl
    21. positive regulation of cell migration Source: Ensembl
    22. positive regulation of cell size Source: Ensembl
    23. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
    24. positive regulation of heart rate Source: Ensembl
    25. positive regulation of hormone secretion Source: Ensembl
    26. positive regulation of JUN kinase activity Source: Ensembl
    27. positive regulation of mitosis Source: Ensembl
    28. positive regulation of prostaglandin-endoperoxide synthase activity Source: Ensembl
    29. positive regulation of receptor biosynthetic process Source: Ensembl
    30. positive regulation of renal sodium excretion Source: Ensembl
    31. positive regulation of sarcomere organization Source: Ensembl
    32. positive regulation of smooth muscle cell proliferation Source: Ensembl
    33. positive regulation of urine volume Source: Ensembl
    34. prostaglandin biosynthetic process Source: Ensembl
    35. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    36. protein kinase C deactivation Source: Ensembl
    37. regulation of pH Source: Ensembl
    38. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
    39. regulation of vasoconstriction Source: InterPro
    40. respiratory gaseous exchange Source: Ensembl
    41. response to hypoxia Source: Ensembl
    42. rhythmic excitation Source: Ensembl
    43. vein smooth muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    Vasoactive, Vasoconstrictor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin-1
    Short name:
    ET-1
    Alternative name(s):
    Preproendothelin-1
    Short name:
    PPET1
    Gene namesi
    Name:EDN1
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Chromosome 12

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 5027PRO_0000008069Add
    BLAST
    Peptidei53 – 7321Endothelin-1PRO_0000008070Add
    BLAST
    Propeptidei74 – 202129PRO_0000008071Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 67By similarity
    Disulfide bondi55 ↔ 63By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000011526.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni110 – 12415Endothelin-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the endothelin/sarafotoxin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46593.
    GeneTreeiENSGT00530000063310.
    HOGENOMiHOG000231110.
    HOVERGENiHBG051441.
    OMAiMDYFPMI.
    OrthoDBiEOG7PS1H7.
    TreeFamiTF333184.

    Family and domain databases

    InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view]
    PfamiPF00322. Endothelin. 1 hit.
    [Graphical view]
    PRINTSiPR00365. ENDOTHELIN.
    SMARTiSM00272. END. 2 hits.
    [Graphical view]
    PROSITEiPS00270. ENDOTHELIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P29560-1 [UniParc]FASTAAdd to Basket

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    MDYFSMMVSL LLVAFHGAPE TAASGTELST GAENPGEKPP ASAPWRPRRS    50
    KRCSCSSLMD KECVYFCHLD IIWVNTPGHI VPYGLGSPSR SKRSLKDLFP 100
    TRAAYHKNRC QCTSPHDKKC WNFCQAGTEL RAQETMEKGR NNLKKGKDCS 150
    KLGKKCILQK LMQGRKIRRL EAISNSIKTS FHAAQLRAQL HREQKVTHNR 200
    TH 202
    Length:202
    Mass (Da):22,828
    Last modified:April 1, 1993 - v1
    Checksum:i22B41EA286D51286
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59931 mRNA. Translation: CAA42555.1.
    PIRiS20609.
    RefSeqiNP_001095166.1. NM_001101696.1.
    UniGeneiOcu.5758.

    Genome annotation databases

    EnsembliENSOCUT00000013396; ENSOCUP00000011526; ENSOCUG00000013396.
    GeneIDi100009270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59931 mRNA. Translation: CAA42555.1 .
    PIRi S20609.
    RefSeqi NP_001095166.1. NM_001101696.1.
    UniGenei Ocu.5758.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000011526.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSOCUT00000013396 ; ENSOCUP00000011526 ; ENSOCUG00000013396 .
    GeneIDi 100009270.

    Organism-specific databases

    CTDi 1906.

    Phylogenomic databases

    eggNOGi NOG46593.
    GeneTreei ENSGT00530000063310.
    HOGENOMi HOG000231110.
    HOVERGENi HBG051441.
    OMAi MDYFPMI.
    OrthoDBi EOG7PS1H7.
    TreeFami TF333184.

    Family and domain databases

    InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view ]
    Pfami PF00322. Endothelin. 1 hit.
    [Graphical view ]
    PRINTSi PR00365. ENDOTHELIN.
    SMARTi SM00272. END. 2 hits.
    [Graphical view ]
    PROSITEi PS00270. ENDOTHELIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of endothelin-1 cDNA from rabbit endothelial cells."
      Marsden P.A., Sultan P., Cybulsky M., Gimbrone M.A. Jr., Brenner B.M., Collins T.
      Biochim. Biophys. Acta 1129:249-250(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiEDN1_RABIT
    AccessioniPrimary (citable) accession number: P29560
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3