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Protein

Endothelin-1

Gene

EDN1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei73 – 742Cleavage; by KELBy similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Gene namesi
Name:EDN1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811 Componenti: Chromosome 12

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 5027PRO_0000008069Add
BLAST
Peptidei53 – 7321Endothelin-1PRO_0000008070Add
BLAST
Propeptidei74 – 202129PRO_0000008071Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 67By similarity
Disulfide bondi55 ↔ 63By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000011526.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 12415Endothelin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46593.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP29560.
KOiK16366.
OMAiCASQKDK.
OrthoDBiEOG7PS1H7.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYFSMMVSL LLVAFHGAPE TAASGTELST GAENPGEKPP ASAPWRPRRS
60 70 80 90 100
KRCSCSSLMD KECVYFCHLD IIWVNTPGHI VPYGLGSPSR SKRSLKDLFP
110 120 130 140 150
TRAAYHKNRC QCTSPHDKKC WNFCQAGTEL RAQETMEKGR NNLKKGKDCS
160 170 180 190 200
KLGKKCILQK LMQGRKIRRL EAISNSIKTS FHAAQLRAQL HREQKVTHNR

TH
Length:202
Mass (Da):22,828
Last modified:April 1, 1993 - v1
Checksum:i22B41EA286D51286
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59931 mRNA. Translation: CAA42555.1.
PIRiS20609.
RefSeqiNP_001095166.1. NM_001101696.1.
UniGeneiOcu.5758.

Genome annotation databases

EnsembliENSOCUT00000013396; ENSOCUP00000011526; ENSOCUG00000013396.
GeneIDi100009270.
KEGGiocu:100009270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59931 mRNA. Translation: CAA42555.1.
PIRiS20609.
RefSeqiNP_001095166.1. NM_001101696.1.
UniGeneiOcu.5758.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000011526.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000013396; ENSOCUP00000011526; ENSOCUG00000013396.
GeneIDi100009270.
KEGGiocu:100009270.

Organism-specific databases

CTDi1906.

Phylogenomic databases

eggNOGiNOG46593.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP29560.
KOiK16366.
OMAiCASQKDK.
OrthoDBiEOG7PS1H7.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of endothelin-1 cDNA from rabbit endothelial cells."
    Marsden P.A., Sultan P., Cybulsky M., Gimbrone M.A. Jr., Brenner B.M., Collins T.
    Biochim. Biophys. Acta 1129:249-250(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiEDN1_RABIT
AccessioniPrimary (citable) accession number: P29560
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 22, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.