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Protein

Lantibiotic nisin-Z

Gene

nisZ

Organism
Lactococcus lactis subsp. lactis (Streptococcus lactis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Bacteriocin, Lantibiotic

Names & Taxonomyi

Protein namesi
Recommended name:
Lantibiotic nisin-Z
Gene namesi
Name:nisZ
OrganismiLactococcus lactis subsp. lactis (Streptococcus lactis)
Taxonomic identifieri1360 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Chemistry databases

DrugBankiDB07780 FARNESYL DIPHOSPHATE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000171241 – 23Add BLAST23
PeptideiPRO_000001712524 – 57Lantibiotic nisin-ZAdd BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei252,3-didehydrobutyrine1 Publication1
Cross-linki26 ↔ 30Lanthionine (Ser-Cys)1 Publication
Modified residuei282,3-didehydroalanine (Ser)1 Publication1
Cross-linki31 ↔ 34Beta-methyllanthionine (Thr-Cys)1 Publication
Cross-linki36 ↔ 42Beta-methyllanthionine (Thr-Cys)1 Publication
Cross-linki46 ↔ 49Beta-methyllanthionine (Thr-Cys)1 Publication
Cross-linki48 ↔ 51Beta-methyllanthionine (Thr-Cys)1 Publication
Modified residuei562,3-didehydroalanine (Ser)1 Publication1

Post-translational modificationi

Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor.
The structure of the 2,3-didehydrobutyrine is not discussed in PubMed:15361862. It is probably the Z-isomer by similarity.

Keywords - PTMi

Thioether bond

Interactioni

GO - Molecular functioni

Structurei

Secondary structure

157
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi32 – 35Combined sources4
Turni38 – 40Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WCONMR-N24-57[»]
ProteinModelPortaliP29559
SMRiP29559
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29559

Family & Domainsi

Sequence similaritiesi

Belongs to the type A lantibiotic family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR006079 Lantibiotic_typ-A_Bacillales
PfamiView protein in Pfam
PF02052 Gallidermin, 1 hit
PRINTSiPR00324 NISIN
TIGRFAMsiTIGR03731 lantibio_gallid, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29559-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKDFNLDL VSVSKKDSGA SPRITSISLC TPGCKTGALM GCNMKTATCN

CSIHVSK
Length:57
Mass (Da):5,940
Last modified:April 1, 1993 - v1
Checksum:iDF5E4428AC70BFEF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti50N → H in strain: JCM 7638. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61144 Genomic DNA Translation: CAA43440.1
D10768 Genomic DNA Translation: BAA01598.1
Z18947 Genomic DNA Translation: CAA79467.1
RefSeqiWP_015425978.1, NZ_PKRZ01000001.1

Similar proteinsi

Entry informationi

Entry nameiLANZ_LACLL
AccessioniPrimary (citable) accession number: P29559
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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