Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P29560

- EDN1_RABIT

UniProt

P29560 - EDN1_RABIT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Endothelin-1

Gene

EDN1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei73 – 742Cleavage; by KELBy similarity

GO - Biological processi

  1. body fluid secretion Source: Ensembl
  2. calcium-mediated signaling Source: Ensembl
  3. cartilage development Source: Ensembl
  4. dorsal/ventral pattern formation Source: Ensembl
  5. glucose transport Source: Ensembl
  6. heart development Source: Ensembl
  7. inositol phosphate-mediated signaling Source: Ensembl
  8. in utero embryonic development Source: Ensembl
  9. middle ear morphogenesis Source: Ensembl
  10. negative regulation of cAMP biosynthetic process Source: Ensembl
  11. negative regulation of cellular protein metabolic process Source: Ensembl
  12. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  13. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  14. neural crest cell development Source: Ensembl
  15. nitric oxide transport Source: Ensembl
  16. patterning of blood vessels Source: Ensembl
  17. peptide hormone secretion Source: Ensembl
  18. phosphatidylinositol 3-kinase signaling Source: Ensembl
  19. phospholipase D-activating G-protein coupled receptor signaling pathway Source: Ensembl
  20. positive regulation of cardiac muscle hypertrophy Source: Ensembl
  21. positive regulation of cell migration Source: Ensembl
  22. positive regulation of cell size Source: Ensembl
  23. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  24. positive regulation of heart rate Source: Ensembl
  25. positive regulation of hormone secretion Source: Ensembl
  26. positive regulation of JUN kinase activity Source: Ensembl
  27. positive regulation of mitosis Source: Ensembl
  28. positive regulation of prostaglandin-endoperoxide synthase activity Source: Ensembl
  29. positive regulation of receptor biosynthetic process Source: Ensembl
  30. positive regulation of renal sodium excretion Source: Ensembl
  31. positive regulation of sarcomere organization Source: Ensembl
  32. positive regulation of smooth muscle cell proliferation Source: Ensembl
  33. positive regulation of urine volume Source: Ensembl
  34. prostaglandin biosynthetic process Source: Ensembl
  35. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  36. protein kinase C deactivation Source: Ensembl
  37. regulation of pH Source: Ensembl
  38. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
  39. regulation of vasoconstriction Source: InterPro
  40. respiratory gaseous exchange Source: Ensembl
  41. response to hypoxia Source: Ensembl
  42. rhythmic excitation Source: Ensembl
  43. vein smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Gene namesi
Name:EDN1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Chromosome 12

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 5027PRO_0000008069Add
BLAST
Peptidei53 – 7321Endothelin-1PRO_0000008070Add
BLAST
Propeptidei74 – 202129PRO_0000008071Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 67By similarity
Disulfide bondi55 ↔ 63By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000011526.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 12415Endothelin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46593.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP29560.
OMAiMDYFPMI.
OrthoDBiEOG7PS1H7.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29560 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYFSMMVSL LLVAFHGAPE TAASGTELST GAENPGEKPP ASAPWRPRRS
60 70 80 90 100
KRCSCSSLMD KECVYFCHLD IIWVNTPGHI VPYGLGSPSR SKRSLKDLFP
110 120 130 140 150
TRAAYHKNRC QCTSPHDKKC WNFCQAGTEL RAQETMEKGR NNLKKGKDCS
160 170 180 190 200
KLGKKCILQK LMQGRKIRRL EAISNSIKTS FHAAQLRAQL HREQKVTHNR

TH
Length:202
Mass (Da):22,828
Last modified:April 1, 1993 - v1
Checksum:i22B41EA286D51286
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59931 mRNA. Translation: CAA42555.1.
PIRiS20609.
RefSeqiNP_001095166.1. NM_001101696.1.
UniGeneiOcu.5758.

Genome annotation databases

EnsembliENSOCUT00000013396; ENSOCUP00000011526; ENSOCUG00000013396.
GeneIDi100009270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59931 mRNA. Translation: CAA42555.1 .
PIRi S20609.
RefSeqi NP_001095166.1. NM_001101696.1.
UniGenei Ocu.5758.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000011526.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSOCUT00000013396 ; ENSOCUP00000011526 ; ENSOCUG00000013396 .
GeneIDi 100009270.

Organism-specific databases

CTDi 1906.

Phylogenomic databases

eggNOGi NOG46593.
GeneTreei ENSGT00530000063310.
HOGENOMi HOG000231110.
HOVERGENi HBG051441.
InParanoidi P29560.
OMAi MDYFPMI.
OrthoDBi EOG7PS1H7.
TreeFami TF333184.

Family and domain databases

InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view ]
Pfami PF00322. Endothelin. 1 hit.
[Graphical view ]
PRINTSi PR00365. ENDOTHELIN.
SMARTi SM00272. END. 2 hits.
[Graphical view ]
PROSITEi PS00270. ENDOTHELIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of endothelin-1 cDNA from rabbit endothelial cells."
    Marsden P.A., Sultan P., Cybulsky M., Gimbrone M.A. Jr., Brenner B.M., Collins T.
    Biochim. Biophys. Acta 1129:249-250(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiEDN1_RABIT
AccessioniPrimary (citable) accession number: P29560
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3