SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P29560

- EDN1_RABIT

UniProt

P29560 - EDN1_RABIT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Endothelin-1

Gene
EDN1
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei73 – 742Cleavage; by KEL By similarity

GO - Biological processi

  1. body fluid secretion Source: Ensembl
  2. calcium-mediated signaling Source: Ensembl
  3. cartilage development Source: Ensembl
  4. dorsal/ventral pattern formation Source: Ensembl
  5. glucose transport Source: Ensembl
  6. heart development Source: Ensembl
  7. inositol phosphate-mediated signaling Source: Ensembl
  8. in utero embryonic development Source: Ensembl
  9. middle ear morphogenesis Source: Ensembl
  10. negative regulation of cAMP biosynthetic process Source: Ensembl
  11. negative regulation of cellular protein metabolic process Source: Ensembl
  12. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  13. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  14. neural crest cell development Source: Ensembl
  15. nitric oxide transport Source: Ensembl
  16. patterning of blood vessels Source: Ensembl
  17. peptide hormone secretion Source: Ensembl
  18. phosphatidylinositol 3-kinase signaling Source: Ensembl
  19. phospholipase D-activating G-protein coupled receptor signaling pathway Source: Ensembl
  20. positive regulation of cardiac muscle hypertrophy Source: Ensembl
  21. positive regulation of cell migration Source: Ensembl
  22. positive regulation of cell size Source: Ensembl
  23. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  24. positive regulation of heart rate Source: Ensembl
  25. positive regulation of hormone secretion Source: Ensembl
  26. positive regulation of JUN kinase activity Source: Ensembl
  27. positive regulation of mitosis Source: Ensembl
  28. positive regulation of prostaglandin-endoperoxide synthase activity Source: Ensembl
  29. positive regulation of receptor biosynthetic process Source: Ensembl
  30. positive regulation of renal sodium excretion Source: Ensembl
  31. positive regulation of sarcomere organization Source: Ensembl
  32. positive regulation of smooth muscle cell proliferation Source: Ensembl
  33. positive regulation of urine volume Source: Ensembl
  34. prostaglandin biosynthetic process Source: Ensembl
  35. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  36. protein kinase C deactivation Source: Ensembl
  37. regulation of pH Source: Ensembl
  38. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
  39. regulation of vasoconstriction Source: InterPro
  40. respiratory gaseous exchange Source: Ensembl
  41. response to hypoxia Source: Ensembl
  42. rhythmic excitation Source: Ensembl
  43. vein smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Gene namesi
Name:EDN1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Chromosome 12

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Propeptidei24 – 5027PRO_0000008069Add
BLAST
Peptidei53 – 7321Endothelin-1PRO_0000008070Add
BLAST
Propeptidei74 – 202129PRO_0000008071Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 67 By similarity
Disulfide bondi55 ↔ 63 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000011526.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 12415Endothelin-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46593.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
OMAiMDYFPMI.
OrthoDBiEOG7PS1H7.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29560-1 [UniParc]FASTAAdd to Basket

« Hide

MDYFSMMVSL LLVAFHGAPE TAASGTELST GAENPGEKPP ASAPWRPRRS    50
KRCSCSSLMD KECVYFCHLD IIWVNTPGHI VPYGLGSPSR SKRSLKDLFP 100
TRAAYHKNRC QCTSPHDKKC WNFCQAGTEL RAQETMEKGR NNLKKGKDCS 150
KLGKKCILQK LMQGRKIRRL EAISNSIKTS FHAAQLRAQL HREQKVTHNR 200
TH 202
Length:202
Mass (Da):22,828
Last modified:April 1, 1993 - v1
Checksum:i22B41EA286D51286
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59931 mRNA. Translation: CAA42555.1.
PIRiS20609.
RefSeqiNP_001095166.1. NM_001101696.1.
UniGeneiOcu.5758.

Genome annotation databases

EnsembliENSOCUT00000013396; ENSOCUP00000011526; ENSOCUG00000013396.
GeneIDi100009270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59931 mRNA. Translation: CAA42555.1 .
PIRi S20609.
RefSeqi NP_001095166.1. NM_001101696.1.
UniGenei Ocu.5758.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000011526.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSOCUT00000013396 ; ENSOCUP00000011526 ; ENSOCUG00000013396 .
GeneIDi 100009270.

Organism-specific databases

CTDi 100009270.

Phylogenomic databases

eggNOGi NOG46593.
GeneTreei ENSGT00530000063310.
HOGENOMi HOG000231110.
HOVERGENi HBG051441.
OMAi MDYFPMI.
OrthoDBi EOG7PS1H7.
TreeFami TF333184.

Family and domain databases

InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view ]
Pfami PF00322. Endothelin. 1 hit.
[Graphical view ]
PRINTSi PR00365. ENDOTHELIN.
SMARTi SM00272. END. 2 hits.
[Graphical view ]
PROSITEi PS00270. ENDOTHELIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of endothelin-1 cDNA from rabbit endothelial cells."
    Marsden P.A., Sultan P., Cybulsky M., Gimbrone M.A. Jr., Brenner B.M., Collins T.
    Biochim. Biophys. Acta 1129:249-250(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiEDN1_RABIT
AccessioniPrimary (citable) accession number: P29560
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi